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Hepatic cirrhosis cytology

Jodie A Barkin, Cynthia Levy, Enrico O Souto
Primary sclerosing cholangitis (PSC) remains a rare but potentially devastating chronic, cholestatic liver disease. PSC causes obstruction of intra- and/or extra-hepatic bile ducts by inflammation and fibrosis, leading to biliary obstruction, cirrhosis and portal hypertension with all associated sequelae. The most dreaded consequence of PSC is cholangiocarcinoma, occurring in 10-20% of patients with PSC, and with population-based estimates of a 398-fold increased risk of cholangiocarcinoma in patients with PSC compared to the general population...
November 2017: Annals of Hepatology
Abdul Hamid Alraiyes, Pichapong Tunsupon, Fayez Kheir, Daniel A Salerno
OBJECTIVE: We presented a rare case of recurrent hepatocellular carcinoma after liver transplant manifested as an isolated mediastinal mass. METHODS: A 62-year-old man was referred for evaluation of atypical chest pain and abnormal finding of a computed tomography of the chest. He had history of chronic hepatitis C liver cirrhosis and hepatocellular carcinoma underwent orthotopic liver transplant as a curative treatment three years earlier. RESULTS: The computed tomography of the chest demonstrated paratracheal mediastinal lymphadenopathy...
2016: SAGE open medical case reports
Ghassan M Hammoud, Jamal A Ibdah
Endoscopic ultrasound (EUS) has revolutionized the diagnostic and therapeutic approach to patients with gastrointestinal disorders. Its application in patients with liver disease and portal hypertension is increasing. Patients with chronic liver disease are at risk for development of portal hypertension sequale such as ascites, spontaneous bacterial peritonitis and gastroesophageal varices. Bleeding esophageal and gastric varices are among the most common causes of mortality in patients with cirrhosis. Thus, early detection and treatment improve the outcome in this population...
October 21, 2014: World Journal of Gastroenterology: WJG
Aileen Wee
The differential diagnoses of fine needle aspiration (FNA) biopsy of a well-differentiated hepatocellular nodule (WDHN) in a woman with hepatitis B cirrhosis are discussed. Radiological diagnosis was a large regenerative nodule containing fat.Establish representative sampling.In cirrhosis, differential diagnosis include large regenerative nodule, dysplastic nodule (low- or high-grade), and early to progressed hepatocellular carcinoma (HCC). A nodule-in-nodule lesion occurs when there is malignant transformation in a benign parent nodule...
October 2014: Pathology
Răzvana Munteanu Dănulescu, C Stanciu, Anca Trifan
AIM: The current trend is to analyze predictive factors of transition from compensated to decompensated stage by the onset of ascites and later of spontaneous bacterial peritonitis (SBP), which would make possible an early diagnosis of liver cirrhosis at the compensated stage. The aim of the study is to evaluate patients with liver cirrhosis, assessing the rate and the risk factors of decompensation by ascites and SBP. MATERIAL AND METHODS: The prospective study included patients with cirrhosis of different etiologies admitted to a ward of the Institute of Gastroenterology and Hepatology of Iaşi in the period 1st January 2010-31st December 2010, which were reassessed clinically and in laboratory for 2 years...
April 2014: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Simone Maurea, Pier Paolo Mainenti, Annamaria Tambasco, Massimo Imbriaco, Carmine Mollica, Ettore Laccetti, Luigi Camera, Raffaele Liuzzi, Marco Salvatore
To compare the diagnostic value of gadolinium (Gd) and ultrasmall superparamagnetic iron oxide (SPIO) contrast media for characterization of focal liver lesions (FLL), we retrospectively evaluated the results of magnetic resonance (MR) imaging in 68 patients (40 M, 28 F, age from 22 to 81 yrs) of which 36 with diagnosis of colo-rectal cancer, 26 with hepatic cirrhosis and 6 with incidental imaging detection of FLL. MR (Gyroscan Intera 1.5 T, Philips Medical Systems) study was performed using T1 and T2 fast-field-echo (FFE) and T2 turbo-spin-echo (TSE) sequences in axial and coronal views...
June 2014: Quantitative Imaging in Medicine and Surgery
He-Bin Fan, Dong-Liang Yang, Yong Guo, An-Shen Chen, Mu-Xiu Zhou, Juan-Juan Wu, Xiao-Ju Ma, Zhi Li
This study describes a rare case of Human Immunodeficiency Virus and Human Herpes Virus 8 (HHV-8) negative primary effusion lymphoma (PEL)-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis, diagnosed in a 66-year-old male who rapidly progressed to a sense of abdominal fullness. Cytological analysis of the pleural effusion demonstrated large atypical lymphoid cells with rounded nuclei, prominent nucleoli, and abundant cytoplasm. Immunocytochemistry of the pleural effusion detected atypical CD20(+) lymphoid cells...
February 2014: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Sana Ben Amor, Mohamed Zakaria Saied, Mohamed Salah Harzallah, Sofiene Benammou
PURPOSE: The present report illustrates two men aged for 59 and 43 years, respectively, who presented with slowly progressive spastic paraparesis. STUDY DESIGN: Two case reports and review of literature. METHODS: The patent's history, clinical examination, biology, magnetic resonance imaging (MRI) findings and treatment are reported. We also discuss the pathogenesis and various treatment options. RESULTS: Neurologic examination showed spastic paraparesis without other neurological disorders...
May 2014: European Spine Journal
Mihaela Dinu, Ana Claudia Georgescu, Raluca Niculina Ciurea, Mirela Ştefan
Cirrhosis, end-stage of many liver diseases, presents many complications during its evolution. One of these is the presence of pleural fluid collection syndrome. This may be a direct consequence of liver disease (hepatic hydrothorax) or may be a random association. A formidable complication due to its consequences is spontaneous pleural empyema. The present study aimed to assess the incidence, the factors that influence its occurrence, and the frequency of the infectious complication.
2012: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Anna Mrzljak, Ika Kardum-Skelin, Darko Blasković, Dinko Skegro, Stipislav Jadrijević, Vesna Colić-Cvrlje
Ultrasound guided fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) are effective methods for the diagnosis of focal hepatic lesions. In case of neoplastic lesions, however, this may be followed by the seeding of malignant cells along the needle tract. We report a case of subcutaneous needle tract seeding of hepatocellular carcinoma (HCC) 25 months after liver transplantation. A 57-year-old man with compensated hepatitis-B-related liver cirrhosis was diagnosed with HCC by CNB, and the lesion was resected...
September 2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Branislav Kocman, Ika Kardum-Skelin, Tajana Filipec-Kanizaj, Anna Mrzljak, Slavica Naumovski-Mihalić, Zeljko Vidas, Dragica Obad Kovacević, Ivica Kocman
Hepatocellular carcinoma mostly develops in patients with liver cirrhosis due to chronic hepatitis C virus (HCV) infection. A case is presented of a patient with hepatorenal syndrome as a sequel of liver cirrhosis due to HCV infection. Primary tumor of the liver was not diagnosed by routine procedures, but by fine needle aspiration cytology of the extensive osteolytic lesion of the pelvic bone, performed as part of the pre-transplantation workup. Transplantation procedure was abandoned because of inappropriate donor liver (hepatic artery thrombosis), and palliative pain-relieving irradiation was recommended...
September 2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Nataliya Razumilava, Gregory J Gores
Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. Classification of CCAs into intrahepatic, perihilar, and distal subgroups has helped standardize the registration, treatment, and study of this lethal malignancy. Physicians should remain aware that cirrhosis and viral hepatitis B and C are predisposing conditions for intrahepatic CCA. Treatment options under development include locoregional therapies and a chemotherapy regimen of gemcitabine and cisplatin...
January 2013: Clinical Gastroenterology and Hepatology
Ozlem Guzel Tunccan, Abdurrahman Tufan, Gülçin Telli, Nalan Akyürek, Merve Pamukçuoğlu, Güldal Yılmaz, Kenan Hızel
Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In addition to typical clinical findings as fever, hepatosplenomegaly, and cachexia, VL is associated with autoimmune phenomena. To date, VL mimicking or exacerbating various autoimmune diseases have been described, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and autoimmune hepatitis (AIH). Herein, we presented a patient with VL who had overlapping clinical features with SLE, AIH, as well as antimitochondrial antibody (AMA-M2) positive primary biliary cirrhosis...
June 2012: Korean Journal of Parasitology
Ryan McKnight, Aziza Nassar, Cynthia Cohen, Momin T Siddiqui
BACKGROUND: Arginase-I is a key urea cycle metalloenzyme that has been used as an immunohistochemistry (IHC) marker for hepatocellular carcinoma (HCC). Previous studies have demonstrated the efficacy of HepPar-1 and glypican-3 (GPC-3) IHC in liver fine needle aspiration (FNA) cytology. METHODS: Arginase-1 IHC was performed on FNA cell blocks, and its performance characteristics were compared with HepPar-1 and GPC-3. Ninety-two formalin-fixed, paraffin-embedded cell blocks were selected (HCC [n = 44], cirrhosis [n = 2], focal nodular hyperplasia [n = 3], hepatic adenomas [n = 2], dysplastic nodules [n = 6], and metastatic carcinomas [n = 35])...
August 25, 2012: Cancer Cytopathology
Mallikarjuna Cm Swamy, Ca Arathi, Cr Kodandaswamy
BACKGROUND: The evaluation and management of various hepatic lesions is a common clinical problem and their appropriate clinical management depends on accurate diagnoses. AIMS: To study the cytomorphological features of distinctive non-neoplastic and neoplastic lesions of the liver and to evaluate the sensitivity, specificity and diagnostic accuracy of ultrasonography (USG)-guided fine needle aspiration cytology (FNAC) in the diagnosis of liver diseases. MATERIALS AND METHODS: Seventy-two patients with evidence of liver diseases underwent USG-guided, percutaneous FNAC...
October 2011: Journal of Cytology
Aileen Wee
The role of hepatic fine-needle aspiration (FNA) biopsy has evolved. Advances in imaging modalities have obviated the need for tissue confirmation in most hepatocellular carcinomas (HCCs). There is risk of needle-tract seeding. Increasingly, small nodules are being detected on ultrasound surveillance of high-risk patients. Diagnostic challenges associated with cirrhosis include distinction of benign hepatocellular nodules, namely, large regenerative nodules and dysplastic nodules, from reactive hepatocytes; and distinction of well-differentiated HCCs from benign hepatocellular nodules...
2011: Pathology Research International
S Friman
The treatment for cholangiocarcinoma (CCA) remains a challenge because of the aggressive nature of the disease and the absence of effective treatments besides surgical resection (HR) and liver transplantation (LT). In intrahepatic CCA, HR remains the treatment of choice whereas with concomitant liver disease such as cirrhosis or primary sclerosing cholangitis (PSC), LT is the only option. Hilar CCA or Klatskin tumours have in recent decades been managed with a more aggressive surgical approach to achieve R0 resection...
2011: Scandinavian Journal of Surgery: SJS
Josué Barahona-Garrido, Jorge Hernández-Calleros, Félix I Téllez-Avila, Norberto C Chávez-Tapia, José M Remes-Troche, Aldo Torre
AIM: To analyze the mortality risk factors in cirrhotic patients with bacterial meningitis (BM). BACKGROUND: Cirrhotic patients are susceptible to infections. Despite its high mortality rate, BM has not been extensively studied in this group of patients. STUDY: BM patients diagnosed with cirrhosis, between 1987 and 2008, were studied. BM was defined as the presence of signs or symptoms of meningitis and a cerebrospinal fluid (CSF) leukocyte count >100/mm3 or the presence of bacteria in CSF...
October 2010: Journal of Clinical Gastroenterology
Catharine M Sturgeon, Michael J Duffy, Barry R Hofmann, Rolf Lamerz, Herbert A Fritsche, Katja Gaarenstroom, Johannes Bonfrer, Thorsten H Ecke, H Barton Grossman, Peter Hayes, Ralf-Thorsten Hoffmann, Seth P Lerner, Florian Löhe, Johanna Louhimo, Ihor Sawczuk, Kazuhisa Taketa, Eleftherios P Diamandis
BACKGROUND: Updated National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been developed. METHODS: Published reports relevant to use of tumor markers for 4 cancer sites--liver, bladder, cervical, and gastric--were critically reviewed. RESULTS: Alpha-fetoprotein (AFP) may be used in conjunction with abdominal ultrasound for early detection of hepatocellular carcinoma (HCC) in patients with chronic hepatitis or cirrhosis associated with hepatitis B or C virus infection...
June 2010: Clinical Chemistry
V A Ershov, A L Biazovaia, O V Narvskaia
Trepan biopsy specimens were studied in 12 patients with hepatic cirrhosis-cancer and in 22 patients with hepatic cirrhosis. Blood antibodies to hepatitis C virus (HCV) or HBsAg were detected in 50% of the patients with hepatic cirrhosis-cancer and in 18.1% of those with hepatic cirrhosis. Polymerase chain reaction detection of HCV DNA in the cells of trepan biopsy specimens suggests its role in the pathogenesis of hepatic cirrhosis and hepatic cirrhosis-cancer. The cytological criteria for hepatic cirrhosis-cancer, unlike hepatic cirrhosis, are that the cytological specimen shows a preponderance of atypical hepatocytes with hyperchromic angular nuclei occupying the bulk of a cell, as well as mitoses in them...
September 2009: Klinicheskaia Laboratornaia Diagnostika
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