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cervicouterine cancer

Luis Sánchez-Sánchez, María Guadalupe Hernández-Linares, María L Escobar, Hugo López-Muñoz, Edgar Zenteno, María A Fernández-Herrera, Gabriel Guerrero-Luna, Alan Carrasco-Carballo, Jesús Sandoval-Ramírez
Steroidal sapogenins have shown antiproliferative effects against several tumor cell lines; and their effects on human cancer cells are currently under study. Changes in the functionality on the steroidal structure make it possible to modify the biological activity of compounds. Herein, we report the synthesis and in vitro antitumor activity of two steroidal oxime compounds on cervical cancer cells. These derivatives were synthesized from the steroidal sapogenin diosgenin in good yields. The in vitro assays show that the steroidal oximes show significant antiproliferative activity compared to the one observed for diosgenin...
November 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Víctor Manuel Vargas-Hernández, Víctor Manuel Vargas-Aguilar, José María Tovar-Rodríguez
Cervico-uterine cancer screening with cytology decrease incidence by more than 50%. The cause of this cancer is the human papilloma virus high risk, and requires a sensitive test to provide sufficient sensitivity and specificity for early detection and greater interval period when the results are negative. The test of the human papilloma virus high risk, is effective and safe because of its excellent sensitivity, negative predictive value and optimal reproducibility, especially when combined with liquid-based cytology or biomarkers with viral load, with higher sensitivity and specificity, by reducing false positives for the detection of cervical intraepithelial neoplasia grade 2 or greater injury, with excellent clinical benefits to cervical cancer screening and related infection of human papilloma virus diseases, is currently the best test for early detection infection of human papillomavirus and the risk of carcinogenesis...
September 2015: Cirugia y Cirujanos
Elsa Yunes-Díaz, Patricia Alonso-de Ruiz, Eduardo Lazcano-Ponce
BACKGROUND AND AIMS: An assessment was performed of the quality of Pap readings in 19 cytology laboratories (CLs) in Mexico from the Cervical Cancer Screening Program. METHODS: Nine CLs were affiliated with the Health Ministry (SSA), and ten were affiliated with the Mexican Social Security Institute (IMSS). Two sets of 200 cervical cytology specimens were prepared, one set for each institution. Fourteen percent of the specimens were positive and six were inappropriate for diagnosis (3%)...
May 2015: Archives of Medical Research
María A Fernández-Herrera, Jesús Sandoval-Ramírez, Luis Sánchez-Sánchez, Hugo López-Muñoz, María L Escobar-Sánchez
Diverse steroidal compounds have shown antiproliferative activity on certain tumor cell lines; however, their complete role on cancer cells has not been extensively established since the research is quite recent. Hence, deeper study in this field is required. Due to the importance of selenium in animal and human health; herein, we report the synthesis, characterization, and biological evaluation of two novel 22-oxo-26-selenocyanocholestanic steroids on cervicouterine cancer cells and non-tumor cells. The title compounds were straightforward prepared from diosgenin and hecogenin in excellent overall yields...
March 3, 2014: European Journal of Medicinal Chemistry
María Gloria González-Medrano, Luz María Uribe-Koch, María Rocío del Estrada-Hernández, Roberto Carlos Ojendiz-Nava, Alejandra Pérez-Morales
The pyometra is a rare condition, with an incidence of less than 1%. In patients with cervical cancer, spontaneous rupture of pyometra manifests as a generalized peritonitis, which is extremely rare, in the literature only seven cases are described. This paper reports the case of a patient with a history of postmenopausal vaginal bleeding one month before her admission to the hospital; she attended because of acute abdomen. The CT scan reported air in the abdominal cavity and the uterus with air at the periphery, so she underwent an exploratory laparotomy in which purulent material was found with two perforations in the uterine fundus...
July 2013: Ginecología y Obstetricia de México
María A Fernández-Herrera, Hugo López-Muñoz, José M V Hernández-Vázquez, Luis Sánchez-Sánchez, María L Escobar-Sánchez, B Mario Pinto, Jesús Sandoval-Ramírez
The synthesis of glucosamine derivatives of the steroidal sapogenins diosgenin and hecogenin using the N-phthaloyl protected trichloroacetimidate of d-glucosamine as donor and TMSOTf as promoter is reported. The corresponding glycoconjugates were transformed into their acetamido derivatives and the hydrochloride salt (from diosgenin) and tested against HeLa, CaSki, and ViBo cervicouterine cancer cells. These compounds showed low cytotoxicity values on tumor cells and human lymphocytes, indicating that the main cell death process is presumably not necrosis...
August 2012: European Journal of Medicinal Chemistry
María A Fernández-Herrera, Hugo López-Muñoz, José M V Hernández-Vázquez, Moisés López-Dávila, Sankar Mohan, María L Escobar-Sánchez, Luis Sánchez-Sánchez, B Mario Pinto, Jesús Sandoval-Ramírez
The synthesis and biological evaluation of the new cholestane glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside starting from diosgenin is described. This compound showed selective antiproliferative activity against CaSki, ViBo, and HeLa cervicouterine cancer cells. Its effect on the cell-cycle was determined. The cytotoxic effects of the title compound on cervicouterine cancer cell lines and human lymphocytes indicate that the main cell death process is not necrosis; hence it is not cytotoxic...
September 2011: European Journal of Medicinal Chemistry
Filiberto Linaldi-Yépez, Leticia Hernández-Cruz, Teresa Apresa-García, Dulce María Hernández-Hernández, Jorge Martínez-Torres
BACKGROUND: to determine the quality of a prompt cervical cancer detection program (TDC CC) according to the indicators for prevention and diagnosis. METHODS: cross-sectional and comparative study conducted in four primary care units. We selected 400 patients who attended preventive services to participate in the study of cervical cytology (Pap). The evaluation of the Program of TDC CC was obtained by the degree of fulfillment of quality and productivity outlined by an institutional program...
May 2010: Revista Médica del Instituto Mexicano del Seguro Social
Carlos Ramón Jiménez-Vieyra
BACKGROUND: It has been considered the incidence and the prevalence of the disease of sexual transmission with base in the different data banks. Unfortunately, each of these sources has limitations. OBJECTIVE: To evaluate annual prevalence of genital condiloma acuminate in the women who go to opportune detection of cervicouterine cancer. MATERIAL AND METHOD: Study realized in a first level of attention, the Zaragoza clinic of the System of Collective Transport Metro of Mexico City; of January of the year 2000 to June of year 2009...
February 2010: Ginecología y Obstetricia de México
María A Fernández-Herrera, Sankar Mohan, Hugo López-Muñoz, José M V Hernández-Vázquez, Esmeralda Pérez-Cervantes, María L Escobar-Sánchez, Luis Sánchez-Sánchez, Ignacio Regla, B Mario Pinto, Jesús Sandoval-Ramírez
The synthesis of the new glycoside (25R)-3β,16β-diacetoxy-12,22-dioxo-5α-cholestan-26-yl β-D-glucopyranoside starting from hecogenin is described. This compound showed anti-cancer activity against cervicouterine cancer cells HeLa, CaSki and ViBo in the micromolar range. Its effect on cell proliferation, cell cycle and cell death is also described. The cytotoxic effect of the title compound on HeLa, CaSki and ViBo cells and human lymphocytes was evaluated through the LDH released in the culture supernatant, indicating that the main cell death process is not necrosis; the null effect on lymphocytes implies that it is not cytotoxic...
November 2010: European Journal of Medicinal Chemistry
Gustavo López-Arce, Felix I Téllez-Avila, Sandra García-Osogobio, Norberto C Chavez-Tapia, Josué Barahona-Garrido, Rafael Barreto-Zúñiga, Francisco Valdovinos-Andraca
INTRODUCTION: Postradiation proctopathy (PP) is a major complication in patients who receive radiotherapy for cancer. Medical treatments of this entity are unsatisfactory. Argon plasma coagulation (APC) had been shown to be successful with low complications. The aim was to describe our experience with APC in the management of PP. METHODS: We conducted a retrospective analysis of electronic- and paper-based records of patients with PP managed with APC. RESULTS: Nineteen patients with PP were included, nine were women...
July 2010: International Journal of Colorectal Disease
Amada Aparicio Llanos, Melvin Morera Salas
OBJECTIVE: To measure the results of early detection and a timely approach to cervical cancer in the three Health Networks of the Costa Rican Public Health System. DESIGN: Descriptive cross-sectional study. LOCATION: Primary health areas and hospitals of the Public Health System. PARTICIPANTS: The 639,229 Papanicolaou smears performed in the period 2004-2005 were examined and a representative sample of 7,342 abnormal cytology and 7,729 colposcopies in 2005...
June 2009: Atencion Primaria
Esperanza Rosalba Rodriguez-Reyes, Ricardo M Cerda-Flores, Juan M Quiñones-Pérez, Elva I Cortés-Gutiérrez
OBJECTIVE: to evaluate the validity (sensitivity, specificity, and accuracy) of three screening methods used in the early detection of the cervical carcinoma versus the histopathology diagnosis. METHODS: a selected sample of 107 women attended in the Opportune Detection of Cervicouterine Cancer Program in the Hospital de Zona 46, Instituto Mexicano del Seguro Social in Durango, during the 2003 was included. The application of Papa-nicolaou, acetic acid test, and molecular detection of human papillomavirus, and histopatholgy diagnosis were performed in all the patients at the time of the gynecological exam...
May 2008: Revista Médica del Instituto Mexicano del Seguro Social
Wendoline Rojo Contreras, Héctor Montoya Fuentes, Jorge I Gámez Nava, Angel E Suárez Rincón, Jesús Vázquez Salcedo, Miguel Padilla Rosas, Luz M Baltazar Rodríguez, Xochitl Trujillo, Mario Ramírez Flores, Benjamín Trujillo Hernández, Laura González López
BACKGROUND: Nevertheless its association with cervicouterine cancer, there is no information about cervical human papillomavirus infection prevalence in patients with rheumatoid arthritis. OBJECTIVE: To evaluate human papillomavirus infection prevalence through molecular biology tests, and to analyze this infection related factors in patients with rheumatoid arthritis. MATERIAL AND METHOD: Analytic, transversal study to 250 patients: 61 women with rheumatoid arthritis selected from a rheumatologic external consult of a second level hospital, and 189 healthy women, with cervical cytology, of a first level hospital...
January 2008: Ginecología y Obstetricia de México
María de los Angeles Madrigal de la Campa, Eduardo Cesar Lazcano Ponce, Claudia Infante Castañeda
BACKGROUND: Cervicouterine cancer is one of the main public health problems in Mexico. Several problems related to the low effectiveness of the Program of Opportune Detection of Cervicouterine Cancer have been identified, among them: low cover of the disease detection and absence of quality control in the detection, diagnosis and treatment of it. In Mexico the quality control problem in cytology has been taken with success, but the opposite occurs with colposcopy practice. For that reason this service is overused by patients with low risk cancer and is not accessible for the high risk population...
December 2005: Ginecología y Obstetricia de México
L A Salazar-Olivo, V Paz-González
Bioactivities present in three honeybee royal jelly (RJ) protein fractions were screened for diverse in vitro model systems. RJCP, a RJ crude protein extract, stimulated cell growth of Tn-5B1-4 insect cells inducing 6.5 population doublings per mg of protein added to culture medium, meanwhile fetal bovine serum, the usual growth supplement, gave rise only to 2.55 population doublings. RJCP, as well as the fractions RJP30 and RJP60 obtained by precipitation with ammonium sulfate, also affected Tn-5B1-4 cell shape and stimulated adhesion of these cells to the substrate...
August 2005: Toxicology in Vitro: An International Journal Published in Association with BIBRA
José Manuel Castro Ruíz, Angélica Hernández Guerrero, Sergio Sobrino Cossio, Octavio Alonso, Leopoldo Rivero Trejo
OBJECTIVE: Our objective was to evaluate response to bipolar electrocoagulation (BICAP) in patients with persistent rectorragia (PR) secondary to PRP (post-radiation proctitis) degree II (telangiectasias). MATERIAL AND METHODS: We had 64 cases prospective and conducted study cohort of 257 patients, with cervicouterine cancer, radiated, PRP degree II, and PR. DESIGN: We conducted prospective, cross-sectional and descriptive study. Patients were divided in three groups: (group 1), with hemodynamical instability; (group 2) with chronic anemia, and (group 3), without data of chronic anemia (Table 1)...
July 2003: Revista de Gastroenterología de México
Marvin J Lopez, Pedro Luna-Pérez
BACKGROUND: In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis. METHODS: Thirty-four of 625 patients undergoing radical pelvic procedures had an en bloc resection of pelvic organs with portions of the bony pelvis. There were 19 female and 15 male patients, and the median age was 59 years...
January 2004: Annals of Surgical Oncology
No abstract text is available yet for this article.
December 4, 1959: Prensa Médica Argentina
No abstract text is available yet for this article.
July 1964: Revista Mexicana de Urología
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