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environmental endocrine disturber

Shibin Li, Daniel L Villeneuve, Jason P Berninger, Brett R Blackwell, Jenna E Cavallin, Megan N Hughes, Kathleen M Jensen, Zachary Jorgenson, Michael D Kahl, Anthony L Schroeder, Kyle E Stevens, Linnea M Thomas, Matthew A Weberg, Gerald T Ankley
Environmental assessment of complex mixtures typically requires integration of chemical and biological measurements. This study demonstrates the use of a combination of instrumental chemical analyses, effects-based monitoring, and bio-effects prediction approaches to help identify potential hazards and priority contaminants in two Great Lakes Areas of Concern (AOCs), the Lower Green Bay/Fox River located near Green Bay, WI, USA and the Milwaukee Estuary, located near Milwaukee, WI, USA. Fathead minnows were caged at four sites within each AOC (eight sites total)...
November 17, 2016: Science of the Total Environment
A M Cardoso, M G Alves, P P Mathur, P F Oliveira, J E Cavaco, L Rato
In the last decades, several studies evidenced a decrease in male fertility in developed countries. Although the aetiology of this trend in male reproductive health remains a matter of debate, environmental compounds that predispose to weight gain, namely obesogens, are appointed as contributors because of their action as endocrine disruptors. Obesogens favour adipogenesis by an imbalance of metabolic processes and can be found virtually everywhere. These compounds easily accumulate in tissues with high lipid content...
October 24, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Miroslav B Milovanović, Dragan S Antić, Marko T Milojković, Saša S Nikolić, Staniša Lj Perić, Miodrag D Spasić
A new intelligent hybrid structure used for online tuning of a PID controller is proposed in this paper. The structure is based on two adaptive neural networks, both with built-in Chebyshev orthogonal polynomials. First substructure network is a regular orthogonal neural network with implemented artificial endocrine factor (OENN), in the form of environmental stimuli, to its weights. It is used for approximation of control signals and for processing system deviation/disturbance signals which are introduced in the form of environmental stimuli...
September 5, 2016: Neural Networks: the Official Journal of the International Neural Network Society
Mariagrazia Granata, Evangelia Skarmoutsou, Chiara Trovato, Giulio A Rossi, Maria Clorinda Mazzarino, Fabio D'Amico
Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases...
September 17, 2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Pingping Wang, Zhongkun Du, Shixiang Gao, Xiaowei Zhang, J P Giesy
Effects of chemical mixtures at environmentally relevant concentrations on endocrine systems of aquatic organisms are of concern. Triclocarban (TCC) and inorganic mercury (Hg(2+)) are ubiquitous in aquatic environments, and are known to interfere with endocrine pathways via different mechanisms of toxic action. However, effects of mixtures of the two pollutants on aquatic organisms and associated molecular mechanisms were unknown. This study examined effects of binary mixtures of TCC and Hg(2+) on histopathological and biochemical alteration of reproductive organs in zebrafish (Danio rerio) after 21 d exposure...
September 6, 2016: Ecotoxicology and Environmental Safety
Małgorzata M Dobrzyńska
UNLABELLED: The general exposure to endocrine disruptors, including phthalates, is considered as one of the reason diminished sperm count and deteriorated sperm quality, which may lead to infertility and higher incidence of congenital malformations of the genital tract. This article describes the effects of selected phthalates di(2-ethylhexyl)phthalate (DEHP), dibutyl phthalate (DBP); butylbenzyl phthalate (BBP), diethyl phthalate (DEP), di-isononyl phthalate (DINP) on the male gametes, reproduction and the offspring of exposed animals...
2016: Roczniki Państwowego Zakładu Higieny
Aritro Sen, Michael T Sellix
The internal or circadian timing system is deeply integrated in female reproductive physiology. Considerable details of rheostatic timing function in the neuroendocrine control of pituitary hormone secretion, adenohypophyseal hormone gene expression and secretion, gonadal steroid hormone biosynthesis and secretion, ovulation, implantation, and parturition have been reported. The molecular clock, an autonomous feedback loop oscillator of interacting transcriptional regulators, dictates the timing and amplitude of gene expression in each tissue of the female hypothalamic-pituitary-gonadal (HPG) axis...
September 2016: Endocrinology
Michal Zeman, Lubos Molcan, Iveta Herichova, Monika Okuliarova
Disturbances in regular circadian oscillations can have negative effects on cardiovascular function, but epidemiological data are inconclusive and new data from animal experiments elucidating critical biological mechanisms are needed. To evaluate the consequences of chronic phase shifts of the light/dark (LD) cycle on hormonal and cardiovascular rhythms, two experiments were performed. In Experiment 1, male rats were exposed to either a regular 12:12 LD cycle (CONT) or rotating 8-h phase-delay shifts of LD every second day (SHIFT) for 10 weeks...
2016: Chronobiology International
Christophe Regnault, John Willison, Sylvie Veyrenc, Antinéa Airieau, Patrick Méresse, Marlène Fortier, Michel Fournier, Pauline Brousseau, Muriel Raveton, Stéphane Reynaud
Despite numerous studies suggesting that amphibians are highly sensitive to cumulative anthropogenic stresses, the role played by endocrine disruptors (EDs) in the decline of amphibian populations remains unclear. EDs have been extensively studied in adult amphibians for their capacity to disturb reproduction by interfering with the sexual hormone axis. Here, we studied the in vivo responses of Xenopus tropicalis males exposed to environmentally relevant concentrations of each ED, benzo[a]pyrene (BaP) and triclosan (TCS) alone (10 μg L(-1)) or a mixture of the two (10 μg L(-1) each) over a 24 h exposure period by following the modulation of the transcription of key genes involved in metabolic, sexual and immunity processes and the cellular changes in liver, spleen and testis...
July 2016: Chemosphere
Anne Lafontaine, Eric Gismondi, Céline Boulangé-Lecomte, Perrine Geraudie, Nathalie Dodet, Fanny Caupos, Soazig Lemoine, Laurent Lagadic, Jean-Pierre Thomé, Joëlle Forget-Leray
Chlordecone (CLD) is an organochlorine insecticide abundant in aquatic environment of the French West Indies. However, few studies have investigated its impact on freshwater invertebrates. Whereas CLD is suspected of inducing endocrine disruption, this work aimed to study the effects of environmentally relevant concentrations of CLD on the 20-hydroxyecdysone (20-HE) hormone concentration and on the chitobiase activity, both having key roles in the molting process of crustaceans. In addition, the bioaccumulation of CLD was measured in the muscle tissue of Macrobrachium rosenbergii to underline potential dose-response relationship...
July 2016: Aquatic Toxicology
Lianguo Chen, Rui Ye, Weipeng Zhang, Chenyan Hu, Bingsheng Zhou, Drew R Peterson, Doris W T Au, Paul K S Lam, Pei-Yuan Qian
Despite being proposed as a promising antifouling and chemopreventive agent, the environmental risks of 3,3'-diindolylmethane (DIM) are scarcely investigated. Therefore, this study used adult marine medaka (Oryzias melastigma) as a model organism to examine the toxicological effects and underlying mechanism of DIM throughout the hypothalamus-pituitary-gonadal-liver (HPGL) axis following 28 days of exposure to low DIM concentrations (0 and 8.46 μg/L). The results showed that altered gene transcription in the hypothalamus, pituitary, and gonads contributed to the great imbalance in hormone homeostasis...
June 20, 2016: Chemical Research in Toxicology
Irene Ozáez, Mónica Aquilino, Gloria Morcillo, José-Luis Martínez-Guitarte
Organic ultraviolet (UV) filters are emerging contaminants that are ubiquitous in fresh and marine aquatic systems due to their extensive use in cosmetics, plastics, paints, textiles, and many other industrial products. The estrogenic effects of organic UV filters have been long demonstrated in vertebrates, and other hormonal activities may be altered, according to more recent reports. The impact of UV filters on the endocrine system of invertebrates is largely unknown. We have previously reported that some UV filters may affect ecdysone-related genes in the aquatic insect Chironomus riparius, an ecotoxicologically important model organism...
July 2016: Environmental Pollution
Wenhui Qiu, Jingsi Chen, Yijie Li, Zhong Chen, Lihui Jiang, Ming Yang, Minghong Wu
Bisphenol A (BPA) is a well-known endocrine disrupting chemical (EDC), ubiquitous in the aquatic environment, which poses an ecotoxicological risk to the health of aquatic organisms. However, the immunotoxic effects of its long-term exposure on fish have received limited attention. We examined a number of typical immune-related parameters and oxidative stress indices in the liver and blood serum of the red common carp (Cyprinus carpio), following a 30-day exposure to five different concentrations of BPA (0...
August 2016: Ecotoxicology and Environmental Safety
Rainer H Straub, Carsten Schradin
It has been recognized that during chronic inflammatory systemic diseases (CIDs) maladaptations of the immune, nervous, endocrine and reproductive system occur. Maladaptation leads to disease sequelae in CIDs. The ultimate reason of disease sequelae in CIDs remained unclear because clinicians do not consider bodily energy trade-offs and evolutionary medicine. We review the evolution of physiological supersystems, fitness consequences of genes involved in CIDs during different life-history stages, environmental factors of CIDs, energy trade-offs during inflammatory episodes and the non-specificity of CIDs...
January 27, 2016: Evolution, Medicine, and Public Health
Changwoo Han, Yun-Chul Hong
Bisphenol A (BPA) exposure has become one of the most common environmental chemical exposures in humans. There is growing evidence regarding an association between BPA exposure, hypertension, and cardiovascular diseases (CVD). If BPA exposure is indeed associated with raised blood pressure and CVD, it would be a major public health problem. Therefore, we reviewed the epidemiological, laboratory, and clinical trial evidence for an association between BPA exposure, CVD, and hypertension, and discussed the possible mechanisms in this article...
February 2016: Current Hypertension Reports
Demian Halperin
Environmental noise, especially that caused by transportation means, is viewed as a significant cause of sleep disturbances. Poor sleep causes endocrine and metabolic measurable perturbations and is associated with a number of cardiometabolic, psychiatric and social negative outcomes both in adults and children. Nocturnal environmental noise also provokes measurable biological changes in the form of a stress response, and clearly affects sleep architecture, as well as subjective sleep quality. These sleep perturbations are similar in their nature to those observed in endogenous sleep disorders...
December 2014: Sleep Science
Bridget F Healy, Karin R English, Paul Jagals, Peter D Sly
Bisphenol A (BPA) is a plasticiser found in a number of household plastics, electronics, and food-packaging materials. Over the past 5 years, several human epidemiological studies have reported a positive association between BPA exposure and adverse health outcomes in children, including obesity, asthma, preterm birth, and neuro-behavioural disturbances. These findings are in conflict with international environmental risk assessment models, which predict daily exposure levels to BPA should not pose a risk to child health...
November 2015: Journal of Exposure Science & Environmental Epidemiology
Ewa Dopierała, Janusz Rybakowski
Disturbances of circadian rhythms play an important role in the pathogenesis of affective illnesses, and their normalisation with methods of chronotherapy might become an important element of therapeutic treatment. Chronotherapy is based on a controlled exposure to environmental stimuli which affect biorhythms. One of the chronotherapeutic methods is sleep deprivation (SD). The article discusses the present status of SD in psychiatry, its methods and application in depression treatment. Presently the most recommended pattern is combining total sleep deprivation (TSD), sleep phase advance (SPA), pharmacotherapy, and sometimes also phototherapy...
May 2015: Psychiatria Polska
Ana Cristina Kalb, Ana Luiza Kalb, Tainã Figueiredo Cardoso, Cristina Gevehr Fernandes, Carine Dahl Corcini, Antonio Sergio Varela Junior, Pablo Elías Martínez
The health effects of environmental chemicals on animals and humans are of growing concern. Human epidemiological and animal study data indicate that reproductive disorders and diseases begin early during prenatal and postnatal development. An increase of human male reproductive disturbance in the past several decades was associated to chemicals called endocrine disruptors (ED). Bisphenol A (BPA) is a ubiquitous organic environmental contaminant with ED activity. This study verified the effect of BPA exposure via breast milk during the lactation (early postnatal) period in male mice...
May 2016: Archives of Environmental Contamination and Toxicology
Ana Luzio, Sandra M Monteiro, Sofia Garcia-Santos, Eduardo Rocha, António A Fontaínhas-Fernandes, Ana M Coimbra
Current knowledge on zebrafish (Danio rerio) sex determination suggests that this trait has a polygenic genetic basis, although environmental factors, such as endocrine disrupting chemicals (EDC), may also be involved in modeling or disturbing the species sex differentiation and development. This study aimed to assess how sex steroids imbalance triggers impact on sex differentiation and gonad development in zebrafish. Fish where exposed to an estrogen (EE2, i.e. 17α-ethinylestradiol, 4ng/L), to an inhibitor of estrogen synthesis (Fad, i...
September 2015: Aquatic Toxicology
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