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environmental endocrine disturber

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https://www.readbyqxmd.com/read/28987407/electron-beam-irradiation-induced-degradation-of-antidepressant-drug-fluoxetine-in-water-matrices
#1
Hai-Yang Shao, Ming-Hong Wu, Fei Deng, Gang Xu, Ning Liu, Xu Li, Liang Tang
With the development of psychiatric disorder in the current society, abuse of antidepressant drug fluoxetine (FLX) has made such compound an emerging contaminant in natural waters, and causes endocrine systems disturbance on some aquatic species. Herein, an efficient advanced oxidation process (AOP), electron beam irradiation was carried out to investigate the decomposition characteristics of such novel environmental pollutant, including the effects of initial concentration, pH, radical scavengers and anions...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28936425/gut-dysbiosis-in-animals-due-to-environmental-chemical-exposures
#2
REVIEW
Cheryl S Rosenfeld
The gut microbiome consists of over 10(3)-10(4) microorganism inhabitants that together possess 150 times more genes that the human genome and thus should be considered an "organ" in of itself. Such communities of bacteria are in dynamic flux and susceptible to changes in host environment and body condition. In turn, gut microbiome disturbances can affect health status of the host. Gut dysbiosis might result in obesity, diabetes, gastrointestinal, immunological, and neurobehavioral disorders. Such host diseases can originate due to shifts in microbiota favoring more pathogenic species that produce various virulence factors, such as lipopolysaccharide...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28935448/perinatal-effects-of-exposure-to-pcbs-on-social-preferences-in-young-adult-and-middle-aged-offspring-mice
#3
Alaa Karkaba, Nidhal Soualeh, Rachid Soulimani, Jaouad Bouayed
In social species, social interactions between conspecifics constitute a fundamental component to establish relations, provide best chances to reproduce, and even improve survival rates. In this study, a three-chambered social approach test was used to estimate the level of sociability and level of preference for social novelty in both male and female young adult (postnatal day (PND) 50) and middle-aged (PND 330) offspring mice (n=10 per group) that were perinatally exposed to a mixture of six polychlorinated biphenyls (PCBs), 28, 52, 101, 138, 153, and 180, at environmentally low doses (10 and 1000ng/kg b...
September 28, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28903489/from-the-cover-exposure-to-an-environmentally-relevant-mixture-of-brominated-flame-retardants-decreased-p-%C3%AE-cateninser675-expression-and-its-interaction-with-e-cadherin-in-the-mammary-glands-of-lactating-rats
#4
Elham Dianati, Michael G Wade, Barbara F Hales, Bernard Robaire, Isabelle Plante
Proper mammary gland development and function require precise hormonal regulation and bidirectional cross talk between cells provided by means of paracrine factors as well as intercellular junctions; exposure to environmental endocrine disruptors can disturb these processes. Exposure to one such family of chemicals, the brominated flame retardants (BFRs), is ubiquitous. Here, we tested the hypothesis that BFR exposures disrupt signaling pathways and intercellular junctions that control mammary gland development...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28826789/environmental-endocrine-disruptors-new-diabetogens
#5
Patrick Fénichel, Nicolas Chevalier
The prevalence of type-2 diabetes has dramatically increased worldwide during the last few decades. While lifestyle factors (sedentariness, noxious food), together with genetic susceptibility, are well-known actors, there is accumulating evidence suggesting that endocrine disrupting chemicals (EDCs) may also play a pathophysiological role in the occurrence of metabolic diseases. Both experimental and epidemiological evidence support a role for early and chronic exposure to low doses of chemical pollutants with endocrine and metabolic disrupting effects...
August 18, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28790390/involvement-of-insulin-signaling-disturbances-in-bisphenol-a-induced-alzheimer-s-disease-like-neurotoxicity
#6
Tingwei Wang, Cuiwei Xie, Pengfei Yu, Fangfang Fang, Jingying Zhu, Jie Cheng, Aihua Gu, Jun Wang, Hang Xiao
Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that brain insulin resistance may contribute to neurodegenerative diseases. However, the associated mechanisms that underlie BPA-induced brain-related outcomes remain largely unknown. In the present study, we identified significant insulin signaling disturbances in the SH-SY5Y cell line that were mediated by BPA, including the inhibition of physiological p-IR Tyr1355 tyrosine, p-IRS1 tyrosine 896, p-AKT serine 473 and p-GSK3α/β serine 21/9 phosphorylation, as well as the enhancement of IRS1 Ser307 phosphorylation; these effects were clearly attenuated by insulin and rosiglitazone...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774687/the-environment-and-male-reproduction-the-effect-of-cadmium-exposure-on-reproductive-function-and-its-implication-in-fertility
#7
REVIEW
Cristina de Angelis, Mariano Galdiero, Claudia Pivonello, Ciro Salzano, Daniele Gianfrilli, Prisco Piscitelli, Andrea Lenzi, Annamaria Colao, Rosario Pivonello
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptible to cadmium, and testis injury occurs at high but even low levels of exposure. Cadmium reproductive toxicity is mediated by multiple mechanisms, including structural damage to testis vasculature and blood-testis barrier, inflammation, cytotoxicity on Sertoli and Leydig cells, oxidative stress, apoptosis, interference with selected signaling pathways involved in the regulation of reproductive function, epigenetic modifications, and disturbance of the hypothalamus-pituitary-gonadal axis...
August 1, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28764642/the-susceptibility-of-fshb-211g%C3%A2-%C3%A2-t-and-fshr-g-29a-919a%C3%A2-%C3%A2-g-2039a%C3%A2-%C3%A2-g-polymorphisms-to-men-infertility-an-association-study-and-meta-analysis
#8
Qiuyue Wu, Jing Zhang, Peiran Zhu, Weijun Jiang, Shuaimei Liu, Mengxia Ni, Mingchao Zhang, Weiwei Li, Qing Zhou, Yingxia Cui, Xinyi Xia
BACKGROUND: Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb normal spermatogenesis and affect male reproductive ability. METHODS: To further ascertain the aforementioned effects, we conducted a case-control study of 255 infertile men and 340 fertile controls from South China using the Mass ARRAY method, which was analyzed by the t-tests and logistic regression analysis using SPSS for Windows 14...
August 1, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28763935/parental-exposure-to-microcystin-lr-induced-thyroid-endocrine-disruption-in-zebrafish-offspring-a-transgenerational-toxicity
#9
Houcheng Cheng, Wei Yan, Qin Wu, Chunsheng Liu, Xiuying Gong, Tien-Chieh Hung, Guangyu Li
Microcystin-LR is the most poisonous and commonly encountered hepatotoxin produced by cyanobacteria in an aquatic ecosystem, and it may cause thyroid dysfunction in fish. The present study aimed to reveal the effects of transgenerational toxicity of MCLR on the thyroid endocrine system under sub-chronic exposure conditions. Adult zebrafish (F0) were exposed to environmentally relevant concentrations (1, 5 and 25 μg/L) of MCLR for 45 days. The produced F1 embryos were then tested without further MCLR treatment...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28757214/vulnerability-of-marsh-frog-pelophylax-ridibundus-to-the-typical-wastewater-effluents-ibuprofen-triclosan-and-estrone-detected-by-multi-biomarker-approach
#10
Halina I Falfushynska, Lesya L Gnatyshyna, Oksana Horyn, Oksana B Stoliar
Pharmaceutical and personal care products (PPCPs) are the environmental pollutants of growing concern. The aim of this study was to indicate the effects of typical PPCPs on the marsh frog Pelophylax ridibundus. We treated male frogs with waterborne ibuprofen (IBU, 250ng·L(-1)), triclosan (TCS, 500ng·L(-1)), or estrone (E1, 100ng·L(-1)) for 14days. Common vulnerability of the frogs was detected from dramatic decrease of Zn, total and metalated metallothionein (MT) concentrations, Zn/Cu ratio, the elevation of activity of glutathione-S-transferase, cathepsin D and DNA instability in the liver, the depletion of cholinesterase in the brain and cortisol in the blood plasma in all exposures...
November 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28741210/effects-of-bpf-on-steroid-hormone-homeostasis-and-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis-of-zebrafish
#11
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish...
July 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28723674/nanoparticles-and-female-reproductive-system-how-do-nanoparticles-affect-oogenesis-and-embryonic-development
#12
REVIEW
Cong-Cong Hou, Jun-Quan Zhu
Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman's body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28483365/endocrine-disrupting-chemicals-and-growth-of-children
#13
Jérémie Botton, Manik Kadawathagedara, Blandine de Lauzon-Guillain
According to the "environmental obesogen hypothesis", early-life (including in utero) exposure to endocrine disrupting chemicals (EDCs) may disturb the mechanisms involved in adipogenesis or energy storage, and thus may increase the susceptibility to overweight and obesity. Animal models have shown that exposure to several of these chemicals could induce adipogenesis and mechanisms have been described. Epidemiological studies are crucial to know whether this effect could also be observed in humans. We aimed at summarizing the literature in epidemiology on the relationship between EDCs exposure and child's growth...
May 5, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28482050/parallel-assessment-of-the-effects-of-bisphenol-a-and-several-of-its-analogs-on-the-adult-human-testis
#14
C Desdoits-Lethimonier, L Lesné, P Gaudriault, D Zalko, J P Antignac, Y Deceuninck, C Platel, N Dejucq-Rainsford, S Mazaud-Guittot, B Jégou
STUDY QUESTION: Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER: The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. WHAT IS KNOWN ALREADY: The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption...
July 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28431277/endocrine-disruption-by-environmental-gestagens-in-amphibians-a-short-review-supported-by-new-in%C3%A2-vitro-data-using-gonads-of-xenopus-laevis
#15
REVIEW
Andrea Ziková, Claudia Lorenz, Frauke Hoffmann, Wibke Kleiner, Ilka Lutz, Matthias Stöck, Werner Kloas
Endocrine disruption caused by various anthropogenic compounds is of persisting concern, especially for aquatic wildlife, because surface waters are the main sink of these so-called endocrine disruptors (ED). In the past, research focused on (anti)estrogenic, (anti)androgenic, and (anti)thyroidal substances, affecting primarily reproduction and development in vertebrates; however, other endocrine systems might be also targeted by ED. Environmental gestagens, including natural progestogens (e.g. progesterone (P4)) and synthetic progestins used for contraception, are supposed to affect vertebrate reproduction via progesterone receptors...
August 2017: Chemosphere
https://www.readbyqxmd.com/read/28369636/maternal-fenvalerate-exposure-induces-fetal-intrauterine-growth-restriction-through-disrupting-placental-thyroid-hormone-receptor-signaling
#16
Bo Wang, Ji-Jie Liu, Yan Wang, Lin Fu, Ru Shen, Zhen Yu, Hua Wang, Yuan-Hua Chen, Cheng Zhang, Xiu-Hong Meng, De-Xiang Xu
Fenvalerate is an environmental endocrine disruptor that disrupts testosterone and estradiol synthesis. Nevertheless, whether fenvalerate disturbs placental TR signaling remains unclear. The aim of this study was to investigate whether maternal fenvalerate exposure causes fetal intrauterine growth restriction (IUGR) and to explore the role of placental thyroid hormone receptor (TR) signaling. Pregnant mice except controls were orally administered to fenvalerate (0.2, 2.0, or 20 mg/kg) daily throughout pregnancy...
June 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28065941/di2-ethylhexyl-phthalate-disrupts-thyroid-hormone-homeostasis-through-activating-the-ras-akt-trhr-pathway-and-inducing-hepatic-enzymes
#17
Hanfeng Ye, Mei Ha, Min Yang, Ping Yue, Zhengyuan Xie, Changjiang Liu
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28031325/diethylstilbestrol-activates-catsper-and-disturbs-progesterone-actions-in-human-spermatozoa
#18
Qian-Xing Zou, Zhen Peng, Qing Zhao, Hou-Yang Chen, Yi-Min Cheng, Qing Liu, Yuan-Qiao He, Shi-Qi Weng, Hua-Feng Wang, Tao Wang, Li-Ping Zheng, Tao Luo
STUDY QUESTION: Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions? SUMMARY ANSWER: DES promoted Ca(2+) flux into human spermatozoa by activating the cation channel of sperm (CatSper) and suppressed progesterone-induced Ca(2+) signaling, tyrosine phosphorylation and sperm functions. WHAT IS KNOWN ALREADY: DES significantly impairs the male reproductive system both in fetal and postnatal exposure...
December 28, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27933203/maternal-inflammatory-bowel-disease-and-hypospadias-in-male-offspring-a-population-based-study-in-denmark
#19
Ane Birgitte Telén Andersen, Vera Ehrenstein, Rune Erichsen, Trine Frøslev, Henrik Toft Sørensen
BACKGROUND: The occurrence of inflammatory bowel disease (IBD) and hypospadias has been concurrently increasing, possibly through shared environmental risk factors such as endocrine disrupting compounds. Also, maternal IBD may disturb the normal development of the fetal reproductive tract. However, whether maternal IBD increases the risk of hypospadias in male offspring is unknown. We compared hypospadias risk in sons of mothers with and without IBD. METHODS: We used Danish nationwide population-based registries to conduct a longitudinal prevalence study including all live-born boys from 1979 through 2009...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27866739/an-integrated-approach-for-identifying-priority-contaminant-in-the-great-lakes-basin-investigations-in-the-lower-green-bay-fox-river-and-milwaukee-estuary-areas-of-concern
#20
Shibin Li, Daniel L Villeneuve, Jason P Berninger, Brett R Blackwell, Jenna E Cavallin, Megan N Hughes, Kathleen M Jensen, Zachary Jorgenson, Michael D Kahl, Anthony L Schroeder, Kyle E Stevens, Linnea M Thomas, Matthew A Weberg, Gerald T Ankley
Environmental assessment of complex mixtures typically requires integration of chemical and biological measurements. This study demonstrates the use of a combination of instrumental chemical analyses, effects-based monitoring, and bio-effects prediction approaches to help identify potential hazards and priority contaminants in two Great Lakes Areas of Concern (AOCs), the Lower Green Bay/Fox River located near Green Bay, WI, USA and the Milwaukee Estuary, located near Milwaukee, WI, USA. Fathead minnows were caged at four sites within each AOC (eight sites total)...
February 1, 2017: Science of the Total Environment
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