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https://www.readbyqxmd.com/read/27933377/radiofrequency-ablation-of-hepatocellular-carcinoma-with-a-nodule-in-nodule-appearance-long-term-follow-up-and-clinical-implications
#1
Tae Wook Kang, Hyunchul Rhim, Kyoung Doo Song, Min Woo Lee, Dong Ik Cha, Sang Yun Ha, Joong Hyun Ahn
PURPOSE: Hepatocellular carcinoma (HCC) with a "nodule-in-nodule" (NIN) appearance has unique histological characteristics as an early HCC. We assessed long-term therapeutic outcomes of radiofrequency ablation (RFA) in HCC patients considering this appearance. MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and the requirement for written informed consent was waived. Between May 2006 and April 2012, a total of 572 patients underwent RFA for single HCC as a first-line treatment...
December 8, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27932862/role-of-the-treating-surgeon-in-the-consent-process-for-elective-refractive-surgery
#2
Steven C Schallhorn, Stephen J Hannan, David Teenan, Julie M Schallhorn
PURPOSE: To compare patient's perception of consent quality, clinical and quality-of-life outcomes after laser vision correction (LVC) and refractive lens exchange (RLE) between patients who met their treating surgeon prior to the day of surgery (PDOS) or on the day of surgery (DOS). DESIGN: Retrospective, comparative case series. SETTING: Optical Express, Glasgow, UK. METHODS: Patients treated between October 2015 and June 2016 (3972 LVC and 979 RLE patients) who attended 1-day and 1-month postoperative aftercare and answered a questionnaire were included in this study...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27931691/risk-assessment-of-hepatotoxicity-among-tuberculosis-and-human-immunodeficiency-virus-aids-coinfected-patients-under-tuberculosis-treatment
#3
Williams Ngouleun, Prosper Cabral Biapa Nya, Anatole Constant Pieme, Phelix Bruno Telefo
OBJECTIVE/BACKGROUND: Tuberculosis (TB) is a worldwide public health problem. It is a contagious and grave disease caused by Mycobacterium tuberculosis. Current drugs such as isoniazid, pyrazinamide, and rifampicin used for the treatment of tuberculosis are potentially hepatotoxic and can lead to drug hepatitis. In order to improve the follow-up of TB patients in Cameroon, we carried out a study which aimed to evaluate the hepatotoxicity risk factors associated with anti-TB drugs. METHODS: The studies were performed on 75 participants who had visited the Loum District Hospital located in the littoral region of Cameroon for their routine consultation...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27931548/percutaneous-transvenous-mitral-commissurotomy-in-mitral-stenosis-and-left-atrial-appendage-clot-patients-in-special-conditions-hospital-based-study
#4
Rajib Rajbhandari, Rabi Malla, Arun Maskey, Yadav Bhatta, Yubraj Limbu, Ranjit Sharma, Satish Singh, Chandramani Adhikari, Sundeep Mishra
BACKGROUND: The percutaneous transvenous mitral commissurotomy is an important procedure for the treatment of mitral stenosis. A lot of mitral stenosis cases have left atrial appendage clot which precludes the patient from the benefit of this procedure. The aim of the study was to study the feasibility and safety of the procedure in a patient with appendage clot in the setup of certain urgent conditions. METHOD: All cases of mitral stenosis with significant dyspnea and mitral valve area <1...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931515/autologous-adipose-derived-mesenchymal-stromal-cells-for-the-treatment-of-psoriasis-vulgaris-and-psoriatic-arthritis-a-case-report
#5
Miguel M De Jesus, Jayson S Santiago, Camille V Trinidad, Melvin E See, Kimberly R Semon, Manuel O Fernandez, Francisco S Chung
Psoriasis is a dermatologic disease of immune origins with no definitive cure. We report the Makati Medical Center experience of utilizing autologous mesenchymal stromal cells (MSCs) for one patient with psoriasis vulgaris (PV) and another with psoriatic arthritis (PA). Patients were educated and gave informed consent, according to the principles of the Declaration of Helsinki. The protocol was approved by the Cellular Transplantation Ethics Committee of the Makati Medical Center. Autologous MSCs were cultured from lipoaspirate and expanded in a clean room class 100 facility (Cellular Therapeutics Center, Makati Medical Center)...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27931241/surveillance-of-nosocomial-infections-in-the-yaounde-university-teaching-hospital-cameroon
#6
Julienne Stéphanie Nouetchognou, Jérôme Ateudjieu, Bonaventure Jemea, Edmond Nzene Mesumbe, Dora Mbanya
BACKGROUND: Nosocomial infections (NI) represent a real public health problem in developing countries. Their surveillance is recommended to provide needed information for better control. The aim of this study was to describe the frequency and distribution of NI in the Yaoundé University Teaching Hospital (YUTH). METHODS: It was a longitudinal and descriptive study targeting hospitalized patients in the intensive care, gynaecological, surgical and neonatal units...
December 8, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27931056/-guideline-s2k-awmf-of-the-deutsche-gesellschaft-f%C3%A3-r-pneumologie-und-beatmungsmedizin-and-the-deutsche-gesellschaft-f%C3%A3-r-arbeitsmedizin-und-umweltmedizin-diagnostics-and-expert-opinion-in-the-occupational-disease-no-4101-silicosis-including-coal-worker-s-pneumoconiosis
#7
X Baur, M Heger, R M Bohle, K G Hering, K Hofmann-Preiß, D Nowak, A Tannapfel, H Teschler, T Voshaar, T Kraus
During the last 1.5 years an update of the guideline on silicosis was made by an interdisciplinary working group. New medical and scientific knowledge and the experience in expert opinion practice were taken into account.By preparing the initial guideline in 2010 standardization of diagnostics and adaption of the "Moers convention" which was not based on medical knowledge was in the focus, whereas the current update deals with fine emendation and extension, especially of the compensation rate (adaption with the Reichenhall recommendation)...
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27930091/arthroscopic-hip-surgery-frequency-of-postoperative-mr-arthrographic-findings-in-asymptomatic-and-symptomatic-patients
#8
Chan-Hi Olaf Kim, Tobias J Dietrich, Patrick O Zingg, Claudio Dora, Christian W A Pfirrmann, Reto Sutter
Purpose To determine and compare the frequency of imaging abnormalities in asymptomatic and symptomatic patients after arthroscopic hip surgery. Materials and Methods This study was approved by the institutional review board. Informed consent was obtained from all patients. Thirty-four patients (17 asymptomatic and 17 symptomatic patients) underwent 1.5-T magnetic resonance (MR) arthrography of the hip 1 year after arthroscopic treatment of femoroacetabular impingement. Two readers independently analyzed all MR arthrographic images for the presence of abnormal imaging findings, including capsular adhesions at the femoral neck, obliteration of the paralabral sulcus, labral defects, and defects of the hip capsule in several anatomic positions (anterior to posterior)...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27930089/radiation-segmentectomy-versus-tace-combined-with-microwave-ablation-for-unresectable-solitary-hepatocellular-carcinoma-up-to-3-cm-a-propensity-score-matching-study
#9
Derek M Biederman, Joseph J Titano, Vivian L Bishay, Raisa J Durrani, Etan Dayan, Nora Tabori, Rahul S Patel, Francis S Nowakowski, Aaron M Fischman, Edward Kim
Purpose To compare the outcomes of radiation segmentectomy (RS) and transarterial chemoembolization (TACE) combined with microwave ablation (MWA) in the treatment of unresectable solitary hepatocellular carcinoma (HCC) up to 3 cm. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. From January 2010 to June 2015, a total of 417 and 235 consecutive patients with HCC underwent RS and TACE MWA, respectively. A cohort of 121 patients who had not previously undergone local-regional therapy (RS, 41; TACE MWA, 80; mean age, 65...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27929929/diffusion-kurtosis-imaging-study-of-rectal-adenocarcinoma-associated-with-histopathologic-prognostic-factors-preliminary-findings
#10
Lan Zhu, Zilai Pan, Qian Ma, Wenjie Yang, Hongyuan Shi, Caixia Fu, Xu Yan, Lianjun Du, Fuhua Yan, Huan Zhang
Purpose To determine the correlation between diffusion kurtosis imaging (DKI)-derived parameters and prognostic factors for rectal adenocarcinoma. Materials and Methods This study was approved by the local institute review board, and written informed consent was obtained from each patient. Data from 56 patients (median age, 59.5 years; age range, 31-86 years) with rectal adenocarcinoma between April 2014 and September 2015 were involved in this prospective study. DKI (b = 0, 700, 1400, and 2100 sec/mm(2)) and conventional diffusion-weighted imaging (b = 0, 1000 sec/mm(2)) were performed...
December 5, 2016: Radiology
https://www.readbyqxmd.com/read/27928840/development-of-assessment-toolkits-for-improving-the-diagnosis-of-the-lewy-body-dementias-feasibility-study-within-the-diamond-lewy-study
#11
Alan J Thomas, John Paul Taylor, Ian McKeith, Claire Bamford, David Burn, Louise Allan, John O'Brien
OBJECTIVE: The Lewy body dementias (LBD, dementia with Lewy bodies and Parkinson's disease dementia) are the second most common cause of neurodegenerative dementia but remain under-recognised, with long delays from initial assessment to diagnosis. Whilst validated instruments have been developed for key symptoms, there is no brief instrument for overall diagnostic assessment suitable for routine practice. We here report the development of such assessment toolkits. METHODS: We developed the LBD assessment toolkits in three stages...
December 8, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27928375/a-randomised-controlled-trial-of-treatment-for-post-stroke-homonymous-hemianopia-screening-and-recruitment
#12
Fiona J Rowe, Elizabeth J Conroy, P Graham Barton, Emma Bedson, Emma Cwiklinski, Caroline Dodridge, Avril Drummond, Marta Garcia-Finana, Claire Howard, Stevie Johnson, Claire MacIntosh, Carmel P Noonan, Alex Pollock, Janet Rockliffe, Catherine M Sackley, Tracey Shipman
The authors report the screening process and recruitment figures for the VISION (Visual Impairment in Stroke; Intervention Or Not) trial. This is a prospective, randomised, single-blinded, three-arm controlled trial in 14 UK acute hospital stroke units. Stroke teams identified stroke survivors suspected as having homonymous hemianopia. Interventions included Fresnel prisms versus visual search training versus standard care (information only). Primary outcome was change in visual field assessment from baseline to 26 weeks...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27927932/ethical-clinical-translation-of-stem-cell-interventions-for-neurologic-disease
#13
David J Cote, Annelien L Bredenoord, Timothy R Smith, Mario Ammirati, Jannick Brennum, Ivar Mendez, Ahmed S Ammar, Naci Balak, Gene Bolles, Ignatius Ngene Esene, Tiit Mathiesen, Marike L Broekman
The application of stem cell transplants in clinical practice has increased in frequency in recent years. Many of the stem cell transplants in neurologic diseases, including stroke, Parkinson disease, spinal cord injury, and demyelinating diseases, are unproven-they have not been tested in prospective, controlled clinical trials and have not become accepted therapies. Stem cell transplant procedures currently being carried out have therapeutic aims, but are frequently experimental and unregulated, and could potentially put patients at risk...
December 7, 2016: Neurology
https://www.readbyqxmd.com/read/27924721/structural-brain-connectome-and-cognitive-impairment-in-parkinson-disease
#14
Sebastiano Galantucci, Federica Agosta, Elka Stefanova, Silvia Basaia, Martijn P van den Heuvel, Tanja Stojković, Elisa Canu, Iva Stanković, Vladana Spica, Massimiliano Copetti, Delia Gagliardi, Vladimir S Kostić, Massimo Filippi
Purpose To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27922974/training-and-validating-a-deep-convolutional-neural-network-for-computer-aided-detection-and-classification-of-abnormalities-on-frontal-chest-radiographs
#15
Mark Cicero, Alexander Bilbily, Errol Colak, Tim Dowdell, Bruce Gray, Kuhan Perampaladas, Joseph Barfett
OBJECTIVES: Convolutional neural networks (CNNs) are a subtype of artificial neural network that have shown strong performance in computer vision tasks including image classification. To date, there has been limited application of CNNs to chest radiographs, the most frequently performed medical imaging study. We hypothesize CNNs can learn to classify frontal chest radiographs according to common findings from a sufficiently large data set. MATERIALS AND METHODS: Our institution's research ethics board approved a single-center retrospective review of 35,038 adult posterior-anterior chest radiographs and final reports performed between 2005 and 2015 (56% men, average age of 56, patient type: 24% inpatient, 39% outpatient, 37% emergency department) with a waiver for informed consent...
December 5, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27922563/-sign-here-nursing-value-and-the-process-of-informed-consent
#16
Wesley E Cook
Protecting patient autonomy is a key nursing role. The Code of Ethics (American Nurses Association, 2010), contextualizes the nurse's call to advocacy within the doctrine of informed consent. This article offers a primer on the legal, ethical, and practical aspects of procedural informed consent and examines the value of nursing's role within the process. The theory of nursing's value is sound, but the literature lacks data. Higher levels of evidence are necessary to make sound decisions about best practice for the process of informed consent...
October 2016: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/27922504/genetic-testing-of-presymptomatic-individuals-at-risk-for-progressive-myopathy
#17
Zachary Simmons
Patients and their family members often ask about genetic testing for asymptomatic individuals who are at risk for developing a genetic disorder. Ordering a genetic test is a complex process involving consideration of many basic ethical principles including autonomy, beneficence, and nonmaleficence, as well as the physician's duty to act in the patient's best interest. Physicians have many choices regarding what tests to order, and they must develop the knowledge and skills to best discuss genetic testing with their patients...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27922202/current-practices-for-screening-consent-and-care-of-related-donors-in-france-haematopoietic-stem-cell-transplantation-coordinator-nurses-perceptions
#18
A Polomeni, C Bompoint, A Gomez, E Brissot, A Ruggeri, R Belhocine, M Mohty
Haematopoietic stem cell transplantation-coordinating nurses (HSCT-CNs) play an important role in informing related donors (RDs) and in organising human leucocyte antigen (HLA) tests, pre-donation workup and stem cells collection. Our pilot study aimed to explore French HSCT-CNs' perceptions of RD care issues. Twenty-nine French HSCT adult units were sent a questionnaire on the subject of donation procedures, HSCT-CNs' data and their professional experience of related donation issues. Twenty-two HSCT-CNs returned a completed questionnaire, and 90% of HSCT units were involved to some degree in both patient and donor care...
December 6, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27920510/the-clock-in-the-box-a-brief-cognitive-screen-is-associated-with-failure-to-return-home-in-an-elderly-hospitalized-sample
#19
Colleen E Jackson, Laura J Grande, Kelly Doherty, Elizabeth Archambault, Brittany Kelly, Jane A Driver, William P Milberg, Regina McGlinchey, James L Rudolph
PURPOSE: Cognitive screening upon hospital admission can provide important information about the patient's ability to process information during the inpatient stay. The Clock-in-the-Box (CIB) is a rapidly administered cognitive screening measure which has been previously validated with cognitive screening and neuropsychological assessments. The purpose of this study is to demonstrate the predictive validity of the CIB for discharge location among a sample of older medical inpatients. PATIENTS AND METHODS: Hospitalized Veterans (N=218), aged 55 years and older, were recruited on the day after admission after they gave their consent...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27920496/fabrication-of-anti-vitiligo-ointment-containing-psoralea-corylifolia-in-vitro-and-in-vivo-characterization
#20
Irshad Hussain, Nisar Hussain, Abdul Manan, Abdur Rashid, Barkat Khan, Sattar Bakhsh
BACKGROUND: Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%-2% of the population worldwide. Different therapeutic regimens have been deployed to treat vitiligo, but none of them could stand alone to be stated as a perfect cure. Recently, a change has been observed through novel experimental-designed optimization leading to the development of an anti-vitiligo ointment containing Psoralea corylifolia (PC) seed powder...
2016: Drug Design, Development and Therapy
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