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Maternal obesity

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https://www.readbyqxmd.com/read/28441394/maternal-obese-type-gut-microbiota-differentially-impact-cognition-anxiety-and-compulsive-behavior-in-male-and-female-offspring-in-mice
#1
Annadora J Bruce-Keller, Sun-Ok Fernandez-Kim, R Leigh Townsend, Claudia Kruger, Richard Carmouche, Susan Newman, J Michael Salbaum, Hans-Rudolf Berthoud
Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact physiological function. To determine if maternal diet-induced gut dysbiosis can disrupt offspring neurobehavioral function, we transplanted high fat diet- (HFD) or control low fat diet-associated (CD) gut microbiota to conventionally-housed female mice. Recipient mice were then bred and the behavioral phenotype of male and female offspring was tracked...
2017: PloS One
https://www.readbyqxmd.com/read/28441347/association-between-sleep-and-body-weight-a-panel-data-model-based-on-a-retrospective-longitudinal-cohort-of-chinese-infants
#2
Tingting Sha, Yan Yan, Xiao Gao, Shiting Xiang, Guangyu Zeng, Shiping Liu, Qiong He
The focus of this article is on sleep duration and sleep problems in infants and their association with body weight. A retrospective birth cohort of 519 infants was enrolled in a community-based study conducted in Changsha, China. Infant weight and other health-related information were collected during regular standard checkups at the Community Health Service Centers when infants were 1, 3, 6, 8, and 12 months old. The sleep duration and sleep problems of infants were assessed by maternal self-reports. Panel data model was used to evaluate the association of sleep duration and sleep problems with infant body weight...
April 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28440693/maternal-history-of-child-abuse-and-obesity-risk-in-offspring-mediation-by-weight-in-pregnancy
#3
Stephanie A Leonard, Lucia C Petito, David H Rehkopf, Lorrene D Ritchie, Barbara Abrams
BACKGROUND: Women's experience of childhood adversity may contribute to their children's risk of obesity. Possible causal pathways include higher maternal weight and gestational weight gain, which have been associated with both maternal childhood adversity and obesity in offspring. METHODS: This study included 6718 mother-child pairs from the National Longitudinal Survey of Youth 1979 in the United States (1979-2012). We applied multiple log-binomial regression models to estimate associations between three markers of childhood adversity (physical abuse, household alcoholism, and household mental illness) and offspring obesity in childhood...
April 25, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28439600/factors-affecting-pregnancy-weight-gain-and-relationships-with-maternal-fetal-outcomes-in-turkey
#4
Nilufer Akgun, Huseyin L Keskin, Isık Ustuner, Gulden Pekcan, Ayse F Avsar
To determine the effects of pre-pregnancy body mass index (BMI) and gestational weight gain on maternal and fetal complications, and to examine whether Turkish women achieve the recommended gestational weight gain. We also investigated the relationship between pregnancy weight gain and mode of delivery, with an examination of maternal anthropometry.  Methods: A retrospective cross-sectional study was conducted on a population of 986 pregnant women between November 2011 and November 2015 at Atatürk Education and Research Hospital, Ankara, Turkey...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28438607/obesity-exposed-oocytes-accumulate-and-transmit-damaged-mitochondria-due-to-an-inability-to-activate-mitophagy
#5
Anna L Boudoures, Jessica Saben, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Wendy Zhang, Kelle H Moley
Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a specialized autophagy pathway. However, evidence from previous work investigating the more general macroautophagy pathway in oocytes suggests that mitophagy may not be active in the oocyte. This would leave the vast numbers of mitochondria - poised to be inherited by the offspring - vulnerable to damage. Here we test the hypothesis that inactive mitophagy in the oocyte underlies maternal transmission of dysfunctional mitochondria...
April 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28438062/associations-of-maternal-obesity-and-smoking-status-with-perinatal-outcomes
#6
Julie K Phillips, Sarah E King, Ira M Bernstein, Joan M Skelly, Stephen T Higgins
Maternal obesity and smoking are associated with adverse perinatal outcomes. These prevalent conditions contribute to health disparities. In this study we examine whether maternal BMI moderates the impact of smoking cessation on short-term perinatal outcomes. This is a secondary analysis of assessments conducted from several prospective clinical trials examining the efficacy of incentives to promote smoking cessation during pregnancy. Participants were randomly assigned to receive financial incentives contingent upon smoking abstinence or a control condition...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28434193/mediators-of-socioeconomic-differences-in-adiposity-among-youth-a-systematic-review
#7
REVIEW
M K Gebremariam, N Lien, R A Nianogo, O A Arah
BACKGROUND: Youth with a low socioeconomic position in developed countries are at a disproportionately higher risk of being overweight or obese than their counterparts. Tackling these inequalities requires that the mechanisms behind them are well understood. OBJECTIVES: The aim of this review was to summarize existing evidence regarding the factors that mediate or contribute to the explanation of the relationship between socioeconomic position and adiposity among youth...
April 23, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28434107/early-life-obesity-prevention-critique-of-intervention-trials-during-the-first-one-thousand-days
#8
REVIEW
John J Reilly, Anne Martin, Adrienne R Hughes
PURPOSE OF REVIEW: To critique the evidence from recent and ongoing obesity prevention interventions in the first 1000 days in order to identify evidence gaps and weaknesses, and to make suggestions for more informative future intervention trials. RECENT FINDINGS: Completed and ongoing intervention trials have had fairly modest effects, have been limited largely to high-income countries, and have used relatively short-term interventions and outcomes. Comparison of the evidence from completed prevention trials with the evidence from systematic reviews of behavioral risk factors shows that some life-course stages have been neglected (pre-conception and toddlerhood), and that interventions have neglected to target some important behavioral risk factors (maternal smoking during pregnancy, infant and child sleep)...
April 22, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28434072/risk-factors-for-childhood-obesity-do-the-birth-weight-type-of-delivery-and-mother-s-overweight-have-an-implication-on-current-weight-status
#9
Aysel Vehapoglu, Nilufer Goknar, Ozden Turel, Emel Torun, Gamze Ozgurhan
BACKGROUND: The aim of this study was to identify risk factors, including the type of delivery, breastfeeding and its duration, birth weight, the timing of solid food introduction, the mother's education level at birth, and smoking status during pregnancy, that are associated with obesity in children living in Istanbul. METHODS: This study involving 4990 healthy children aged 2-14 years, at an outpatient clinic in a tertiary care hospital from June 2012 to July 2014...
April 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28433734/prospective-association-of-fetal-liver-blood-flow-at-30-weeks-gestation-with-newborn-adiposity
#10
Satoru Ikenoue, Feizal Waffarn, Masanao Ohashi, Kaeko Sumiyoshi, Chigusa Ikenoue, Claudia Buss, Daniel L Gillen, Hyagriv N Simhan, Sonja Entringer, Pathik D Wadhwa
BACKGROUND: The production of variation in adipose tissue accretion represents a key fetal adaptation to energy substrate availability during gestation. Because umbilical venous blood transports nutrient substrate from the maternal to the fetal compartment, and the fetal liver is the primary organ where nutrient inter-conversion occurs, it has been proposed that variations in the relative distribution of umbilical venous blood flow shunting either through ductus venosus or perfusing the fetal liver represents a mechanism underlying this adaptation...
April 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28428763/adhd-lifestyles-and-comorbidities-a-call-for-an-holistic-perspective-from-medical-to-societal-intervening-factors
#11
REVIEW
Simon Weissenberger, Radek Ptacek, Martina Klicperova-Baker, Andreja Erman, Katerina Schonova, Jiri Raboch, Michal Goetz
The review examines Attention Deficit Hyperactivity Disorder (ADHD in its Child and Adult form) and its various presentations (Hyperactive Impulsive, Inattentive, and Combined) with a particular focus on environmental (incl. social factors), lifestyles and comorbidities. It is argued that ADHD is best understood in a holistic and interactive context and a vast empirical literature is presented to illustrate the point: Environmental factors include stress in general as well as exposure to toxins (phthalates, bisphenol A)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28427374/prenatal-determinants-of-physical-activity-and-cardiorespiratory-fitness-in-adolescence-northern-finland-birth-cohort-1986-study
#12
Marjaana Tikanmäki, Tuija Tammelin, Marja Vääräsmäki, Marika Sipola-Leppänen, Satu Miettola, Anneli Pouta, Marjo-Riitta Järvelin, Eero Kajantie
BACKGROUND: Lower levels of physical activity and cardiorespiratory fitness are key risk factors of chronic adult diseases. Physical activity and cardiorespiratory fitness are predicted by birth weight, but the underlying parental and pregnancy-related factors remain largely unknown. We examined how prenatal determinants are associated with physical activity and cardiorespiratory fitness in adolescence. METHODS: Of the 16-year-old members of the population-based Northern Finland Birth Cohort 1986 (NFBC 1986), 6682 singletons with no major physical disability reported their amount of physical activity outside school hours, and 4706 completed a submaximal cycle ergometer test assessing cardiorespiratory fitness...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28426649/the-importance-of-appropriate-initial-bacterial-colonization-of-the-intestine-in-newborn-child-and-adult-health
#13
REVIEW
W Allan Walker
The fetus does not reside in a sterile intrauterine environment and is exposed to commensal bacteria from the maternal gut/blood stream which crosses the placenta and enters the amniotic fluid. This intestinal exposure to colonizing bacteria continues at birth and during the first year of life and has a profound influence on lifelong health. Why is this important? Intestinal crosstalk with colonizing bacteria in the developing intestine affects the infant's adaptation to extrauterine life (immune homeostasis) and provides protection against disease expression (allergy, autoimmune disease, obesity, etc...
April 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28425976/prenatal-exposure-to-a-maternal-high-fat-diet-affects-histone-modification-of-cardiometabolic-genes-in-newborn-rats
#14
Bijaya Upadhyaya, Tricia Larsen, Shivon Barwari, Eli J Louwagie, Michelle L Baack, Moul Dey
Infants born to women with diabetes or obesity are exposed to excess circulating fuels during fetal heart development and are at higher risk of cardiac diseases. We have previously shown that late-gestation diabetes, especially in conjunction with a maternal high-fat (HF) diet, impairs cardiac functions in rat-offspring. This study investigated changes in genome-wide histone modifications in newborn hearts from rat-pups exposed to maternal diabetes and HF-diet. Chromatin-immunoprecipitation-sequencing revealed a differential peak distribution on gene promoters in exposed pups with respect to acetylation of lysines 9 and 14 and to trimethylation of lysines 4 and 27 in histone H3 (all, false discovery rate, FDR < 0...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28424020/the-utility-of-an-obesity-specific-small-for-gestational-age-standard-for-pregnancies-complicated-by-maternal-obesity
#15
Ruofan Yao, Sarah E Foster, Aaron B Caughey
INTRODUCTION: An obesity-specific standard for small for gestational age (SGA) pregnancies may help identify additional at risk pregnancies. METHODS: This was a retrospective cohort study of all non-anomalous singleton neonates born in Texas from 2006-2011. Analysis was limited to births between 34 and 42 weeks gestation. Two SGA birth weight standards (birth weight ≤ 10(th) centile) were generated, one using the entire population (SGApop) and another using obese pregnancies (SGAcust)...
April 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28422809/associations-between-dietary-intake-prior-to-6-months-of-age-and-rapid-weight-gain-among-hiv-exposed-uninfected-infants
#16
Daniela Neri, Fernanda C Oliveira, Aline M Carvalho, Gabriel A Somarriba, Gwendolyn B Scott, Tracie L Miller
INTRODUCTION: HIV-exposed, uninfected (HEU) infants are potentially at risk for cardiovascular disease due to in utero exposures. Feeding practices of the infant could compound this risk. However, few studies have evaluated dietary intake of HEU infants. We determined dietary factors associated with rapid weight gain (RWG) among HEU infants from birth to 6 months followed at the University of Miami HIV Screening Program. METHODS: In this cross-sectional analysis, logistic regression was used to determine dietary factors associated with RWG defined as a greater than 0...
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28421783/factors-associated-with-body-mass-index-in-brazilian-children-structural-equation-model
#17
Tatiane Géa-Horta, Rita De Cássia Ribeiro Silva, Rosemeire Leovigildo Fiaccone, Maurício Lima Barreto, Gustavo Velásquez Meléndez
INTRODUCTION: Overweight and obesity in children is an important global problem. Its prevalence is increasing in developed and developing countries. OBJECTIVE: The aim of this study was to evaluate the association between socioeconomic conditions, maternal body mass index (BMI), food security, and intake of obesogenic foods on excess body weight in children. METHODS: A cross-sectional study was conducted, using the data of 3,676 children from the latest National Demographic and Health Survey in Brazil...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421691/the-impact-of-maternal-employment-on-children-s-adiposity-evidence-from-china-s-labor-policy-reform
#18
Young Jo, Qing Wang
BACKGROUND: China has experienced a rapid growth in childhood adiposity in recent years. Although a large number of studies examine the effect of maternal employment on children's adiposity in developed countries, only a few studies investigate the issue in developing countries. Moreover, existing studies tend to suffer from a potential endogeneity issue. AIMS: We provide new evidence on the causal effect of maternal employment on children's adiposity in China. MATERIALS AND METHODS: We employ a difference-in-difference strategy that takes advantage of China's 1995 legislative change to labor regulations, which reduced the number of workdays from 6 to 5 days per week...
April 19, 2017: Health Economics
https://www.readbyqxmd.com/read/28421604/comparison-of-adverse-pregnancy-outcomes-based-on-the-new-iadpsg-2010-gestational-diabetes-criteria-and-maternal-body-mass-index
#19
Shan Jiang, David Chipps, Wah N Cheung, Max Mongelli
BACKGROUND: The diagnostic criteria for gestational diabetes (GDM) have been controversial following the International Association for Pregnancy Study Groups (IADPSG) 2010 recommendations to lower the diagnostic fasting blood sugar level threshold. AIM: To assess the pregnancy-related outcomes of women according to the different diagnostic criteria for GDM adjusting for body mass index categories. METHOD: A retrospective observational cohort study was conducted on 4081 pregnant women with positive 50 g glucose challenge test but without pre-gestational diabetes...
April 19, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28420495/fetal-programming-of-the-metabolic-syndrome
#20
REVIEW
Aleksandra Marciniak, Jolanta Patro-Małysza, Żaneta Kimber-Trojnar, Beata Marciniak, Jan Oleszczuk, Bożena Leszczyńska-Gorzelak
Prenatal development is currently recognized as a critical period in the etiology of human diseases. This is particularly so when an unfavorable environment interacts with a genetic predisposition. The fetal programming concept suggests that maternal nutritional imbalance and metabolic disturbances may have a persistent and intergenerational effect on the health of offspring and on the risk of diseases such as obesity, diabetes, and cardiovascular diseases.
April 2017: Taiwanese Journal of Obstetrics & Gynecology
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