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Chronic Venous Disease

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https://www.readbyqxmd.com/read/29158886/noninvasive-evaluation-of-portal-hypertension-using-a-supervised-learning-technique
#1
Mindaugas Marozas, Romanas Zykus, Andrius Sakalauskas, Limas Kupčinskas, Arūnas Lukoševičius
Portal hypertension (PHT) is a key event in the evolution of different chronic liver diseases and leads to the morbidity and mortality of patients. The traditional reliable PHT evaluation method is a hepatic venous pressure gradient (HVPG) measurement, which is invasive and not always available or acceptable to patients. The HVPG measurement is relatively expensive and depends on the experience of the physician. There are many potential noninvasive methods to predict PHT, of which liver transient elastography is determined to be the most accurate; however, even transient elastography lacks the accuracy to be a perfect noninvasive diagnostic method of PHT...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29143147/-esc-guidelines-2017-on-peripheral-arterial-diseases-summary-of-the-most-important-recommendations-and-innovations
#2
C Espinola-Klein
The current European Society of Cardiology (ESC) guidelines on peripheral arterial diseases include recommendations on diagnostics and treatment of atherosclerotic manifestations in peripheral arteries. Because of the high coincidence of atherosclerosis in different arterial territories, screening for other atherosclerotic lesions is necessary in patients with clinical symptoms in one vascular bed. Consistent treatment of cardiovascular risk factors is important in all patients with peripheral atherosclerosis...
November 15, 2017: Herz
https://www.readbyqxmd.com/read/29138677/oxidative-stress-in-hemodialysis-patients-a-review-of-the-literature
#3
REVIEW
Vassilios Liakopoulos, Stefanos Roumeliotis, Xenia Gorny, Evangelia Dounousi, Peter R Mertens
Hemodialysis (HD) patients are at high risk for all-cause mortality and cardiovascular events. In addition to traditional risk factors, excessive oxidative stress (OS) and chronic inflammation emerge as novel and major contributors to accelerated atherosclerosis and elevated mortality. OS is defined as the imbalance between antioxidant defense mechanisms and oxidant products, the latter overwhelming the former. OS appears in early stages of chronic kidney disease (CKD), advances along with worsening of renal failure, and is further exacerbated by the HD process per se...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29132859/lymphedema-diagnostic-workup-and-management
#4
REVIEW
Ayman A Grada, Tania J Phillips
Lymphedema is a localized form of tissue swelling resulting from excessive retention of lymphatic fluid in the interstitial compartment. It is caused by impaired lymphatic drainage. Lymphedema is a chronic progressive disease with serious physical and psychosocial implications. It can be challenging to diagnose, especially in obese patients and in those with coexisting venous disease. We performed PubMed and Google Scholar searches of the English-language literature (1966-2017) using the terms lymphedema, lymphedema management, and lymphatic complications...
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29123633/efficiency-of-a-new-combined-laser-therapy-in-patients-with-trophic-ulcers-of-lower-extremities-and-chronic-venous-insufficiency
#5
Sergey Vladimirovich Moskvin, Aleksandr Vladimirovich Geynitz, Evgeniy Valer'yevich Askhadulin
Introduction: Treating patients with trophic ulcers (TUs) of venous etiology (VE) is a complicated socio-medical and economic problem. One of the ways to increase treatment efficiency can be a complex therapy, including combined laser action. Methods: The objective of this study was a comparative evaluation of the efficiency of traditional treatment methods in patients with chronic venous diseases of C6 class, and combined laser therapy (LT) according to a new method by LASMIK® device. External exposure was conducted on the 1-4 affected area during one session for 2 minutes per zone (pulsed mode, light pulse duration of 100-130 ns, wavelength 635 nm, by a matrix emitter consisting of eight laser diodes with a surface area of 8 cm2, at a distance of up to 7 cm, pulsed power 40 W)...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29118492/association-of-ocular-findings-and-outcome-in-cerebral-venous-thrombosis
#6
Samira Yadegari, Alireza Keshtkar Jafari, Elham Ashrafi
BACKGROUND: Cerebral venous thrombosis (CVT) is a potentially life-threatening underdiagnosed disease. Headache is a common but nonspecific finding in CVT. Other features such as ocular finding can assist to correct diagnosis, but their frequency in CVT has not been previously evaluated. The aim of this study is to evaluate the ocular symptoms and signs in CVT and their association with outcome. METHODS: The demographic, clinical, laboratory, radiological, and outcome data were collected and analyzed from patients referred to a tertiary hospital during 6 years...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29115714/deep-vein-thrombosis-in-pediatric-patients
#7
REVIEW
Julie Jaffray, Guy Young
Due to advances in caring for critically ill children and those with chronic diseases, rates of deep vein thrombosis (DVT) are increasing in children. Risk factors consist of central venous catheters, chronic medical conditions, thrombophilia, and various medications. Compression Doppler ultrasonography is the method most commonly used to diagnose DVT, and patients will usually present with pain and swelling of the affected limb. Anticoagulation via subcutaneous injection is the most common treatment regime for children with DVT, and the new, direct oral anticoagulants are currently under investigation...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29107971/sex-differences-in-the-characteristics-and-short-term-prognosis-of-patients-presenting-with-acute-symptomatic-pulmonary-embolism
#8
Deisy Barrios, Raquel Morillo, Ina Guerassimova, Esther Barbero, Héctor Escobar-Morreale, Alexander T Cohen, Cecilia Becattini, Victor Tapson, Roger Yusen, David Jimenez
BACKGROUND: We sought to examine sex-related differences in the characteristics and outcome in patients presenting with acute symptomatic pulmonary embolism (PE). METHODS: We conducted a retrospective cohort study of 2,096 patients diagnosed with acute PE. The characteristics were recorded at presentation. Treatment was at the discretion of patients' physicians. The primary study outcome, all-cause mortality, and the secondary outcomes of PE-specific mortality, recurrent venous thromboembolism, and major bleeding were assessed during the first month of follow-up after PE diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/29102174/spleen-stiffness-is-positively-correlated-with-hvpg-and-decreases-significantly-after-tips-implantation
#9
Matthias Buechter, Paul Manka, Jens M Theysohn, Marcus Reinboldt, Ali Canbay, Alisan Kahraman
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is indicated in patients with decompensated portal hypertension (PH). Hepatic venous pressure gradient (HVPG) is considered gold standard for assessment of PH. Because HVPG measurement is invasive, non-invasive methods for evaluating severity of PH are warranted. PATIENTS AND METHODS: We retrospectively correlated spleen stiffness as measured by FibroScan with HVPG in patients who underwent TIPS. Twenty-four patients with spleen stiffness measurement (SSM) one day before (D-1), one day after (D+1) and 28 days after TIPS (D+28) were included...
October 10, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29098740/does-non-contact-low-frequency-ultrasound-nlfu-therapy-contribute-to-wound-healing-at-the-molecular-level
#10
Cornelia Wiegand, Kyle Bittenger, Robert D Galiano, Vickie R Driver, Gary W Gibbons
Non-contact low frequency ultrasound (NLFU) is used to treat various types of chronic wounds including venous, diabetic and pressure ulcers. The objective for this sub study of the IN BALANCE RCT VLU trial was to characterize and compare the NLFU treatment group and patients receiving standard of care (SOC) with respect to the effect of the assigned study treatment on content/quantity of inflammatory cytokines and fibrinogen as well as bacteria. Higher mean wound area reduction was observed in the NLFU treatment group (67...
November 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29097175/characteristics-of-patients-and-patterns-of-chronic-venous-disease-of-the-lower-limbs-in-a-referral-hospital-in-cameroon
#11
Marcus Fokou, Boniface Moifo, Emmanuel Fongang, Abel Teyang, Wallinjon Muna
OBJECTIVE: The objective of this study was to investigate the magnitude of chronic venous disease (CVD) in sub-Saharan Africa, specifically the characteristics of the patients, the symptoms, the signs, and the severity. METHODS: From December 2013 to December 2016, a cross-sectional study was conducted of all consecutive patients with CVD aged ≥18 years and attending the outpatient clinic of the Yaoundé General Hospital in Cameroon. We recorded information on demographics, relevant medical history, symptoms, lifestyle, and clinical presentation...
October 30, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29096125/biaxial-mechanical-behavior-of-bovine-saphenous-venous-valve-leaflets
#12
Jiaqi Lu, Hsiao-Ying Shadow Huang
Chronic venous disease is caused by chronic venous insufficiency (CVI), which results in significant symptoms such as venous ulcers, ankle eczema, leg swelling, etc. Venous valve incompetence is a major cause of CVI. When the valves of veins in the leg become incompetent (i.e., do not close properly), blood is able to flow backwards (i.e., reflux), which results in blood pooling in the lower extremities, distal venous hypertension, and CVI. Current clinical therapies, such as surgical venous valve reconstruction and bioprosthetic venous valve replacement, are highly invasive and only moderately successful...
October 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29094875/heart-failure-with-preserved-ejection-fraction-diagnosis-and-management
#13
John D Gazewood, Patrick L Turner
Heart failure with preserved ejection fraction, also referred to as diastolic heart failure, causes almost one-half of the 5 million cases of heart failure in the United States. It is more common among older patients and women, and results from abnormalities of active ventricular relaxation and passive ventricular compliance, leading to a decline in stroke volume and cardiac output. Heart failure with preserved ejection fraction should be suspected in patients with typical symptoms (e.g., fatigue, weakness, dyspnea, orthopnea, paroxysmal nocturnal dyspnea, edema) and signs (S3 heart sound, displaced apical pulse, and jugular venous distension) of chronic heart failure...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29091810/chronic-kidney-disease-is-associated-with-increased-risk-of-venous-thromboembolism-recurrence
#14
Marcello Rattazzi, Sabina Villalta, Lara De Lucchi, Alessandra Sponchiado, Silvia Galliazzo, Elisabetta Faggin, Valeria Pagliara, Chiara Zilli, Elena Callegari, Livio Caberlotto, Massimo Puato, Paolo Pauletto
INTRODUCTION: It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS: We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were included in the retrospective analysis whereas a subgroup of 260 individuals, without history of recurrence and that stopped oral anticoagulation, were then followed-up for a mean of 52...
October 16, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29079553/c%C3%A3-te-d-ivoire-dual-burden-of-disease-codubu-study-protocol-to-investigate-the-co-occurrence-of-chronic-infections-and-noncommunicable-diseases-in-rural-settings-of-epidemiological-transition
#15
Ikenna C Eze, Clémence Esse, Fidèle K Bassa, Siaka Koné, Felix Acka, Loukou Yao, Medea Imboden, Fabienne N Jaeger, Christian Schindler, Mireille Dosso, Véronique Laubhouet-Koffi, Dinard Kouassi, Eliézer K N'Goran, Jürg Utzinger, Bassirou Bonfoh, Nicole Probst-Hensch
BACKGROUND: Individual-level concomitance of infectious diseases and noncommunicable diseases (NCDs) is poorly studied, despite the reality of this dual disease burden for many low- and middle-income countries (LMICs). OBJECTIVE: This study protocol describes the implementation of a cohort and biobank aiming for a better understanding of interrelation of helminth and Plasmodium infections with NCD phenotypes like metabolic syndrome, hypertension, and diabetes. METHODS: A baseline cross-sectional population-based survey was conducted over one year, in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d'Ivoire...
October 27, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29077500/behcet-s-diseasea-case-report
#16
James M Mahoney, Kelsey Millonig
Behcet's disease is a rare autoimmune systemic vasculitis. It usually presents with a symptom complex involving primarily mucocutaneous lesions, genital lesions, and uveitis. When it involves the lower extremity, venous and arterial disease predominates, and joint involvement occurs in approximately 50% of patients. We present a patient with Behcet's disease who was initially referred to us for chronic toenail pathology.
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29074714/potential-for-non-invasive-assessment-of-lung-inhomogeneity-using-highly-precise-highly-time-resolved-measurements-of-gas-exchange
#17
James E Mountain, Peter Santer, David Patrick O'Neill, Nicholas M J Smith, Luca Ciaffoni, John H Couper, Grant A D Ritchie, Gus Hancock, Jonathan P Whiteley, Peter A Robbins
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesised that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity non-invasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance and deadspace, all relative to lung volume...
October 26, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29063748/new-data-on-chronic-venous-disease-a-new-place-for-cyclo-3%C3%A2-fort
#18
Stravos K Kakkos, Eliete Bouskela, Arkadiusz Jawien, Andrew N Nicolaides
With our increasing knowledge of the epidemiology, pathophysiology, investigation and clinical aspects of chronic venous disease (CVD) and new data on the various therapies available, an update of the recommendations on CVD and its management appears to be necessary. The symposium "New Data on Chronic Venous Disease, New Place for Cyclo 3® Fort", held at the annual meeting of the European Venous Forum (EVF) on June 30th, 2017 in Porto, Portugal, reported the recent developments on Ruscus+HMC+Vit C (Cyclo 3® Fort), including the results of a series of in vivo pharmacological experiments and a recent meta-analysis...
October 23, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29056449/venous-disease-patient-registries-available-in-the-united-states
#19
Fedor Lurie, Andrea Obi, Marlin Schul, Lawrence V Hofmann, Gregory Kasper, Thomas Wakefield
Patient registries are beneficial in that they allow the collection of prospective data focused on a specific medical issue. These registries give providers a "real-world" view of patient outcomes. Many medical disciplines have a long history of developing and using patient registries; the first patient registry for chronic venous disease in the United States was launched in 2011, fairly recently in comparison. Registries included in this review were identified by surveying members of major academic societies that focus on the care of chronic venous disease and by searching MEDLINE and Embase databases using Ovid interface...
October 19, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29049990/inhibition-of-pten-activity-aggravates-post-renal-fibrosis-in-mice-with-ischemia-reperfusion-induced-acute-kidney-injury
#20
Jun Zhou, Jiying Zhong, Sen Lin, Zhenxing Huang, Hongtao Chen, Simin Tang, Chengxiang Yang, Youling Fan
BACKGROUND: Renal fibrosis is a common pathophysiological feature of chronic kidney disease. Acute kidney injury (AKI) is defined as an independent causal factor of chronic kidney disease, with a pathological representation of post renal fibrosis. However, the etiopathogenesis underlying post renal fibrosis induced by AKI is not completely understood. METHODS: BALB/c mice were treated with bpv or vehicle controls and were, respectively, the ischemia reperfusion (IR) model group and control group...
October 19, 2017: Cellular Physiology and Biochemistry
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