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Peripheral blood morphology

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https://www.readbyqxmd.com/read/29773403/synthesis-of-chitin-glucan-aldehyde-quercetin-conjugate-and-evaluation-of-anticancer-and-antioxidant-activities
#1
Anu Singh, P K Dutta, Hridyesh Kumar, Amit Kumar Kureel, Ambak Kumar Rai
In the present study, we have synthesized chitin-glucan-aldehyde-quercetin (chi-glu-ald-que) conjugate via condensation reaction. Synthesis of chitin-glucan-aldehyde (chi-glu-ald) complex was facilitated by the oxidation of chitin-glucan (chi-glu) complex. Formation of conjugate was confirmed by Proton nuclear magnetic resonance spectroscopy (1 H NMR) and Fourier-transform infrared spectroscopy (FT-IR). Morphological studies showed that after grafting of quercetin, several changes on surface were depicted and a more crystalline nature was observed...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772575/therapeutic-effect-of-cd4-cd25-regulatory-t-cells-amplified-in-vitro-on-experimental-autoimmune-neuritis-in-rats
#2
Feng-Jie Wang, Dan Cui, Wei-Dong Qian
BACKGROUND/AIMS: This study aimed to explore whether the adoptive transfusion of autologous CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) has a therapeutic effect on Experimental autoimmune neuritis (EAN) model rats, and it provides new experimental and theoretical bases for the immunotherapy of Guillain-Barre syndrome (GBS). METHODS: CD4+CD25+ Tregs were sorted from the spleens of rats using immunomagnetic bead separation techniques combined with flow cytometry...
May 14, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29760710/ionizing-radiation-induces-morphological-changes-and-immunological-modulation-of-jurkat-cells
#3
Patrick Voos, Sebastian Fuck, Fabian Weipert, Laura Babel, Dominique Tandl, Tobias Meckel, Stephanie Hehlgans, Claudia Fournier, Anna Moroni, Franz Rödel, Gerhard Thiel
Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation and alters functional properties of these immune cells, we exposed human immortalized Jurkat cells and peripheral blood lymphocytes (PBL) to X-ray doses between 0.1 and 5 Gy. This resulted in cellular responses, which are typically observed also in naïve T-lymphocytes in response of T-cell receptor immune stimulation or mitogens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755847/-18-f-fdg-pet-ct-findings-in-hepatosplenic-gamma-delta-t-cell-lymphoma-case-reports-and-review-of-the-literature
#4
Michael W Cho, Bennett B Chin
Hepatosplenic Gamma Delta T cell lymphoma (γδHSTL) is a rare, highly aggressive, and rapidly lethal T cell lymphoma which manifests 18 F-FDG PET/CT findings that can mimic benign conditions. Patients with γδHSTL present with unexplained symptoms of a hematologic malignancy like the B symptoms of lymphoma including weight loss, fevers, and night sweats, as well as, splenomegaly and hepatomegaly. Thrombocytopenia, anemia, or neutropenia are also common due to spleen, liver and bone marrow involvement. The peripheral blood, however, typically does not show abnormal T cells...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29750898/mebendazole-exhibits-potent-anti-leukemia-activity-on-acute-myeloid-leukemia
#5
Licai He, Liuzhi Shi, Zhuanyun Du, He Huang, Rui Gong, Lan Ma, Lianjuan Chen, Shenmeng Gao, Jianxin Lyu, Haihua Gu
Acute myeloid leukemia (AML) is one of the most common types of acute leukemia in adults with the lowest survival rate of all leukemia. Resistance to cytarabine and anthracycline-based chemotherapy is a major cause of treatment failure. Thus, finding new drugs with anti-leukemia activities and minimal side effect is urgently needed. Here through screening more than 1000 drugs approved by the Food and Drug Administration (FDA) of United States, the antihelmintic drug mebendazole (MBZ) was found to inhibit the growth of AML cell lines (THP-1, U937, NB4 and K562) and bone marrow mononuclear cells (BM-MNCs) from AML patients at pharmacologically achievable concentrations...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29744321/morphology-of-intra-articular-structures-and-histology-of-menisci-of-knee-joint
#6
Monika Gupta, Parmod Kumar Goyal, Poonam Singh, Anu Sharma
Introduction: Menisci and cruciate ligaments are intra-articular structures of knee, and injury to these structures is common. Morphometric data gained in the study will help in analyzing the variations among humans and correlating it with the possibility, location, and type of injuries as well as better interpretation of structures during magnetic resonance imaging and arthroscopy which will further help in reconstructive surgeries of knee. Materials and Methods: Width and thickness of the medial menisci (MM), lateral menisci (LM), and maximum length and width of anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) were taken on twenty knees...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29742495/progressive-degeneration-and-inhibition-of-peripheral-nerve-regeneration-in-the-sod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#7
Binbin Deng, Wenjing Lv, Weisong Duan, Yakun Liu, Zhongyao Li, Yanqin Ma, Guisen Zhang, Xueqin Song, Can Cui, Xiaoming Qi, Yuan Li, Chunyan Li
BACKGROUND: Myelination, degeneration and regeneration are implicated in crucial responses to injury in the peripheral nervous system. Considering the progression of amyotrophic lateral sclerosis (ALS), we used the superoxide dismutase 1 (SOD1)-G93A transgenic mouse model of ALS to investigate the effects of mutant SOD1 on the peripheral nerves. METHODS: Changes in peripheral nerve morphology were analyzed in SOD1 mutant mice at various stages of the disease by toluidine blue staining and electron microscopy (EM)...
May 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29741258/image-processing-and-machine-learning-in-the-morphological-analysis-of-blood-cells
#8
J Rodellar, S Alférez, A Acevedo, A Molina, A Merino
INTRODUCTION: This review focuses on how image processing and machine learning can be useful for the morphological characterization and automatic recognition of cell images captured from peripheral blood smears. METHODS: The basics of the 3 core elements (segmentation, quantitative features, and classification) are outlined, and recent literature is discussed. Although red blood cells are a significant part of this context, this study focuses on malignant lymphoid cells and blast cells...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29741256/optimizing-morphology-through-blood-cell-image-analysis
#9
REVIEW
A Merino, L Puigví, L Boldú, S Alférez, J Rodellar
INTRODUCTION: Morphological review of the peripheral blood smear is still a crucial diagnostic aid as it provides relevant information related to the diagnosis and is important for selection of additional techniques. Nevertheless, the distinctive cytological characteristics of the blood cells are subjective and influenced by the reviewer's interpretation and, because of that, translating subjective morphological examination into objective parameters is a challenge. METHODS: The use of digital microscopy systems has been extended in the clinical laboratories...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29741254/present-status-and-perspective-of-laboratory-hematology-in-japan-on-the-standardization-of-blood-cell-morphology-including-myelodysplasia-on-behalf-of-the-japanese-society-for-laboratory-hematology
#10
REVIEW
K Tohyama
The Japanese Society for Laboratory Hematology (JSLH) was launched in 2000 and has been developed by a mutual collaboration of hematologists, medical technologists, and the companies involved in hematological laboratory testing. The aim of JSLH is the progress and development of laboratory hematology by academic conferences, periodic publication of academic journal, training and education (in the meeting, the journal, or the website), promotion of the standardization of laboratory hematology, and certification of the laboratory hematology specialists...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29737108/-clinical-and-ultrasonographic-features-of-hepatic-infantile-hemangioendothelioma
#11
Hong Wang, Huan Zhang, Ting-Ting Qiu, Yu-Lan Peng
OBJECTIVE: To investigate the clinical manifestations and ultrasound features of hepatic infantile hemangioendothelioma (IHE). METHODS: This study retrospectively analyzed the clinical features and ultrasound characteristics of 8 patients of IHE,whose diagnosis was confirmed by surgery or liver biopsy from January 2010 to October 2016. RESULTS: Among the eight IHE patients,the male-to-female ratio was 1:1,with the mean age ranged from 15 d to 3 yr...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29725528/-blastoid-variant-of-burkitt-lymphoma-with-additional-partial-1q-tetrasomy
#12
Ahsan Siddiqi, Sheshadri Madhusudhana, Alexey Glazyrin
Burkitt lymphoma is cytogenetically characterized by t(8;14)(q24;q32) translocation, sometimes accompanied by additional cytogenetic abnormalities. These abnormalities usually result in more aggressive clinical presentation and morphology of the disease. The current report presens a case of Burkitt lymphoma with t(8;14)(q24;q32) accompanied by partial tetrasomy of chromosome 1(47,XY,+1,i(1)(q10),t(8;14)(q24;q32)[2]/46,XY[18]). The patient was a 59-year-old male who presented with abdominal pain, leukocytosis and tumor lysis syndrome...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29716882/vacuolization-in-myeloid-and-erythroid-precursors-in-a-child-with-menkes-disease
#13
Seçil Sayın, Şule Ünal, Mualla Cetin, Fatma Gumruk
A five year-old boy, who was under follow-up with a clinical and biochemical diagnosis of Menkes Disease (MD) since ten months of age, was admitted with diarrhea. On examination he had a characteristic cherubic face hypopigmented, sparse hair, hepatosplenomegaly, hypotonia with brisk deep tendon reflexes. Hemogram revealed: Hb:5.5g/dL, Hct:16.2%, RBC:1.69x1012/L, MCV:95.8fL, MCH:32.3pg, RDW:19.2%, WBC:2.2x109/L and platelet count;157x109/L. Serum vitamin B12 level was 575pg/mL. Serum copper level was 81μg/dL and serum zinc level was 152μg/dL...
April 30, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29715554/rehmannia-glutinosa-polysaccharide-promoted-activation-of-human-dendritic-cells
#14
Yuhua Wang, Minseok Kwak, Peter Chang-Whan Lee, Jun-O Jin
In our previous study, we showed that Rehmannia glutinosa polysaccharide (RGP) treatment induced maturation of dendritic cells (DCs) and that it had an anticancer effect in mice. The effect of RGP has not been studied in human DCs, including monocyte-derived DCs (MDDCs) and peripheral blood DCs (PBDCs). In this study, we examined DC activation by RGP in human cells. The dendritic morphology of RGP-treated MDDCs was substantially altered as compared with that of phosphate-buffered saline (PBS)-treated control cells...
April 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29703492/predictive-factors-of-fatal-bleeding-in-acute-promyelocytic-leukemia
#15
Simon Mantha, Martin S Tallman, Sean M Devlin, Gerald A Soff
Acute promyelocytic leukemia (APL) is associated with a profound coagulopathy. Based on retrospective assessments, several potential risk factors for hemorrhagic morbidity and mortality have emerged. Several studies have shown elevated white blood cell (WBC) count at presentation to be a robust predictor of bleeding events. Other clinical and laboratory parameters have been evaluated with variable association with hemorrhagic morbidity or mortality. These include ECOG performance status, age, morphological subtype, platelet count, peripheral blood blast count, ethnicity, body mass index, prothrombin time, activated partial thromboplastin time, lactate dehydrogenase, d-dimers, creatinine and fibrinogen levels...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29692815/n-cadherin-upregulation-promotes-the-neurogenic-differentiation-of-menstrual-blood-derived-endometrial-stem-cells
#16
Yanli Liu, Fen Yang, Shengying Liang, Qing Liu, Sulei Fu, Zhenyu Wang, Ciqing Yang, Juntang Lin
Peripheral nerve injuries are typically caused by either trauma or medical disorders, and recently, stem cell-based therapies have provided a promising treatment approach. Menstrual blood-derived endometrial stem cells (MenSCs) are considered an ideal therapeutic option for peripheral nerve repair due to a noninvasive collection procedure and their high proliferation rate and immunological tolerance. Here, we successfully isolated MenSCs and examined their biological characteristics including their morphology, multipotency, and immunophenotype...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29686568/significance-of-green-granules-in-neutrophils-and-monocytes
#17
Tina Gorup, Andrea T Cohen, Amelia B Sybenga, Edward S Rappaport
Intracytoplasmic green granules in neutrophils have been the subject of conjecture and discussion. Sometimes nicknamed "death cells," these granules are often associated with severe liver disease and have been said to predict acute bad outcomes in severely ill patients. Some recommend that the laboratory community report these granules to treating clinicians as an indication of poor prognosis. We report two patients presenting with secondary liver disease who were found to have blue-green neutrophilic inclusions on the peripheral blood smear...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29668284/the-double-edged-effect-of-hydroxychloroquine-on-human-umbilical-cord-derived-mesenchymal-stem-cells-treating-lupus-nephritis-in-mrl-lpr-mice
#18
Shaoshan Mai, Lin Zou, Xiaoyan Tian, Xiao Liao, Yizhao Luan, Xing Han, Yuling Wei, Yue Wu, Shengnan Kuang, Yang Yang, Jie Ma, Qi Chen, Junqing Yang
Hydroxychlorquine(HCQ) and human umbilical cord-derived mesenchymal stem cells (UC-MSCs) were used to treat systemic lupus erythematosus(SLE),respectively. However, the effect of HCQ on UC-MSCs in lupus nephritis (LN) has not been investigated. In this study, HCQ and UC-MSCs were used in MRL/lpr mice. Surprisingly, although the treatment of both HCQ and UC-MSCs could ameliorate renal damage separately, the presence of HCQ decreased unexpectedly the therapeutic effects of UC-MSCs through interfering expression of IFN-γ...
April 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29659673/evaluation-of-the-utility-of-bone-marrow-morphology-and-ancillary-studies-in-pediatric-patients-under-surveillance-for-myelodysplastic-syndrome
#19
Karen M Chisholm, Min Xu, Billy Davis, Amy Ogi, M Cristina Pacheco, Amy E Geddis, Karen D Tsuchiya, Joe C Rutledge
Objectives: To evaluate the utility of flow cytometry, karyotype, and a fluorescence in situ hybridization (FISH) panel in screening children for myelodysplastic syndrome (MDS). Methods: Bone marrow morphology, flow cytometry, karyotype, and FISH reports from 595 bone marrow specimens (246 patients) were analyzed. Results: By morphology, 8.7% of cases demonstrated at least unilineage dysplasia and/or increased blasts. Flow cytometry identified definitive abnormalities in 2...
April 25, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29658918/whole-mount-confocal-microscopy-for-adult-ear-skin-a-model-system-to-study-neuro-vascular-branching-morphogenesis-and-immune-cell-distribution
#20
Tomoko Yamazaki, Wenling Li, Yoh-Suke Mukouyama
Here, we present a protocol of a whole-mount adult ear skin imaging technique to study comprehensive three-dimensional neuro-vascular branching morphogenesis and patterning, as well as immune cell distribution at a cellular level. The analysis of peripheral nerve and blood vessel anatomical structures in adult tissues provides some insights into the understanding of functional neuro-vascular wiring and neuro-vascular degeneration in pathological conditions such as wound healing. As a highly informative model system, we have focused our studies on adult ear skin, which is readily accessible for dissection...
March 29, 2018: Journal of Visualized Experiments: JoVE
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