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Colchicin

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https://www.readbyqxmd.com/read/29142436/high-performance-thin-layer-chromatographic-densitometric-quantification-and-recovery-of-bioactive-compounds-for-identification-of-elite-chemotypes-of-gloriosa-superba-l-collected-from-sikkim-himalayas-india
#1
Ankita Misra, Pushpendra Kumar Shukla, Bhanu Kumar, Jai Chand, Poonam Kushwaha, Md Khalid, Ajay Kumar Singh Rawat, Sharad Srivastava
Background: Gloriosa superba L. (Colchicaceae) is used as adjuvant therapy in gout for its potential antimitotic activity due to high colchicine(s) alkaloids. Objective: This study aimed to develop an easy, cheap, precise, and accurate high-performance thin-layer chromatographic (HPTLC) validated method for simultaneous quantification of bioactive alkaloids (colchicine and gloriosine) in G. superba L. and to identify its elite chemotype(s) from Sikkim Himalayas (India)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29130561/mechanism-of-action-of-camphoryl-benzene-sulfonamide-derivative-on-glucose-uptake-in-adipose-tissue
#2
Marisa Jádna Silva Frederico, Allisson Jhonatan Gomes Castro, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Fabíola Branco Filippin Monteiro, Alessandra Mascarello, Ricardo José Nunes, Fátima Regina Mena Barreto Silva
The aim of the present study was to investigate the mechanism of action of a sulfonamide derivative on glucose uptake in adipose tissue, as well as to characterize the effects of this compound on intestinal disaccharidases and advanced glycation end-products (AGEs) formation. Camphoryl-benzene sulfonamide (CS) was able to stimulate glucose uptake in isolated adipocytes, adipose tissue and in soleus muscle. The stimulatory effect of the compound (10 μM) on glucose uptake on adipose tissue was blocked by diazoxide, wortmannin, U73122, colchicine, and N-ethylmaleimide...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29121194/cost-effectiveness-of-colchicine-treatment-on-post-operative-atrial-fibrillation-poaf-events-in-patients-of-major-cardiac-surgery
#3
M Barman, Mahmoud Tantawy, Mark Sopher, Carsten Lennerz
Background: Post-operative atrial fibrillation (POAF) occurs in 20-50% of patients amid post-operative stay after Cardiac Surgery. We intend to determine whether colchicine therapy in patients undergoing cardiac surgery is a cost-effective strategy for prevention of postoperative atrial fibrillation. To undertake cost utility analysis and calculate ICUR for colchicine therapy in these subgroup of patients. Design: Decision tree model to calculate the incremental cost utility ratio comparing two treatment strategies in patients undergoing cardiac surgery...
November 7, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29121120/nature-is-the-best-source-of-anticancer-drugs-indexing-natural-products-for-their-anticancer-bioactivity
#4
Anwar Rayan, Jamal Raiyn, Mizied Falah
Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity...
2017: PloS One
https://www.readbyqxmd.com/read/29119082/cardiac-manifestations-of-familial-mediterranean-fever
#5
REVIEW
Ahmad Alsarah, Osama Alsara, Heather S Laird-Fick
Familial Mediterranean fever (FMF) is autoinflammatory disorder characterized by sporadic attacks of fever, peritonitis, pleuritis, and arthritis. It is mainly seen in patients from Mediterranean origins, but it is now reported more frequently in Europe and North America due to immigration. To analyze the data on the cardiovascular manifestations in FMF patients, we searched PubMed using the terms "Familial Mediterranean Fever" or "FMF" in combination with other key words including "cardiovascular diseases" "pericardial diseases" "atherosclerosis" "coronary artery diseases" "cardiomyopathy" "pulmonary hypertension" or "valvular diseases...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29110592/recent-developments-on-phenstatins-as-potent-antimitotic-agents
#6
Xing Chen, Shi-Meng Wang, Gajjela Bharath Kumar, Grant A L Bare, Jing Leng, Syed Nasir Abbas Bukhari, Hua-Li Qin
Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Phenstatins inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. Moreover, the structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. In addition, phenstatin derivatives are undergoing clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic properties...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29108466/-express-colchicine-alleviates-acute-postoperative-pain-but-delays-wound-repair-in-mice-roles-of-neutrophils-and-macrophages
#7
Asami Sukeishi, Koichi Isami, Haruka Hiyama, Satoshi Imai, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29102957/stepwise-dose-increase-of-febuxostat-is-comparable-with-colchicine-prophylaxis-for-the-prevention-of-gout-flares-during-the-initial-phase-of-urate-lowering-therapy-results-from-fortune-1-a-prospective-multicentre-randomised-study
#8
Hisashi Yamanaka, Shigenori Tamaki, Yumiko Ide, Hyeteko Kim, Kouichi Inoue, Masayuki Sugimoto, Yuji Hidaka, Atsuo Taniguchi, Shin Fujimori, Tetsuya Yamamoto
OBJECTIVES: To determine whether febuxostat with stepwise dose increase is as useful as colchicine prophylaxis in reducing gout flares during the initial introduction of urate-lowering therapy in patients with gout in comparison with febuxostat with no dose titration. METHODS: In this prospective, multicentre, randomised open-label comparative study, patients were randomised to group A (stepwise dose increase of febuxostat from 10 to 40 mg/day), group B (fixed-dose febuxostat 40 mg/day plus colchicine 0...
November 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29102632/structure-of-a-benzylidene-derivative-of-9-10h-anthracenone-in-complex-with-tubulin-provides-a-rationale-for-drug-design
#9
Jie Cheng, Yangping Wu, Yuxi Wang, Chengdi Wang, Yanyan Wang, Chengyong Wu, Shaoxue Zeng, Yamei Yu, Qiang Chen
Microtubules are composed of αβ-tubulin heterodimers and have been treated as highly attractive targets for antitumor drugs. A broad range of agents bind to tubulin and interfere with microtubule assembly, including colchicine binding site inhibitors (CBSIs). Tubulin Polymerization Inhibitor I (TPI1), a benzylidene derivative of 9(10H)-anthracenone, is a CBSI that inhibits the assembly of microtubules. However, for a long time, the design and development of anthracenone family drugs have been hindered by the lack of structural information of the tubulin-agent complex...
November 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29101915/pericarditis
#10
Atifur Rahman, Avadhesh Saraswat
BACKGROUND: Pericarditis is an important diagnosis to consider, along with various other differential diagnoses, in a patient who presents with chest pain. OBJECTIVE: This article describes in detail the common features, management and complications of pericarditis in the general practice setting. DISCUSSION: Characteristic clinical findings in pericarditis include pleuritic chest pain and pericardial friction rub on auscultation of the left lower sternal border...
November 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29101676/long-term-follow-up-of-paediatric-mefv-carriers
#11
Balahan Makay, Nesrin Gülez
Although familial Mediterranean fever (FMF) is inherited autosomal recessively, some heterozygotes may express disease phenotype and require therapy. To date, there is no study in the literature about how to follow-up Mediterranean fever (MEFV) heterozygotes who do not fulfil FMF criteria in the paediatric age group. This study aims to share a single-centre experience of the long-term clinical and laboratory follow-up of paediatric MEFV carriers. We reviewed the charts of 69 children who were heterozygous for MEFV variants...
November 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29100504/associated-factors-with-functional-disability-and-health-related-quality-of-life-in-chinese-patients-with-gout-a-case-control-study
#12
Ting Fu, Haixia Cao, Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Liren Li, Zhifeng Gu
BACKGROUND: Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. METHODS: A total of 226 consecutive gout patients and 232 age- and gender-matched healthy individuals were involved in the study...
November 3, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29090618/increased-platelet-reactivity-as-measured-by-plasma-glycoprotein-vi-in-gout
#13
Richard Conway, Claire-Louise Murphy, Anne Madigan, Patricia Kavanagh, Liz Geraghty, Niamh Redmond, Laura Helbert, John J Carey, Eimear Dunne, Dermot Kenny, Geraldine M McCarthy
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI (sGPVI). Therefore, elevated sGPVI is a marker of platelet activation and a risk marker for cardiovascular events. The aim of this study was to assess platelet activation, as measured by plasma sGPVI level in gout. Blood samples were taken from patients with gout or osteoarthritis, and from healthy volunteers...
November 1, 2017: Platelets
https://www.readbyqxmd.com/read/29078848/partially-purified-gloriosa-superba-peptides-inhibit-colon-cancer-cell-viability-by-inducing-apoptosis-through-p53-upregulation
#14
Prapaphan Budchart, Ariya Khamwut, Chomdao Sinthuvanich, Sunanta Ratanapo, Yong Poovorawan, Nattanan Panjaworayan T-Thienprasert
BACKGROUND: Colon cancer is a major health problem worldwide. Available treatments such as surgery, chemotherapy, radiation and anticancer drugs are limited due to stage of cancer, side effects and altered biodistribution. The use of peptides extracted from natural products has appeared as a potential therapy. Gloriosa superba is known to contain colchicine and other alkaloids with anticancer activity. However, these peptides contained within the extracts have not been studied. This study, therefore, focuses on an investigation of anti-colon cancer activity from a partially purified protein hydrolysate of G superba rhizome...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29075112/effect-of-inhibitors-of-endocytosis-and-nf-kb-signal-pathway-on-folate-conjugated-nanoparticle-endocytosis-by-rat-kupffer-cells
#15
Hongbo Tang, Hongli Chen, Yajing Jia, Xiaoyan Liu, Zhaohong Han, Aihua Wang, Qi Liu, Xinlei Li, Xin Feng
The regular accumulation of nanoparticles in the liver makes them hepatotoxic and decreases the circulation time, thus reducing their therapeutic effect. Resolving this problem will be significant in improving bioavailability and reducing side effects. In this study, we reduced the phagocytosis of epirubicin (EPI)-loaded folic acid-conjugated pullulan acetate (FPA/EPI) nanoparticles by Kupffer cells (KCs) through internalization and nuclear factor kappa B (NF-kB) signal pathway inhibitors, thus allowing development of FPA/EPI nanoparticles as a nanodrug delivery system (NDDS) based on our previous study...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29074436/dhpac-a-novel-synthetic-microtubule-destabilizing-agent-possess-high-anti-tumor-activity-in-vincristine-resistant-oral-epidermoid-carcinoma-in-vitro-and-in-vivo
#16
Ying Zhang, Fu-Lian Gong, Zhen-Ning Lu, Hong-Yuan Wang, Yan-Na Cheng, Zhao-Peng Liu, Lu-Gang Yu, Hui-Hui Zhang, Xiu-Li Guo
Multidrug resistance (MDR) is one of major obstacles to effective chemotherapeutic treatment of cancer. This study showed that DHPAC, 2-(6-ethoxy-3-(3-ethoxyphenylamino) -1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy) acetamide, a novel compound that binds to the same site on microtubules as colchicine, has high anti-tumour activity in vincristine-resistant oral epidermoid carcinoma (KB/V) cells. It found that the presence of DHPAC strongly inhibited KB/V cell growth in vivo and in mice xenograft. The inhibitory effect of DHPAC is much stronger than that by colchicine in these KB/V cells (IC50: 64...
October 23, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29073610/an-overlooked-potentially-treatable-disorder-idiopathic-mesenteric-panniculitis
#17
Abdurrahman Sahin, Hakan Artas, Yesim Eroglu, Nurettin Tunc, Ulvi Demirel, Ibrahim Halil Bahcecioglu, Mehmet Yalniz
OBJECTIVE: The aim of this study was to determine the prevalence of mesenteric panniculitis (MP) and to describe its clinical characteristics, therapy and outcome. SUBJECTS AND METHODS: This retrospective study was carried out among patients defined as MP according to computed tomography (CT) scans from January 2012 to December 2015. The CT images were reanalyzed by study radiologists to confirm the previous MP diagnosis. Patients were divided into two groups, idiopathic and secondary, based on the presence or absence of associated predisposing factors such as trauma, malignancy, autoimmune disorders, ischemia or previous abdominal surgery...
October 26, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29069746/wx-132-18b-a-novel-microtubule-inhibitor-exhibits-promising-anti-tumor-effects
#18
Fang Guan, Rui Ding, Qi Zhang, Wei Chen, Feifei Li, Long Long, Wei Li, Linna Li, Dexuan Yang, Lan Xie, Shoujun Yuan, Lili Wang
Cancer drug researchers have been seeking microtubule-inhibiting agents (MIAs) with higher bioactivity and lower toxicity than currently marketed drugs. WX-132-18B, a novel structural compound synthesized at our institute, specifically bound to the colchicine-binding site on tubulin rather than the vinblastine site, and concentration-dependently reduced microtubule content via depolymerization. It exhibited the same cellular phenotypic profiles as the classic MIAs (colchicine, vincristine, and taxol), including inducing cell cycle arrest at the G2/M phase, triggering tumor cell apoptosis, promoting nuclear membrane permeability, reducing mitochondrial membrane potential, and disrupting the redox system balance...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29061810/anticancer-effects-of-colchicine-on-hypopharyngeal-cancer
#19
Jung Hae Cho, Young Hoon Joo, Eun Young Shin, Eun Ji Park, Min Sik Kim
Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay showed that colchicine inhibited the growth and proliferation of human hypopharyngeal cancer cells (FaDu and SNU1041) in a dose- and time-dependent manner. Colchicine also inhibited the migration, invasion, and adhesion of hypopharyngeal cancer cells in a dose-dependent manner...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29055633/colchicine-therapy-and-plaque-stabilization-in-patients-with-acute%C3%A2-coronary-syndrome-a-ct-coronary-angiography-study
#20
Kaivan Vaidya, Clare Arnott, Gonzalo J Martínez, Bernard Ng, Samuel McCormack, David R Sullivan, David S Celermajer, Sanjay Patel
OBJECTIVES: The authors sought to evaluate the plaque-modifying effects of low-dose colchicine therapy plus optimal medical therapy (OMT) in patients post-acute coronary syndrome (ACS), as assessed by coronary computed tomography angiography (coronary CTA). BACKGROUND: Colchicine therapy has been postulated to have beneficial anti-inflammatory effects in patients with ACS, translating into reduction in future adverse cardiovascular events. However, whether favorable plaque modification underpins this is yet unproven...
October 14, 2017: JACC. Cardiovascular Imaging
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