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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#2
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29929206/an-integrated-strategy-to-qualitatively-differentiate-components-of-raw-and-processed-viticis-fructus-based-on-nir-hplc-and-uplc-ms-analysis
#3
Jiayin Diao, Can Xu, Huiting Zheng, Siyi He, Shumei Wang
Viticis Fructus is a traditional Chinese herbal drug processed by various methods to achieve different clinical purposes. Thermal treatment potentially alters chemical composition, which may impact on effectiveness and toxicity. In order to interpret the constituent discrepancies of raw versus processed (stir-fried) Viticis Fructus, a multivariate detection method (NIR, HPLC, and UPLC-MS) based on metabonomics and chemometrics was developed. Firstly, synergy interval partial least squares and partial least squares-discriminant analysis were employed to screen the distinctive wavebands (4319 - 5459 cm-1 ) based on preprocessed near-infrared spectra...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929077/design-synthesis-and-evaluation-of-some-pyrazolo-3-4-d-pyrimidine-derivatives-bearing-thiazolidinone-moiety-as-anti-inflammatory-agents
#4
Gina N Tageldin, Salwa M Fahmy, Hayam M Ashour, Mounir A Khalil, Rasha A Nassra, Ibrahim M Labouta
Two new series of pyrazolo[3,4-d]pyrimidine bearing thiazolidinone moiety were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro (COX-1 and COX-2) inhibitory assay. Compounds that showed promising COX-2 selectivity were further subjected to in vivo anti-inflammatory screening applying formalin induced paw edema (acute model) and cotton-pellet induced granuloma (chronic model) assays using celecoxib and diclofenac sodium as reference drugs. The histopathological and ulcerogenic potential were also determined...
June 5, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29929060/perfusion-pressure-of-a-new-cannulating-fenestrated-pedicle-screw-during-cement-augmentation
#5
Zhirong Wang, Wen Zhang, Hao Xu, Aiqing Lu, Huilin Yang, Zong-Ping Luo
BACKGROUND: Cannulating fenestrated pedicle screws are effective for fixating osteoporotic vertebrae. However, a major limitation is the excessive pressure required to inject a sufficient amount of cement into the vertebral body through the narrow hole of a pedicle screw. We have recently proposed a new cannulating fenestrated pedicle screw with a large hole diameter and a matched inner pin for screw-strength maintenance. Our purpose was to determine whether the new screw can significantly reduce bone-cement perfusion pressure during cement augmentation, METHODS: Two different methods were used to examine perfusion pressure...
June 18, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29929019/the-rehabilitation-of-advanced-heart-failure-patients-after-left-ventricular-assist-device-a-narrative-review
#6
REVIEW
Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29929009/safety-immunogenicity-and-protection-of-a-h3n2-live-attenuated-influenza-vaccines-containing-wild-type-nucleoprotein-in-a-ferret-model
#7
Daniil A Korenkov, Karen L Laurie, Patrick C Reading, Louise A Carolan, Kok Fei Chan, Irina I Isakova-Sivak, Tatiana A Smolonogina, Kanta Subbarao, Ian G Barr, Julie Villanueva, Svetlana Shcherbik, Tatiana Bousse, Larisa G Rudenko
Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection from influenza due to their ability to stimulate cross-reactive T cells against influenza pathogens. One of the major targets for cytotoxic T-cell immunity is viral nucleoprotein (NP), which is relatively conserved among antigenically distant influenza viruses. Nevertheless, a diversity of epitope composition has been found in the NP protein of different lineages of influenza A viruses. The H2N2 master donor virus which is currently used as a backbone for the LAIV and donor of the six genomic segments encoding the internal proteins, A/Leningrad/134/17/57 (MDV Len/17), was isolated 60 years ago...
June 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29928924/navigate-ii-randomized-double-blind-trial-of-the-exhalation-delivery-system-with-fluticasone-eds-flu-for-nasal-polyposis
#8
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928914/rifm-fragrance-ingredient-safety-assessment-hexyl-benzoate-cas-registry-number-6789-88-4
#9
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
June 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29928869/focal-cryoballoon-versus-radiofrequency-ablation-of-dysplastic-barrett-s-esophagus-impact-on-treatment-response-and-postprocedural-pain
#10
Sanne N van Munster, Anouk Overwater, Rehan Haidry, Raf Bisschops, Jacques J G H M Bergman, Bas L A M Weusten
BACKGROUND AND AIMS: Radiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE), but associated with significant postprocedural pain. Alternatively, balloon-based focal cryoablation (CRYO) has recently been developed, which preserves the extracellular matrix and might therefore be less painful. Although data for CRYO are still limited, uncontrolled studies suggest comparable safety and efficacy to RFA in eradicating limited BE areas. Therefore, secondary endpoints such as pain might become decisive for treatment selection...
June 18, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29928754/-a-phd-completed-pre-surgical-assessment-of-the-mandibular-body-and-canal-using-cbct-imaging
#11
N L Gerlach
The aim of this study was to determine the accuracy of the pre-surgical assessment of the mandible using cone beam computed tomography (CBCT) images. For surgical procedures in the mandible, it is important to determine the position of the mandibular canal in order to avoid damage to the inferior alveolar nerve (IAN). The best method to investigate this nerve is with the help of panoramic reconstructed images combined with cross-sectional reconstructed images. To protect the IAN during treatment, this research indicates that a minimal safety zone of 1...
June 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29928660/rho-kinase-inhibitors-do-not-expand-hematoma-volume-in-acute-experimental-intracerebral-hemorrhage
#12
Murtaza Akhter, Tom Qin, Paul Fischer, Homa Sadeghian, Hyung Hwan Kim, Michael J Whalen, Joshua N Goldstein, Cenk Ayata
Rho-associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre-hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform-nonselective inhibitor fasudil, or ROCK2-selective inhibitor KD025, or their vehicles...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928538/developing-a-basic-scale-for-workers-psychological-burden-from-the-perspective-of-occupational-safety-and-health
#13
Kyung Woo Kim, Ho Chan Lim, Jae Hee Park, Sang Gyu Park, Ye Jin Park, Hm Hak Cho
Background: Organizations are pursing complex and diverse aims to generate higher profits. Many workers experience high work intensity such as workload and work pressure in this organizational environment. Especially, psychological burden is a commonly used term in workplace of Republic of Korea. This study focused on defining the psychological burden from the perspective of occupational safety and health and tried to develop a scale for psychological burden. Methods: The 48 preliminary questionnaire items for psychological burden were prepared by a focus group interview with 16 workers through the Copenhagen Psychosocial Questionnaire II and Mindful Awareness Attention Scale...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928535/field-study-of-effects-of-night-shifts-on-cognitive-performance-salivary-melatonin-and-sleep
#14
Reza Kazemi, Majid Motamedzade, Rostam Golmohammadi, Hamidreza Mokarami, Rasoul Hemmatjo, Rashid Heidarimoghadam
Background: Night shift work is associated with many problems such as sleep deprivation, sleepiness, decreased cognitive performance, increased human errors, and fatigue. This study set out to measure cognitive performance, melatonin rhythms, and sleep after different consecutive night shifts (7 vs. 4) among control room operators (CORs). Methods: The participants included 60 CORs with a mean age of 30.2 years (standard deviation, 2.0) from a petrochemical complex located in Southern Iran...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928530/safety-knowledge-and-changing-behavior-in-agricultural-workers-an-assessment-model-applied-in-central-italy
#15
Massimo Cecchini, Roberto Bedini, Davide Mosetti, Sonia Marino, Serenella Stasi
Background: In recent years, the interest in health and safety in the workplace has increased. Agriculture is one of the human work activities with the highest risk indexes. Studies on risk perception of agricultural workers are often referred to as specific risk factors (especially pesticides), but the risk perception plays an important role in preventing every kind of accident and occupational disease. Methods: The aim of this research is to test a new method for understanding the relation between risk perception among farmers and the main risk factors to which they are exposed...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928529/assessment-of-sleep-deprivation-and-fatigue-among-chemical-transportation-drivers-in-chonburi-thailand
#16
Nantaporn Phatrabuddha, Tanongsak Yingratanasuk, Piti Rotwannasin, Wanlop Jaidee, Narin Krajaiklang
Background: Fatigue and sleepiness are inter-related and common among road transport drivers. In this study, sleep deprivation and fatigue among chemical transportation drivers were examined. Methods: A cross-sectional study surveying 107 drivers from three hazardous types of chemical production and transportation industries (nonflammable gases, flammable gases, and flammable liquids) was conducted. Data on sleep deprivation were collected using questionnaires of the Stanford Sleeping Scale and the Groningen Sleep Quality Scale...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928528/a-method-to-protect-mine-workers-in-hot-and-humid-environments
#17
Maurice Sunkpal, Pedram Roghanchi, Karoly C Kocsis
Background: Work comfort studies have been extensively conducted, especially in the underground and meteorological fields resulting in an avalanche of recommendations for their evaluation. Nevertheless, no known or universally accepted model for comprehensively assessing the thermal work condition of the underground mine environment is currently available. Current literature presents several methods and techniques, but none of these can expansively assess the underground mine environment since most methods consider only one or a few defined factors and neglect others...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928526/development-and-validation-of-a-practical-instrument-for-injury-prevention-the-occupational-safety-and-health-monitoring-and-assessment-tool-osh-mat
#18
Yi Sun, Martin Arning, Frank Bochmann, Jutta Börger, Thomas Heitmann
Background: The Occupational Safety and Health Monitoring and Assessment Tool (OSH-MAT) is a practical instrument that is currently used in the German woodworking and metalworking industries to monitor safety conditions at workplaces. The 12-item scoring system has three subscales rating technical, organizational, and personnel-related conditions in a company. Each item has a rating value ranging from 1 to 9, with higher values indicating higher standard of safety conditions. Methods: The reliability of this instrument was evaluated in a cross-sectional survey among 128 companies and its validity among 30,514 companies...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928524/vibration-and-ergonomic-exposures-associated-with-musculoskeletal-disorders-of-the-shoulder-and-neck
#19
REVIEW
Luenda E Charles, Claudia C Ma, Cecil M Burchfiel, Renguang G Dong
Background: According to the US Bureau of Labor Statistics, musculoskeletal disorders (MSDs) accounted for 32% of all nonfatal injury and illness cases in 2014 among full-time workers. Our objective was to review and summarize the evidence linking occupational exposures to vibration and awkward posture with MSDs of the shoulder and neck. Methods: A literature search was conducted using the terms musculoskeletal disorders, vibration, and awkward posture. All types of observational epidemiologic studies, with the exception of case reports, published during 1998-2015 were included...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928468/tolerability-and-safety-profile-of-a-new-brand-generic-product-of-glatiramer-acetate-in-iranian-patients-with-relapsing-remitting-multiple-sclerosis-an-observational-cohort-study
#20
Roya Abolfazli, Shirin Pournourmohammadi, Ahmadreza Shamshiri, Sara Samadzadeh
Background: The aim of this study was to evaluate the safety, tolerability, and efficacy of a brand-generic glatiramer acetate product in patients with relapsing-remitting multiple sclerosis over a 12-month period. A noninterventional cohort study was conducted on 185 patients. The patients had a confirmed and documented diagnosis of relapsing-remitting multiple sclerosis as defined by the Revised McDonald Criteria (2010), were ambulatory with a Kurtzke Expanded Disability Status Scale score of 0 to 5...
2018: Current Therapeutic Research, Clinical and Experimental
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