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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/29677636/aunp-rf-sensor-an-innovative-application-of-rf-technology-for-sensing-pathogens-electrically-in-liquids-spel-within-the-food-supply-chain
#2
Leann Lerie Matta, Saranraj Karuppuswami, Premjeet Chahal, Evangelyn C Alocilja
Rapid detection techniques of pathogenic bacteria in the liquid food supply chain are of significant research interest due to their pivotal role in preventing foodborne outbreaks, and in maintaining high standards of public health and safety. Milk and dairy products are of particular interest due to their widespread consumption across the globe. In this paper, a biosensor for detecting pathogenic bacteria in milk using dextrin-capped gold nanoparticles (d-AuNP) as labels decoded at microwave frequencies is presented...
April 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29677580/effects-of-a-skill-demonstration-video-delivered-by-smartphone-on-facilitating-nursing-students-skill-competencies-and-self-confidence-a-randomized-controlled-trial-study
#3
Yeu-Hui Chuang, Fu-Chih Lai, Chia-Chi Chang, Hsu-Tien Wan
BACKGROUND: The correct and appropriate performance of nursing skills by students can ensure patient safety and care quality. However, developing appropriate teaching and learning strategies to enhance nursing students' nursing skills and knowledge are challenging tasks for nursing faculty members. Nowadays, smartphones are popular mobile devices that are used on campuses by students and could be considered a potential tool to deliver learning materials to nursing students. OBJECTIVES: This study aimed to examine the effects of a skill demonstration video delivered by smartphone on facilitating nursing students' nursing skill competency and confidence...
April 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29677575/sustainability-of-a-person-centered-ward-atmosphere-and-possibility-to-provide-person-centered-forensic-psychiatric-care-after-facility-relocation
#4
Eirini Alexiou, Helle Wijk, Gustaf Ahlquist, Anette Kullgren, Alessio Degl' Innocenti
OBJECTIVE: This longitudinal study aims to assess the sustainability of staff perceptions of ward atmosphere and their possibility to provide person-centered forensic psychiatric care after relocation to new hospitals that aimed to provide supportive work conditions for the staff to be able to perform care of high quality. METHODS: In this study we only present the result for the repeated measures, that is, only the individuals that performed both the questionnaires at baseline and at the three follow-ups...
April 11, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29677551/growth-detection-and-virulence-of-listeria-monocytogenes-in-the-presence-of-other-microorganisms-microbial-interactions-from-species-to-strain-level
#5
REVIEW
Evangelia A Zilelidou, Panagiotis N Skandamis
Like with all food microorganisms, many basic aspects of L. monocytogenes life are likely to be influenced by its interactions with bacteria living in close proximity. This pathogenic bacterium is a major concern both for the food industry and health organizations since it is ubiquitous and able to withstand harsh environmental conditions. Due to the ubiquity of Listeria monocytogenes, various strains may contaminate foods at different stages of the supply chain. Consequently, simultaneous exposure of consumers to multiple strains is also possible...
April 12, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29677412/gunderkids-design-of-a-clinical-care-management-program-for-parents-with-substance-abuse-and-their-newborn-children-with-a-focus-on-preventing-child-abuse
#6
Ann E Budzak-Garza, Allison L Allmon Dixson, Renee A Holzer, Kaitlin E Lillard-Pierce, Carolynn J Devine
BACKGROUND: In response to an increased need to care for babies born to mothers with substance abuse issues, we developed GunderKids, a care management program that provides integrated medical care beyond standard-of-care, well-child appointments for these socially complex families. METHODS: The program incorporates frequent visits to the pediatrician and the care team, which includes pediatric nurses, a pediatric social worker, and a child psychologist. Enrollment is voluntary...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677303/association-between-use-of-sodium-glucose-cotransporter-2-inhibitors-glucagon-like-peptide-1-agonists-and-dipeptidyl-peptidase-4-inhibitors-with-all-cause-mortality-in-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#7
Sean L Zheng, Alistair J Roddick, Rochan Aghar-Jaffar, Matthew J Shun-Shin, Darrel Francis, Nick Oliver, Karim Meeran
Importance: The comparative clinical efficacy of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors for treatment of type 2 diabetes is unknown. Objective: To compare the efficacies of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality and cardiovascular end points using network meta-analysis. Data Sources: MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, and published meta-analyses from inception through October 11, 2017...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677267/the-short-lived-epidemic-of-botulism-from-commercially-canned-foods-in-the-united-states-1919-to-1925
#8
Powel Kazanjian
In 1919, three deadly outbreaks of botulism caused by consumption of canned olives packed in California captured national headlines. In all of the outbreaks, which occurred in separate locales, unsuspecting people died after consuming tainted food during a banquet or family meal. The press's sensational portrayal of canned food as hazardous aroused alarm among consumers at a time when commercial canning was becoming more common. Intent on restoring the image of their product as safe and wholesome, canning industry leaders funded a "botulism commission" of scientific experts in 1919 to investigate how to systematically eliminate the threat of botulism that had imperiled their business...
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677133/modified-fusarium-mycotoxins-in-cereals-and-their-products-metabolism-occurrence-and-toxicity-an-updated-review
#9
REVIEW
Marcin Bryła, Agnieszka Waśkiewicz, Edyta Ksieniewicz-Woźniak, Krystyna Szymczyk, Renata Jędrzejczak
Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Under the influence of various factors, mycotoxins may undergo modifications of their chemical structure. One of the methods of mycotoxin modification is a transformation occurring in plant cells or under the influence of fungal enzymes. This paper reviews the current knowledge on the natural occurrence of the most important trichothecenes and zearalenone in cereals/cereal products, their metabolism, and the potential toxicity of the metabolites...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29677063/the-anesthesia-perioperative-call-for-help-experience-at-a-quaternary-pediatric-medical-center-analysis-of-67-564-anesthesia-encounters
#10
Bistra G Vlassakova, Sean M Sinnott, Nissa Askins, Matthew X Callahan, Izabela C Leahy, David Zurakowski, Paul R Hickey, Joseph P Cravero
BACKGROUND: During the past several decades, anesthesia has become increasingly safe. Truly major adverse events are rare, and anesthesia quality researchers have instituted programs to evaluate "near miss" or less critical adverse events to evaluate the safety of anesthesia delivery. In this study, we aimed to evaluate calls for emergency help in our institution as a surrogate for pending critical events. We hypothesized that calls would be more common in patients with high American Society of Anesthesiologists (ASA) physical status, history of prematurity, and children with recent respiratory illness compared to those without these characteristics...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29677053/safety-profile-of-baroreflex-activation-therapy-neo-in-patients-with-resistant-hypertension
#11
Manuel Wallbach, Enrico Böhning, Luca-Yves Lehnig, Charlotte Schroer, Gerhard Anton Müller, Rolf Wachter, Stephan Lüders, Dieter Zenker, Michael Johann Koziolek
OBJECTIVE: Unlike safety data of baroreflex activation therapy device (Rheos), only few data of the currently used second device (Barostim neo) are available and little is reported about common side effects. METHODS: We prospectively analyzed patients with resistant hypertension treated with Barostim neo. A standardized interview regarding side effects of the therapy was performed in routine follow-up visits after device implantation in 42 patients to determine adverse events staged into three degrees...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29677030/a-cadaveric-study-of-ultrasound-guided-maxillary-nerve-block-via-the-pterygopalatine-fossa-a-novel-technique-using-the-lateral-pterygoid-plate-approach
#12
Wirinaree Kampitak, Tanvaa Tansatit, Yasuyuki Shibata
BACKGROUND AND OBJECTIVES: This study aimed to describe and assess the accuracy and feasibility of a novel technique for ultrasound-guided maxillary nerve block using the lateral pterygoid plate (LPP) approach via the pterygopalatine fossa (PPF) in a soft cadaveric model. METHODS: Ten soft cadavers were studied. The curved array ultrasound transducer probe was applied over 1 side of the face of the cadavers in the open-mouth posture. It was placed transversely below the zygomatic arch for identifying the border of the maxillary tuberosity and the LPP...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29677018/examining-the-efficacy-of-calcium-hydroxylapatite-filler-with-integral-lidocaine-in-correcting-volume-loss-of-the-jawline-a-pilot-study
#13
Margit L W Juhász, Ellen S Marmur
BACKGROUND: Patients seek 3-dimensional volume restoration of the jawline to obtain a "defined" line. Injection of filler into the jawline is not approved by the Food and Drug Administration; however, dermatologists have injected this area with positive results, minimal adverse events, and high patient satisfaction. OBJECTIVE: This study explores the efficacy of premixed calcium hydroxylapatite filler with integral lidocaine [CaHA(+)] to correct volume defects of the jawline...
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29677015/oral-tranexamic-acid-for-the-treatment-of-melasma-a-review
#14
Harini R Bala, Senhong Lee, Celestine Wong, Amit G Pandya, Michelle Rodrigues
BACKGROUND: Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action. OBJECTIVE: To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma. MATERIALS AND METHODS: The literature was searched for publications on TXA in the treatment of melasma using MEDLINE, Scopus, and Google Scholar...
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29677007/near-continuous-glucose-monitoring-makes-glycemic-control-safer-in-icu-patients
#15
Jean-Charles Preiser, Olivier Lheureux, Aurelie Thooft, Serge Brimioulle, Jacques Goldstein, Jean-Louis Vincent
OBJECTIVES: Tight glycemic control using intermittent blood glucose measurements is associated with a risk of hypoglycemia. Glucose concentrations can now be measured near continuously (every 5-15 min). We assessed the quality and safety of glycemic control guided by a near-continuous glucose monitoring system in ICU patients. DESIGN: Prospective, cluster-randomized, crossover study. SETTING: Thirty-five-bed medico-surgical department of intensive care with four separate ICUs...
April 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29676956/high-intensity-interval-training-after-stroke-an-opportunity-to-promote-functional-recovery-cardiovascular-health-and-neuroplasticity
#16
Jennifer Crozier, Marc Roig, Janice J Eng, Marilyn MacKay-Lyons, Joyce Fung, Michelle Ploughman, Damian M Bailey, Shane N Sweet, Nicholas Giacomantonio, Alexander Thiel, Michael Trivino, Ada Tang
INTRODUCTION: Stroke is the leading cause of adult disability. Individuals poststroke possess less than half of the cardiorespiratory fitness (CRF) as their nonstroke counterparts, leading to inactivity, deconditioning, and an increased risk of cardiovascular events. Preserving cardiovascular health is critical to lower stroke risk; however, stroke rehabilitation typically provides limited opportunity for cardiovascular exercise. Optimal cardiovascular training parameters to maximize recovery in stroke survivors also remains unknown...
April 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29676947/intravenous-chemotherapy-compounding-errors-in-a-follow-up-pan-canadian-observational-study
#17
Rachel E Gilbert, Melissa C Kozak, Roxanne B Dobish, Venetia C Bourrier, Paul M Koke, Vishal Kukreti, Heather A Logan, Anthony C Easty, Patricia L Trbovich
PURPOSE: Intravenous (IV) compounding safety has garnered recent attention as a result of high-profile incidents, awareness efforts from the safety community, and increasingly stringent practice standards. New research with more-sensitive error detection techniques continues to reinforce that error rates with manual IV compounding are unacceptably high. In 2014, our team published an observational study that described three types of previously unrecognized and potentially catastrophic latent chemotherapy preparation errors in Canadian oncology pharmacies that would otherwise be undetectable...
April 20, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29676941/pk-pd-evaluation-of-fimasartan-for-the-treatment-of-hypertension-current-evidences-and-future-perspectives
#18
Fabio Angeli, Paolo Verdecchia, Monica Trapasso, Marina Pane, Sara Signorotti, Gianpaolo Reboldi
Fimasartan is the ninth and latest Angiotensin Receptor Blockers for the treatment of hypertension. Fimasartan is a derivative of losartan in which the imidazole ring has been replaced, a change that provided higher potency and longer duration than losartan. It provides a selective type 1 angiotensin II receptor antagonist effect with noncompetitive, insurmountable binding. Fimasartan is rapidly absorbed following oral administration with an oral bioavailability of 18.6 ± 7.2 %. Fimasartan is relatively stable in terms of metabolism and more than 90 % of circulating fimasartan moieties in the plasma are in the parent form; fecal elimination and biliary excretion are the predominant elimination pathways of fimasartan...
April 20, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29676935/current-and-emerging-two-drug-approaches-for-hiv-1-therapy-in-art-na%C3%A3-ve-and-art-experienced-virologically-suppressed-patients
#19
Barbara Rossetti, Francesca Montagnani, Andrea De Luca
Current guidelines recommend a 2-drug antiretroviral regimen as an alternative to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and costs. Areas covered: This review is intended to provide insight into the efficacy, safety and tolerability of 2-drug versus 3-drug ART in naïve and in treatment-experienced virologically-suppressed patients. Expert opinion: Dual therapy regimens are not feasible in HBV-coinfected individuals and should not be applied during pregnancy. Positive data on 2-drug ART in drug naïve patients are still limited, while, in virologically-suppressed individuals, several regimens have shown non-inferiority as compared to 3-drug regimens...
April 20, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29676864/bioequivalence-of-canakinumab-injected-subcutaneously-via-an-autoinjector-device-or-a-prefilled-safety-syringe-device-in-healthy-subjects
#20
SivaNaga S Anumolu, Sam Lindgren, Janardhana Vemula, David Floch, Christine Reynolds, Hans-Joachim Wallny, Haiying Sun
Canakinumab, a high-affinity human anti-interleukin-1β monoclonal antibody, is being used for the treatment of a broad spectrum of inflammatory diseases. This phase 1 study compared the relative bioavailability of a single dose of subcutaneous canakinumab either self-administered with an autoinjector (AI) or administered by a health care professional (HCP) with a prefilled safety syringe (SS) in healthy subjects. The study enrolled 80 subjects randomized 1:1 to receive 150 mg/mL of a liquid formulation of canakinumab via an AI or SS into either the thigh or abdomen...
April 20, 2018: Clinical Pharmacology in Drug Development
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