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https://www.readbyqxmd.com/read/29244834/factors-influencing-psychological-well-being-in-patients-with-parkinson-s-disease
#1
Alessandra Nicoletti, Giovanni Mostile, Fabrizio Stocchi, Giovanni Abbruzzese, Roberto Ceravolo, Pietro Cortelli, Marco D'Amelio, Maria F De Pandis, Giovanni Fabbrini, Claudio Pacchetti, Gianni Pezzoli, Alessandro Tessitore, Margherita Canesi, Mario Zappia
BACKGROUND: Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. OBJECTIVES: To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates...
2017: PloS One
https://www.readbyqxmd.com/read/29244799/prenatal-and-early-postnatal-measures-of-brain-development-and-childhood-sleep-patterns
#2
Desana Kocevska, Maria E Verhoeff, Selma Meinderts, Vincent W Jaddoe, Frank C Verhulst, Sabine J Roza, Maartje P C M Luijk, Henning Tiemeier
BACKGROUND: Brain development underlies maturation of sleep patterns throughout childhood. Intrauterine head growth -marker of early neurodevelopment- has not been associated with childhood sleep characteristics. We explored associations between ultrasonographic measures of prenatal and early postnatal neurodevelopment and childhood sleep. METHODS: Six-thousand-five-hundred-twenty-eight children from a population-based birth cohort (Generation R) were included. Head circumference (HC) and lateral ventricles size were assessed with mid- and late-pregnancy fetal ultrasounds, and with cranial ultrasound 3-20 weeks postnatally...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244798/amplitude-integrated-electroencephalography-during-the-first-72-hours-after-birth-in-neonates-diagnosed-prenatally-with-congenital-heart-disease
#3
Mirthe J Mebius, Nathalie J E Oostdijk, Sara J Kuik, Arend F Bos, Rolf M F Berger, Caterina M Bilardo, Elisabeth M W Kooi, Hendrik J Ter Horst
BACKGROUND: Little is known on amplitude-integrated electroencephalography (aEEG) during the first days after birth in neonates with CHD. Our aim was, therefore, to assess electro-cortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG. METHODS: Neonates with CHD that were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244642/sex-sleep-deprivation-and-the-anxious-brain
#4
Andrea N Goldstein-Piekarski, Stephanie M Greer, Jared M Saletin, Allison G Harvey, Leanne M Williams, Matthew P Walker
Insufficient sleep is a known trigger of anxiety. However, not everyone experiences these effects to the same extent. One determining factor is sex, wherein women experience a greater anxiogenic impact in response to sleep loss than men. However, the underlying brain mechanism(s) governing this sleep-loss-induced anxiety increase, including the markedly different reaction in women and men, is unclear. Here, we tested the hypothesis that structural brain morphology in a discrete network of emotion-relevant regions represents one such explanatory factor...
December 15, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29244233/inadequate-brain-glycogen-or-sleep-increases-spreading-depression-susceptibility
#5
Kivilcim Kilic, Hulya Karatas, Buket Donmez-Demir, Emine Eren-Kocak, Yasemin Gursoy-Ozdemir, Alp Can, Jean-Marie Petit, Pierre J Magistretti, Turgay Dalkara
OBJECTIVE: Glycogen in astrocyte endfeet contributes to maintenance of low extracellular glutamate and K+ concentrations around synapses. Sleep deprivation (SD), a common migraine trigger induces transcriptional changes in astrocytes reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin-1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29244226/high-frequency-oscillations-are-not-better-biomarkers-of-epileptogenic-tissues-than-spikes
#6
Nicolas Roehri, Francesca Pizzo, Stanislas Lagarde, Isabelle Lambert, Anca Nica, Aileen McGonigal, Bernard Giusiano, Fabrice Bartolomei, Christian-George Bénar
OBJECTIVE: High-frequency oscillations (HFOs) in intracerebral EEG (stereoelectroencephalography, SEEG) are considered as better biomarkers of epileptogenic tissues than spikes. How this can be applied at the patient level remains poorly understood. We investigated how well the HFOs and the spikes can predict epileptogenic regions with a large spatial sampling at the patient level. METHODS: We analyzed non-REM sleep SEEG recordings sampled at 2,048Hz of thirty patients...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29244201/sleep-disturbances-in-treatment-seeking-ocd-patients-changes-after-concentrated-exposure-treatment
#7
Håkon Nordahl, Audun Havnen, Bjarne Hansen, Lars-Göran Öst, Gerd Kvale
Research indicates that patients with Obsessive Compulsive Disorder (OCD) frequently suffer from comorbid sleep difficulties, and that these difficulties often are not clinically recognized and diagnosed. There has been limited research investigating if comorbid sleep difficulties impair treatment outcome for OCD and if the sleep difficulties change following OCD-treatment. Thirty-six patients with obsessive compulsive disorder underwent concentrated exposure treatment delivered in a group over four consecutive days and were assessed with measures of OCD, depressive symptoms and sleep disturbance at three different time points (pre, post and 6 months follow-up)...
December 15, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29244170/sleep-deprivation-triggers-cognitive-control-impairments-in-task-goal-switching
#8
Hichem Slama, Daphne Olivia Chylinski, Gaétane Deliens, Rachel Leproult, Rémy Schmitz, Philippe Peigneux
Study objectives: This study investigates the impact of sleep deprivation (SD) on task-goal switching, a key component of cognitive flexibility. Methods: Task-goal switching performance was tested after one night of regular sleep (n = 17 participants) or of total SD (n = 18). To understand the relationships between task-switching performance and other cognitive processes following SD, participants were tested for other key attentional (alertness and vigilance) and executive (inhibition and working memory) functions...
December 13, 2017: Sleep
https://www.readbyqxmd.com/read/29243461/physicians-working-conditions-health-and-working-capacity
#9
Marko Elovainio, Marianna Virtanen, Tuula Oksanen
Changes in the working environment will also influence the work of physicians. The greatest of these changes on the Finnish scale, the SOTE reform (the reform in social welfare and public health services), still lies ahead. Labor shortage, on-call duties and patient record systems providing little support to work add to the burden. In surveys related to psychosocial working conditions, physicians' greatest work load factors have been rush, forced working pace and poor communication despite the fact that, on average, they consider their working conditions to be good, frequently better than those of other professional groups, and are committed to carry on with their work until retirement age...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243448/obstructive-sleep-apnea-are-we-going-overboard
#10
Nicole Riem
No abstract text is available yet for this article.
December 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29243344/intensive-care-survivor-reported-symptoms-a-longitudinal-study-of-survivors-symptoms
#11
Anne Kathrine Langerud, Tone Rustøen, Milaancarova Småstuen, Ulf Kongsgaard, Audun Stubhaug
BACKGROUND: There is growing interest in potential long-term outcomes following intensive care, but few researchers have studied the prevalence of multiple symptoms or the association between pain and other symptoms. AIMS: To investigate the prevalence of anxiety, depression, fatigue, sleep disturbance and post-traumatic stress symptoms (PTSS) among intensive care survivors 3 months and 1 year after being discharged from an intensive care unit (ICU) and to determine whether pain is associated with higher prevalence of these symptoms 3 months and 1 year after ICU stay...
December 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/29243273/long-term-use-of-continuous-positive-airway-pressure-therapy-in-coronary-artery-disease-patients-with-nonsleepy-obstructive-sleep-apnea
#12
Faith S Luyster, Patrick J Strollo, Erik Thunström, Yüksel Peker
BACKGROUND: Excessive daytime sleepiness is a frequent symptom of obstructive sleep apnea (OSA) and has been proposed as a motivator for adherence to continuous positive airway pressure (CPAP) therapy. However, excessive daytime sleepiness is absent in many patients with coronary artery disease (CAD) and concomitant OSA. We evaluated long-term use of CPAP and predictors of CPAP use in nonsleepy and sleepy OSA patients from a CAD cohort. HYPOTHESIS: Long-term CPAP use is lower in CAD patients with nonsleepy OSA vs sleepy OSA...
December 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#13
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29242818/exploring-accelerometer-versus-self-report-sleep-assessment-in-youth-with-concussion
#14
Ivona Berger, Joyce Obeid, Brian W Timmons, Carol DeMatteo
This study examines accelerometer-based and self-report assessment of sleep disturbance from a larger prospective cohort of youth 5 to 18 years of age with postconcussive injury. Twenty-one participants with self-reported sleep disturbance were evaluated using accelerometers. Participants completed the Pittsburgh Sleep Quality Index (PSQI) every 48 hours and also measured sleep via accelerometry. Correlations were conducted matching PSQI scores to accelerometry assessment. PSQI scores were significantly correlated only with "average number of awakenings" (r = -0...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29242809/effect-of-levodopa-carbidopa-intestinal-gel-on-non-motor-symptoms-in-patients-with-advanced-parkinson-s-disease
#15
David G Standaert, Ramon L Rodriguez, John T Slevin, Michael Lobatz, Susan Eaton, Krai Chatamra, Maurizio F Facheris, Coleen Hall, Kavita Sail, Yash J Jalundhwala, Janet Benesh
Background: Levodopa-carbidopa intestinal gel (LCIG; carbidopa-levodopa enteral suspension in the United States), delivered via percutaneous gastrojejunostomy (PEG-J) and titrated in the inpatient setting, is an established treatment option for advanced Parkinson's disease (PD) patients with motor fluctuations. However, long-term prospective data on the efficacy of LCIG on non-motor symptoms and the safety of outpatient titration are limited. Methods: In this 60-week, open-label phase 3b study, LCIG titration was initiated in an outpatient setting following PEG-J placement in PD patients...
November 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29242807/parents-and-child-s-concussion-history-as-predictors-of-parental-attitudes-and-knowledge-of-concussion-recognition-and-response
#16
Melissa C Kay, Johna K Register-Mihalik, Cassie B Ford, Richelle M Williams, Tamara C Valovich McLeod
Background: Parents' knowledge of and attitudes toward concussions are often vital factors that affect care for injured adolescent athletes. It is important to understand the role that parents' personal experiences with concussions play with regard to current concussion knowledge and attitudes so that clinicians may tailor their educational approaches. Purpose/Hypothesis: The purpose of this study was to determine an association between parents' personal experiences and their child's experiences with concussions as well as parental concussion knowledge and attitudes...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29242263/temporal-trajectories-of-novel-object-recognition-performance-in-mice-exposed-to-intermittent-hypoxia
#17
David Gozal, Abdelnaby Khalyfa, Zhuanghong Qiao, Isaac Almendros, Ramon Farré
Intermittent hypoxia is one of the major perturbations of sleep-disordered breathing and has been causally implicated in neurocognitive deficits. However, the reversibility of such deficits is unclear.Male C57BL/6J mice were exposed to either intermittent hypoxia or room air for 3-240 days, and then half were randomly selected and allowed to recover in normoxic conditions for the same duration of the previous exposure. A novel object recognition (NOR) test was performed.NOR performance was stable over time in room air...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29242137/sleep-deprivation-decreases-neuronal-excitability-and-responsiveness-in-rats-both-in-vivo-and-ex-vivo
#18
Sándor Borbély, Ildikó Világi, Zsófia Haraszti, Örs Szalontai, Tünde Hajnik, Attila Tóth, László Détári
Sleep deprivation has severe consequences for higher nervous functions. Its effects on neuronal excitability may be one of the most important factors underlying functional deterioration caused by sleep loss. In the present work, excitability changes were studied using two complementary in vivo and ex vivo models. Auditory evoked potentials were recorded from freely-moving animals in vivo. Amplitude of evoked responses showed a near-continuous decrease during deprivation. Prevention of sleep also reduced synaptic efficacy ex vivo, measured from brain slices derived from rats that underwent sleep deprivation...
December 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29242090/the-effect-of-brahmi-vati-and-sarpagandha-ghana-vati-in-management-of-essential-hypertension-a-randomized-double-blind-controlled-clinical-study
#19
Dhanpat Mishra, Basavaraj R Tubaki
BACKGROUND: Essential hypertension (EHTN) is emerging as one of the most prevalent disorder with higher rate of complications, morbidity and mortality. Brahmi vati, an Ayurvedic medicine is explored for its efficacy in the management of EHTN. METHODS: 68 patients of age group 20-60 years, of either sex meeting the JNC 7 criteria of EHTN were randomly divided into two groups, group A and group B. Group A and group B received capsule Brahmi vati 500 mg and capsule Sarpagandha Ghana vati 500 mg respectively twice a day for 30 days...
December 11, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29241946/youth-with-psychogenic-non-syncopal-collapse-have-more-somatic-and-psychiatric-symptoms-and-lower-perceptions-of-peer-relationships-than-youth-with-syncope
#20
Geoffrey L Heyer
BACKGROUND: Little is known about somatic and psychiatric symptoms and perceived peer relationships of patients with psychogenic nonsyncopal collapse. OBJECTIVE: This study aimed to compare somatic and psychiatric symptoms and other elements potentially related to functional neurological symptom disorders between youth with psychogenic nonsyncopal collapse and those with neurally mediated syncope. METHODS: Before testing, patients completed a structured interview and questionnaire addressing current symptoms, previous psychiatric diagnoses, referrals, diagnostic testing, prescribed medications, and patient self-ratings of anxiety, depression, and perceived peer relationships...
November 20, 2017: Pediatric Neurology
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