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Curcumin AND beta catenin

Xia Yang, Jian-Ning Lv, Hui Li, Bo Jiao, Qiu-Hong Zhang, Yong Zhang, Jie Zhang, Yan-Qin Liu, Ming Zhang, Hu Shan, Jin-Zhao Zhang, Run-Miao Wu, Ya-Li Li
OBJECTIVES: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported that curcumin regulated Wnt/β-catenin signaling in lots of cells. However, whether curcumin regulates the levels of Wnt/β-Catenin signaling in lung tissues and DCs (dendritic cells) remains unclear. In this study, we assessed the effects of curcumin on DCs and asthma...
May 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Muobarak Jaber Tuorkey
There is no doubt that diet could effectively improve health and halt cancers. Dietary phytochemical compounds and their derivatives represent a cornucopia of effectively anticancer compounds. This review discusses existing data on the anticancer activities of curcumin, and then offers possible explanations for and mechanisms of its cancer-preventive action. This review also offers insights into the molecular mechanism and targets through which curcumin modulates cell cycle, apoptotic signals, anti-apoptotic proteins, miRNAs, Wnt/beta-catenin signaling, protein kinases, nuclear factor-κB, proteasome activation, epigenetic regulation including DNA methylation and histone modification...
December 2014: Interventional Medicine & Applied Science
W Feng, C X Yang, L Zhang, Y Fang, M Yan
OBJECTIVE: The current study aimed to explore the effect ofcurcumin on androgen receptor (AR) expression in endometrial carcinoma cells, as well as the underlying mechanisms. MATERIALS AND METHODS: Endometrial carcinoma cells were treated with curcumin (10, 50, and 100 micromol/l) for 12, 24, and 48 hours. Their growth curves were drawn using MTT assays and their apoptotic rates were determined using flow cytometry. The mRNA and protein expression of AR was detected using PCR and that of the Wnt signal related nucleopro- tein beta-cantenin was observed using western blot analysis...
2014: European Journal of Gynaecological Oncology
Shravanti Mukherjee, Minakshi Mazumdar, Samik Chakraborty, Argha Manna, Shilpi Saha, Poulami Khan, Pushpak Bhattacharjee, Deblina Guha, Arghya Adhikary, Sanhita Mukhjerjee, Tanya Das
INTRODUCTION: The existence of cancer stem cells (CSCs) has been associated with tumor initiation, therapy resistance, tumor relapse, angiogenesis, and metastasis. Curcumin, a plant ployphenol, has several anti-tumor effects and has been shown to target CSCs. Here, we aimed at evaluating (i) the mechanisms underlying the aggravated migration potential of breast CSCs (bCSCs) and (ii) the effects of curcumin in modulating the same. METHODS: The migratory behavior of MCF-7 bCSCs was assessed by using cell adhesion, spreading, transwell migration, and three-dimensional invasion assays...
2014: Stem Cell Research & Therapy
Yan Li, Jiying Wang, Xiaoyan Li, Yujiao Jia, Lei Huai, Kan He, Pei Yu, Min Wang, Haiyan Xing, Qing Rao, Zhen Tian, Kejing Tang, Jianxiang Wang, Yingchang Mi
The Wilms' tumor 1 (WT1) gene is one of the regulating factors in cell proliferation and development. It is a double-functional gene: an oncogene and a tumor suppressor. This gene was found to be highly expressed in many leukemic cell lines and in patients with acute myeloid leukemia. In the present study, we demonstrated that the WT1 gene was commonly expressed in leukemic cell lines apart from U937 cells. The K562 cell line which expresses WT1 at a high level (mRNA and protein) was used in the entire experiment...
December 2014: Oncology Reports
Murali M Yallapu, Sheema Khan, Diane M Maher, Mara C Ebeling, Vasudha Sundram, Neeraj Chauhan, Aditya Ganju, Swathi Balakrishna, Brij K Gupta, Nadeem Zafar, Meena Jaggi, Subhash C Chauhan
Prostate cancer is the most commonly diagnosed cancer disease in men in the Unites States and its management remains a challenge in everyday oncology practice. Thus, advanced therapeutic strategies are required to treat prostate cancer patients. Curcumin (CUR) is a promising anticancer agent for various cancer types. The objective of this study was to evaluate therapeutic potential of novel poly(lactic-co-glycolic acid)- CUR nanoparticles (PLGA-CUR NPs) for prostate cancer treatment. Our results indicate that PLGA-CUR NPs efficiently internalize in prostate cancer cells and release biologically active CUR in cytosolic compartment of cells for effective therapeutic activity...
October 2014: Biomaterials
Lei Cui, Xin Jia, Qian Zhou, Xuguang Zhai, Yajun Zhou, Huixia Zhu
OBJECTIVES: Emerging evidence indicates that Wnt/β-catenin pathway is linked to the fibrosis of different organs including liver fibrosis. β-Catenin promotes hepatic stellate cells (HSCs) activation, a key event in the development of liver fibrosis, and has emerged as a novel mediator of fibrosis. Curcumin, a natural active ingredient derived from turmeric, possesses an inhibitory effect on liver fibrosis. This study is aimed to examine whether curcumin affects β-catenin expression/activity in HSCs and explores the underlying mechanisms...
November 2014: Journal of Pharmacy and Pharmacology
Shashi Kant Tiwari, Swati Agarwal, Brashket Seth, Anuradha Yadav, Saumya Nair, Priyanka Bhatnagar, Madhumita Karmakar, Manisha Kumari, Lalit Kumar Singh Chauhan, Devendra Kumar Patel, Vikas Srivastava, Dhirendra Singh, Shailendra Kumar Gupta, Anurag Tripathi, Rajnish Kumar Chaturvedi, Kailash Chand Gupta
Neurogenesis, a process of generation of new neurons, is reported to be reduced in several neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis by targeting endogenous neural stem cells (NSC) could be a promising therapeutic approach to such diseases by influencing the brain self-regenerative capacity. Curcumin, a neuroprotective agent, has poor brain bioavailability. Herein, we report that curcumin-encapsulated PLGA nanoparticles (Cur-PLGA-NPs) potently induce NSC proliferation and neuronal differentiation in vitro and in the hippocampus and subventricular zone of adult rats, as compared to uncoated bulk curcumin...
January 28, 2014: ACS Nano
Pay-Chin Leow, Priti Bahety, Choon Pei Boon, Chong Yew Lee, Kheng Lin Tan, Tianming Yang, Pui-Lai Rachel Ee
Osteosarcoma is a primary bone malignancy with aggressive metastatic potential and poor prognosis rates. In our earlier work we have investigated the therapeutic potential of curcumin as an anti-invasive agent in osteosarcoma by its ability to regulate the Wnt/β-catenin signaling pathway. However, the clinical use of curcumin is limited owing to its low potency and poor pharmacokinetic profile. In this study, an attempt was made to achieve more potent Wnt inhibitory activity in osteosarcoma cells by carrying out synthetic chemical modifications of curcumin...
January 2014: European Journal of Medicinal Chemistry
Marvin Xuejun Xu, Linlin Zhao, Chaoyang Deng, Lu Yang, Yang Wang, Tao Guo, Lifang Li, Jianping Lin, Lirong Zhang
Curcumin from the rhizome of Curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in G2 and modulating the wnt signaling pathway. We found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (HCC) cells in a concentration-dependent manner. We identified that curcumin interrupts wnt signaling by decreasing β-catenin activity, which in turn suppresses the expression of β-catenin target genes (c-myc, VEGF and cyclin D1)...
December 2013: International Journal of Oncology
Juliana Bender Hoppe, Rudimar Luiz Frozza, Elisa Nicoloso Simões Pires, André Bevilacqua Meneghetti, Christianne Salbego
OBJECTIVE: Accumulating evidence indicates that curcumin potently protects against beta-amyloid (Abeta) due to its oxygen free radicals scavenging and anti-inflammatory properties. However, cellular mechanisms that may underlie the neuroprotective effect of curcumin in Abeta-induced toxicity are not fully understood yet. The present study was undertaken to investigate the mechanisms involved in neuroprotective effects of curcumin, particularly involving Wnt/beta-catenin and PI3K pathways...
October 2013: Neurological Research
Ishfaq Ahmed, Parthasarathy Chandrakesan, Ossama Tawfik, Lijun Xia, Shrikant Anant, Shahid Umar
Notch and Wnt/β-catenin signals play essential roles in intestinal development and homeostasis. Citrobacter rodentium induces transmissible murine colonic hyperplasia (TMCH) and various degrees of inflammation, depending upon the genetic background. We aimed at delineating the role of the Notch and Wnt/β-catenin pathways in the regulation of colonic crypt hyperplasia and/or colitis following C. rodentium infection. During TMCH, relative levels of the Notch intracellular domain (NICD) increased significantly, along with increases in Jagged-1 and Hes-1 coinciding with the progression and regression phases of hyperplasia...
September 2012: Infection and Immunity
Ali Mohammad Alizadeh, Mahmood Khaniki, Saleh Azizian, Mohammad Ali Mohaghgheghi, Majid Sadeghizadeh, Farhood Najafi
Curcumin is a potential natural anticancer drug with limited bioavailability due to the lack of solubility in aqueous solvents. The present study is designed to investigate the preventive effects of polymeric nanocarrier-curcumin (PNCC) on colon carcinogenesis in an azoxymethane-induced rat tumor. Forty rats were divided into control, curcumin- and PNCC-treated groups. Animals received azoxymethane (AOM) as a carcinogenic agent (15 mg/kg, s.c.) weekly for two consecutive weeks. They were given curcumin 0.2% and PNCC two weeks before till 14 weeks after the last injection of AOM...
August 15, 2012: European Journal of Pharmacology
Vasudha Sundram, Subhash C Chauhan, Mara Ebeling, Meena Jaggi
Prostate cancer is the most commonly diagnosed cancer affecting 1 in 6 males in the US. Understanding the molecular basis of prostate cancer progression can serve as a tool for early diagnosis and development of novel treatment strategies for this disease. Protein Kinase D1 (PKD1) is a multifunctional kinase that is highly expressed in normal prostate. The decreased expression of PKD1 has been associated with the progression of prostate cancer. Therefore, synthetic or natural products that regulate this signaling pathway can serve as novel therapeutic modalities for prostate cancer prevention and treatment...
2012: PloS One
Ching-Shu Lai, Jia-Ching Wu, Shih-Feng Yu, Vladimir Badmaev, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
SCOPE: Tetrahydrocurcumin (THC), a major metabolite of curcumin (CUR), has been demonstrated to be anti-cancerogenic and anti-angiogenic and prevents type II diabetes. In this present study, we investigated the chemopreventive effects and underlying molecular mechanisms of dietary administration of CUR and THC in azoxymethane (AOM)-induced colon carcinogenesis in mice. METHODS AND RESULTS: All mice were sacrificed at 6 and 23 wk, and colonic tissue was collected and examined...
December 2011: Molecular Nutrition & Food Research
Marie-Hélène Teiten, François Gaascht, Mario Dicato, Marc Diederich
The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell polarity, Wnt/Ca²⁺" pathways are activated. This offers multiple possibilities to target the aberrant regulation of this signaling pathway in order to counteract cancer proliferation...
January 2012: Current Pharmaceutical Biotechnology
Xiong Zhang, Wen-ke Yin, Xiao-dong Shi, Yu Li
Wnt/β-catenin signaling pathway plays an important role in the genesis and development of Alzheimer's disease. The study aims to investigate the effect of Curcumin on the expression of GSK-3β, β-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/β-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer's disease. Plasmid APPswe and BACE1-mychis were transiently co-transfected into SHSY5Y cells by Liposfectamin™2000...
April 18, 2011: European Journal of Pharmaceutical Sciences
Yanyan Li, Max S Wicha, Steven J Schwartz, Duxin Sun
The emergence of cancer stem cell theory has profound implications for cancer chemoprevention and therapy. Cancer stem cells give rise to the tumor bulk through continuous self-renewal and differentiation. Understanding the mechanisms that regulate self-renewal is of greatest importance for discovery of anticancer drugs targeting cancer stem cells. Naturally occurring dietary compounds have received increasing attention in cancer chemoprevention. The anticancer effects of many dietary components have been reported for both in vitro and in vivo studies...
September 2011: Journal of Nutritional Biochemistry
Antony Hsieh, Hyeon-Seop Kim, Seung-Oe Lim, Dae-Yeul Yu, Guhung Jung
HBV X protein is a transactivator of several cellular signaling pathways including Wnt which contributes to HBV associated neoplasia. The Wnt/β-catenin pathway is associated with HCC-initiating cells. Here we perform a functional screen for host factors involved in the transactivational properties of HBx. We identify adenomatous polyposis coli (APC) as a binding partner of HBx and further determine that HBx competitively binds APC to displace β-catenin from its degradation complex. This results in β-catenin upregulation in the nucleus and the activation of Wnt signaling...
January 28, 2011: Cancer Letters
Isabel Villegas, Susana Sánchez-Fidalgo, Catalina Alarcón de la Lastra
SCOPE: Curcumin is a polyphenol with a variety of pharmacologic effects. We evaluate the effect of dietary curcumin on the severity of repeated colitis-associated colorectal cancer. METHODS AND RESULTS: Six-week-old C57BL/6 mice were randomized into two dietary groups: standard diet and curcumin at 0.6% diet. The mice were exposed to 15 cycles of 0.7% dextran sodium sulphate for 1 week followed by distilled water for 10 days. After curcumin diet, the disease activity index presented a statistical reduction in the last cycles, macroscopic tumors were not seen and the microscopic study showed minor neoplasic lesions with respect to standard diet-group...
February 2011: Molecular Nutrition & Food Research
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