keyword
MENU ▼
Read by QxMD icon Read
search

blue zones

keyword
https://www.readbyqxmd.com/read/27906063/characterization-of-a-multiprotein-complex-involved-in-excitation-transcription-coupling-of-skeletal-muscle
#1
Manuel Arias-Calderón, Gonzalo Almarza, Alexis Díaz-Vegas, Ariel Contreras-Ferrat, Denisse Valladares, Mariana Casas, Héctor Toledo, Enrique Jaimovich, Sonja Buvinic
BACKGROUND: Electrical activity regulates the expression of skeletal muscle genes by a process known as "excitation-transcription" (E-T) coupling. We have demonstrated that release of adenosine 5'-triphosphate (ATP) during depolarization activates membrane P2X/P2Y receptors, being the fundamental mediators between electrical stimulation, slow intracellular calcium transients, and gene expression. We propose that this signaling pathway would require the proper coordination between the voltage sensor (dihydropyridine receptor, DHPR), pannexin 1 channels (Panx1, ATP release conduit), nucleotide receptors, and other signaling molecules...
April 11, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27893522/zone-i-of-tear-microdesiccates-is-a-lipid-containing-structure
#2
Felipe Traipe, Leonidas Traipe, Daniela Salinas-Toro, Daniela López, Felipe Valenzuela, Claudio Pérez, Cristian Cartes, Francisca Zuazo, Patricia Varela, Héctor Toledo-Araya, Remigio López-Solís
PURPOSE: Morphological features of tear microdesiccates on glass surfaces have been associated with tear fluid status. Tear-film lipids play a critical role in the pathophysiology of some ocular surface disorders. Tear microdesiccates display 4 distinctive morphological domains (zones I, II, III, and transition band). In this study, we investigated the lipid location in tear microdesiccates. METHODS: Tear from individual healthy eyes (assessed by symptoms, signs, and slit-lamp examination) was collected using absorbing minisponges...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27867742/dermoscopic-appearance-of-an-amelanotic-mucosal-melanoma
#3
Andreas Blum, Ulrike Beck-Zoul, Laura Held, Sylvie Haase
BACKGROUND: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. CASE: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27845261/ddit3-suppresses-the-differentiation-of-mouse-chondroprogenitor-cells
#4
Miao Yu, Si-Qi Yi, Yan-Ru Wu, Hua-Ling Sun, Fang-Fang Song, Jia-Wei Wang
Endochondral ossification is an essential skeletal development process which is strongly linked to chondrocyte differentiation. DNA damage-inducible transcript 3 (Ddit3), a member of the CCAAT/enhancer-binding protein family of transcription factors, is highly expressed in the cartilage plate. However, the role of DNA damage-inducible transcript 3 in chondrocyte differentiation remains to be investigated. Immunofluorescent staining was used to detect Ddit3 expression in the mouse growth plate and in the mouse chondroprogenitor cell line ATDC5...
November 11, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27805766/determination-of-dasatinib-in-the-tablet-dosage-form-by-ultra-high-performance-liquid-chromatography-capillary-zone-electrophoresis-and-sequential-injection-analysis
#5
Aroa Garcia Gonzalez, Lukáš Taraba, Jakub Hraníček, Petr Kozlík, Pavel Coufal
Dasatinib is a novel oral prescription drug proposed for treating adult patients with chronic myeloid leukemia. Three analytical methods, namely ultra high performance liquid chromatography, capillary zone electrophoresis, and sequential injection analysis, were developed, validated and compared for determination of the drug in the tablet dosage form. The total analysis time of optimized ultra high performance liquid chromatography and capillary zone electrophoresis methods was 2.0 and 2.2 min, respectively...
November 2, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27794149/microleakage-of-glass-ionomer-based-provisional-cement-in-cad-cam-fabricated-interim-crowns-an-in-vitro-study
#6
Ra'fat I Farah, Naji Al-Harethi
AIM: The aim of this study was to compare in vitro the marginal microleakage of glass ionomer-based provisional cement with resin-based provisional cement and zinc oxide non-eugenol (ZONE) provisional cement in computer-aided design and computer-aided manufacturing (CAD/CAM)-fabricated interim restorations. MATERIALS AND METHODS: Fifteen intact human premolars were prepared in a standardized manner for complete coverage of crown restorations. Interim crowns for the prepared teeth were then fabricated using CAD/CAM, and the specimens were randomized into three groups of provisional cementing agents (n = 5 each): Glass ionomer-based provisional cement (GC Fuji TEMP LT™), bisphenol-A-glycidyldimethacrylate (Bis-GMA)/ triethylene glycol dimethacrylate (TEGDMA) resin-based cement (UltraTemp® REZ), and ZONE cement (TempBond NE)...
October 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27773269/ultrasound-irradiation-based-in-situ-synthesis-of-star-like-tragacanth-gum-zinc-oxide-nanoparticles-on-cotton-fabric
#7
Soraya Ghayempour, Majid Montazer
Application of natural biopolymers for green and safe synthesis of zinc oxide nanoparticles on the textiles is a novel and interesting approach. The present study offers the use of natural biopolymer, Tragacanth gum, as the reducing, stabilizing and binding agent for in-situ synthesis of zinc oxide nanoparticles on the cotton fabric. Ultrasonic irradiation leads to clean and easy synthesis of zinc oxide nanoparticles in short-time at low-temperature. FESEM/EDX, XRD, FT-IR spectroscopy, DSC, photocatalytic activities and antimicrobial assay are used to characterize Tragacanth gum/zinc oxide nanoparticles coated cotton fabric...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27771412/co-precipitation-synthesis-and-characterization-of-co-doped-sno2-nps-hsa-interaction-via-various-spectroscopic-techniques-and-their-antimicrobial-and-photocatalytic-activities
#8
Zeba Nasir, Mohammad Shakir, Rizwan Wahab, Mohd Shoeb, Parvez Alam, Rizwan Hasan Khan, Mohammad Mobin, Lutfullah
Sn1-xCoxO2 (x=0.00, 0.01, 0.03, 0.05) nanoparticles (NPs) of average size ∼30-40nm were synthesized by co-precipitation method. The interaction of Co doped SnO2 NPs with human serum albumin (HSA) and their photocatalytic and antimicrobial properties were studied. The structural analysis and morphology of Co doped SnO2 NPs were analysed via X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), high resolution transmission electron microscopy (HRTEM) and Fourier transform infrared spectroscopy (FT-IR)...
October 19, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27769905/improved-method-for-effective-screening-of-acc-1-aminocyclopropane-1-carboxylate-deaminase-producing-microorganisms
#9
Chandrashekhar Patil, Rahul Suryawanshi, Sunil Koli, Satish Patil
Aminocyclopropane-1-carboxylate deaminase (ACCD) producing microorganisms support plant growth under a variety of biotic and abiotic stress conditions such as drought, soil salinity, flooding, heavy metal pollution and phyto-pathogen attack. Available screening methods for ACCD give idea only about its primary microbial ACCD activity than the actual potential. In the present investigation, we have simply improved screening method by incorporating pH indicator dyes (phenol red and bromothymol blue) in ACC containing medium...
October 18, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27746263/the-optical-imaging-and-clinical-features-of-tamoxifen-associated-macular-hole-a-case-report-and-review-of-the-literatures
#10
Yuedong Hu, Liu Ningning, Yanyan Chen
We report a case of tamoxifen associated macular hole with typical optical imaging and clinical features. A 53-year-old woman came to our department for gradual decrees of vision acuity in both eyes for 3 months after 30 months low-dosage-tamoxifen treatment as adjuvant treatment for invasive ductal breast carcinoma. Her best corrected visual acuity (BCVA) was 0.4 in the right eye and 0.12 in the left eye. Dilated fundus examination showed macular multiple, fine, crystalline deposits and small white points in retina of both eyes...
October 13, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27704539/poison-frog-color-morphs-express-assortative-mate-preferences-in-allopatry-but-not-sympatry
#11
Yusan Yang, Corinne L Richards-Zawacki, Anisha Devar, Matthew B Dugas
The concurrent divergence of mating traits and preferences is necessary for the evolution of reproductive isolation via sexual selection, and such coevolution has been demonstrated in diverse lineages. However, the extent to which assortative mate preferences are sufficient to drive reproductive isolation in nature is less clear. Natural contact zones between lineages divergent in traits and preferences provide exceptional opportunities for testing the predicted evolutionary consequences of such divergence...
October 5, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27690648/safety-of-stereotactic-laser-ablations-performed-as-treatment-for-glioblastomas-in-a-conventional-magnetic-resonance-imaging-suite
#12
Robert C Rennert, Kate T Carroll, Mir Amaan Ali, Thomas Hamelin, Leon Chang, Brian P Lemkuil, Clark C Chen
OBJECTIVE Stereotactic laser ablation (SLA) is typically performed in the setting of intraoperative MRI or in a staged manner in which probe insertion is performed in the operating room and thermal ablation takes place in an MRI suite. METHODS The authors describe their experience, in which SLA for glioblastoma (GBM) treatment was performed entirely within a conventional MRI suite using the SmartFrame stereotactic device. RESULTS All 10 patients with GBM (2 with isocitrate dehydrogenase 1 mutation [mIDH1] and 8 with wild-type IDH1 [wtIDH1]) were followed for > 6 months...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27623531/comprehensive-assessment-of-soil-erosion-risk-for-better-land-use-planning-in-river-basins-case-study-of-the-upper-blue-nile-river
#13
Nigussie Haregeweyn, Atsushi Tsunekawa, Jean Poesen, Mitsuru Tsubo, Derege Tsegaye Meshesha, Ayele Almaw Fenta, Jan Nyssen, Enyew Adgo
In the drought-prone Upper Blue Nile River (UBNR) basin of Ethiopia, soil erosion by water results in significant consequences that also affect downstream countries. However, there have been limited comprehensive studies of this and other basins with diverse agroecologies. We analyzed the variability of gross soil loss and sediment yield rates under present and expected future conditions using a newly devised methodological framework. The results showed that the basin generates an average soil loss rate of 27...
September 10, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27602397/antimicrobial-activity-of-peganum-harmala-l-on-streptococcus-mutans-compared-to-0-2-chlorhexidine
#14
Mohammad Motamedifar, Hengameh Khosropanah, Shima Dabiri
STATEMENT OF THE PROBLEM: Dental caries is one the most prevalent diseases that affects humans throughout their lives. Streptococcus mutans (S. mutans) is recognized as the most important microorganism during tooth cariogenicity. Reducing this germ in oral cavity can reduce the rate of tooth decays in humans. PURPOSE: The present study compared the antimicrobial activity of ethanolic extract of Peganum harmala L. seeds and 0.2% chlorhexidine on S. mutans. MATERIALS AND METHOD: Agar diffusion technique and micro broth dilution method were employed to test the antimicrobial effects of these two agents on S...
September 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27596274/the-neuromelanin-related-t2-contrast-in-postmortem-human-substantia-nigra-with-7t-mri
#15
Jae-Hyeok Lee, Sun-Yong Baek, YoungKyu Song, Sujeong Lim, Hansol Lee, Minh Phuong Nguyen, Eun-Joo Kim, Gi Yeong Huh, Se Young Chun, HyungJoon Cho
High field magnetic resonance imaging (MRI)-based delineation of the substantia nigra (SN) and visualization of its inner cellular organization are promising methods for the evaluation of morphological changes associated with neurodegenerative diseases; however, corresponding MR contrasts must be matched and validated with quantitative histological information. Slices from two postmortem SN samples were imaged with a 7 Tesla (7T) MRI with T1 and T2* imaging protocols and then stained with Perl's Prussian blue, Kluver-Barrera, tyrosine hydroxylase, and calbindin immunohistochemistry in a serial manner...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27590267/methylene-blue-promotes-cortical-neurogenesis-and-ameliorates-behavioral-deficit-after-photothrombotic-stroke-in-rats
#16
Mohammad Ejaz Ahmed, Donovan Tucker, Yan Dong, Yujiao Lu, Ningjun Zhao, Ruimin Wang, Quanguang Zhang
Ischemic stroke in rodents stimulates neurogenesis in the adult brain and the proliferation of newborn neurons that migrate into the penumbra zone. The present study investigated the effect of Methylene Blue (MB) on neurogenesis and functional recovery in a photothrombotic (PT) model of ischemic stroke in rats. PT stroke model was induced by photo-activation of Rose Bengal dye in cerebral blood flow by cold fiber light. Rats received intraperitoneal injection of either MB (0.5mg/kg/day) from day 1 to day 5 after stroke or an equal volume of saline solution as a control...
November 12, 2016: Neuroscience
https://www.readbyqxmd.com/read/27574787/acetylcholinesterase-regulates-skeletal-in-ovo-development-of-chicken-limbs-by-ach-dependent-and-independent-mechanisms
#17
Janine Spieker, Anica Ackermann, Anika Salfelder, Astrid Vogel-Höpker, Paul G Layer
Formation of the vertebrate limb presents an excellent model to analyze a non-neuronal cholinergic system (NNCS). Here, we first analyzed the expression of acetylcholinesterase (AChE) by IHC and of choline acetyltransferase (ChAT) by ISH in developing embryonic chicken limbs (stages HH17-37). AChE outlined formation of bones, being strongest at their distal tips, and later also marked areas of cell death. At onset, AChE and ChAT were elevated in two organizing centers of the limb anlage, the apical ectodermal ridge (AER) and zone of polarizing activity (ZPA), respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27562128/-bizarre-parosteal-osteochondromatous-proliferation-of-the-metatarsal-bone
#18
C Hartog, V Centmaier-Molnar, R Patzwahl, D Pfofe, M Wiewiorski
A bizarre parosteal osteochondromatous proliferation (BPOP), also known as a Nora lesion, is a rare benign bone formation. It emanates mainly from the intact cortex of the metaphysis of short tubular bones (hands or feet). Conventional radiographs should be complemented using cross-sectional imaging modalities (CT/MRI). In the absence of symptoms a non-operative regime with radiological and clinical controls is possible. If symptomatic, excision biopsy is the treatment of choice, though a high recurrence rate has been reported...
October 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27554633/a-simple-paper-based-colorimetric-device-for-rapid-mercury-ii-assay
#19
Weiwei Chen, Xueen Fang, Hua Li, Hongmei Cao, Jilie Kong
Contamination of the environment by mercury(II) ions (Hg(2+)) poses a serious threat to human health and ecosystems. Up to now, many reported Hg(2+) sensors require complex procedures, long measurement times and sophisticated instrumentation. We have developed a simple, rapid, low cost and naked-eye quantitative method for Hg(2+) environmental analysis using a paper-based colorimetric device (PCD). The sample solution to which platinum nanoparticles (PtNPs) have been added is dispensed to the detection zone on the PCD, where the 3,3,5,5-tetramethylbenzidine (TMB) substrate has been pre-loaded...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27544889/cu-from-dissolution-of-cuo-nanoparticles-signals-changes-in-root-morphology
#20
Josh Adams, Melanie Wright, Hannah Wagner, Jonathan Valiente, David Britt, Anne Anderson
Utilization of CuO nanoparticles (NPs) in agriculture, as fertilizers or pesticides, requires understanding of their impact on plant metabolism. Inhibition of root elongation by CuO NPs (>10 mg Cu/kg) occurred in wheat grown in sand. Morphological changes included root hair proliferation and shortening of the zones of division and elongation. The epidermal cells in the compressed root tip were abnormal in shape and file patterning but staining with SYTOX Blue did not reveal a general increase in epidermal cell death...
August 8, 2016: Plant Physiology and Biochemistry: PPB
keyword
keyword
74087
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"