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William hersh

Derek J Williams, Matthew Hall, Jeffrey S Gerber, Mark I Neuman, Adam L Hersh, Thomas V Brogan, Kavita Parikh, Sanjay Mahant, Anne J Blaschke, Samir S Shah, Carlos G Grijalva
BACKGROUND: We evaluated the impact of the 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America pneumonia guideline and hospital-level implementation efforts on antibiotic prescribing for children hospitalized with pneumonia. METHODS: We assessed inpatient antibiotic prescribing for pneumonia at 28 children's hospitals between August 2009 and March 2015. Each hospital was also surveyed regarding local implementation efforts targeting antibiotic prescribing and organizational readiness to adopt guideline recommendations...
March 8, 2017: Pediatrics
Eveline Teresa Hidalgo, Cordelia Orillac, Andrew Hersh, David H Harter, William B Rizzo, Howard L Weiner
Intrathecal baclofen therapy is widely accepted as a treatment option for patients with severe spasticity. The current treatment of spasticity in patients with Sjögren-Larsson syndrome is largely symptomatic, given that no effective causal therapy treatments are available. We report the outcome of 2 patients with Sjögren-Larsson syndrome who had pump implantation for intrathecal baclofen. We observed a positive response, with a decrease of spasticity, reflecting in the Modified Ashworth Scale, and parents and caregivers observed a functional improvement in both patients...
January 2017: Journal of Child Neurology
Elliot Hersh, Bernard Schachtel, William Kozarek, Emily Schachtel, Mark Marino
The Publisher regrets that this abstract is an accidental duplication of abstract (431), also published in the 2016 American Pain Society Scientific Meeting abstracts supplement: J Pain 17:S82, 2016, The duplicate abstract (438) has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at
April 2016: Journal of Pain: Official Journal of the American Pain Society
Nicole Wake, Temitope Rude, Stella K Kang, Michael D Stifelman, James F Borin, Daniel K Sodickson, William C Huang, Hersh Chandarana
OBJECTIVE: To determine whether patient-specific 3D printed renal tumor models change pre-operative planning decisions made by urological surgeons in preparation for complex renal mass surgical procedures. MATERIALS AND METHODS: From our ongoing IRB approved study on renal neoplasms, ten renal mass cases were retrospectively selected based on Nephrometry Score greater than 5 (range 6-10). A 3D post-contrast fat-suppressed gradient-echo T1-weighted sequence was used to generate 3D printed models...
January 7, 2017: Abdominal Radiology
J Michael Wells, Raul San Jose Estepar, Merry-Lynn N McDonald, Surya P Bhatt, Alejandro A Diaz, William C Bailey, Francine L Jacobson, Mark T Dransfield, George R Washko, Barry J Make, Richard Casaburi, Edwin J R van Beek, Eric A Hoffman, Frank C Sciurba, James D Crapo, Edwin K Silverman, Craig P Hersh
BACKGROUND: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic at baseline. We hypothesized that a combination of clinical, physiologic, and radiographic characteristics would predict development of resting hypoxemia after 5-years of follow-up in participants with moderate to severe COPD METHODS: We analyzed 678 participants with moderate-to-severe COPD recruited into the COPDGene cohort who completed baseline and 5-year follow-up visits and who were normoxic by pulse oximetry at baseline...
December 1, 2016: BMC Pulmonary Medicine
Jennifer C Fuller, Sumi Sinha, Paul A Caruso, Cheryl J Hersh, William E Butler, Kalpathy S Krishnamoorthy, Christopher J Hartnick
Chronic aspiration poses a major health risk to the pediatric population. We describe four cases in which work up for chronic aspiration with a brain MRI revealed a Chiari I malformation, a poorly described etiology of pediatric aspiration. All patients had at least one non-specific neurologic symptom but had swallow studies more characteristic of an anatomic than a neurologic etiology. Patients were referred to neurosurgery and underwent posterior fossa decompression with symptom improvement. A high index of suspicion for Chiari malformation should be maintained when the standard work up for aspiration is non-diagnostic, particularly when non-specific neurologic symptoms are present...
September 2016: International Journal of Pediatric Otorhinolaryngology
Christopher A Longhurst, Natalie M Pageler, Jonathan P Palma, John T Finnell, Bruce P Levy, Thomas R Yackel, Vishnu Mohan, William R Hersh
Since the launch of the clinical informatics subspecialty for physicians in 2013, over 1100 physicians have used the practice and education pathways to become board-certified in clinical informatics. Starting in 2018, only physicians who have completed a 2-year clinical informatics fellowship program accredited by the Accreditation Council on Graduate Medical Education will be eligible to take the board exam. The purpose of this viewpoint piece is to describe the collective experience of the first four programs accredited by the Accreditation Council on Graduate Medical Education and to share lessons learned in developing new fellowship programs in this novel medical subspecialty...
July 2016: Journal of the American Medical Informatics Association: JAMIA
Elliot Hersh, Bernard Schachtel, William Kozarek, Emily Schachtel, Mark Marino
The Publisher regrets that this abstract is an accidental duplication of abstract (431), also published in the 2016 American Pain Society Scientific Meeting abstracts supplement: J Pain 17:S82, 2016, The duplicate abstract (438) has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at
April 2016: Journal of Pain: Official Journal of the American Pain Society
Ankur M Doshi, Justin M Ream, Andrea S Kierans, Matthew Bilbily, Henry Rusinek, William C Huang, Hersh Chandarana
OBJECTIVE: The purpose of this study was to determine whether qualitative and quantitative MRI feature analysis is useful for differentiating type 1 from type 2 papillary renal cell carcinoma (PRCC). MATERIALS AND METHODS: This retrospective study included 21 type 1 and 17 type 2 PRCCs evaluated with preoperative MRI. Two radiologists independently evaluated various qualitative features, including signal intensity, heterogeneity, and margin. For the quantitative analysis, a radiology fellow and a medical student independently drew 3D volumes of interest over the entire tumor on T2-weighted HASTE images, apparent diffusion coefficient parametric maps, and nephrographic phase contrast-enhanced MR images to derive first-order texture metrics...
March 2016: AJR. American Journal of Roentgenology
Karen B Eden, Annette M Totten, Steven Z Kassakian, Paul N Gorman, Marian S McDonagh, Beth Devine, Miranda Pappas, Monica Daeges, Susan Woods, William R Hersh
OBJECTIVES: We conducted a systematic review of studies assessing facilitators and barriers to use of health information exchange (HIE). METHODS: We searched MEDLINE, PsycINFO, CINAHL, and the Cochrane Library databases between January 1990 and February 2015 using terms related to HIE. English-language studies that identified barriers and facilitators of actual HIE were included. Data on study design, risk of bias, setting, geographic location, characteristics of the HIE, perceived barriers and facilitators to use were extracted and confirmed...
April 2016: International Journal of Medical Informatics
Kavita Parikh, Matt Hall, Anne J Blaschke, Carlos G Grijalva, Thomas V Brogan, Mark I Neuman, Derek J Williams, Jeffrey S Gerber, Adam L Hersh, Samir S Shah
BACKGROUND: National guidelines for the management of community-acquired pneumonia (CAP) in children were published in 2011. These guidelines discourage most diagnostic testing for outpatients, as well as repeat testing for hospitalized patients who are improving. We sought to evaluate the temporal trends in diagnostic testing associated with guideline implementation among children with CAP. METHODS: Children 1 to 18 years old who were discharged with pneumonia after emergency department (ED) evaluation or hospitalization from January 1, 2008 to June 30, 2014 at any of 32 children's hospitals participating in the Pediatric Health Information System were included...
May 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
William R Hersh, Annette M Totten, Karen B Eden, Beth Devine, Paul Gorman, Steven Z Kassakian, Susan S Woods, Monica Daeges, Miranda Pappas, Marian S McDonagh
BACKGROUND: Health information exchange (HIE), the electronic sharing of clinical information across the boundaries of health care organizations, has been promoted to improve the efficiency, cost-effectiveness, quality, and safety of health care delivery. OBJECTIVE: To systematically review the available research on HIE outcomes and analyze future research needs. METHODS: Data sources included citations from selected databases from January 1990 to February 2015...
2015: JMIR Medical Informatics
Sajal Das, Dongsub Hong, Zhiwei Chen, Zhigang She, William H Hersh, Gopal Subramaniam, Yu Chen
An auto-tandem palladium catalysis from halogen-substituted isoxazoles and Michael acceptors is described. It involves two mechanistically distinct palladium-catalyzed reactions, a Heck reaction and a rearrangement, leading to 2-azafluorenones. It is the first example of palladium-catalyzed ring opening of isoxazoles and rearrangement of the β-imino ketone ring-opening product.
November 20, 2015: Organic Letters
Erik Ekengard, Lotta Glans, Irwin Cassells, Thibault Fogeron, Preshendren Govender, Tameryn Stringer, Prinessa Chellan, George C Lisensky, William H Hersh, Isa Doverbratt, Sven Lidin, Carmen de Kock, Peter J Smith, Gregory S Smith, Ebbe Nordlander
Eight new ruthenium and five new osmium p-cymene half-sandwich complexes have been synthesized, characterized and evaluated for antimalarial activity. All complexes contain ligands that are based on a 4-chloroquinoline framework related to the antimalarial drug chloroquine. Ligands HL(1-8) are salicylaldimine derivatives, where HL(1) = N-(2-((2-hydroxyphenyl)methylimino)ethyl)-7-chloroquinolin-4-amine, and HL(2-8) contain non-hydrogen substituents in the 3-position of the salicylaldimine ring, viz. F, Cl, Br, I, NO2, OMe and (t)Bu for HL(2-8), respectively...
November 28, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Vinod H Thourani, Hanna A Jensen, Vasilis Babaliaros, Susheel K Kodali, Jeevanantham Rajeswaran, John Ehrlinger, Eugene H Blackstone, Rakesh M Suri, Creighton W Don, Gabriel Aldea, Mathew R Williams, Raj Makkar, Lars G Svensson, James M McCabe, Larry S Dean, Samir Kapadia, David J Cohen, Augusto D Pichard, Wilson Y Szeto, Howard C Herrmann, Chandan Devireddy, Bradley G Leshnower, Gorav Ailawadi, Hersh S Maniar, Rebecca T Hahn, Martin B Leon, Michael Mack
BACKGROUND: This study describes short-term and mid-term outcomes of nonagenarian patients undergoing transfemoral or transapical transcatheter aortic valve replacement (TAVR) in the Placement of Aortic Transcatheter Valve (PARTNER)-I trial. METHODS: From April 2007 to February 2012, 531 nonagenarians, mean age 93 ± 2.1 years, underwent TAVR with a balloon-expandable prosthesis in the PARTNER-I trial: 329 through transfemoral (TF-TAVR) and 202 transapical (TA-TAVR) access...
September 2015: Annals of Thoracic Surgery
Vinod H Thourani, Hanna A Jensen, Vasilis Babaliaros, Rakesh Suri, Sreekanth Vemulapalli, David Dai, J Matthew Brennan, John Rumsfeld, Fred Edwards, E Murat Tuzcu, Lars Svensson, Wilson Y Szeto, Howard Herrmann, Ajay J Kirtane, Susheel Kodali, David J Cohen, Stamatios Lerakis, Chandan Devireddy, Eric Sarin, John Carroll, David Holmes, Frederick L Grover, Mathew Williams, Hersh Maniar, David Shahian, Michael Mack
BACKGROUND: When transcatheter aortic valve replacement (TAVR) cannot be carried out through transfemoral access, alternative access TAVR is indicated. The purpose of this study was to explore inhospital and 1-year outcomes of patients undergoing alternative access TAVR through the transapical (TA) or transaortic (TAo) techniques in the United States. METHODS: Clinical records of 4,953 patients undergoing TA (n = 4,085) or TAo (n = 868) TAVR from 2011 to 2014 in The Society of Thoracic Surgeons (STS)/American College of Cardiology Transcatheter Valve Therapy Registry were linked to Centers for Medicare and Medicaid Services hospital claims...
November 2015: Annals of Thoracic Surgery
Reuben Granich, Somya Gupta, Bradley Hersh, Brian Williams, Julio Montaner, Benjamin Young, José M Zuniga
BACKGROUND: Antiretroviral therapy (ART) prevents human immunodeficiency virus (HIV) disease progression, mortality and transmission. We assess the impact of expanded HIV treatment for the prevention of Acquired Immunodeficiency Syndrome (AIDS)-related deaths and simulate four treatment scenarios for Nigeria and South Africa. METHODS: For 1990-2013, we used the Joint United Nations Programme on HIV/AIDS (UNAIDS) database to examine trends in AIDS deaths, HIV incidence and prevalence, ART coverage, annual AIDS death rate, AIDS death-to-treatment and HIV infections to treatment ratios for the top 30 countries with the highest AIDS mortality burden and compare them with data from high-income countries...
2015: PloS One
Derek J Williams, Kathryn M Edwards, Wesley H Self, Yuwei Zhu, Krow Ampofo, Andrew T Pavia, Adam L Hersh, Sandra R Arnold, Jonathan A McCullers, Lauri A Hicks, Anna M Bramley, Seema Jain, Carlos G Grijalva
INTRODUCTION: The 2011 national guidelines for the management of childhood community-acquired pneumonia (CAP) recommended narrow-spectrum antibiotics (eg, ampicillin) for most children hospitalized with CAP. We assessed the impact of these guidelines on antibiotic prescribing at 3 children's hospitals. METHODS: Children hospitalized with clinical and radiographic CAP were enrolled from January 1, 2010, through June 30, 2012, at 3 hospitals in Tennessee and Utah as part of the Centers for Disease Control and Prevention Etiology of Pneumonia in the Community study...
July 2015: Pediatrics
William R Hersh, James Cimino, Philip R O Payne, Peter Embi, Judith Logan, Mark Weiner, Elmer V Bernstam, Harold Lehmann, George Hripcsak, Timothy Hartzog, Joel Saltz
There is an increasing amount of clinical data in operational electronic health record (EHR) systems. Such data provide substantial opportunities for their re-use for many purposes, including comparative effectiveness research (CER). In a previous paper, we identified a number of caveats related to the use of such data, noting that they may be inaccurate, incomplete, transformed in ways that undermine their meaning, unrecoverable for research, of unknown provenance, of insufficient granularity, or incompatible with research protocols...
2013: EGEMS
William H Hersh
The reaction of the diamidite, (iPr2N)2PH, with acyl chlorides proceeds with the loss of HCl to give the corresponding acyl diamidites, RC(O)P(N(iPr)2)2 (R = Me (7), Ph (9)), without the intervention of sodium to give a phosphorus anion. The structure of 9 was confirmed by single-crystal X-ray diffraction. The coupling of the diamidites 7 and 9 with 5'-O-DMTr-thymidine was carried out with N-methylimidazolium triflate as the activator to give the monoamidites 3'-O-(P(N(iPr)2)C(O)R)-5'-O-DMTr-thymidine, and further coupling with 3'-O-(tert-butyldimethylsilyl)thymidine was carried out with activation by pyridinium trifluoroacetate/N-methylimidazole...
2015: Beilstein Journal of Organic Chemistry
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