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Corneal graft rejection

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https://www.readbyqxmd.com/read/29777547/tacrolimus-induced-asymptomatic-thrombotic-microangiopathy-diagnosed-by-laboratory-tests-in-pig-to-rhesus-corneal-xenotransplantation-a-case-report
#1
Jong-Min Kim, Jaeyoung Kim, Se-Hyun Choi, Jun-Seop Shin, Byoung-Hoon Min, Won Young Jeong, Ga-Eul Lee, Min-Sun Kim, Seeun Kwon, Mee Kum Kim, Chung-Gyu Park
Tacrolimus-associated thrombotic microangiopathy (TA-TMA) is a rare complication. TA-TMA is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage due to thrombus. We report asymptomatic TA-TMA diagnosed by laboratory tests in pig-to-rhesus corneal xenotransplantation. Corneal transplantation had been conducted from a wild-type SNU miniature pig to a rhesus macaque. The veterinary records were retrospectively reviewed in this case. The immunosuppressive regimen consisted of rituximab, basiliximab, and IVIg as inductive therapies, and steroids with tacrolimus (0...
May 18, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29773311/-corneal-endothelial-cell-therapy-a-review
#2
REVIEW
V Kocaba, O Damour, C Auxenfans, C Burillon
In France, endothelial dysfunction represents approximately one half of the indications for corneal transplants performed each year. However, the use of endothelial keratoplasty is limited by the technical difficulty of the procedure, a shortage of available grafts, and the potential for graft failure or rejection. These limitations are driving researchers to develop new, less invasive, and more effective therapies. Corneal endothelial cell therapy is being explored as a potential therapeutic measure, to avoid the uncertainty associated with grafting...
May 14, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29756410/the-feasibility-and-efficacy-of-preparing-porcine-descemet-s-membrane-endothelial-keratoplasty-dmek-grafts-by-two-techniques-an-ex-vivo-investigation-for-future-xeno-dmek
#3
Yang Liu, Jing Zhang, Yingnan Zhang, Mingyang Yin, Sen Miao, Qingfeng Liang, Zhiqiang Pan
BACKGROUND: Descemet's membrane endothelial keratoplasty (DMEK) might be a promising technique for future xeno-corneal transplantation due to its ultrathin graft, extremely low rejection occurrence, suture-free graft fixation, and minimal immunosuppressive regime usage. The aim of this study is to explore the feasibility and efficacy of preparing porcine DMEK grafts by 2 techniques and investigate the graft ultrastructure. METHODS: Two mainstream techniques, mechanical stripping technique and liquid bubble technique, were modified to prepare the porcine DMEK grafts...
May 13, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29735006/rejection-prophylaxis-in-corneal-transplant
#4
Daniel Böhringer, Birgit Grotejohann, Gabriele Ihorst, Helga Reinshagen, Eric Spierings, Thomas Reinhard
BACKGROUND: Graft rejection. Twenty to thirty percent of patients with corneal transplants experience at least one rejection episode in the first 5 years after transplantation. Prophylaxis through matching for human leukocyte antigens (HLA) is controversial. We herein report the results of the Functional ANtigen matChing in keratoplastY (FANCY) trial. METHODS: FANCY was a randomized, double-blind, multicenter clinical trial. The primary objective was to evaluate superiority of HLA matching versus random graft assignment...
April 13, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29734357/cyclosporine-a-drug-delivery-system-for-high-risk-penetrating-keratoplasty-stabilizing-the-intraocular-immune-microenvironment
#5
Ting Zhang, Zhiyuan Li, Ting Liu, Suxia Li, Hua Gao, Chao Wei, Weiyun Shi
Cyclosporine A (CsA) is an essential medication used to prevent corneal allograft rejection. Our preliminary studies revealed that CsA drug-delivery system (DDS) was more effective in preventing high-risk corneal allograft rejection than topical CsA application. However, the impacts of CsA DDS on the intraocular immune microenvironment were not fully elucidated. In the present study, we investigated the effect of CsA DDS on the cornea allograft, aqueous humor, and iris-ciliary body using a rabbit model of high-risk penetrating keratoplasty...
2018: PloS One
https://www.readbyqxmd.com/read/29731147/five-year-graft-survival-of-descemet-membrane-endothelial-keratoplasty-ek-versus-descemet-stripping-ek-and-the-effect-of-donor-sex-matching
#6
David A Price, Meagan Kelley, Francis W Price, Marianne O Price
PURPOSE: To determine whether the reduced risk of immunologic rejection with Descemet membrane endothelial keratoplasty (DMEK) results in a 5-year survival advantage relative to Descemet stripping endothelial keratoplasty (DSEK) and to determine whether matching the donor and recipient sex affects the rejection episode and graft survival rates. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients with Fuchs' endothelial corneal dystrophy treated with DSEK or DMEK...
May 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29715322/clinical-analysis-of-fungal-keratitis-in-patients-with-and-without-diabetes
#7
Jing Dan, Qingjun Zhou, Hualei Zhai, Jun Cheng, Lei Wan, Cheng Ge, Lixin Xie
We compared the clinical characteristics, treatments, and prognoses of fungal keratitis in patients with and without diabetes. Patients diagnosed with fungal keratitis at Shandong Eye Institute between January 2010 and December 2016 were retrospectively reviewed and classified as diabetic and nondiabetic groups. One-hundred-and-eleven patients (111 eyes) with diabetes and 740 patients (740 eyes) without diabetes were included. The diabetic patients showed significantly older (p< 0.05) and lower male:female ratio (p<0...
2018: PloS One
https://www.readbyqxmd.com/read/29697353/graft-failure-and-repeat-penetrating-keratoplasty
#8
Ozlem Barut Selver, Irmak Karaca, Melis Palamar, Sait Egrilmez, Ayse Yagci
OBJECTIVES: In this study, we report the indications and outcomes of repeat penetrating keratoplasty and the reasons for graft failure. MATERIALS AND METHODS: We performed a retrospective data analysis of patients who had undergone 2 or more penetrating keratoplasties for the same eye between 1991 and 2016. RESULTS: Among 1613 penetrating keratoplasties, 149 regrafts of 105 eyes were reviewed. The mean follow-up time after repeat penetrating keratoplasty was 3...
April 26, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29681179/-femtosecond-laser-assisted-keratoplasty
#9
László Módis, Eszter Szalai, Zsuzsanna Flaskó, Bence Kolozsvári, András Berta
INTRODUCTION AND AIM: To present our results on femtosecond laser-assisted penetrating keratoplasty. PATIENTS AND METHOD: Twenty-five eyes of 25 patients underwent surgery with the following indications: pseudophakic bullous keratopathy (n = 10), keratoconus (n = 4), corneal dystrophy (n = 5), corneal scar (n = 4), band keratopathy (n = 2). Trephination of both the donor and recipient corneas were performed with VisuMax femtosecond laser device (Carl Zeiss Meditec AG, Jena, Germany)...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29677004/new-surgical-modality-for-management-of-corneal-perforation-using-bowman-membrane
#10
Dharamveer Singh Choudhary, Nikhil Agrawal
PURPOSE: To describe a new surgical modality, "Bowman membrane tuck-in," for management of small to medium sized corneal perforation of a noninfectious etiology. METHODS: Two patients with corneal perforation of a noninfectious etiology and less than 4 mm in size underwent Bowman membrane tuck-in, a new surgical procedure. In this technique, Bowman membrane harvested from the donor cornea was tucked inside the stromal pocket of host tissue, which was prepared by 360-degree anterior stromal lamellar dissection...
April 19, 2018: Cornea
https://www.readbyqxmd.com/read/29676312/outcomes-of-keratoplasty-in-lattice-corneal-dystrophy-in-a-large-cohort-of-indian-eyes
#11
Ashik Mohamed, Sunita Chaurasia, Muralidhar Ramappa, Somasheila I Murthy, Prashant Garg
Purpose: The purpose of this study is to evaluate the outcomes of keratoplasty for lattice corneal dystrophy (LCD) performed at a tertiary eye care center. Methods: A retrospective review of medical records of those patients who were clinically diagnosed to have LCD (72 eyes of 57 patients) and underwent either penetrating keratoplasty (PK, 58 eyes of 46 patients) or deep anterior lamellar keratoplasty (DALK, 14 eyes of 13 patients) between the years 1987 and 2014 was performed...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29673063/uv-light-crosslinking-regresses-mature-corneal-blood-and-lymphatic-vessels-and-promotes-subsequent-high-risk-corneal-transplant-survival
#12
Yanhong Hou, Viet Nhat Hung Le, Gábor Tóth, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen
Immunological graft rejection is the main complication after corneal transplantation into pathologically prevascularized so-called high risk eyes. Aim of this study was to evaluate whether UV-light crosslinking can regress pathological corneal blood and lymphatic vessels, and thereby improve subsequent graft survival. Using the murine model of suture-induced corneal neovascularization, we found that corneal crosslinking with ultraviolet (UV) A-light and riboflavin regressed both preexisting blood and lymphatic vessels significantly via inducing apoptosis in vascular endothelial cells...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29658366/a-novel-case-using-femtosecond-laser-acquired-lenticule-for-recurrent-pterygium-case-report-and-literature-review
#13
Om Prakash Pant, Ji-Long Hao, Dan-Dan Zhou, Fan Wang, Cheng-Wei Lu
Small incision lenticule extraction (SMILE) is a minimally invasive, safe and flapless femtosecond laser technique used mainly to correct myopia through extraction of a corneal lenticule. Lenticules obtained in this way are transparent and of high quality, and thus, can be used to treat other corneal diseases. A 65-year-old male patient presented with recurrent pterygium complicated by thin cornea. The patient was treated surgically using a SMILE-extracted lenticule to avoid further complications and to maintain eyeball integrity...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29607856/hybrid-contact-lenses-for-visual-management-of-patients-after-keratoplasty
#14
Y Altay, O Balta, A Burcu, F Ornek
Aim: This study aims to report the outcomes of new-generation hybrid contact lenses for visual rehabilitation of postkeratoplasty patients. Materials and Methods: Twenty eyes of twenty postkeratoplasty patients were fitted with hybrid lenses. Each patient's keratometric values, ocular surface irregularity indices, central corneal thickness (CCT), uncorrected visual acuity (UCVA), spectacle-corrected visual acuity, contact lens-corrected visual acuity, contact lens fitting data, and contact lens daily wearing time were recorded...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29602717/skin-xenotransplantation-historical-review-and-clinical-potential
#15
REVIEW
Takayuki Yamamoto, Hayato Iwase, Timothy W King, Hidetaka Hara, David K C Cooper
Half a million patients in the USA alone require treatment for burns annually. Following an extensive burn, it may not be possible to provide sufficient autografts in a single setting. Pig skin xenografts may provide temporary coverage. However, preformed xenoreactive antibodies in the human recipient activate complement, and thus result in rapid rejection of the graft. Because burn patients usually have some degree of immune dysfunction and are therefore at increased risk of infection, immunosuppressive therapy is undesirable...
March 27, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29595762/transplantation-blues-inadvertent-staining-of-amyloid-deposits-with-trypan-blue
#16
Agathe Marcon, Nicolas Périllat, Thibaud Garcin, Rémy Jullienne, Zhiguo He, Fabien Forest, Anne Sophie Gauthier, Philippe Gain, Gilles Thuret
PURPOSE: To describe inadvertent persistent staining of stromal amyloid deposits by trypan blue (TB) after penetrating keratoplasty (PK) and Descemet membrane endothelial keratoplasty (DMEK) performed in patients with corneal amyloidosis. METHODS: Case series of patients with corneal amyloidosis in whom intraoperative TB was used. RESULTS: One patient, hospitalized for acute rejection 6 weeks after DMEK, presented with an intense blue staining of small, spindle-shaped structures in the anterior half of the cornea...
March 27, 2018: Cornea
https://www.readbyqxmd.com/read/29576879/the-balance-of-th1-th2-and-lap-tregs-th17-cells-is-crucial-for-graft-survival-in-allogeneic-corneal-transplantation
#17
Shang Li, Jing Yu, Chungang Guo, Ying Jie, Zhiqiang Pan
Purpose: CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs). The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods: A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29567793/corneal-transplant-follow-up-study-ii-ctfs-ii-a-prospective-clinical-trial-to-determine-the-influence-of-hla-class-ii-matching-on-corneal-transplant-rejection-baseline-donor-and-recipient-characteristics
#18
W John Armitage, Helen L Winton, Mark N A Jones, Julie M Crewe, Chris A Rogers, Derek M Tole, Andrew D Dick
PURPOSE: To describe a study to determine the influence of HLA class II matching on allograft rejection of high-risk, full-thickness corneal transplants. METHODS: A prospective, longitudinal, clinical trial (ISRCTN25094892) with a primary outcome measure of time to first clinically determined rejection episode. Tissue typing used DNA-based techniques. Corneas were allocated to patients with ≤2 human leucocyte antigen (HLA) class I antigen mismatches by cohort minimisation to achieve 0, 1 or 2 HLA class II (HLA-DR) antigen mismatches...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29543665/immunologic-stromal-rejection-after-deep-anterior-lamellar-keratoplasty-with-grafts-of-a-larger-size-9-mm-for-various-stromal-diseases
#19
Giuseppe Giannaccare, Jayne S Weiss, Laura Sapigni, Cristina Bovone, Leila Mattioli, Emilio C Campos, Massimo Busin
PURPOSE: To evaluate the rate and outcomes of immunologic stromal rejection occurring after large deep anterior lamellar keratoplasty (DALK) and the effect of the underlying disease on the cumulative probability of rejection. METHODS: This was a retrospective chart review of all eyes that underwent a 9-mm DALK at Ospedali Privati Forlì (Forlì, Italy). On the basis of preoperative diagnosis, eyes were assigned to group 1: keratoconus, group 2: stromal disease with a low risk for rejection, or group 3: stromal disease with a high risk for rejection...
March 14, 2018: Cornea
https://www.readbyqxmd.com/read/29502597/descemet-membrane-endothelial-keratoplasty-for-corneal-decompensation-caused-by-herpes-simplex-virus-endotheliitis
#20
Fatema Asi, Georgia Milioti, Berthold Seitz
We report a case of corneal decompensation caused by recurrent herpetic endotheliitis that was treated successfully with Descemet membrane endothelial keratoplasty (DMEK). A 62-year-old woman presented with a history of recurrent herpetic infections in the right cornea. After topical and systemic treatment with antivirals and steroids for 5 months, DMEK combined with cataract surgery was performed. Two weeks after DMEK, the corrected distance visual acuity (CDVA) in the affected eye was 0.3 (20/60). One year postoperatively, the CDVA was 1...
January 2018: Journal of Cataract and Refractive Surgery
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