keyword
MENU ▼
Read by QxMD icon Read
search

Bacteria host pathogen

keyword
https://www.readbyqxmd.com/read/29166596/the-gcn2-atf4-signaling-pathway-induces-4e-bp-to-bias-translation-and-boost-antimicrobial-peptide-synthesis-in-response-to-bacterial-infection
#1
Deepika Vasudevan, Nicholas K Clark, Jessica Sam, Victoria C Cotham, Beatrix Ueberheide, Michael T Marr, Hyung Don Ryoo
Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulated by the inhibitor of cap-dependent translation, 4E-BP (eIF4E-binding protein; encoded by the Thor gene). We found that 4E-BP is induced upon infection with pathogenic bacteria by the stress-response transcription factor ATF4 and its upstream kinase, GCN2...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29165845/wolbachia-infection-alters-the-relative-abundance-of-resident-bacteria-in-adult-aedes-aegypti-mosquitoes-but-not-larvae
#2
Michelle D Audsley, Andrei Seleznev, D Albert Joubert, Megan Woolfit, Scott L O'Neill, Elizabeth A McGraw
Insect-symbiont interactions are known to play key roles in host functions and fitness. The common insect endosymbiont Wolbachia can reduce the ability of several human pathogens, including arboviruses and the malaria parasite, to replicate in insect hosts. Wolbachia does not naturally infect Aedes aegypti, the primary vector of dengue virus, but transinfected Ae. aegypti have anti-dengue virus properties and are currently being trialled as a dengue biocontrol strategy. Here, we assess the impact of Wolbachia infection of Ae...
November 22, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29164472/rodent-borne-bartonella-infection-varies-according-to-host-species-within-and-among-cities
#3
Anna C Peterson, Bruno M Ghersi, Fernando Alda, Cadhla Firth, Matthew J Frye, Ying Bai, Lynn M Osikowicz, Claudia Riegel, W Ian Lipkin, Michael Y Kosoy, Michael J Blum
It is becoming increasingly likely that rodents will drive future disease epidemics with the continued expansion of cities worldwide. Though transmission risk is a growing concern, relatively little is known about pathogens carried by urban rats. Here, we assess whether the diversity and prevalence of Bartonella bacteria differ according to the (co)occurrence of rat hosts across New Orleans, LA (NO), where both Norway (Rattus norvegicus) and roof rats (Rattus rattus) are found, relative to New York City (NYC) which only harbors Norway rats...
November 21, 2017: EcoHealth
https://www.readbyqxmd.com/read/29164073/streptococcus-equi-subsp-zooepidemicus-invades-and-survives-in-epithelial-cells
#4
Bolette Skive, Manfred Rohde, Gabriella Molinari, Thomas Hartig Braunstein, Anders M Bojesen
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an opportunistic pathogen of several species including humans. S. zooepidemicus is found on mucus membranes of healthy horses, but can cause acute and chronic endometritis. Recently S. zooepidemicus was found able to reside in the endometrium for prolonged periods of time. Thus, we hypothesized that an intracellular phase may be part of the S. zooepidemicus pathogenesis and investigated if S. zooepidemicus was able to invade and survive inside epithelial cells...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29164069/iron-acquisition-mechanisms-and-their-role-in-the-virulence-of-burkholderia-species
#5
REVIEW
Aaron T Butt, Mark S Thomas
Burkholderia is a genus within the β-Proteobacteriaceae that contains at least 90 validly named species which can be found in a diverse range of environments. A number of pathogenic species occur within the genus. These include Burkholderia cenocepacia and Burkholderia multivorans, opportunistic pathogens that can infect the lungs of patients with cystic fibrosis, and are members of the Burkholderia cepacia complex (Bcc). Burkholderia pseudomallei is also an opportunistic pathogen, but in contrast to Bcc species it causes the tropical human disease melioidosis, while its close relative Burkholderia mallei is the causative agent of glanders in horses...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29163628/a-conserved-basal-transcription-factor-is-required-for-the-function-of-diverse-tal-effectors-in-multiple-plant-hosts
#6
Renyan Huang, Shugang Hui, Meng Zhang, Pei Li, Jinghua Xiao, Xianghua Li, Meng Yuan, Shiping Wang
Many Xanthomonas bacteria use transcription activator-like effector (TALE) proteins to activate plant disease susceptibility (S) genes, and this activation contributes to disease. We recently reported that rice basal transcription factor IIA gamma subunit, OsTFIIAγ5, is hijacked by TALE-carrying Xanthomonas oryzae infecting the plants. However, whether TFIIAγs are also involved in TALE-carrying Xanthomonas-caused diseases in other plants is unknown. Here, molecular and genetic approaches were used to investigate the role of TFIIAγs in other plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163544/macrophage-autophagy-and-bacterial-infections
#7
REVIEW
Aïcha Bah, Isabelle Vergne
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can have non-canonical functions such as LC3-associated phagocytosis. In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria-macrophage interaction...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163512/carboxyl-terminal-residues-n478-and-v479-required-for-the-cytolytic-activity-of-listeriolysin-o-play-a-critical-role-in-listeria-monocytogenes-pathogenicity
#8
Changyong Cheng, Li Jiang, Tiantian Ma, Hang Wang, Xiao Han, Jing Sun, Yongchun Yang, Zhongwei Chen, Huifei Yu, Yi Hang, Fengdan Liu, Bosen Wang, Weihuan Fang, Huarong Huang, Chun Fang, Chang Cai, Nancy Freitag, Houhui Song
Listeria monocytogenes is a facultative intracellular pathogen that secretes the cytolysin listeriolysin O (LLO), which enables the bacteria to cross the phagosomal membrane. L. monocytogenes regulates LLO activity in the phagosome and minimizes its activity in the host cytosol. Mutants that fail to compartmentalize LLO activity are cytotoxic and have attenuated virulence. Here, we showed that residues N478 and V479 of LLO are required for LLO hemolytic activity and bacterial virulence. A single N478A mutation (LLON478A) significantly increased the hemolytic activity of LLO at a neutral pH, while no difference was observed at the optimum acidic pH, compared with wild-type LLO...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163445/in-silico-analysis-of-putrefaction-pathways-in-bacteria-and-its-implication-in-colorectal-cancer
#9
Harrisham Kaur, Chandrani Das, Sharmila S Mande
Fermentation of undigested proteins in human gastrointestinal tract (gut) by the resident microbiota, a process called bacterial putrefaction, can sometimes disrupt the gut homeostasis. In this process, essential amino acids (e.g., histidine, tryptophan, etc.) that are required by the host may be utilized by the gut microbes. In addition, some of the products of putrefaction, like ammonia, putrescine, cresol, indole, phenol, etc., have been implicated in the disease pathogenesis of colorectal cancer (CRC). We have investigated bacterial putrefaction pathways that are known to be associated with such metabolites...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163381/functional-characterization-of-acinetobacter-baumannii-lacking-the-rna-chaperone-hfq
#10
Han-Yueh Kuo, Hsuan-Hao Chao, Po-Cheng Liao, Long Hsu, Kai-Chih Chang, Chi-Hua Tung, Chang-Hua Chen, Ming-Li Liou
The RNA chaperone Hfq is involved in the riboregulation of diverse genes via small RNAs. Recent studies have demonstrated that Hfq contributes to the stress response and the virulence of several pathogens, and the roles of Hfq vary among bacterial species. Here, we attempted to elucidate the role of Hfq in Acinetobacter baumannii ATCC 17978. In the absence of hfq, A. baumannii exhibited retarded cell growth and was highly sensitive to environmental stress, including osmotic and oxidative pressure, pH, and temperature...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162982/future-directions-and-molecular-basis-of-ventilator-associated-pneumonia
#11
REVIEW
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanir Basaranoglu
Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. A lot of microbes are detected as a causative agent of VAP. The most common isolated VAP pathogens in pediatric patients are Staphylococcus aureus, Pseudomonas aeruginosa, and other gram negative bacteria...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29162713/capsular-polysaccharide-interferes-with-biofilm-formation-by-pasteurella-multocida-serogroup-a
#12
Briana Petruzzi, Robert E Briggs, W Edward Swords, Cristina De Castro, Antonio Molinaro, Thomas J Inzana
Pasteurella multocida is an important multihost animal and zoonotic pathogen that is capable of causing respiratory and multisystemic diseases, bacteremia, and bite wound infections. The glycosaminoglycan capsule of P. multocida is an essential virulence factor that protects the bacterium from host defenses. However, chronic infections (such as swine atrophic rhinitis and the carrier state in birds and other animals) may be associated with biofilm formation, which has not been characterized in P. multocida Biofilm formation by clinical isolates was inversely related to capsule production and was confirmed with capsule-deficient mutants of highly encapsulated strains...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162709/ehrlichia-chaffeensis-and-its-invasin-etpe-block-reactive-oxygen-species-generation-by-macrophages-in-a-dnase-x-dependent-manner
#13
Omid Teymournejad, Mingqun Lin, Yasuko Rikihisa
The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrlichia uses the C terminus of its surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C), which directly binds the mammalian cell surface receptor glycosylphosphatidylinositol-anchored protein DNase X...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162541/a-mini-review-on-immune-role-of-chemokines-and-its-receptors-in-snakehead-murrel-channa-striatus
#14
REVIEW
Prasanth Bhatt, Venkatesh Kumaresan, Rajesh Palanisamy, Gayathri Ravichandran, Kanchana Mala, S M Nurul Amin, Aziz Arshad, Fatimah Md Yusoff, Jesu Arockiaraj
Chemokines are ubiquitous cytokine molecules involved in migration of cells during inflammation and normal physiological processes. Though the study on chemokines in mammalian species like humans have been extensively studied, characterization of chemokines in teleost fishes is still in the early stage. The present review provides an overview of chemokines and its receptors in a teleost fish, Channa striatus. C. striatus is an air breathing freshwater carnivore, which has enormous economic importance. This species is affected by an oomycete fungus, Aphanomyces invadans and a Gram negative bacteria Aeromonas hydrophila is known to cause secondary infection...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29161862/modeling-co-infection-of-ixodes-tick-borne-pathogens
#15
Yijun Lou, Li Liu, Daozhou Gao
Ticks, including the Ixodes ricinus and Ixodes scapularis hard tick species, are regarded as the most common arthropod vectors of both human and animal diseases in Europe and the United States capable of transmitting a large number of bacteria, viruses and parasites. Since ticks in larval and nymphal stages share the same host community which can harbor multiple pathogens, they may be co-infected with two or more pathogens, with a subsequent high likelihood of co-transmission to humans or animals. This paper is devoted to the modeling of co-infection of tick-borne pathogens, with special focus on the co-infection of Borrelia burgdorferi (agent of Lyme disease) and Babesia microti (agent of human babesiosis)...
October 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29160206/an-orphan-cbb3-type-cytochrome-oxidase-subunit-supports-pseudomonas-aeruginosa-biofilm-growth-and-virulence
#16
Jeanyoung Jo, Krista L Cortez, William Cole Cornell, Alexa Price-Whelan, Lars Ep Dietrich
Hypoxia is a common challenge faced by bacteria during associations with hosts due in part to the formation of densely packed communities (biofilms). cbb3-type cytochrome c oxidases, which catalyze the terminal step in respiration and have a high affinity for oxygen, have been linked to bacterial pathogenesis. The pseudomonads are unusual in that they often contain multiple full and partial (i.e. 'orphan') operons for cbb3-type oxidases and oxidase subunits. Here, we describe a unique role for the orphan catalytic subunit CcoN4 in colony biofilm development and respiration in the opportunistic pathogen Pseudomonas aeruginosa PA14...
November 21, 2017: ELife
https://www.readbyqxmd.com/read/29160202/re-classification-of-clavibacter-michiganensis-subspecies-on-the-basis-of-whole-genome-and-multi-locus-sequence-analyses
#17
Xiang Li, James Tambong, Kat Xiaoli Yuan, Wen Chen, Huimin Xu, C André Lévesque, Solke H De Boer
Although the genus Clavibacter was originally proposed to accommodate all phytopathogenic coryneform bacteria containing B2γ diaminobutyrate in the peptidoglycan, reclassification of all but one species into other genera has resulted in the current monospecific status of the genus. The single species in the genus, Clavibacter michiganensis, has multiple subspecies, which are all highly host-specific plant pathogens. Whole genome analysis based on average nucleotide identity and digital DNA-DNA hybridization as well as multi-locus sequence analysis (MLSA) of seven housekeeping genes support raising each of the C...
November 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29158778/helicobacter-pylori-and-gut-microbiota-in-multiple-sclerosis-versus-alzheimer-s-disease-10-pitfalls-of-microbiome-studies
#18
Ah-Mee Park, Seiichi Omura, Mitsugu Fujita, Fumitaka Sato, Ikuo Tsunoda
Alteration of microbiota has been associated with intestinal, inflammatory, and neurological diseases. Abundance of "good bacteria" such as Bifidobacterium, or their products have been generally believed to be beneficial for any diseases, while "bad bacteria" such as pathogenic Helicobacter pylori are assumed to be always detrimental for hosts. However, this is not the case when we compare and contrast the association of the gut microbiota with two neurological diseases, multiple sclerosis (MS) and Alzheimer's disease (AD)...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29158434/high-levels-of-cyclic-di-gmp-in-klebsiella-pneumoniae-attenuate-virulence-in-the-lung
#19
David A Rosen, Joy Twentyman, David A Hunstad
The bacterial second messenger, bis-(3' -5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has been shown to influence expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant pathogen Klebsiella pneumoniae Here, expression in K. pneumoniae of a heterologous diguanylate cyclase increased bacterial c-di-GMP concentration and attenuated pathogenesis in murine pneumonia. This attenuation remained evident in mice lacking the c-di-GMP sensor STING, indicating that high c-di-GMP exerted its influence not on host responses, but on bacterial physiology...
November 20, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29154855/identification-and-characterization-of-a-calcium-dependent-lily-type-lectin-from-black-rockfish-sebastes-schlegelii-molecular-antennas-are-involved-in-host-defense-via-pathogen-recognition
#20
Roopasingam Kugapreethan, Qiang Wan, Jehanathan Nilojan, Jehee Lee
Lily-type lectins (LTLs) are soluble pathogen recognition receptors (PRRs) that contain one or more characteristic carbohydrate recognition domains (CRDs), through which LTLs bind reversibly and specifically to cognate sugar moieties present on the invading pathogen membrane and trigger the host innate immune responses. In this study, we identified a LTL homolog (SsLTL) from black rockfish (Sebastes schlegelii) transcriptome database and its functional roles in innate immunity was investigated in vitro and in vivo...
November 14, 2017: Developmental and Comparative Immunology
keyword
keyword
7408
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"