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https://www.readbyqxmd.com/read/29233839/genetics-of-tumors-of-the-adrenal-cortex
#1
Fidéline Bonnet-Serrano, Jerome Bertherat
This review describes the molecular alterations observed in the various types of tumors of the adrenal cortex, excluding Conn adenomas, especially the alterations identified by genomic approaches these last five years. Two main forms of bilateral adrenocortical tumors can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenal disease (PPNAD) which can be sporadic or part of Carney complex, and primary bilateral macro nodular adrenal hyperplasia (PBMAH). The bilateral nature of tumors suggests the existence of an underlying genetic predisposition...
December 12, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29233068/altered-functional-expression-of-%C3%AE-adrenergic-receptors-in-rhesus-monkey-embryonic-stem-cell-derived-cardiomyocytes
#2
Nermeen Ahmed Mohamed Eldabah, Erastus Nembu Nembo, Judith Semmler, Marina Penner, Marek Molcanyi, Rania Swelem, Amina Hassab, Juergen Hescheler, Filomain Nguemo
Pluripotent stem cells have demonstrated the potential to generate large numbers of functional cardiomyocytes (CMs) from different cell sources. Besides Wnt signaling, additional pathways are involved in early cardiac development and function. To date however, no study exists showing the effects of perturbing the canonical Wnt pathway using non-human primate embryonic stem (ES) cells. Here we investigated the effect of canonical Wnt inhibition during differentiation of non-human primate ES cell-derived CMs under defined, growth factors conditions...
December 12, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29216763/upregulated-mir-29c-suppresses-silica-induced-lung-fibrosis-through-the-wnt-%C3%AE-catenin-pathway-in-mice
#3
X Wang, K Xu, X Y Yang, J Liu, Q Zeng, F S Wang
Silicosis is an irreversible lung disease resulting from long-term inhalation of occupational dust containing silicon dioxide. However, the pathogenesis of silicosis has not been clearly understood yet. Accumulating evidence suggests that miR-29 may have a significant anti-fibrotic capacity, meanwhile it may relate to Wnt/β-catenin pathway. The purpose of this study was to discuss the role of miR-29 in the progression of silicosis. A lentiviral vector was constructed, named Lv-miR-29c, which was overexpressing miR-29c...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29212159/lef1-tfe3-and-ar-are-putative-diagnostic-markers-of-solid-pseudopapillary-neoplasms
#4
Eun Kyung Kim, Mi Jang, Minhee Park, Hoguen Kim
The diagnosis of solid pseudopapillary neoplasms (SPNs) is challenging because some SPNs share many similar morphological and immunohistochemical features with other pancreatic neoplasms. In this study, we investigated potential diagnostic markers of SPN. Based on the SPN-specific upregulated genes from a previous DNA microarray and proteome study, we selected six immunohistochemical markers [beta-catenin, androgen receptor (AR), lymphoid enhancer-binding factor 1 (LEF1), transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3), fused in sarcoma (FUS), and WNT inhibitory factor 1 (WIF-1)]...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29169144/targeting-the-wnt-beta-catenin-pathway-in-cancer-update-on-effectors-and-inhibitors
#5
REVIEW
Nithya Krishnamurthy, Razelle Kurzrock
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions like stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and the non-canonical or beta-catenin-independent pathway, the latter includes the Wnt/Ca2+ and Planar Cell Polarity pathway (PCP). Wnt activation occurs at the intestinal crypt floor, and is critical to optimal maintenance of stem cells...
November 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29163478/editorial-cross-talk-mechanisms-of-wnt-beta-catenin-signaling-components-with-tlr-activated-signaling-molecules-in-the-inflammatory-response
#6
EDITORIAL
Víctor M Baizabal-Aguirre
No abstract text is available yet for this article.
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163160/aberrant-wnt-beta-catenin-pathway-activation-in-dialysate-induced-peritoneal-fibrosis
#7
Yuanyuan Guo, Lin Sun, Li Xiao, Rong Gou, Yudong Fang, Yan Liang, Ruiqiang Wang, Ningjun Li, Fuyou Liu, Lin Tang
Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its contribution to the development of peritoneal damage. We isolated mesothelial cells (MC) from the effluent of PD patients and found that the expressions of Wnt1, Wnt5a, β-catenin, and LEF1 were increased in patients with more than 1-year PD compared with patients who just started with PD (<1 month)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29151265/cnn3-regulates-neural-tube-morphogenesis-and-neuronal-stem-cell-properties
#8
Dirk Junghans, Sebastian Herzog
Calponin 3 (Cnn3) is a member of the calponin family of actin binding molecules that is highly expressed in the mammalian brain and has been shown to control dendritic spine morphology, density and plasticity by regulating actin cytoskeletal reorganization and dynamics. However, little is known about the role of Cnn3 during embryonic development. In this study we analyzed mutant animals deficient in Cnn3 to gain a better understanding of its role in brain morphogenesis. Embryos lacking Cnn3 exhibited massive malformation of the developing brain including exoencephaly, closure defects at the rostral neural tube and strong enlargement of brain tissue...
November 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29146887/targeted-therapy-of-gastroenteropancreatic-neuroendocrine-tumours-preclinical-strategies-and-future-targets
#9
Elke Tatjana Aristizabal Prada, Christoph J Auernhammer
Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) system currently encompasses approved therapy with the mTOR-inhibitor everolimus and the multi-tyrosinkinase inhibitor sunitinib. However clinical efficacy of these treatment strategies is limited by low objective response rates and limited progression free survival due to tumor resistance. Further novel strategies for molecular targeted therapy of NETs of the GEP-system are needed. This paper reviews preclinical research models and signaling pathways in NETs of the GEP-system...
November 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29146051/beta-catenin-and-p53-expression-in-topographic-compartments-of-colorectal-cancer-and-its-prognostic-value-following-surgery
#10
Juan Daniel Prieto, Martina Álvarez, María Isabel Hierro, Isabel García, Luis Vicioso
Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and the fourth cause of cancer-related death. From Vogelstein's initial model, new molecular knowledge has been incorporated which includes an elevated number of genetic mutations, many of them located in the Wnt pathway, which affect its principle effector: β-catenin. Additionally, it is necessary to keep the heterogeneity of CRCs in mind, both in terms of morphology and biology. The aim of this work is to study the interaction between the Wnt molecular pathway, by means of immunoexpression of β-catenin, in CRC and other molecular mechanisms, such as the p53 pathway, in order to determine the pattern - if one exists - of different immunohistochemical expression of β-catenin and p53 in the superficial and deep tumor components, and lastly, to determine the impact of these markers on prognosis...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29133594/competitive-kinase-enrichment-proteomics-reveals-that-abemaciclib-inhibits-gsk3%C3%AE-and-activates-wnt-signaling
#11
Emily M Cousins, Dennis Goldfarb, Feng Yan, Jose Roques, David B Darr, Gary L Johnson, Michael B Major
The cellular and organismal phenotypic response to a small-molecule kinase inhibitor is defined collectively by the inhibitor's targets and their functions. The selectivity of small-molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competitive chemical proteomics has emerged as a complementary, unbiased, cell-based methodology to define the target landscape of kinase inhibitors. Here, we evaluated and optimized a competitive multiplexed inhibitor bead mass spectrometry (MIB/MS) platform using cell lysates, live cells, and treated mice...
November 13, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29125885/mir-376c-inhibits-osteoblastogenesis-by-targeting-wnt3-and-arf-gef-1-facilitated-augmentation-of-beta-catenin-transactivation
#12
Jyoti Kureel, Aijaz A John, Ravi Prakash, Divya Singh
Wnt signaling pathway plays important role in all aspects of skeletal development which include chondrogenesis, osteoblastogenesis, and osteoclastogenesis. Induction of the Wnt signaling pathway promotes bone formation while inactivation of the pathway leads to bone related disorders like osteoporosis. Wnt signaling thus has become a desired target to treat osteogenic disorders. MicroRNAs (miRNAs) represent an important category of elements that interact with Wnt signaling molecules to regulate osteogenesis...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29118355/decoy-wnt-receptor-slrp6e1e2-expressing-adenovirus-induces-anti-fibrotic-effect-via-inhibition-of-wnt-and-tgf-%C3%AE-signaling
#13
Won Jai Lee, Jung-Sun Lee, Hyo Min Ahn, Youjin Na, Chae Eun Yang, Ju Hee Lee, JinWoo Hong, Chae-Ok Yun
Aberrant activation of the canonical Wingless type (Wnt) signaling pathway plays a key role in the development of hypertrophic scars and keloids, and this aberrant activation of Wnt pathway can be a potential target for the development of novel anti-fibrotic agents. In this study, we evaluated the anti-fibrotic potential of a soluble Wnt decoy receptor (sLRP6E1E2)-expressing non-replicating adenovirus (Ad; dE1-k35/sLRP6E1E2) on human dermal fibroblasts (HDFs), keloid fibroblasts (KFs), and keloid tissue explants...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113300/deletion-of-tumor-suppressors-adenomatous-polyposis-coli-and-smad4-in-murine-luminal-epithelial-cells-causes-invasive-prostate-cancer-and-loss-of-androgen-receptor-expression
#14
Kenneth C Valkenburg, Angelo M De Marzo, Bart O Williams
Prostate cancer is the most diagnosed non-skin cancer in the US and kills approximately 27,000 men per year in the US. Additional genetic mouse models are needed that recapitulate the heterogeneous nature of human prostate cancer. The Wnt/beta-catenin signaling pathway is important for human prostate tumorigenesis and metastasis, and also drives tumorigenesis in mouse models. Loss of Smad4 has also been found in human prostate cancer and drives tumorigenesis and metastasis when coupled with other genetic aberrations in mouse models...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103082/mir-324-3p-promotes-gastric-cancer-development-by-activating-smad4-mediated-wnt-beta-catenin-signaling-pathway
#15
Guang-Li Sun, Zheng Li, Wei-Zhi Wang, Zheng Chen, Lei Zhang, Qing Li, Song Wei, Bo-Wen Li, Jiang-Hao Xu, Liang Chen, Zhong-Yuan He, Kai Ying, Xuan Zhang, Hao Xu, Dian-Cai Zhang, Ze-Kuan Xu
BACKGROUND: Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to function in several carcinomas, but its role in gastric cancer (GC) is still unknown. This study aims to explore the effects of miR-324-3p on the development of GC. METHODS: Expression of miR-324-3p was examined in GC cells and tissues by qRT-PCR. Effects of miR-324-3p on GC cells were evaluated by cell vitality assay, colony formation assay, cell migration assay, and flow cytometric assay...
November 4, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29102319/wnt-signaling-pathway-correlates-with-ossification-of-the-spinal-ligament-a-microrna-array-and-immunohistochemical-study
#16
Takafumi Yayama, Kanji Mori, Noriaki Okumura, Kazuya Nishizawa, Kosuke Kumagai, Akira Nakamura, Shinji Imai
BACKGROUND: Ossification of the posterior longitudinal ligament or the ligamentum flavum parallels endochondral ossification. Cell differentiation at the ossification front is known to be important during this process, although the factors regulating its initiation and progression are still unclear. The purpose of this study was to identify factors important for the regulation of chondrocyte/osteoblast differentiation during spinal ossification. METHODS: Ligamentum flavum tissue was isolated from 25 patients who underwent decompressive surgery for cervical ossification of the posterior longitudinal ligament...
October 25, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29099279/mtor-signaling-is-essential-for-the-development-of-thymic-epithelial-cells-and-the-induction-of-central-immune-tolerance
#17
Zhanfeng Liang, Lianjun Zhang, Huiting Su, Rong Luan, Ning Na, Lina Sun, Yang Zhao, Xiaodong Zhang, Qian Zhang, Juan Li, Lianfeng Zhang, Yong Zhao
Thymic epithelial cells (TECs) are critical for the establishment and maintenance of appropriate microenvironment for the positive and negative selection of thymocytes and the induction of central immune tolerance. Yet, little about the molecular regulatory network on TEC development and function is understood. Here, we demonstrate that MTOR (mechanistic target of rapamycin [serine/threonine kinase]) is essential for proper development and functional maturation of TECs. Pharmacological inhibition of MTOR activity by rapamycin (RPM) causes severe thymic atrophy and reduction of TECs...
November 3, 2017: Autophagy
https://www.readbyqxmd.com/read/29079516/pharmacological-blockade-of-the-wnt-beta-catenin-signaling-a-possible-first-in-kind-dmoad
#18
EDITORIAL
F Dell'Accio, F Cailotto
No abstract text is available yet for this article.
October 25, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29057980/rock-inhibition-with-fasudil-induces-beta-catenin-nuclear-translocation-and-inhibits-cell-migration-of-mda-mb-231-human-breast-cancer-cells
#19
Fabiana Sélos Guerra, Ramon Guerra de Oliveira, Carlos Alberto Manssour Fraga, Claudia Dos Santos Mermelstein, Patricia Dias Fernandes
Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilization of actin filaments and stress fiber formation. In this study we show that Fasudil, a ROCK inhibitor, inhibited the migration of MDA-MB 231 and A549 cells, without altering the viability of these cells at the concentration of 10 μM, modified tumor cell morphology, with disorganization of stress fibers and promotes activation of the canonical-Wnt/beta-catenin pathway...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029464/mir-324-3p-promotes-tumor-growth-through-targeting-dact1-and-activation-of-wnt-%C3%AE-catenin-pathway-in-hepatocellular-carcinoma
#20
Hang Tuo, Yufeng Wang, Liang Wang, Bowen Yao, Qing Li, Cong Wang, Zhikui Liu, Shaoshan Han, Guozhi Yin, Kangsheng Tu, Qingguang Liu
Recently, it has been reported that miR-324-3p participates in regulation of the carcinogenesis and tumor progression in various cancers. However, the expression and function of miR-324-3p in hepatocellular carcinoma (HCC) remain unclear. In the current study, miR-324-3p expression was significantly up-regulated in HCC tissues and cell lines. HCC patients with high miR-324-3p level showed poor prognostic features and shorter overall survival and disease-free survival. And in vitro and in vivo experiments revealed that miR-324-3p promoted cell viability, colony formation, proliferation and cell cycle progression of HCC cells...
September 12, 2017: Oncotarget
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