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alkali ingestion

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https://www.readbyqxmd.com/read/27718577/characterization-of-nitric-oxide-modulatory-activities-of-alkaline-extracted-and-enzymatic-modified-arabinoxylans-from-corn-bran-in-cultured-human-monocytes
#1
Zhengxiao Zhang, Christopher John Smith, Weili Li, Jason Ashworth
The ingestion of foods and food-derived substances that may mediate the immune system is widely studied. Evidence suggests cereal arabinoxylans (AXs) have immunomodulatory activities that may impart health benefits in terms of immune enhancement. This study extracted AXs from corn bran using alkali and developed a modification process using three endoxylanases to obtain fractions of lower molecular weight ranges. In vitro studies showed extracted and modified AXs significantly (P < 0.05) elevated nitric oxide (NO) synthesis by the human U937 monocytic cell line (ranging from 53...
October 10, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27717297/dysphagia-progression-and-feeding-skills-following-pediatric-alkali-ingestion-injury-two-case-reports
#2
Anna M Follent, Anna F Rumbach, Elizabeth C Ward, Jeanne Marshall, Pamela Dodrill, Peter Lewindon
PURPOSE: There is limited information regarding the nature of dysphagia and feeding difficulties following alkali ingestion injury to inform multidisciplinary intervention. The aim was to describe the history and nature of chronic dysphagia and feeding difficulties in two children following severe alkali ingestion injury. METHODS: Medical records, primary caregiver report, and clinical assessment were used to compile detailed case histories and assess current dysphagia and feeding skills...
October 7, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27626140/the-challenges-of-dysphagia-management-and-rehabilitation-in-two-complex-cases-post-chemical-ingestion-injury
#3
Anna F Rumbach, Rebecca Cremer, Astra Chatwood, Sari Fink, Sadaf Haider, Michelle Yee
Purpose: Dysphagia is common sequelae of chemical ingestion injury, resulting from damage to critical swallowing structures. From a speech-language pathology perspective, this study outlines the physiological deficits in 2 individuals with severe injury (1 woman, acid; 1 man, alkali) and the pattern of dysphagia rehabilitation and recovery. Method: A retrospective chart review of clinical and instrumental assessments was conducted to examine swallow characteristics and speech-language pathology management (compensatory and rehabilitation strategies) at multiple time points...
November 1, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27460661/severe-hypercalcemia-in-a-postpartum-patient
#4
Megan L Murphy, Michael J Mattingly, Craig T Meisner
BACKGROUND: There are multiple clinical manifestations of hypercalcemia and several causes of hypercalcemia. Hypercalcemia caused by milk-alkali syndrome is increasing in frequency. CASE REPORT: A 26-year-old woman presented after having undergone caesarian section. She complained of severe myalgias, arthralgias, an inability to ambulate, nausea, vomiting, abdominal pain, and marked depression. Each of these symptoms has a broad differential diagnosis, but when considered together the theme "stones, bones, moans, and groans," seen in patients with hypercalcemia, is evident...
October 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27424019/caustic-agent-ingestion-by-a-1-5-year-old-boy
#5
Behdad Gharib, Masoud Mohammadpour, Bahareh Yaghmaie, Meisam Sharifzadeh, Mehrzad Mehdizadeh, Fatemeh Zamani, Rouhollah Edalatkhah, Reihaneh Mohsenipour
We present a case of caustic ingestion by a 1.5-year-old boy. The caustic agent was drain opener which is a strong alkaline substance. Children in Iran and many other countries are still exposed to not "child proof" (child resistant packaging) toxic substance containers. Ingestion of caustic agents may lead to necrosis, perforation, and strictures. Substances that are ingested more frequently are liquid alkali material which causes severe, deep liquefaction necrosis. Common signs and symptoms of caustic agents are vomiting, drooling, refusal to drink, oral burns, stridor, hematemesis, dyspnea, dysphagia and abdominal pain...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27409090/-caustics-injuries-in-the-upper-gastrointestinal-tract-clinical-and-endoscopic-features
#6
Briny Omar Rodríguez Vargas, Eduardo Monge Salgado, Pedro Montes Teves, Sonia Salazar Ventura, Edson Guzmán Calderón
OBJECTIVE: To describe the clinical and endoscopic features of caustics injuries in the upper gastrointestinal tract in patients of the National Hospital Daniel Alcides Carrión. MATERIALS AND METHODS: A descriptive study was conducted; the study populations were patients diagnosed with caustic ingestion who were admitted into the Gastroenterology service of the HNDAC to perform an upper endoscopy during the period of January 2009 to December 2012. We documented the type of caustic substance ingested, cause of intake, amount ingested, intake mode, signs or symptoms present, endoscopic findings as classified by Zargar, presence of complications and treatment performed...
April 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27394396/esophageal-remnant-cancer-35-years-after-acidic-caustic-injury-a-case-report
#7
Ioannis Ntanasis-Stathopoulos, Stamatina Triantafyllou, Vasiliki Xiromeritou, Nikolaos Bliouras, Chriso Loizou, Dimitrios Theodorou
INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interposition. Recently, she presented with worsening dysphagia, weight loss, neck swelling and chest pain. After the diagnostic workup, an invasive squamous cell carcinoma of the esophagus was confirmed...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27335601/hypercalcemia-as-a-cause-of-kidney-failure-case-report
#8
Olivera Stojceva-Taneva, Borjanka Taneva, Gjulsen Selim
BACKGROUND: Hypercalcemia is a common manifestation in clinical practice and occurs as a result of primary hyperparathyroidism, malignancy, milk-alkali syndrome, hyper or hypothyroidism, sarcoidosis and other known and unknown causes. Patients with milk-alkali syndrome typically are presented with renal failure, hypercalcemia, and metabolic alkalosis caused by the ingestion of calcium and absorbable alkali. This syndrome is caused by high intake of milk and sodium bicarbonate. CASE PRESENTATION: We present a 28-year old male admitted to hospital with a one-month history of nausea, vomiting, epigastric pain, increased blood pressure and worsening of renal function with hypercalcemia...
June 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27184240/hypercalcemia-due-to-milk-alkali-syndrome-and-fracture-induced-immobilization-in-an-adolescent-boy-with-hypoparathyroidism
#9
Rohan K Henry, Rachel I Gafni
BACKGROUND: Hypercalcemia of immobilization, while rare, may occur in adolescent boys after fracture. Although not fully understood, the mechanism appears to be related to bone turnover uncoupling, in part mediated by upregulation of RANKL. Animal studies suggest that parathyroidectomy suppresses RANKL-stimulated osteoclastogenesis in immobilized bone. Thus, immobilization-induced hypercalcemia should be uncommon in patients with hypoparathyroidism. METHODS/RESULTS: We present a 15-year-old boy with well-controlled hypoparathyroidism who developed hypercalcemia and milk-alkali syndrome 5 weeks after sustaining a severe tibia/fibula fracture requiring bedrest...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27068119/acute-emergency-care-and-airway-management-of-caustic-ingestion-in-adults-single-center-observational-study
#10
Manuel F Struck, André Beilicke, Albrecht Hoffmeister, Ines Gockel, André Gries, Hermann Wrigge, Michael Bernhard
BACKGROUND: Caustic ingestions are rare but potentially life-threatening events requiring multidisciplinary emergency approaches. Although particularly respiratory functions may be impaired after caustic ingestions, studies involving acute emergency care are scarce. The goal of this study was to explore acute emergency care with respect to airway management and emergency department (ED) infrastructures. METHODS: We retrospectively evaluated adult patients after caustic ingestions admitted to our university hospital over a 10-year period (2005-2014)...
2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/26989301/autopsy-results-of-a-case-of-ingestion-of-sodium-hydroxide-solution
#11
Yuko Emoto, Katsuhiko Yoshizawa, Nobuaki Shikata, Airo Tsubura, Yasushi Nagasaki
Sodium hydroxide is a strongly corrosive alkali. We describe herein a case of suicide by ingestion of sodium hydroxide. A man in his 80s was found dead with a mug and a bottle of caustic soda. Macroscopically, liquefaction and/or disappearance of esophagus, trachea and lung tissue and a grayish discoloration of the mucosa of the stomach were seen along with blackish brown coloration of the skin, mouth, and oral cavity. The contents of the gastrointestinal tract showed a pH level of 7-8 on pH indicator strips...
January 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/26932179/an-unexpected-cause-of-acute-kidney-injury-in-a-patient-with-anca-associated-vasculitis
#12
Wajid M Choudhry, Uday S Nori, Tibor Nadasdy, Anjali A Satoskar
Diagnostic kidney biopsies sometimes yield clinically unsuspected diagnoses. We present a case of a 69-year-old woman with established ANCA-associated vasculitis (AAV) of 4 years duration who was in clinical remission following cytotoxic therapy and was on maintenance immunosuppression. She presented to the hospital with acute kidney injury (AKI), symptoms suggestive of a systemic vasculitis, and in addition had hypercalcemia, metabolic alkalosis. A relapse in the AAV was suspected but a diagnostic kidney biopsy showed acute tubular necrosis, patchy interstitial inflammation, and calcium phosphate deposits...
May 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/26920407/the-damage-pattern-to-the-gastrointestinal-tract-depends-on-the-nature-of-the-ingested-caustic-agent
#13
Romain Ducoudray, Antoine Mariani, Helene Corte, Aurore Kraemer, Nicolas Munoz-Bongrand, Emile Sarfati, Pierre Cattan, Mircea Chirica
BACKGROUND: The mechanisms of damage to the gastrointestinal tract after caustic ingestion are conditioned by the nature of the ingested agent. Whether the nature of the ingested agent has a direct influence on patient outcomes is unknown. METHODS: From January 2013 to April 2015, 144 patients underwent emergency management for caustic injuries at the Saint Louis Hospital in Paris. There were 51 men (51 %) and the median age was 44 years [39, 48]. The ingested agents were soda-based strong alkali in 85 patients (59 %), strong acids in 36 patients (25 %), and bleach in 23 patients (16 %)...
July 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26813230/evaluation-of-968-children-with-corrosive-substance-ingestion
#14
İbrahim Karaman, Orhan Koç, Ayşe Karaman, Derya Erdoğan, Yusuf Hakan Çavuşoğlu, Çağatay Evrim Afşarlar, Engin Yilmaz, Ahmet Ertürk, Özlem Balci, Ismet Faruk Özgüner
BACKGROUND AND AIMS: The aim of the study was to evaluate the etiology, treatment, and prognosis in children who had presented at our clinic with corrosive substance ingestion and comparison of our results with the literature. MATERIALS AND METHODS: The patients were put on nil by mouth and broad-spectrum antibiotics were administered. Oral fluids were started for patients whose intraoral lesions resolved and who could swallow their saliva. Steroids were not given, a nasogastric catheter was not placed, and early endoscopy was not used...
December 2015: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26371603/caustic-oesophagitis-in-children-prevalence-the-corrosive-agents-involved-and-management-from-primary-care-through-to-surgery
#15
REVIEW
Ibrahim Uygun
PURPOSE OF REVIEW: Caustic substance ingestion (CSI) remains a major health issue, particularly in developing countries, where laws are not effectively enforced. This review offers a thorough analysis of the current epidemiology, clinical features, management, treatment, and long-term complications of CSI in children. RECENT FINDINGS: Strong alkalis sold in liquid and granular forms, particularly crystalline grease cleaners (concentrated sodium hydroxide), are the principal causes of severe oesophageal damage...
December 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/26363860/-ingestion-of-caustic-substances-in-children-3-years-of-experience
#16
María Losada M, María Rubio M, Jose Antonio Blanca G, Cristina Pérez A
INTRODUCTION: There is no clear consensus on the management of accidental ingestion of caustic substances in paediatrics. The aim of this study was to determine the profile of the paediatric population treated due to caustic ingestion in a Healthcare Centre. PATIENTS AND METHOD: A descriptive study was conducted on patients treated for the ingestion of caustic substances in our hospital during the period 2008-2011. RESULTS: A total of 12 patients were treated, with a mean age of 3...
May 2015: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/26335553/dietary-interventions-to-improve-outcomes-in-chronic-kidney-disease
#17
REVIEW
Nimrit Goraya, Donald E Wesson
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a major epidemic which has global outcomes with increased morbidity and mortality. Given the global implications of CKD, interventions that target modifiable risk factors for CKD are needed. Despite the effectiveness of kidney protection strategies such as hypertension and lipid control as well as the use of antiangiotensin II drugs, the nephropathy in many patients with CKD and reduced glomerular filtration rate (GFR) nevertheless continues to progress toward complete kidney failure...
November 2015: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/26239247/hypercalcemia-associated-with-calcium-supplement-use-prevalence-and-characteristics-in-hospitalized-patients
#18
Maria C Machado, Araba Bruce-Mensah, Melanie Whitmire, Ali A Rizvi
BACKGROUND: The ingestion of large amounts of milk and antacids to treat peptic ulcer disease was a common cause of hypercalcemia in the past (the "milk-alkali syndrome"). The current popularity of calcium and supplements has given rise to a similar problem. OBJECTIVES: To evaluate the prevalence and characteristics of hypercalcemia induced by calcium intake ("calcium supplement syndrome"; or CSS) in hospitalized patients. METHODS: We conducted a retrospective; electronic health record (EHR)-based review of patients with hypercalcemia over a 3-year period...
2015: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25984015/baking-soda-induced-severe-metabolic-alkalosis-in-a-haemodialysis-patient
#19
Yalcin Solak, Kultigin Turkmen, Huseyin Atalay, Suleyman Turk
Metabolic alkalosis is a rare occurence in hemodialysis population compared to metabolic acidosis unless some precipitating factors such as nasogastric suction, vomiting and alkali ingestion or infusion are present. When metabolic alkalosis develops, it may cause serious clinical consequences among them are sleep apnea, resistent hypertension, dysrhythmia and seizures. Here, we present a 54-year-old female hemodialysis patient who developed a severe metabolic alkalosis due to baking soda ingestion to relieve dyspepsia...
August 2009: NDT Plus
https://www.readbyqxmd.com/read/25790550/gastrointestinal-system-lesions-in-children-due-to-the-ingestion-of-alkali-and-acid-corrosive-substances
#20
Kaan Demirören, Halil Kocamaz, Yaşar Doğan
BACKGROUND/AIM: TO examine esophageal and gastric lesions in children due to the ingestion of alkali and acid corrosive substances and to emphasize all related complications. MATERIALS AND METHODS: The reports of 103 children who ingested or were suspected to have ingested corrosive substances and who then underwent upper gastrointestinal endoscopic inspections were evaluated retrospectively. RESULTS: Of the patients, the mean age was 41 ± 3...
2015: Turkish Journal of Medical Sciences
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