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Macrophage silicon oil

Marlus Chorilli, Roberta B Rigon, Giovana Calixto, Pedro M F Cartezani, Maria C A P Ribeiro, Maria L Polacow, Paulo Sérgio Cerri, Victor H V Sarmento, Maria Virgínia Scarpa
Retinyl palmitate (RP) is widely used as a special interest ingredient in dermatological formulations to improve the elasticity of the skin and to reduce wrinkles by stimulating collagen synthesis. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can modulate drug permeation into skin and improve the drug action. The effects of such systems on the skin, however, are not completely known. Possible undesirable effects of these formulations on the skin can be detected and interpreted by histopathology and histomorphometry...
February 2016: Journal of Biomedical Nanotechnology
Márcia Helena Oyafuso, Flávia Chiva Carvalho, Leila Aparecida Chiavacci, Maria Palmira Daflon Gremião, Marlus Chorilli
Nanotechnology offers advantages for new drug delivery design by providing drug targeting while minimizing the side effects. Polyoxyethylene 20 cetyl alcohol (CETETH-20) is a surfactant that may form nanostructured systems, such as liquid crystals, when in contact with water/oil, which are structurally similar to biological membranes and may improve skin interaction. The aim of this study was to develop and characterize CETETH 20-based nanostructured systems by combining CETETH-20 with water and different oily phases, including PEG-12-dimethicone for topical drug administration...
January 2015: Journal of Nanoscience and Nanotechnology
Esthela Loyo, Luis J Jara, Persio David López, Ana Carolina Puig
Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) has been recently proposed by Shoenfeld and Agmon-Levin as a new entity that comprises several conditions: the macrophagic-myofasciitis syndrome, the Gulf War syndrome, silicosis and post-vaccination phenomena, autoimmunity related to infectious fragments, hormones, aluminum, silicone, squalene oil, and pristane. We report the case of a 23-year-old woman who developed serial episodes of high fever, extreme fatigue, transient thrombocytopenia, multiple cervical adenopathies, hepatosplenomegaly, anemia, neutropenia, severe proteinuria and urine sediment abnormalities, elevated serum ferritin levels, and transient low positive antinuclear antibodies 1 year after she had a nickel-titanium chin implant for cosmetic reasons...
April 2013: Auto- Immunity Highlights
J Alijotas-Reig
In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders related to vaccines, infection or other adjuvants such as silicone and other biomaterials. A new term -autoimmune/inflammatory syndrome induced by adjuvants--has recently been coined for a process that includes several clinical features previously described by Miyoshi plus other clinical and laboratory parameters related to exposure to diverse external stimuli...
September 2015: Lupus
Yuzo Deguchi, Takatoshi Maeno, Yuichi Hori, Nobuyuki Hiruta, Daisuke Sasai, Yukihiro Sato
INTRODUCTION: To report a case in which intraocular silicone oil migrated into the upper eyelid and caused ptosis. METHODS: A 65-year-old woman presented with proliferative vitreoretinopathy in the right eye. Vitrectomies, injection of silicone oil and encircling were performed. Two months after the last operation, swelling of her right eyelid occurred. RESULT: Magnetic resonance imaging revealed moisture in the palpebral fat tissue. We incised the bulbar conjunctiva and confirmed silicone oil leakage from the vitreous cavity through the scleral button hole of the encircling suture...
May 2014: Case Reports in Ophthalmology
Sihan Xue, Yao Wang, Mengxing Wang, Lu Zhang, Xiaoxia Du, Hongchen Gu, Chunfu Zhang
In this study, a novel magnetic resonance imaging (MRI)/computed tomography (CT)/fluorescence trifunctional probe was prepared by loading iodinated oil into fluorescent mesoporous silica-coated superparamagnetic iron oxide nanoparticles (i-fmSiO4@SPIONs). Fluorescent mesoporous silica-coated superparamagnetic iron oxide nanoparticles (fmSiO4@SPIONs) were prepared by growing fluorescent dye-doped silica onto superparamagnetic iron oxide nanoparticles (SPIONs) directed by a cetyltrimethylammonium bromide template...
2014: International Journal of Nanomedicine
Andrzej Grzybowski, Janusz Pieczynski, Francisco J Ascaso
Silicone oil (SiO) has a well-established role as a long-term endotamponade agent in the management of complicated retinal detachments. Complications of intraocular SiO include keratopathy, glaucoma, cataract and subretinal migration of the oil droplets. SiO tamponade can also lead to a severe optic neuropathy caused by retrolaminar migration. Nevertheless, intracranial migration of the SiO through the optic nerve posterior to the lamina cribrosa to the optic chiasm and brain is uncommon. The mechanism is still under debate, but it has been suggested elevated intraocular pressure, macrophages or optic nerve head anatomical predispositions as potential explanations...
May 2014: Acta Ophthalmologica
Olga Vera-Lastra, Gabriela Medina, Maria Del Pilar Cruz-Dominguez, Luis J Jara, Yehuda Shoenfeld
An adjuvant is a substance that enhances the antigen-specific immune response, induces the release of inflammatory cytokines, and interacts with Toll-like receptors and the NALP3 inflammasome. The immunological consequence of these actions is to stimulate the innate and adaptive immune response. The activation of the immune system by adjuvants, a desirable effect, could trigger manifestations of autoimmunity or autoimmune disease. Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes postvaccination phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis...
April 2013: Expert Review of Clinical Immunology
Erick Garcia-Garcia, Jun Qing Ge, Ayoola Oladiran, Benjamin Montgomery, Mohamed Gamal El-Din, Leonidas C Perez-Estrada, James L Stafford, Jonathan W Martin, Miodrag Belosevic
We evaluated whether ozonation ameliorated the effects of the organic fraction of oil sands process water (OSPW) on immune functions of mice. Ozonation of OSPW eliminated the capacity of its organic fraction to affect various mouse bone marrow-derived macrophage (BMDM) functions in vitro. These included the production of nitric oxide and the expression of inducible nitric oxide synthase, the production of reactive oxygen intermediates and the expression of NADPH oxidase subunits, phagocytosis, and the expression of pro-inflammatory cytokine genes...
November 15, 2011: Water Research
Erick Garcia-Garcia, Jonathan Pun, Jordan Hodgkinson, Leonidas A Perez-Estrada, Mohamed Gamal El-Din, Daniel W Smith, Jonathan W Martin, Miodrag Belosevic
Naphthenic acids (NAs) are believed to be the major toxic component of oil sands process water (OSPW). Different OSPW preparations have distinct NA compositions, and additional organics, that differ from the commercial NAs (C-NAs) often used for toxicology studies. To evaluate whether C-NAs are an adequate model to study OSPW toxicity in complex organisms, we compared the effects of C-NAs and the extractable organic fraction of OSPW (OSPW-OF) on mice immune mechanisms. Mice were orally exposed to different C-NA doses, or OSPW-OF at the same NA dose, for up to 8 weeks, and the expression of pro-inflammatory genes in different organs was determined using quantitative PCR...
December 2012: Journal of Applied Toxicology: JAT
Louisa Wickham, Paris Tranos, Paul Hiscott, David Charteris
BACKGROUND: Conventional silicone oil provides suboptimal support of the inferior retina. In this study we evaluated the efficacy of Oxane HD in the management of complex retinal detachments involving lower quadrants of the retina. METHODS: A prospective, interventional, comparative study. Eighteen patients were recruited. Treatment outcomes were compared with a historical control group of 14 patients. Patients with grade C3 PVR or greater and inferior retinal breaks, recurrent inferior retinal detachments (with or without PVR) and giant retinal tears were included...
September 2010: Graefe's Archive for Clinical and Experimental Ophthalmology
G M Williams, J Caldwell, D Armstrong, H Bartsch, R Bevan, R W Browne, J K Chipman, M J Iatropoulos, A M Jeffrey, J Lunec, J Nair, D L Page, B C Reeves, A Richardson, B Silverstein, D F Williams
In response to a Hazard Notice by the Medical Devices Agency of the UK in 2000 regarding the Trilucent breast implant (TBI), an expert panel was convened to implement a research program to determine whether genotoxic compounds were formed in the soybean oil filler (SOF) of TBIs and whether these could be released to produce local or systemic genotoxicity. The panel established a research program involving six laboratories. The program recruited 47 patients who had received TBIs (9 patients had received silicone implants previously)...
March 2009: Regulatory Toxicology and Pharmacology: RTP
Jyotirmay Biswas, Aditya Verma, Madhusudan D Davda, Shweta Ahuja, Vaijayanthi Pushparaj
Retrospective clinical and histopathological review of eight silicone oil-filled enucleated eyeballs using light microscopy was carried out in our department of ocular pathology during a period of six years. In all cases, silicone oil vacuoles, both free and incorporated within macrophages were seen in all the retinal layers. Silicone oil vacuoles were seen in the optic nerve, choroid, retinal pigment epithelium, corneal stroma, iris and ciliary body stroma, preretinal and subretinal membranes and retro-corneal membranes...
September 2008: Indian Journal of Ophthalmology
P Carpineto, D Angelucci, M Nubile, A Colasante, L Di Antonio, M Ciancaglini, L Mastropasqua
PURPOSE: To report pre- and post-operative macular optical coherence tomography (OCT) and immunohistochemical findings in a case of long-lasting silicone oil tamponade followed by silicone oil removal and epimacular membrane peeling. METHODS: A 69-year-old man with long-standing silicone oil tamponade and an epiretinal membrane at the posterior pole in his right eye (RE) underwent silicone oil/BSS exchange with epiretinal membrane peeling. Preoperatively, RE best-corrected visual acuity was 20/200 and macular OCT examination revealed a small increase in foveal thickness (250 microm) with the appearance of a linear hyper-reflective signal at the foveal vitreoretinal interface and a thicker (440 microm) hyperreflective finding causing posterior shadowing at the vitreoretinal interface inferiorly to the fovea...
November 2006: European Journal of Ophthalmology
Louisa J Wickham, Riaz H Asaria, Robert Alexander, Phil Luthert, David G Charteris
AIMS: To determine the inflammatory response in retina and epiretinal membranes after intraocular silicone oil tamponade. METHODS: 14 proliferative vitreoretinopathy (PVR) epiretinal membranes, 33 retro-oil epiretinal membranes, 19 retinectomies, 14 retro-oil retinectomies and 37 idiopathic epiretinal membranes (controls) underwent immunohistochemical analysis using the avidin-biotin complex technique and a panel of monoclonal and polyclonal antibodies. The number of positive cells counted in five 0...
February 2007: British Journal of Ophthalmology
Louisa Wickham, Riaz H Asaria, Robert Alexander, Phil Luthert, David G Charteris
AIMS: To characterise the distribution of silicone oil in ocular tissues in globes enucleated after complicated retinal detachment, and to document the distribution and nature of any associated inflammatory response. METHOD: 9 enucleated globes that had previously undergone retinal detachment surgery with silicone oil and 7 control globes that had undergone enucleation after retinal detachment surgery (n = 2) or ocular trauma (n = 5) were studied. Sections were histologically examined using light microscopy to document the distribution of silicone oil in ocular tissues...
February 2007: British Journal of Ophthalmology
Felix Treumer, Arnd Bunse, Martin Rudolf, Johann Roider
PURPOSE: To report intra-and postoperative complications in pars plana vitrectomy, phacoemulsification and intraocular lens implantation. A comparison of the combined versus two step surgical approach is given. METHOD: Medical records and operative notes of 111 eyes with combined surgery and 50 eyes with sequential surgery were retrospectively analysed. Subgroup analysis was performed to evaluate differences in disease groups, the use of endotamponading or endolaser and cryocoagulation...
July 2006: Graefe's Archive for Clinical and Experimental Ophthalmology
Norbert Kociok, Claudia Gavranic, Bernd Kirchhof, Antonia M Joussen
PURPOSE: This study was conducted to investigate whether macrophage activation through cell membrane attachment might be supported by emulsified tamponade droplets of a certain vesicle size. It has been hypothesized that emulsification of vitreous tamponades might stimulate retinal membrane formation. METHODS: In this laboratory investigation, similarly sized vesicles of silicone oil and the partially fluorinated alkane perfluorohexyloctane (F6H8) were produced by extrusion through polycarbonate membranes...
April 2005: Graefe's Archive for Clinical and Experimental Ophthalmology
Xiu-feng Zhong, Yong-ping Li, Jian-xian Lin, Wen-xin Zhang, Jian-liang Zheng, Jian Ge, Guan-guang Feng
OBJECTIVE: To observe morphological changes of oil-associated complications in silicone oil-filled human eyes, and to further explore their pathogenesis. METHODS: The morphology analysis and immunohistochemistrical study were performed in 25 specimens including 8 eyeballs, 1 ocular content, 4 preretinal membranes, 4 corneal buttons and 8 lens from human eyes with silicone oil tamponade. Two of preretinal membranes acquired freshly were also evaluated by transmission electron microscopy (TEM)...
January 2005: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
András Papp, Jeannette Tóth, Tibor Kerényi, Márta Jäckel, Ildikó Süveges
Using this case report, we sought evidence that silicone oil may infiltrate the subarachnoidal space. Vitrectomy combined with silicone oil implantation was performed on the right eye of a 72-year-old woman. The silicone oil was removed 2 months later, because the patient had developed elevated intraocular pressure. The blind and painful eye was subsequently enucleated. By light microscopy, presumed silicone oil bubbles were identified in the optic nerve and the subarachnoidal space of the enucleated eye. These vacuoles were examined by energy-dispersive X-ray analysis (EDAX)...
2004: Pathology, Research and Practice
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