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https://www.readbyqxmd.com/read/29669212/simultaneous-improvement-of-oxidative-and-hydrolytic-resistance-of-polycarbonate-urethanes-based-on-polydimethylsiloxane-poly-hexamethylene-carbonate-mixed-macrodiols
#1
Zhen Li, Jian Yang, Heng Ye, Mingming Ding, Feng Luo, Jianshu Li, Jiehua Li, Hong Tan, Qiang Fu
The degradation behaviors including oxidation and hydrolysis of silicone modified polycarbonate urethanes were thoroughly investigated. These polyurethanes were based on poly hexamethylene carbonate (PHMC) /polydimethylsiloxane (PDMS) mixed macrodiols with molar ratio of PDMS ranging from 5% to 30%. It was proved that PDMS tended to migrate toward surface and even a small amount of PDMS could form a silicone-like surface. Macrophages-mediated oxidation process indicated that the PDMS surface layer was desirable to protect the fragile soft PHMC from the attack of degradative species...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29549051/3d-printed-ifn-%C3%AE-loading-calcium-silicate-%C3%AE-tricalcium-phosphate-scaffold-sequentially-activates-m1-and-m2-polarization-of-macrophages-to-promote-vascularization-of-tissue-engineering-bone
#2
Tao Li, Mingzheng Peng, Zezheng Yang, Xiaojun Zhou, Yuan Deng, Chuan Jiang, Ming Xiao, Jinwu Wang
To promote vascularization of tissue-engineered bone, IFN-γ polarizing macrophages to M1 was loaded on 5% calcium silicate/β-tricalcium phosphate (CaSiO3 -β-TCP) scaffolds. IFN-γ and Si released from the scaffold were designed to polarize M1 and M2 macrophages, respectively. β-TCP, CaSiO3 -β-TCP, and IFN-γ@CaSiO3 -β-TCP were fabricated and biocompatibilities were evaluated. Polarizations of macrophages were detected by flow cytometry. Human umbilical vein endothelial cells with GFP were cultured and induced on Matrigel with conditioned culture medium extracted from culture of macrophages loaded on scaffolds for evaluating angiogenesis...
March 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29471127/targeting-cd14-on-blood-derived-cells-improves-intracortical-microelectrode-performance
#3
Hillary W Bedell, John K Hermann, Madhumitha Ravikumar, Shushen Lin, Ashley Rein, Xujia Li, Emily Molinich, Patrick D Smith, Stephen M Selkirk, Robert H Miller, Steven Sidik, Dawn M Taylor, Jeffrey R Capadona
Intracortical microelectrodes afford researchers an effective tool to precisely monitor neural spiking activity. Additionally, intracortical microelectrodes have the ability to return function to individuals with paralysis as part of a brain computer interface. Unfortunately, the neural signals recorded by these electrodes degrade over time. Many strategies which target the biological and/or materials mediating failure modes of this decline of function are currently under investigation. The goal of this study is to identify a precise cellular target for future intervention to sustain chronic intracortical microelectrode performance...
February 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29420643/immunophenotypic-characterization-of-human-t-cells-after-in-vitro-exposure-to-different-silicone-breast-implant-surfaces
#4
Giuseppe Cappellano, Christian Ploner, Susanne Lobenwein, Sieghart Sopper, Paul Hoertnagl, Christina Mayerl, Nikolaus Wick, Gerhard Pierer, Georg Wick, Dolores Wolfram
The most common complication of silicone breast implants is capsular contracture (massive scar formation around the implant). We postulate that capsular contracture is always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts and macrophages have been used as cell types to evaluate in vitro the biocompatibility of breast implant surfaces. Moreover, also T cells have been found at the implant site at the initial stage of fibrous capsule formation...
2018: PloS One
https://www.readbyqxmd.com/read/29413116/effect-of-silicon-rich-water-intake-on-the-systemic-and-peritoneal-inflammation-of-rats-with-chronic-low-levels-of-aluminum-ingestion
#5
Zoran Radovanovic, Boris Djindjic, Tanja Dzopalic, Andrej Veljkovic, Momir Dunjic, Dejan Krstic, Natasa Djindjic, Biljana Bozic Nedeljkovic
BACKGROUND AND OBJECTIVES: Study evaluated effect of silicon-rich water intake on systemic inflammation and functional characteristics of peritoneal macrophages (PMs) of rats that were chronically exposed to dietary aluminum. METHODS: One month-old female Wistar Albino rats were administered aluminum chloride dissolved in distilled water (1.6mg/kg body weight in 0.5mL) by gavage for 90days. The rats were then given standard (6mg/L) or silicon-rich water (19mg/L silicon) (n=7/group)...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29401612/silica-induced-initiation-of-circular-zc3h4-rna-zc3h4-pathway-promotes-the-pulmonary-macrophage-activation
#6
Xiyue Yang, Jing Wang, Zewei Zhou, Rong Jiang, Jie Huang, Lulu Chen, Zhouli Cao, Han Chu, Bing Han, Yusi Cheng, Jie Chao
Phagocytosis of silicon dioxide (SiO2) into lung cells causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular RNAs (circRNAs) are a subclass of noncoding RNAs that are present within mammalian cells; however, researchers have not determined whether circRNAs are involved in the pathophysiologic process of silicosis. To elucidate the role of these RNAs in SiO2-induced inflammation in pulmonary macrophages, we investigated the upstream molecular mechanisms and functional effects of circRNAs on cell apoptosis, proliferation, and migration...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29374638/fluctuating-hypercalcaemia-caused-by-cavitary-mycobacterium-bovis-pulmonary-infection
#7
Darren Patrick Moloney, Liam Chawke, Mairead Therese Crowley, Terence M O'Connor
Hypercalcaemia occurs in many granulomatous diseases. Among them, sarcoidosis and tuberculosis are the most common causes. Other causes include berylliosis, coccidioidomycosis, histoplasmosis, Crohn's disease, silicone-induced granulomas, cat-scratch disease, Wegener's granulomatosis and Pneumocystis carinii pneumonia. Hypercalcaemia in granulomatous disease occurs as a consequence of dysregulated production of 1,25-(OH)2 D3 (calcitriol) by activated macrophages in granulomas. Hypercalcaemia in patients with Mycobacterium tuberculosis infection has been reported in 0%-28% of cases...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29325699/co-delivery-of-tumor-antigen-and-dual-toll-like-receptor-ligands-into-dendritic-cell-by-silicon-microparticle-enables-efficient-immunotherapy-against-melanoma
#8
Motao Zhu, Xilai Ding, Ruifang Zhao, Xuewu Liu, Haifa Shen, Chunmei Cai, Mauro Ferrari, Helen Y Wang, Rong-Fu Wang
Despite the importance and promise of cancer vaccines for broader prevention and treatment of cancer, limited clinical responses are observed, suggesting that key rational designs are required for inducing potent immune responses against cancer. Here we report a mesoporous silicon vector (MSV) as a multi-functional microparticle for formulating an efficient cancer vaccine composed of B16 melanoma derived-tyrosinase related protein 2 (TRP2) peptide and dual toll-like receptor (TLR) agonists. We demonstrated that MSV microparticles protected the peptide from rapid degradation for prolonged antigen presentation to immune cells...
February 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29290828/circrna-mediates-silica-induced-macrophage-activation-via-hectd1-zc3h12a-dependent-ubiquitination
#9
Zewei Zhou, Rong Jiang, Xiyue Yang, Huifang Guo, Shencun Fang, Yingming Zhang, Yusi Cheng, Jing Wang, Honghong Yao, Jie Chao
Rationale: Phagocytosis of silicon dioxide (SiO2 ) into lung cells causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular RNAs (circRNAs) are a subclass of non-coding RNAs detected within mammalian cells; however, researchers have not determined whether circRNAs are involved in the pathophysiological process of silicosis. The upstream molecular mechanisms and functional effects on cell apoptosis, proliferation and migration were investigated to elucidate the role of circRNAs in SiO2 -induced inflammation in pulmonary macrophages...
2018: Theranostics
https://www.readbyqxmd.com/read/29280498/precision-porous-templated-scaffolds-of-varying-pore-size-drive-dendritic-cell-activation
#10
Ruying Chen, Hongyan Ma, Lei Zhang, James D Bryers
Scaffold based systems have shown significant potential in modulating immune responses in vivo. While there has been much attention on macrophage interactions with tissue engineered scaffolds for tissue regeneration, fewer studies have looked at the effects of scaffold design on the response of immune cells-that is, dendritic cells (DCs). Here, we present the effects of varying pore size of poly (2-hydroxyethyl methacrylate) (pHEMA) and poly(dimethylsiloxane) (PDMS, silicone) scaffolds on the maturation and in vivo enrichment of DCs...
April 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29235541/biodegradable-bisvinyl-sulfonemethyl-crosslinked-gelatin-conduit-promotes-regeneration-after-peripheral-nerve-injury-in-adult-rats
#11
Chien-Hsin Ko, Ming-You Shie, Jia-Horng Lin, Yi-Wen Chen, Chun-Hsu Yao, Yueh-Sheng Chen
In our previous study, we found that gelatin-based materials exhibit good conductivity and are non-cytotoxic. In this study, gelatin was cross-linked with bisvinyl sulfonemethyl (BVSM) to fabricate a biodegradable conduit for peripheral nerve repair. First, BVSM on the prepared conduit was characterized to determine its mechanical properties and contact angle. The maximum tensile strength and water contact angle of the gelatin-BVSM conduits were 23 ± 4.8 MPa and 74.7 ± 9°, which provided sufficient mechanical strength to resist muscular contraction; additionally, the surface was hydrophilic...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29223703/the-foreign-body-response-and-morphometric-changes-associated-with-mesh-style-peripheral-nerve-cuffs
#12
Michael B Christensen, Patrick A Tresco
Nerve cuffs have been used to anchor and protect penetrating electrodes in peripheral nerves and have been used as non-penetrating electrodes for neural recording and nerve stimulation. The material of choice for such applications is silicone, an inert synthetic biomaterial which elicits a minimal chronic foreign body response (FBR). While histological studies of solid silicone cuffs are available, to the best of our knowledge a comparison to other cuff designs is not well documented. Here, we describe the FBR and morphological changes that accompany nerve cuff implantation in the rat sciatic nerve by comparing a metallic mesh with and without a parylene coating to one made of silicone...
February 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29211449/novel-reduced-graphene-oxide-zinc-silicate-calcium-silicate-electroconductive-biocomposite-for-stimulating-osteoporotic-bone-regeneration
#13
Kun Xiong, Tingting Wu, Qingbo Fan, Lin Chen, Minhao Yan
In the absence of external assistance, autogenous healing of bone fracture is difficult due to impaired regeneration ability under osteoporosis pathological conditions. In this study, a reduced graphene oxide/zinc silicate/calcium silicate (RGO/ZS/CS) conductive biocomposite with an optimal surface electroconductivity of 5625 S/m was prepared by a two-step spin-coating method. The presence of lamellar apatite nanocrystals on the surfaces of the biocomposite suggests that it has good in vitro biomineralization ability...
December 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29117574/an-astrocyte-derived-extracellular-matrix-coating-reduces-astrogliosis-surrounding-chronically-implanted-microelectrode-arrays-in-rat-cortex
#14
Robert S Oakes, Michael D Polei, John L Skousen, Patrick A Tresco
Available evidence suggests that the magnitude of the foreign body response (FBR) to implants placed in cortical brain tissue is affected by the extent of vasculature damage following device insertion and the magnitude of the ensuing macrophage response. Since the extracellular matrix (ECM) serves as a natural hemostatic and immunomodulatory agent, we examined the ability of an FDA-approved neurosurgical hemostatic coating and an ECM coating derived from primary rat astrocytes to reduce the FBR surrounding a penetrating microelectrode array chronically implanted in rat cortex...
February 2018: Biomaterials
https://www.readbyqxmd.com/read/29079028/modulating-effect-of-mgo-sio2-nanoparticles-on-immunological-and-histopathological-alterations-induced-by-aflatoxicosis-in-rats
#15
Sara S Essa, Eiman M El-Saied, Osama S El-Tawil, Manal B Mahmoud, Sahar S Abd El-Rahman
INTRODUCTION: AflatoxinB1 (AFB1) is well-known as a feed borne-hepatotoxic and immunosuppressive mycotoxin. This study was conducted to evaluate the efficacy of nanocomposite magnesium oxide and silicon oxide (MgO-SiO2) in reducing the toxic effects of AFB1on the immunity and histological alterations in liver, spleen and intestine of adult male rats. EXPERIMENTAL DESIGN: Animals were divided into a control (Gp1) and three experimental groups (Gps); Gp2 received feed contained 200 ppb AFB1, Gp3 received feed contained 200 ppb AFB1 and 0...
October 25, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29062167/characterization-of-the-foreign-body-response-to-common-surgical-biomaterials-in-a-murine-model
#16
Mohamed Ibrahim, Jennifer Bond, Manuel A Medina, Lei Chen, Carlos Quiles, George Kokosis, Latif Bashirov, Bruce Klitzman, Howard Levinson
BACKGROUND: Implanted biomaterials are subject to a significant reaction from the host, known as the foreign body response (FBR). We quantified the FBR to five materials following subcutaneous implantation in mice. MATERIALS AND METHODS: Polyvinyl alcohol (PVA) and silicone sheets are considered highly biocompatible biomaterials and were cut into 8mm-diameter disks. Expanded PTFE (ePTFE)and polypropylene are also widely used biocompatible biomaterials and were cut into 2cm-long cylinders...
November 2017: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29062065/a-chloroquine-induced-macrophage-preconditioning-strategy-for-improved-nanodelivery
#17
Joy Wolfram, Sara Nizzero, Haoran Liu, Feng Li, Guodong Zhang, Zheng Li, Haifa Shen, Elvin Blanco, Mauro Ferrari
Site-specific localization is critical for improving the therapeutic efficacy and safety of drugs. Nanoparticles have emerged as promising tools for localized drug delivery. However, over 90% of systemically injected nanocarriers typically accumulate in the liver and spleen due to resident macrophages that form the mononuclear phagocyte system. In this study, the clinically approved antimalarial agent chloroquine was shown to reduce nanoparticle uptake in macrophages by suppressing endocytosis. Pretreatment of mice with a clinically relevant dose of chloroquine substantially decreased the accumulation of liposomes and silicon particles in the mononuclear phagocyte system and improved tumoritropic and organotropic delivery...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044021/-asia-syndrome-breast-implant-and-still-s-disease
#18
Cristhian Armenteros, Andrea Odzak, Florencia Arcondo, Marcela De Dios Soler, Tatiana Sinigier, Marcelo Zylberman
Connective tissue diseases associated with silicone breast implants have been widely discussed. In the last decade, siliconosis has been included in the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) next to Gulf War syndrome, macrophage myofascitis and postvaccination phenomena. The ASIA syndrome may appear as lupus, rheumatoid arthritis, or more rarely, as adult Still's disease. We discuss the case of a patient with prolonged fever and clinical criteria for ASIA and Still's disease. The prostheses were resected and pathology showed absence of breast implant associated anaplastic lymphoma ALK (-)...
2017: Medicina
https://www.readbyqxmd.com/read/28987879/thioaptamer-targeted-discoidal-microparticles-increase-self-immunity-and-reduce-mycobacterium-tuberculosis-burden-in-mice
#19
Fransisca Leonard, Ngan P Ha, Preeti Sule, Jenolyn F Alexander, David E Volk, Ganesh L R Lokesh, Xuewu Liu, Jeffrey D Cirillo, David G Gorenstein, Jinyun Yuan, Soumya Chatterjee, Edward A Graviss, Biana Godin
Worldwide, tuberculosis (TB) remains one of the most prevalent infectious diseases causing morbidity and death in >1.5 million patients annually. Mycobacterium tuberculosis (Mtb), the etiologic agent of TB, usually resides in the alveolar macrophages. Current tuberculosis treatment methods require more than six months, and low compliance often leads to therapeutic failure and multidrug resistant strain development. Critical to improving TB-therapy is shortening treatment duration and increasing therapeutic efficacy...
November 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28865177/surface-topography-of-silicon-nitride-affects-antimicrobial-and-osseointegrative-properties-of-tibial-implants-in-a-murine-model
#20
Masahiro Ishikawa, Karen L de Mesy Bentley, Bryan J McEntire, B Sonny Bal, Edward M Schwarz, Chao Xie
While silicon nitride (Si3 N4 ) is an antimicrobial and osseointegrative orthopaedic biomaterial, the contribution of surface topography to these properties is unknown. Using a methicillin-resistant strain of Staphylococcus aureus (MRSA), this study evaluated Si3 N4 implants in vitro utilizing scanning electron microscopy (SEM) with colony forming unit (CFU) assays, and later in an established in vivo murine tibia model of implant-associated osteomyelitis. In vitro, the "as-fired" Si3 N4 implants displayed significant reductions in adherent bacteria versus machined Si3 N4 (2...
December 2017: Journal of Biomedical Materials Research. Part A
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