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Macrophage silicon

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https://www.readbyqxmd.com/read/28213286/investigation-of-silicon-carbon-nitride-nanocomposite-films-as-a-wear-resistant-layer-in-vitro-and-in-vivo-for-joint-replacement-applications
#1
Y Liang, D G Liu, W Q Bai, J P Tu
Silicon-contained CNx nanocomposite films were prepared using the ion beam assisted magnetron sputtering under different nitrogen gas pressure. With increase of the nitrogen pressure, silicon and nitrogen content of the CNx films drastically increase, and is saturated as the PN2 reach about 40%. Surface roughness and the contact angle are increase, while the friction coefficient decreased. The CNx film with 5.7at.% Si content possess the lowest friction coefficient of only 0.07, and exhibited the best tribological properties...
February 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28155844/enhanced-biocompatibility-of-neural-probes-by-integrating-microstructures-and-delivering-anti-inflammatory-agents-via-microfluidic-channels
#2
Bin Liu, Eric Kim, Anika Meggo, Sachin Gandhi, Hao Luo, Srinivas Kallakuri, Yong Xu, Jinsheng Zhang
OBJECTIVE: Biocompatibility is a major issue for chronic neural implants, involving inflammatory and wound healing responses of neurons and glial cells. To enhance biocompatibility, we developed silicon-parylene hybrid neural probes with open architecture electrodes, microfluidic channels and a reservoir for drug delivery to suppress tissue responses. APPROACH: We chronically implanted our neural probes in the rat auditory cortex and investigated (1) whether open architecture electrode reduces inflammatory reaction by measuring glial responses; and (2) whether delivery of antibiotic minocycline reduces inflammatory and tissue reaction...
February 3, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28142331/differential-cytotoxic-and-inflammatory-potency-of-amorphous-silicon-dioxide-nanoparticles-of-similar-size-in-multiple-cell-lines
#3
Dalibor Breznan, Dharani D Das, Julie S O'Brien, Christine MacKinnon-Roy, Surendra Nimesh, Ngoc Q Vuong, Stéphane Bernatchez, Nimal DeSilva, Myriam Hill, Prem Kumarathasan, Renaud Vincent
The likelihood of environmental and health impacts of silicon dioxide nanoparticles (SiNPs) has risen, due to their increased use in products and applications. The biological potency of a set of similarly-sized amorphous SiNPs was investigated in a variety of cells to examine the influence of physico-chemical and biological factors on their toxicity. Cellular LDH and ATP, BrdU incorporation, resazurin reduction and cytokine release were measured in human epithelial A549, human THP-1 and mouse J774A.1 macrophage cells exposed for 24 h to suspensions of 5-15, 10-20 and 12 nm SiNPs and reference particles...
February 1, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28102640/activated-macrophages-as-key-mediators-of-capsule-formation-on-adipose-constructs-in-tissue-engineering-chamber-models
#4
Weiqing Zhan, Feng Lu
In plastic and reconstructive field, it would be much beneficial to fabricate an engineered adipose tissue substitute allowing reliable and complete fat tissue regeneration. Tissue engineering chamber (TEC) holds the promise to optimize an adipogenic configuration that is efficacious as well as reproducible. A frequently occurring complication involves the adipose tissue flap encapsulation and, effectively, its shielding, by a thick fibrous membrane, which hinders development into the proliferative stage. The reason for the deposition of the collagen capsule remains unclear...
January 19, 2017: Cell Biology International
https://www.readbyqxmd.com/read/27982175/biological-tissue-response-to-a-new-formulation-of-a-silicone-based-endodontic-sealer
#5
Flávia Emi Razera Baldasso, Patrícia Maria Poli Kopper, Renata Dornelles Morgental, Liviu Steier, José Antônio Poli de Figueiredo, Roberta Kochenborger Scarparo
Satisfactory biological behavior is a necessary requirement for clinical application of endodontic materials. In this study, the connective tissue responses to silicone (GuttaFlow 2), epoxy resin (AH Plus) and zinc oxide and eugenol (Endofill) based sealers were compared. Twelve Wistar rats had polyethylene tubes (four per animal) containing one of the tested sealers and empty tubes (negative control) implanted in their subcutaneous tissue. The tubes were randomly placed 2 cm from the spine and at least 2 cm apart from one another...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27709146/convex-and-concave-micro-structured-silicone-controls-the-shape-but-not-the-polarization-state-of-human-macrophages
#6
V Malheiro, F Lehner, V Dinca, P Hoffmann, K Maniura-Weber
The typical foreign body response (FBR) to synthetic implants is characterized by local inflammation and tissue fibrosis. Silicone implants have been associated with the development of adverse capsular contraction (ACC); a form of excessive FBR to the material that often requires the replacement of the implant. It has been shown that surface roughening of silicone can reduce the prevalence of ACC, but the mechanisms remain poorly understood. Macrophages are key cells in FBR. They exert their control mainly by polarizing into pro-inflammatory (M1) or pro-healing (M2) cells...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27699693/elemental-and-immunohistochemical-analysis-of-the-lungs-and-hilar-lymph-node-in-a-patient-with-asbestos-exposure-a-pilot-study
#7
Yasuhiko Koga, Takahiro Satoh, Kyoichi Kaira, Masashi Koka, Takeshi Hisada, Junko Hirato, Bolag Altan, Masakiyo Yatomi, Akihiro Ono, Yosuke Kamide, Yasuo Shimizu, Haruka Aoki-Saito, Hiroaki Tsurumaki, Kimihiro Shimizu, Akira Mogi, Tamotsu Ishizuka, Masanobu Yamada, Kunio Dobashi
OBJECTIVES: Studies have shown that inhaled mine dust, such as asbestos, can be translocated to various organs including the lymph nodes. Recently, we have established a protocol that enables us to identify inhaled elements using paraffin embedded lung specimens by in-air microparticle-induced X-ray emission (micro-PIXE). However, little research has examined the concentration of these inhaled fibers in various organs or the mechanisms of their translocation. In this study, we compared the concentration of inhaled fibers in the lung parenchyma to the concentration in the hilar lymph node as well as to determine the elemental spatial distribution of the inhaled fibers in a patient with occupational asbestos exposure...
November 2016: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/27699444/the-safety-of-nanostructured-synthetic-amorphous-silica-sas-as-a-food-additive-e-551
#8
REVIEW
Claudia Fruijtier-Pölloth
Particle sizes of E 551 products are in the micrometre range. The typical external diameters of the constituent particles (aggregates) are greater than 100 nm. E 551 does not break down under acidic conditions such as in the stomach, but may release dissolved silica in environments with higher pH such as the intestinal tract. E 551 is one of the toxicologically most intensively studied substances and has not shown any relevant systemic or local toxicity after oral exposure. Synthetic amorphous silica (SAS) meeting the specifications for use as a food additive (E 551) is and has always been produced by the same two production methods: the thermal and the wet processes, resulting in E 551 products consisting of particles typically in the micrometre size range...
December 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27634631/intravascular-large-b-cell-lymphoma-associated-with-silicone-breast-implant-hla-drb1-11-01-and-hla-dqb1-03-01-manifesting-as-macrophage-activation-syndrome-and-with-severe-neurological-symptoms-a-case-report
#9
Oswald Moling, Andrea Piccin, Martina Tauber, Peter Marinello, Mariagrazia Canova, Marco Casini, Giovanni Negri, Bernd Raffeiner, Raffaella Binazzi, Latha Gandini, Cinzia Vecchiato, Giovanni Rimenti, Atto Billio
BACKGROUND: Silicone implants have been successfully used for breast augmentation and reconstruction in millions of women worldwide. The reaction to the silicone implant is highly variable; it can lead to local inflammatory symptoms, and sometimes to systemic symptoms and disease. Over 80 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma have been reported in patients with silicone breast implants and have been accepted as a new clinical entity. To the best of our knowledge, an intravascular large B-cell lymphoma associated with a silicone breast implant has not been reported previously...
September 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27616297/neogambogic-acid-prevents-silica-induced-fibrosis-via-inhibition-of-high-mobility-group-box-1-and-mcp-1-induced-protein-1
#10
Wei Zhang, Mei Zhang, Zhongjiang Wang, Yusi Cheng, Haijun Liu, Zewei Zhou, Bing Han, Baoan Chen, Honghong Yao, Jie Chao
BACKGROUND: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO2); early stages are characterized by alveolar inflammation, and later stages are characterized by progressive lung fibrosis. Mounting evidence indicates that high-mobility group box 1 (HMGB1) is involved in pulmonary fibrosis. Whether neogambogic acid (NGA) inhibits macrophage and fibroblast activation induced by SiO2 by targeting HMGB1 remains unclear. METHODS AND RESULTS: Experiments using cultured mouse macrophages (RAW264...
October 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27547159/silicon-dioxide-impedes-antiviral-response-and-causes-genotoxic-insult-during-calicivirus-replication
#11
Sudhakar S Agnihothram, Sheryl Anne Vermudez, Lisa Mullis, Todd A Townsend, Mugimane G Manjanatha, Marli P Azevedo
Noroviruses (NoV) are the leading cause of nonbacterial gastroenteritis in humans, and replicate extensively in the human gastrointestinal (GI) tract. Silica (also known as silicon dioxide, SiO2) nanoparticles (NPs) used in processed foods, dairy products, and beverages also accumulate in the GI tract. We investigated the effect of silica NPs on NoV replication and host cell response during virus infection, using murine norovirus (MNV-1) infection of RAW 264.7 murine macrophages. Pretreatment with 10 μg/ml silica significantly reduced the viability of macrophages, but no cumulative effects on viability of macrophages were observed with MNV-1 infection...
July 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27497232/nanocrystallinity-effects-on-osteoblast-and-osteoclast-response-to-silicon-substituted-hydroxyapatite
#12
Laura Casarrubios, María Concepción Matesanz, Sandra Sánchez-Salcedo, Daniel Arcos, María Vallet-Regí, María Teresa Portolés
HYPOTHESIS: Silicon substituted hydroxyapatites (SiHA) are highly crystalline bioceramics treated at high temperatures (about 1200°C) which have been approved for clinical use with spinal, orthopedic, periodontal, oral and craniomaxillofacial applications. The preparation of SiHA with lower temperature methods (about 700°C) provides nanocrystalline SiHA (nano-SiHA) with enhanced bioreactivity due to higher surface area and smaller crystal size. The aim of this study has been to know the nanocrystallinity effects on the response of both osteoblasts and osteoclasts (the two main cell types involved in bone remodelling) to silicon substituted hydroxyapatite...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27445672/in-vivo-characterization-of-amorphous-silicon-carbide-as-a-biomaterial-for-chronic-neural-interfaces
#13
Gretchen L Knaack, Daniel G McHail, German Borda, Beomseo Koo, Nathalia Peixoto, Stuart F Cogan, Theodore C Dumas, Joseph J Pancrazio
Implantable microelectrode arrays (MEAs) offer clinical promise for prosthetic devices by enabling restoration of communication and control of artificial limbs. While proof-of-concept recordings from MEAs have been promising, work in animal models demonstrates that the obtained signals degrade over time. Both material robustness and tissue response are acknowledged to have a role in device lifetime. Amorphous Silicon carbide (a-SiC), a robust material that is corrosion resistant, has emerged as an alternative encapsulation layer for implantable devices...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27341317/miragel-the-immunohistochemical-expression-of-cd3-cd34-and-cd68-in-the-surrounding-capsule
#14
M Roldan-Pallares, M LLanes-Estrada, F LLanes-Menendez
PurposeTo study the immunohistochemical features of the capsule tissue surrounding MIRAgel episcleral buckles.Patients and methodsThis Institutional interventional clinical cohort study examined a consecutive series of 21 referred patients who required MIRAgel removal from July 2009 to July 2013. All patients with hydrated and fragmented MIRAgel episcleral buckles were included in this study. Capsule biopsies from MIRAgel episcleral buckles were obtained from all patients. Capsule specimens of seven patients with extruded silicone bands were processed as controls...
October 2016: Eye
https://www.readbyqxmd.com/read/27305773/rheological-characterization-and-safety-evaluation-of-non-ionic-lamellar-liquid-crystalline-systems-containing-retinyl-palmitate
#15
Marlus Chorilli, Roberta B Rigon, Giovana Calixto, Pedro M F Cartezani, Maria C A P Ribeiro, Maria L Polacow, Paulo Sérgio Cerri, Victor H V Sarmento, Maria Virgínia Scarpa
Retinyl palmitate (RP) is widely used as a special interest ingredient in dermatological formulations to improve the elasticity of the skin and to reduce wrinkles by stimulating collagen synthesis. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can modulate drug permeation into skin and improve the drug action. The effects of such systems on the skin, however, are not completely known. Possible undesirable effects of these formulations on the skin can be detected and interpreted by histopathology and histomorphometry...
February 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27284351/effects-of-bone-marrow-derived-mesenchymal-stem-cells-on-the-autophagic-activity-of-alveolar-macrophages-in-a-rat-model-of-silicosis
#16
Hui-Xing Zhu, Jun-Ling Gao, Man-Man Zhao, Ran Li, Yan-Xia Tian, Xin Wang, Juan Zhang, Ju-Xiang Yuan, Jian-Zhong Cui
The aim of the present study was to evaluate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) on the expression of the autophagy-associated proteins, microtubule-associated protein light chain 3 (LC-3) and autophagy-related gene Beclin-1 (Beclin-1), in alveolar macrophages (AMs) in a rat model of silicosis. Furthermore, the study investigated the molecular mechanisms underlying the effects of BMSC treatment. A population of 60 adult female Sprague-Dawley (SD) rats were allocated at random into three groups, namely the control, model and BMSC treatment groups (n=20 per group)...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27228631/autoimmune-inflammatory-syndrome-induced-by-adjuvants-and-sj%C3%A3-gren-s-syndrome
#17
Serena Colafrancesco, Carlo Perricone, Yehuda Shoenfeld
Sjögren's syndrome (SS), a chronic systemic autoimmune inflammatory condition involving the exocrine glands, has been suggested to be part of the spectrum of the Autoimmune/ inflammatory Syndrome Induced by Adjuvants (ASIA). ASIA incorporates an umbrella of clinical conditions including siliconosis, macrophage myofasciitis syndrome, and post-vaccination phenomena that occur after the exposure to a substance, namely the adjuvant. Interestingly, SS and ASIA share several common features. Firstly, a shared pathogenic mechanism involving a disruption of the immune system balance, with B cell proliferation, cytokine production and tissue infiltration, has been proposed...
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27109196/cochlear-implant-and-inflammation-reaction-safety-study-of-a-new-steroid-eluting-electrode
#18
L Astolfi, E Simoni, N Giarbini, P Giordano, M Pannella, S Hatzopoulos, A Martini
Dexamethasone is a common anti-inflammatory agent added to cochlear implants to reduce hearing loss due to electrode insertion trauma. We evaluated the safety of eluting silicone rods containing 10% dexamethasone in a Guinea pig model. Animals were implanted with a dexamethasone eluting silicone electrode (DER) or with a non-eluting electrode (NER). The control group only underwent a cochleostomy (CS). Prior to implantation and during the two weeks following implantation, the hearing status of the animals was assessed by means of Compound Action Potentials (CAPs) with an electrode placed near the round window...
June 2016: Hearing Research
https://www.readbyqxmd.com/read/27102570/novel-grooved-substrata-stimulate-macrophage-fusion-ccl2-and-mmp-9-secretion
#19
Haisle Moon, Clément V M Cremmel, Alina Kulpa, Nicolas A F Jaeger, Reinhild Kappelhoff, Christopher M Overall, J Douglas Waterfield, Donald M Brunette
Rough surface topographies on implants attract macrophages but the influence of topography on macrophage fusion to produce multinucleated giant cells (MGC) and foreign body giant cells (FBGC) is unclear. Two rough novel grooved substrata, G1 and G2, fabricated by anisotropic etching of Silicon <110> crystals without the use of photolithographic patterning, and a control smooth surface (Pol) were produced and replicated in epoxy. The surfaces were compared for their effects on RAW264.7 macrophage morphology, gene expression, cyto/chemokine secretion, and fusion for one and five days...
September 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27053611/-the-efficiency-of-macrophage-extracellular-trap-formation-induced-by-different-inducers-in-vitro
#20
Chengcheng Su, Guoan Xiang, Yongqiang Ma, Yidan Zhang, Xin Zhou, Shouchun Peng, Luqing Wei, Wenjie Ji
OBJECTIVE: To compare the different methods of inducing the formation of macrophage extracellular trap (MET) in vitro. METHODS: MET release was initiated by culturing RAW264.7 cells with 0.5, 1, 5, 10 μg/mL lipopolysaccharide (LPS), or 10, 25, 50, 80 μmol/L phorbolmyristate acetate (PMA), or 50, 100, 150 μg/mL silicon dioxide (SiO2). Three and 6 hours later, MET were validated by immunofluorescence staining, followed by immunofluorescence-based semi-quantitative analysis...
April 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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