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https://www.readbyqxmd.com/read/29044021/-asia-syndrome-breast-implant-and-still-s-disease
#1
Cristhian Armenteros, Andrea Odzak, Florencia Arcondo, Marcela De Dios Soler, Tatiana Sinigier, Marcelo Zylberman
Connective tissue diseases associated with silicone breast implants have been widely discussed. In the last decade, siliconosis has been included in the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) next to Gulf War syndrome, macrophage myofascitis and postvaccination phenomena. The ASIA syndrome may appear as lupus, rheumatoid arthritis, or more rarely, as adult Still's disease. We discuss the case of a patient with prolonged fever and clinical criteria for ASIA and Still's disease. The prostheses were resected and pathology showed absence of breast implant associated anaplastic lymphoma ALK (-)...
2017: Medicina
https://www.readbyqxmd.com/read/28987879/thioaptamer-targeted-discoidal-microparticles-increase-self-immunity-and-reduce-mycobacterium-tuberculosis-burden-in-mice
#2
Fransisca Leonard, Ngan P Ha, Preeti Sule, Jenolyn F Alexander, David E Volk, Ganesh L R Lokesh, Xuewu Liu, Jeffrey D Cirillo, David G Gorenstein, Jinyun Yuan, Soumya Chatterjee, Edward A Graviss, Biana Godin
Worldwide, tuberculosis (TB) remains one of the most prevalent infectious diseases causing morbidity and death in >1.5 million patients annually. Mycobacterium tuberculosis (Mtb), the etiologic agent of TB, usually resides in the alveolar macrophages. Current tuberculosis treatment methods require more than six months, and low compliance often leads to therapeutic failure and multidrug resistant strain development. Critical to improving TB-therapy is shortening treatment duration and increasing therapeutic efficacy...
October 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28865177/surface-topography-of-silicon-nitride-affects-antimicrobial-and-osseosintegrative-properties-of-tibial-implants-in-a-murine-model
#3
Masahiro Ishikawa, Karen L de Mesy Bentley, Bryan J McEntire, B Sonny Bal, Edward M Schwarz, Chao Xie
While silicon nitride (Si3 N4 ) is an antimicrobial and osseosintegrative orthopaedic biomaterial, the contribution of surface topography to these properties is unknown. Using a methicillin-resistant strain of Staphylococcus aureus (MSRA), this study evaluated Si3 N4 implants in vitro via scanning electron microscopy (SEM) and colony forming unit (CFU) assays, and later in an established in vivo murine tibia model of implant-associated osteomyelitis. In vitro, the "as-fired" Si3 N4 implants displayed significant reductions in adherent bacteria versus machined Si3 N4 (2...
September 2, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28855120/sio2-induced-release-of-svegfrs-from-pulmonary-macrophages
#4
Jie Chao, Yan Lv, Jin Chen, Jing Wang, Honghong Yao
BACKGROUND: The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. However, the role of SCRs in silicosis remains unknown. METHODS AND RESULTS: Luminex assays revealed increased soluble vascular endothelial growth factor receptor (sVEGFR) family levels in the plasma of silicosis patients...
August 30, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28802207/the-effect-of-aluminium-and-sodium-impurities-on-the-in-vitro-toxicity-and-pro-inflammatory-potential-of-cristobalite
#5
C Nattrass, C J Horwell, D E Damby, D Brown, V Stone
BACKGROUND: Exposure to crystalline silica (SiO2), in the form of quartz, tridymite or cristobalite, can cause respiratory diseases, such as silicosis. However, the observed toxicity and pathogenicity of crystalline silica is highly variable. This has been attributed to a number of inherent and external factors, including the presence of impurities. In cristobalite-rich dusts, substitutions of aluminium (Al) for silicon (Si) in the cristobalite structure, and impurities occluding the silica surface, have been hypothesised to decrease its toxicity...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28697402/functional-biocompatibility-testing-of-silicone-breast-implants-and-a-novel-classification-system-based-on-surface-roughness
#6
S Barr, E W Hill, A Bayat
PURPOSE: Increasing numbers of women undergo breast implantation for cosmetic and reconstructive purposes. Contracture of the fibrous capsule, which encases the implant leads to significant pain and reoperation. Texture, wettability and the cellular reaction to implant surfaces are poorly understood determinants of implant biocompatibility. The aim of this study was to evaluate the in-vitro characteristics of a range of commercial available implants using a macrophage based assay of implant biocompatibility and a quantitative assessment of wettability and texture...
June 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28670313/macrophage-polarization-contributes-to-the-anti-tumoral-efficacy-of-mesoporous-nanovectors-loaded-with-albumin-bound-paclitaxel
#7
Fransisca Leonard, Louis T Curtis, Matthew James Ware, Taraz Nosrat, Xuewu Liu, Kenji Yokoi, Hermann B Frieboes, Biana Godin
Therapies targeted to the immune system, such as immunotherapy, are currently shaping a new, rapidly developing branch of promising cancer treatments, offering the potential to change the prognosis of previously non-responding patients. Macrophages comprise the most abundant population of immune cells in the tumor microenvironment (TME) and can undergo differentiation into functional phenotypes depending on the local tissue environment. Based on these functional phenotypes, tumor-associated macrophages (TAMs) can either aid tumor progression (M2 phenotype) or inhibit it (M1 phenotype)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28538471/foreign-body-response-to-silicone-in-cochlear-implant-electrodes-in-the-human
#8
Jennifer T O'Malley, Barbara J Burgess, Donald Galler, Joseph B Nadol
HYPOTHESIS: Silicone as part of a cochlear implant electrode may be responsible for a foreign body response in the human. BACKGROUND: Clinical evidence of a foreign body response to a cochlear implant has been reported. In a previous study, particulate material found within the fibrous sheath and within macrophages surrounding a cochlear implant has been identified as being consistent with platinum. However, to date, there has been no histologic evidence of a role for silicone in this cellular immune response...
August 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28490729/a-comparative-multi-parametric-in-vitro-model-identifies-the-power-of-test-conditions-to-predict-the-fibrotic-tendency-of-a-biomaterial
#9
Maren Jannasch, Sabine Gaetzner, Tobias Weigel, Heike Walles, Tobias Schmitz, Jan Hansmann
Despite growing effort to advance materials towards a low fibrotic progression, all implants elicit adverse tissue responses. Pre-clinical biomaterial assessment relies on animals testing, which can be complemented by in vitro tests to address the Russell and Burch's 3R aspect of reducing animal burden. However, a poor correlation between in vitro and in vivo biomaterial assessments confirms a need for suitable in vitro biomaterial tests. The aim of the study was to identify a test setting, which is predictive and might be time- and cost-efficient...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470152/histological-evaluation-of-flexible-neural-implants-flexibility-limit-for-reducing-the-tissue-response
#10
Heui Chang Lee, Fredrik Ejserholm, Janak Gaire, Seth Currlin, Jens Schouenborg, Lars Wallman, Martin Bengtsson, Kinam Park, Kevin J Otto
OBJECTIVE: Flexible neural probes are hypothesized to reduce the chronic foreign body response (FBR) mainly by reducing the strain-stress caused by an interplay between the tethered probe and the brain's micromotion. However, a large discrepancy of Young's modulus still exists (3-6 orders of magnitude) between the flexible probes and the brain tissue. This raises the question of whether we need to bridge this gap; would increasing the probe flexibility proportionally reduce the FBR? APPROACH: Using novel off-stoichiometry thiol-enes-epoxy (OSTE+) polymer probes developed in our previous work, we quantitatively evaluated the FBR to four types of probes with different softness: silicon (~150 GPa), polyimide (1...
June 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28456077/chitosan-degradation-products-facilitate-peripheral-nerve-regeneration-by-improving-macrophage-constructed-microenvironments
#11
Yahong Zhao, Yongjun Wang, Jiahuan Gong, Liu Yang, Changmei Niu, Xuejun Ni, Yaling Wang, Su Peng, Xiaosong Gu, Cheng Sun, Yumin Yang
Chitosan-based artificial nerve grafts have been widely employed to repair peripheral nerve defects. Our previous study has shown that chitosan constructed nerve graft not only provides suitable scaffolds for nerve regeneration, its degradation products, chitooligosaccharides (COS), also promote nerve repair. However, the involved mechanisms are still not fully elucidated. In the present study, we observed that pro-inflammatory cytokines, as well as macrophage infiltration, were transiently up-regulated in the injured sciatic nerves which were bridged with silicon tubes filled with COS...
February 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28399878/sio2-and-tio2-nanoparticles-synergistically-trigger-macrophage-inflammatory-responses
#12
Misato Tsugita, Nobuyuki Morimoto, Masafumi Nakayama
Silicon dioxide (SiO2) nanoparticles (NPs) and titanium dioxide (TiO2) NPs are the most widely used inorganic nanomaterials. Although the individual toxicities of SiO2 and TiO2 NPs have been extensively studied, the combined toxicity of these NPs is much less understood. In this study, we observed unexpected and drastic activation of the caspase-1 inflammasome and production of IL-1β in mouse bone marrow-derived macrophages stimulated simultaneously with SiO2 and TiO2 NPs at concentrations at which these NPs individually do not cause macrophage activation...
April 11, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28377320/do-il-3-gm-csf-effect-on-the-myofibroblastic-differentiation-of-human-adipose-derived-stromal-cells
#13
Jae-Sun Lee, Son-Seung Tae, Deok-Yeol Kim, Seung-Kyu Han, Woo-Kyung Kim, Eun-Sang Dhong
BACKGROUND: Capsular contracture is an incurable complication after silicone-based implant surgery. Myofibroblast is the predominant cell in the contracted capsule. We hypothesized that human adipose derive stromal cells (hASCs) together with fibroblast may show a similar phenotypic characteristics of myofibroblast after the treatment of inflammatory cytokines in vitro. MATERIALS AND METHODS: Interleukin 3 (IL-3) and granulocyte macrophage colony stimulating factor (GM-CSF) were treated in the culture of hASCs and HDFs...
June 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28213286/investigation-of-silicon-carbon-nitride-nanocomposite-films-as-a-wear-resistant-layer-in-vitro-and-in-vivo-for-joint-replacement-applications
#14
Y Liang, D G Liu, W Q Bai, J P Tu
Silicon-contained CNx nanocomposite films were prepared using the ion beam assisted magnetron sputtering under different nitrogen gas pressure. With increase of the nitrogen pressure, silicon and nitrogen content of the CNx films drastically increase, and is saturated as the PN2 reach about 40%. Surface roughness and the contact angle are increase, while the friction coefficient decreased. The CNx film with 5.7at.% Si content possess the lowest friction coefficient of only 0.07, and exhibited the best tribological properties...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28155844/enhanced-biocompatibility-of-neural-probes-by-integrating-microstructures-and-delivering-anti-inflammatory-agents-via-microfluidic-channels
#15
Bin Liu, Eric Kim, Anika Meggo, Sachin Gandhi, Hao Luo, Srinivas Kallakuri, Yong Xu, Jinsheng Zhang
OBJECTIVE: Biocompatibility is a major issue for chronic neural implants, involving inflammatory and wound healing responses of neurons and glial cells. To enhance biocompatibility, we developed silicon-parylene hybrid neural probes with open architecture electrodes, microfluidic channels and a reservoir for drug delivery to suppress tissue responses. APPROACH: We chronically implanted our neural probes in the rat auditory cortex and investigated (1) whether open architecture electrode reduces inflammatory reaction by measuring glial responses; and (2) whether delivery of antibiotic minocycline reduces inflammatory and tissue reaction...
April 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28142331/differential-cytotoxic-and-inflammatory-potency-of-amorphous-silicon-dioxide-nanoparticles-of-similar-size-in-multiple-cell-lines
#16
Dalibor Breznan, Dharani D Das, Julie S O'Brien, Christine MacKinnon-Roy, Surendra Nimesh, Ngoc Q Vuong, Stéphane Bernatchez, Nimal DeSilva, Myriam Hill, Prem Kumarathasan, Renaud Vincent
The likelihood of environmental and health impacts of silicon dioxide nanoparticles (SiNPs) has risen, due to their increased use in products and applications. The biological potency of a set of similarly-sized amorphous SiNPs was investigated in a variety of cells to examine the influence of physico-chemical and biological factors on their toxicity. Cellular LDH and ATP, BrdU incorporation, resazurin reduction and cytokine release were measured in human epithelial A549, human THP-1 and mouse J774A.1 macrophage cells exposed for 24 h to suspensions of 5-15, 10-20 and 12 nm SiNPs and reference particles...
March 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28102640/activated-macrophages-as-key-mediators-of-capsule-formation-on-adipose-constructs-in-tissue-engineering-chamber-models
#17
REVIEW
Weiqing Zhan, Feng Lu
In plastic and reconstructive field, it would be much beneficial to fabricate an engineered adipose tissue substitute allowing reliable and complete fat tissue regeneration. Tissue engineering chamber (TEC) holds the promise to optimize an adipogenic configuration that is efficacious as well as reproducible. A frequently occurring complication involves the adipose tissue flap encapsulation and, effectively, its shielding, by a thick fibrous membrane, which hinders development into the proliferative stage. The reason for the deposition of the collagen capsule remains unclear...
April 2017: Cell Biology International
https://www.readbyqxmd.com/read/27982175/biological-tissue-response-to-a-new-formulation-of-a-silicone-based-endodontic-sealer
#18
Flávia Emi Razera Baldasso, Patrícia Maria Poli Kopper, Renata Dornelles Morgental, Liviu Steier, José Antônio Poli de Figueiredo, Roberta Kochenborger Scarparo
Satisfactory biological behavior is a necessary requirement for clinical application of endodontic materials. In this study, the connective tissue responses to silicone (GuttaFlow 2), epoxy resin (AH Plus) and zinc oxide and eugenol (Endofill) based sealers were compared. Twelve Wistar rats had polyethylene tubes (four per animal) containing one of the tested sealers and empty tubes (negative control) implanted in their subcutaneous tissue. The tubes were randomly placed 2 cm from the spine and at least 2 cm apart from one another...
October 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27709146/convex-and-concave-micro-structured-silicone-controls-the-shape-but-not-the-polarization-state-of-human-macrophages
#19
V Malheiro, F Lehner, V Dinca, P Hoffmann, K Maniura-Weber
The typical foreign body response (FBR) to synthetic implants is characterized by local inflammation and tissue fibrosis. Silicone implants have been associated with the development of adverse capsular contraction (ACC); a form of excessive FBR to the material that often requires the replacement of the implant. It has been shown that surface roughening of silicone can reduce the prevalence of ACC, but the mechanisms remain poorly understood. Macrophages are key cells in FBR. They exert their control mainly by polarizing into pro-inflammatory (M1) or pro-healing (M2) cells...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27699693/elemental-and-immunohistochemical-analysis-of-the-lungs-and-hilar-lymph-node-in-a-patient-with-asbestos-exposure-a-pilot-study
#20
Yasuhiko Koga, Takahiro Satoh, Kyoichi Kaira, Masashi Koka, Takeshi Hisada, Junko Hirato, Bolag Altan, Masakiyo Yatomi, Akihiro Ono, Yosuke Kamide, Yasuo Shimizu, Haruka Aoki-Saito, Hiroaki Tsurumaki, Kimihiro Shimizu, Akira Mogi, Tamotsu Ishizuka, Masanobu Yamada, Kunio Dobashi
OBJECTIVES: Studies have shown that inhaled mine dust, such as asbestos, can be translocated to various organs including the lymph nodes. Recently, we have established a protocol that enables us to identify inhaled elements using paraffin embedded lung specimens by in-air microparticle-induced X-ray emission (micro-PIXE). However, little research has examined the concentration of these inhaled fibers in various organs or the mechanisms of their translocation. In this study, we compared the concentration of inhaled fibers in the lung parenchyma to the concentration in the hilar lymph node as well as to determine the elemental spatial distribution of the inhaled fibers in a patient with occupational asbestos exposure...
November 2016: Environmental Health and Preventive Medicine
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