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Paroxetine

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https://www.readbyqxmd.com/read/28089628/crf1-but-not-glucocorticoid-receptor-antagonists-reduce-separation-induced-distress-vocalizations-in-guinea-pig-pups-and-crf-overexpressing-mouse-pups-a-combination-study-with-paroxetine
#1
P Monika Verdouw, Joantine C J van Esterik, Bernard W M M Peeters, Mark J Millan, Lucianne Groenink
RATIONALE: Given the large number of patients that does not respond sufficiently to currently available treatment for anxiety disorders, there is a need for improved treatment. OBJECTIVES: We evaluated the anxiolytic effects of corticotropin releasing factor (CRF)1 receptor antagonists and glucocorticoid receptor (GR) antagonists in the separation-induced vocalization test in guinea pigs and transgenic mice with central CRF overexpression. Furthermore, we explored effects of these drugs when given in combination with a suboptimal dose of a selective serotonin re-uptake inhibitor (SSRI)...
January 12, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28088261/parquetina-nigrescens-leaves-chemical-profile-and-influence-on-the-physical-and-biochemical-indices-of-sexual-activity-of-male-wistar-rats
#2
Omowumi Titilola Kayode, Musa Toyin Yakubu
OBJECTIVE: The leaves of Parquetina nigrescens have been claimed in folk medicine to be useful for managing sexual dysfunction, but there is inadequate scientific evidence for this claim. This investigation was conducted to assess the effects of aqueous leaf extract of Parquetina nigrescens (AEPN) in rats induced with sexual dysfunction. METHODS: Male rats were allocated into various groups after being induced into sexual dysfunction with paroxetine hydrochloride...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28079266/risk-of-mortality-in-elderly-nursing-home-patients-with-depression-using-paroxetine
#3
Vishal Bali, Satabdi Chatterjee, Michael L Johnson, Hua Chen, Ryan M Carnahan, Rajender R Aparasu
OBJECTIVE: Among selective serotonin reuptake inhibitors (SSRIs), paroxetine is strongly anticholinergic and might lead to higher risk of adverse outcomes such as mortality. This study examined the risk of mortality in depressed elderly nursing home patients using paroxetine and other SSRIs. METHODS: This study used 2007-2010 Minimum Data Set - linked Medicare data and propensity score-matched retrospective cohort study design to achieve the study objective. New users of paroxetine and other SSRIs were followed until they reached the end of the follow-up period (one year), switched to a different antidepressant class, used psychotherapy, or had a gap of more than 15 days in the use of index antidepressant class, whichever occurred earlier...
January 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28074989/-antidepressants-agents-in-breast-cancer-patients-using-tamoxifen-review-of-basic-and-clinical-evidence
#4
María Elisa Irarrázaval O, Leonardo Gaete G
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed to women with breast cancer not only for depression, but also for anxiety and hot flashes. Some AD are substrates or inhibitors of the Tmf metabolic pathway. Therefore there may be interactions when Tmf and AD are prescribed simultaneously. Oncologic protection afforded by Tmf may become less effective or null when AD are indicated, especially in poor metabolizing patients...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28034961/role-of-prefrontal-serotonergic-and-dopaminergic-systems-in-encounter-induced-hyperactivity-in-methamphetamine-sensitized-mice
#5
Tatsunori Tanaka, Yukio Ago, Chiaki Umehara, Emina Imoto, Shigeru Hasebe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
BACKGROUND: Isolation-reared mice show social encounter-induced hyperactivity with activation of prefrontal serotonergic and dopaminergic systems, but it is not known whether this stress response is observed in other pathological conditions. Here we examined whether the social encounter stimulation induces abnormal behavior during withdrawal in chronic methamphetamine (METH)-treated mice. METHODS: To induce METH-induced behavioral sensitization, male mice were injected with METH (1 mg/kg) once daily for 7 days...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28011020/environmental-photochemical-fate-of-selected-pharmaceutical-compounds-in-natural-and-reconstituted-suwannee-river-water-role-of-reactive-species-in-indirect-photolysis
#6
Hanoz Santoke, William J Cooper
This study reports the impact of two reactive species, hydroxyl radical and singlet oxygen, on the photochemical degradation of three selected pharmaceutical compounds in natural and reconstituted solutions of Suwannee River water. Absolute bimolecular rate constants (M(-1)s(-1)) were determined for the reaction of hydroxyl radical and singlet oxygen with danofloxacin ((6.15±0.11)×10(9); (7.50±0.13)×10(4)), fluvastatin ((6.96±0.16)×10(9); (1.64±0.18)×10(8)), and paroxetine ((8.65±0.12)×10(9), (1.18±0...
December 20, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28005135/psychopharmacotherapy-in-pregnancy-and-breastfeeding
#7
Salvatore Giovanni Vitale, Antonio Simone Laganà, Maria Rosaria Anna Muscatello, Valentina Lucia La Rosa, Veronica Currò, Gianluca Pandolfo, Rocco Antonio Zoccali, Antonio Bruno
Importance: Fifteen percent to 20% of pregnant women suffer from mental disorders, and 86% of them are not treated due to potential teratogenic risks for the fetus. Several drugs seem to be safe during pregnancy but knowledge regarding risks of antenatal exposure to drugs is still limited. Objective: The aim of this article is to provide a review of literature, data, and a clinical guideline concerning the treatment and management of mental disorders during pregnancy and lactation...
December 2016: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28000173/in-vitro-evaluation-of-absorption-characteristics-of-peramivir-for-oral-delivery
#8
Ying Li, Zhiyuan Wang, Xin Li, Wei Gong, Xiangyang Xie, Yang Yang, Wu Zhong, Aiping Zheng
BACKGROUND AND OBJECTIVE: Peramivir is a novel antiviral agent approved for the treatment of severe influenza. However, the development of oral formulation of peramivir has been severely hurdled by poor bioavailability (human, ≤3%). The present work aims to evaluate oral permeability characteristics of peramivir. METHODS: In vitro gastrointestinal stability, metabolic stability in human intestinal S9 fraction and Caco-2 permeability were performed. The liquid chromatography with tandem mass spectrometric (LC-MS/MS) was used to quantify peramivir in buffer and biological sample...
December 21, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27999776/-freeze-don-t-move-how-to-arrest-a-suspect-in-heart-failure-a-review-on-available-grk2-inhibitors
#9
REVIEW
Daniela Sorriento, Michele Ciccarelli, Ersilia Cipolletta, Bruno Trimarco, Guido Iaccarino
Cardiovascular disease and heart failure (HF) still collect the largest toll of death in western societies and all over the world. A growing number of molecular mechanisms represent possible targets for new therapeutic strategies, which can counteract the metabolic and structural changes observed in the failing heart. G protein-coupled receptor kinase 2 (GRK2) is one of such targets for which experimental and clinical evidence are established. Indeed, several strategies have been carried out in place to interface with the known GRK2 mechanisms of action in the failing heart...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27996169/palladium-catalyzed-asymmetric-allylic-allylation-of-racemic-morita-baylis-hillman-adducts
#10
Xubin Wang, Xiaoming Wang, Zhaobin Han, Zheng Wang, Kuiling Ding
A palladium-catalyzed asymmetric allyl-allyl cross-coupling of acetates of racemic Morita-Baylis-Hillman adducts and allylB(pin) has been developed using a spiroketal-based bis(phosphine) as the chiral ligand, thus affording a series of chiral 1,5-dienes bearing a vinylic ester functionality in good yields, high branched regioselectivities, and uniformly excellent enantioselectivities (95-99 % ee). Further synthetic manipulations of the allylation products provided novel ways for rapid access to a range of chiral polycyclic lactones and polycyclic lactams, as well as the antidepressant drug (-)-Paroxetine, in high optical purities...
December 20, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27993427/reconsideration-of-the-diagnosis-and-treatment-of-childhood-migraine-a-practical-review-of-clinical-experiences
#11
Yoshiaki Saito, Gaku Yamanaka, Hideki Shimomura, Kazuhiro Shiraishi, Tomoyuki Nakazawa, Fumihide Kato, Yuko Shimizu-Motohashi, Masayuki Sasaki, Yoshihiro Maegaki
OBJECTIVE: To provide insight into the wide spectrum of migraine during childhood to establish practical and comprehensive treatment strategies. BACKGROUND: Although recent studies have confirmed the effect of anti-migraine agents in childhood headaches fulfilling the criteria of migraine without aura, there have been no studies regarding the efficacy of these drugs in childhood migraine without aura not filling the diagnostic criteria. METHODS: In total, 154 patients with a clinical diagnosis of migraine, with onset of repetitive headaches at the age of ⩽15years, were retrospectively included from clinics in seven tertiary medical centers...
December 16, 2016: Brain & Development
https://www.readbyqxmd.com/read/27987210/anti-anhedonic-effect-of-selective-serotonin-reuptake-inhibitors-with-affinity-for-%C3%AF-1-receptors-in-picrotoxin-treated-mice
#12
S Hasebe, Y Ago, Y Watabe, S Oka, N Hiramatsu, T Tanaka, C Umehara, H Hashimoto, K Takuma, T Matsuda
BACKGROUND AND PURPOSE: We have previously shown that prefrontal dopamine release by the combined activation of 5-HT1A and σ1 receptors is enhanced by the GABAA receptor antagonist picrotoxin in mice. Here, we examined whether this neurochemical event is accompanied by behavioural changes. EXPERIMENTAL APPROACH: Male mice were treated with picrotoxin to decrease GABAA receptor function. Their anhedonic behaviour was measured using the female encounter test. The expression of c-Fos was determined immunohistochemically...
December 17, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27966486/selective-serotonin-reuptake-inhibitor-sertraline-inhibits-voltage-dependent-k-channels-in-rabbit-coronary-arterial-smooth-muscle-cells
#13
Han Sol Kim, Hongliang Li, Hye Won Kim, Sung Eun Shin, Il-Whan Choi, Amy L Firth, Hyoweon Bang, Young Min Bae, Won Sun Park
We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline decreased the Kv channel current in a dose-dependent manner, with an IC50 value of 0.18 mu M and a slope value (Hill coefficient) of 0.61. Although the application of 1 mu M sertraline did not affect the steady-state activation curves, sertraline caused a significant, negative shift in the inactivation curves...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27936523/single-and-multiple-dose-pharmacokinetics-and-tolerability-of-paroxetine-controlled-release-tablet-in-healthy-chinese-subjects%C3%A2
#14
Rui Chen, Kai Shen, Pei Hu
OBJECTIVES: To evaluate the pharmacokinetics of paroxetine controlled-release (CR) tablets after single and multiple oral administrations and to evaluate its safety profile in healthy Chinese subjects. METHODS: This was a phase 1, open-label, single- and multiple-dose combined study. All 12 healthy subjects received a single oral dose of 25-mg paroxetine CR, followed by a washout period of 5 days. Then, the subjects received multiple oral doses of 25-mg paroxetine CR for 14 consecutive days...
December 12, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27929271/hormone-therapy-and-other-treatments-for-symptoms-of-menopause
#15
D Ashley Hill, Mark Crider, Susan R Hill
The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years. Therefore, in women with a uterus, it is recommended that physicians prescribe combination therapy only to treat menopausal symptoms such as vasomotor symptoms (hot flashes) and vaginal atrophy, using the smallest effective dosage for the shortest possible duration...
December 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27920882/paroxetine-can-enhance-neurogenesis-during-neurogenic-differentiation-of-human-adipose-derived-stem-cells
#16
Maliheh Jahromi, Shahnaz Razavi, Nushin Amirpour, Zahra Khosravizadeh
BACKGROUND: Some antidepressant drugs can promote neuronal cell proliferation in vitro as well as hippocampal neurogenesis in human and animal models. Furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. Therefore, human Adipose-Derived Stem Cells (hAD-SCs) may be a suitable source for regenerative medical applications. Since there is no evidence for the effect of Paroxetine as the most commonly prescribed antidepressant drug for neurogenic potential of hADSCs, an attempt was made to determine the effect of Paroxetine on proliferation and neural differentiation of hADSCs...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27900470/influence-of-the-selective-antagonist-of-the-nr2b-subunit-of-the-nmda-receptor-traxoprodil-on-the-antidepressant-like-activity-of-desipramine-paroxetine-milnacipran-and-bupropion-in-mice
#17
Weronika Stasiuk, Aleksandra Szopa, Anna Serefko, Elżbieta Wyska, Katarzyna Świąder, Jarosław Dudka, Piotr Wlaź, Ewa Poleszak
Pre-clinical and clinical studies indicated that a blockade of the NMDA receptor complex creates new opportunities for the treatment of affective disorders, including depression. The aim of the present study was to assess the influence of traxoprodil (10 mg/kg) on the activity of desipramine (10 mg/kg), paroxetine (0.5 mg/kg), milnacipran (1.25 mg/kg), and bupropion (10 mg/kg), each at sub-therapeutic doses. Moreover, brain levels of traxoprodil and tested agents were determined using HPLC. The obtained results were used to ascertain the nature of occurring interaction between traxoprodil and studied antidepressants...
November 29, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27890601/tramadol-effects-on-sexual-behavior-in-male-rats-are-mainly-caused-by-its-5-ht-reuptake-blocking-effects
#18
Jocelien D A Olivier, Diana C Esquivel Franco, Ronald Oosting, Marcel Waldinger, Zoltan Sarnyai, Berend Olivier
Tramadol is a well-known and effective analgesic. Recently it was shown that tramadol is also effective in human premature ejaculation. The inhibitory effect of tramadol on the ejaculation latency is probably due to its mechanism of action as a μ-opioid receptor agonist and noradrenaline/serotonin (5-HT) reuptake inhibitor. In order to test this speculation, we tested several doses of tramadol in a rat model of male sexual behavior and investigated two types of drugs interfering with the μ-opioid and the 5-HT system...
November 24, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27882176/effect-of-the-interaction-between-atorvastatin-and-selective-serotonin-reuptake-inhibitors-on-the-blood-redox-equilibrium
#19
Mariola Herbet, Monika Gawrońska-Grzywacz, Magdalena Izdebska, Iwona Piątkowska-Chmiel
Cardiovascular disease and depression often occur simultaneously in the same patient. Long-term polypharmacotherapy can lead to drug-induced oxidative stress. Data concerning the effects of concomitant treatment with atorvastatin and selective serotonin reuptake inhibitors (SSRIs) are lacking. The aim of the present study was to examine oxidative stress parameters in the blood of rats after 28 days treatment with atorvastatin combined with fluoxetine or paroxetine. The study was carried out on male Wistar rats weighing 200-250 g...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27867013/characterization-of-p2x4-receptor-agonists-and-antagonists-by-calcium-influx-and-radioligand-binding-studies
#20
Aliaa Abdelrahman, Vigneshwaran Namasivayam, Sonja Hinz, Anke C Schiedel, Meryem Köse, Maggi Burton, Ali El-Tayeb, Michel Gillard, Jürgen Bajorath, Marc de Ryck, Christa E Müller
Antagonists for ATP-activated P2X4 ion channel receptors are currently in the focus as novel drug targets, in particular for the treatment of neuropathic and inflammatory pain. We stably expressed the human, rat and mouse P2X4 receptors in 1321N1 astrocytoma cells, which is devoid of functional nucleotide receptors, by retroviral transfection, and established monoclonal cell lines. Calcium flux assay conditions were optimized for high-throughput screening resulting in a Z'-factor of >0.8. The application of ready-to-use frozen cells did not negatively affect the results of the calcium assays, which is of great advantage for the screening of compound libraries...
November 17, 2016: Biochemical Pharmacology
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