keyword
MENU ▼
Read by QxMD icon Read
search

Paroxetine

keyword
https://www.readbyqxmd.com/read/29131015/therapeutic-response-to-paroxetine-in-major-depressive-disorder-predicted-by-dna-methylation
#1
Naohiro Takeuchi, Shinpei Nonen, Masaki Kato, Masataka Wakeno, Yoshiteru Takekita, Toshihiko Kinoshita, Fumihiko Kugawa
BACKGROUND: Antidepressants have variable therapeutic effects, depending on genetic and environmental factors. Approximately 30% of major depressive disorder (MDD) patients do not respond significantly to antidepressants such as paroxetine, a selective serotonin reuptake inhibitor (SSRI). However, the biological mechanisms behind this phenomenon are mostly unknown. Here, we examined the role of patients' epigenetic background in SSRI efficacy. METHODS: Genome-wide DNA methylation analysis of the peripheral blood of Japanese MDD patients was performed by using the Infinium HumanMethylation450 BeadChip...
November 4, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29102818/pharmacotherapy-for-social-anxiety-disorder-interpersonal-predictors-of-outcome-and-the-mediating-role-of-the-working-alliance
#2
Jonah N Cohen, Deborah A G Drabick, Carlos Blanco, Franklin R Schneier, Michael R Liebowitz, Richard G Heimberg
Social anxiety disorder (SAD) is highly prevalent and associated with high levels of impairment and distress. Therapies for SAD leave many patients symptomatic at the end of treatment, and little is known about predictors or mechanisms of treatment outcome. Given the interpersonal dysfunction fundamental to SAD, this study investigated whether prominent interpersonal features of SAD (submissive behavior, childhood maltreatment, suppression of anger, and depression) predicted attrition and response to pharmacotherapy and whether the working alliance mediated these relationships...
October 27, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29073751/paroxetine-versus-venlafaxine-and-escitalopram-in-korean-patients-with-major-depressive-disorder-a-randomized-rater-blinded-six-week-study
#3
Young Sup Woo, Roger S McIntyre, Jung-Bum Kim, Min-Soo Lee, Jae-Min Kim, Hyeon Woo Yim, Tae-Youn Jun
Objective: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). Methods: A total of 449 Korean MDD patients were recruited in a six-week, randomized, rater-blinded, active-controlled trial and were evenly randomized to paroxetine, venlafaxine, or escitalopram treatment. Results: When comparing the mean difference for the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HDRS) total scores during six weeks, paroxetine (-6...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29073750/early-improvement-and-marriage-are-determinants-of-the-12-month-treatment-outcome-of-paroxetine-in-outpatients-with-panic-disorder
#4
Takashi Watanabe, Mikito Ueda, Shin Ishiguro, Yuki Hayashi, Akiko Aoki, Masataka Shinozaki, Kazuko Kato, Kazufumi Akiyama, Kazutaka Shimoda
Objective: In this study, we investigated the determinants of remission and discontinuation of paroxetine pharmacotherapy in outpatients with panic disorder (PD). Methods: Subjects were 79 outpatients diagnosed with PD who took 10-40 mg/day of paroxetine for 12 months. The candidate therapeutic determinants included the serotonin transporter gene-linked polymorphic region and the -1019C/G promoter polymorphism of the serotonin receptor 1A as genetic factors, educational background and marital status as environmental factors, and early improvement (EI) at 2 weeks as a clinical factor were assessed...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29070696/structural-determinants-influencing-the-potency-and-selectivity-of-indazole-paroxetine-hybrid-g-protein-coupled-receptor-kinase-2-inhibitors
#5
Renee Bouley, Helen V Waldschmidt, M Claire Cato, Alessandro Cannavo, Jianliang Song, Joseph Y Cheung, Xin-Qiu Yao, Walter J Koch, Scott D Larsen, John J Tesmer
G protein-coupled receptor kinases (GRKs) phosphorylate activated receptors to promote arrestin binding, decoupling from heterotrimeric G proteins, and internalization. GRK2 and GRK5 are overexpressed in the failing heart and thus have become therapeutic targets. Previously, we discovered two classes of GRK2-selective inhibitors, one stemming from GSK180736A, a ROCK1 inhibitor, and the other from paroxetine, a selective serotonin-reuptake inhibitor. These two classes of compounds bind to the GRK2 active site in a similar configuration, but contain different hinge-binding "warheads": indazole and benzodioxole, respectively...
October 25, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29063516/paroxetine-and-fluconazole-therapy-for-hiv-associated-neurocognitive-impairment-results-from-a-double-blind-placebo-controlled-trial
#6
Ned Sacktor, Richard L Skolasky, Richard Moxley, Sheng Wang, Michelle M Mielke, Cynthia Munro, Joseph Steiner, Avindra Nath, Norman Haughey, Justin McArthur
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconazole for the treatment of HIV-associated neurocognitive disorder (HAND). A 24-week randomized double-blind, placebo-controlled 2 × 2 factorial design study was used. HIV+ individuals with cognitive impairment were enrolled in the 24-week trial. Participants were randomly assigned to one of four groups: (1) paroxetine 20 mg/day, (2) fluconazole 100 mg every 12 h, (3) paroxetine and fluconazole, or (4) placebo...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29061554/stopping-antidepressants-and-anxiolytics-as-major-concerns-reported-in-online-health-communities-a-text-mining-approach
#7
Adeline Abbe, Bruno Falissard
BACKGROUND: Internet is a particularly dynamic way to quickly capture the perceptions of a population in real time. Complementary to traditional face-to-face communication, online social networks help patients to improve self-esteem and self-help. OBJECTIVE: The aim of this study was to use text mining on material from an online forum exploring patients' concerns about treatment (antidepressants and anxiolytics). METHODS: Concerns about treatment were collected from discussion titles in patients' online community related to antidepressants and anxiolytics...
October 23, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29055264/differences-in-immunomodulatory-properties-between-venlafaxine-and-paroxetine-in-patients-with-major-depressive-disorder
#8
Chun-Yen Chen, Yi-Wei Yeh, Shin-Chang Kuo, Chih-Sung Liang, Pei-Shen Ho, Chang-Chih Huang, Che-Hung Yen, Jia-Fwu Shyu, Ru-Band Lu, San-Yuan Huang
Inflammatory processes play a crucial role in the pathophysiology of depression, and identifying the specific cytokines targeted by different antidepressants is important for personalized treatment. The aims of this study were to examine whether venlafaxine and paroxetine cause different immunomodulatory effects when used to treat patients with major depression and to clarify the relationships between plasma cytokine levels and the therapeutic effectiveness of these drugs. A total of 91 Han Chinese patients with major depression completed the 8-week paroxetine or venlafaxine treatment and 90 healthy controls were recruited...
October 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#9
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29053977/suicidal-ideation-declines-with-improvement-in-the-subjective-symptoms-of-major-depression
#10
John G Keilp, Steven P Ellis, Marianne Gorlyn, Ainsley K Burke, Maria A Oquendo, J John Mann, Michael F Grunebaum
BACKGROUND: Suicidal ideation appears to be more strongly associated with subjective rather than neurovegetative symptoms of depression. Effective treatment, then, should produce reductions in suicidal ideation to the degree that these subjective symptoms are alleviated relative to treatment effects on other symptoms. METHODS: In a randomized clinical trial comparing paroxetine and bupropion for treatment of depression in patients with either suicidal ideation or past attempt, depression severity and suicidal ideation were assessed weekly during the 8-week study...
September 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29044007/depressive-symptoms-monoamines-levels-mao-b-activity-and-effect-of-treatment-in-a-subset-of-depressed-individuals-from-government-sector-hospital-at-karachi
#11
Farah Zeb, Sabira Naqvi, Razaur Rahman, Ahsana Dar Farooq
Depression is one of the leading causes of disability in developing countries including Pakistan. This study was designed to assess the frequency and severity of depressive symptoms, monoamines and their metabolite levels, MAO-B activities before and after treatment with antidepressants in a sub-set of Karachi population in Pakistan. Drug naive depressed subjects were evaluated before and after treatment with selective serotonin reuptake inhibitors. Symptoms of depressed mood and anxiety psychic (90%) were more frequent whereas, suicidal thoughts (~50%) and feelings of guilt (~30%) were less common...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29035934/dextrometorphan-paroxetine-but-not-dronabinol-effective-for-treatment-resistant-aggression-and-agitation-in-an-elderly-patient-with-lewy-body-dementia
#12
Robert Wilhelm, Björn Ahl, Ion-George Anghelescu
No abstract text is available yet for this article.
October 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#13
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29030165/hippocampal-mtor-signaling-is-required-for-the-antidepressant-effects-of-paroxetine
#14
Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui, Bo Jiang
Although thought as a selective serotonin reuptake inhibitor (SSRI), the antidepressant mechanisms of paroxetine remain unknown. Previous studies have shown the role of the mammalian target of rapamycin (mTOR) signaling in depression. In this study, we investigated whether the antidepressant effects of paroxetine require mTOR signaling. We first examined whether chronic paroxetine administration restores the effects of CUMS and CSDS on the mTOR signaling cascade in the hippocampus and prefrontal cortex. Then, the pharmacologcial inhibitors of mTOR signaling (LY294002, U0126 and rapamycin) were used to assay if the paroxetine-induced reversing effects in the CUMS and CSDS models were prevented by mTOR system blockade...
October 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29019422/pharmacotherapy-of-mood-disorders-and-psychosis-in-pre-and-post-natal-women
#15
Beth Smith, Steven L Dubovsky
Untreated mood and psychotic disorders can have substantial adverse impacts on the patient, the fetus and the family, while treatment can ameliorate such problems. To address concerns by clinicians about the risks of psychotropic medications, this review addresses the risk/benefit analysis of somatic therapies for psychiatric disorders during pregnancy and lactation. Areas covered: All available research was reviewed on the impact on pregnancy and breastfeeding of mood and psychotic disorders, and of antidepressants, mood stabilizers, antipsychotic drugs, and electroconvulsive therapy...
November 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29018367/treatment-of-comorbid-alcohol-dependence-and-anxiety-disorder-review-of-the-scientific-evidence-and-recommendations-for-treatment
#16
REVIEW
Carmen Gimeno, Marisa Luisa Dorado, Carlos Roncero, Nestor Szerman, Pablo Vega, Vicent Balanzá-Martínez, F Javier Alvarez
Patients with alcohol-use disorders (AUDs) have a high prevalence of anxiety disorders (AnxDs). "Co-occurring disorders" refers to the coexistence of an AUD and/or drug related disorders with another non-addictive psychiatric disorder. The aim of this study was to assess the effectiveness of psychopharmacological treatments and psychotherapy in patients with AUD and AnxD and to propose recommendations for the treatment of patients with comorbid AnxDs and AUDs. Randomized clinical trials, meta-analyses, and clinical guidelines were retrieved from PubMed, Embase, and Cochrane databases...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28987349/corrigendum-to-high-throughput-liquid-chromatography-tandem-mass-spectrometry-method-for-simultaneous-determination-of-fampridine-paroxetine-and-quinidine-in-rat-plasma-application-to-in%C3%A2-vivo-perfusion-study-j-food-drug-anal-24-2016-866-875
#17
https://www.readbyqxmd.com/read/28983622/novel-insights-into-the-effect-of-paroxetine-administration-in-pilocarpine%C3%A2-induced-chronic-epileptic-rats
#18
Wan-Hui Lin, Xiao-Feng Li, Ming-Xing Lin, Ying Zhou, Hua-Pin Huang
The aim of the present study was to investigate the role of paroxetine intervention in epilepsy, and its association with the expression of serotonin transporter (SERT) and hippocampal apoptosis. Thirty adult male Sprague Dawley rats were divided into control vehicle (n=6) and epileptic (n=24) groups. Status epilepticus (SE) was induced via systemic injection of pilocarpine, and seizure activity was monitored via video electroencephalogram. The epileptic group was then randomly divided into two groups; Four weeks following SE induction, paroxetine (5 mg/kg/day; SE + paroxetine group) or normal saline (SE group) was intraperitoneally injected for 4 weeks...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28968985/stress-inhibits-tryptophan-hydroxylase-expression-in-a-rat-model-of-depression
#19
Yi Chen, Haixia Xu, Mingyue Zhu, Kun Liu, Bo Lin, Ruxian Luo, Chuanbai Chen, Mengsen Li
Serotonin (5-hydroxytryptamine, 5-HT) dysfunction is associated with the pathophysiology of depression. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in 5-HT biosynthesis, is believed to have essential role in many mental disorders, including depression. In the present study, we generated a rat model of depression by exposing the animals to stress, and the rats were then treated with paroxetine. The results indicated that the concentration of 5-HT in the brain and liver tissues were significantly lower in the rat model of depression than in healthy or treated rats...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967737/asymmetric-cycloaddition-and-cyclization-reactions-catalyzed-by-chiral-n-n-dioxide-metal-complexes
#20
Xiaohua Liu, Haifeng Zheng, Yong Xia, Lili Lin, Xiaoming Feng
Catalytic asymmetric cycloadditions and cascade cyclizations are a major focus for the enantioselective construction of chiral carbo- and heterocycles. A number of chiral Lewis acids and organocatalysts have been designed for such reactions. The development of broadly applicable catalysts bearing novel chiral backbones to meet the demands of various applications is an ongoing challenge. Approximately 10 years ago, we introduced a group of conformationally flexible C2-symmetric N,N'-dioxide amide compounds, which represent a new class of privileged ligands...
October 2, 2017: Accounts of Chemical Research
keyword
keyword
74059
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"