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Lichen ruber

Friederike Jonas, Hanna Rolle, Regina Treudler, Wieland Kiess
No abstract text is available yet for this article.
March 2018: Klinische Pädiatrie
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
February 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Pilvi Maliniemi, Kirsi Laukkanen, Liisa Väkevä, Katja Dettmer, Tuomas Lipsanen, Leila Jeskanen, Alban Bessede, Peter J Oefner, Marshall E Kadin, Annamari Ranki
Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens from the total of 90 CTCL patients, including mycosis fungoides (MF, n = 37), lymphomatoid papulosis (LyP, n = 36), primary cutaneous anaplastic large cell lymphoma (pcALCL, n = 4), subcutaneous panniculitis-like T-cell lymphoma (SPTCL n = 13), and 10 patients with inflammatory lichen ruber planus (LRP), were analyzed by immunohistochemistry (IHC), immunofluorescence (IF), quantitative PCR, and/or liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
2017: Oncoimmunology
N Dikopoulos, E Zizer
Chronic hepatitis C infection may be associated with several features of autoimmunity (i. e., detection of different kinds of autoantibodies in the serum). Hepatitis C is also associated with different autoimmune diseases, such as autoimmune thyroiditis, lichen ruber planus, and membranous glomerulonephritis being the most relevant. There are very few cases of a coincidence of chronic hepatitis C with an autoimmune hepatitis, that is usually diagnosed by detection of specific autoantibodies and typical histological features...
August 2016: Zeitschrift Für Gastroenterologie
Martin Grimm, Sebastian Hoefert, Michael Krimmel, Thorsten Biegner, Oliver Feyen, Peter Teriete, Siegmar Reinert
INTRODUCTION: One of the common malignant tumors of the head and neck worldwide with generally unfavorable prognosis is squamous cell carcinoma (OSCC) of the oral cavity. Early detection of primary, secondary, or recurrent OSCC by liquid biopsy tools is much needed. CASE PRESENTATION: Twelve blood biomarkers were used for monitoring a case of OSCC suffering from precancerous oral lichen ruber planus mucosae (OLP). After curative R0 tumor resection of primary OSCC (buccal mucosa), elevated epitope detection in monocytes (EDIM)-Apo10, EDIM-transketolase-like-1 (TKTL1), squamous cell carcinoma antigen (SCC-Ag), total serum lactate dehydrogenase (LDH), and its anaerobic isoforms (LDH-4, LDH-5) decreased to normal levels...
September 2016: Oral and Maxillofacial Surgery
Minna E Kubin, Päivi M Hägg, Nina Kokkonen, Juha P Väyrynen, Kirsi-Maria Haapasaari, Jyri Moilanen, Matti Kallioinen, Tiina Hurskainen, Kaisa Tasanen
BACKGROUND: Glucocorticoids (GC) are the most commonly used anti-inflammatory drugs in dermatology. The actions of GCs are mediated by the glucocorticoid receptor (GR). Alternative splicing of GR mRNA gives rise to different isoforms, GRα and GRβ being the most important. GRβ antagonizes the activity of GRα and its up-regulation has been associated with glucocorticoid insensitivity in several non-cutaneous inflammatory diseases. METHODS: Using immunohistochemical stainings, we analyzed the expression of GRα and GRβ in lesional skin samples of patients with atopic dermatitis, lichen ruber planus, eczema nummulare and lichen simplex chronicus...
January 2016: European Journal of Dermatology: EJD
Xiaoying Wei, Katharina Fricker, Alexander H Enk, Eva N Hadaschik
BACKGROUND: Keratin 14 (K14) is an intermediate filament protein that is mainly expressed in the basal layer of healthy stratified epithelia. K14 has been identified as an autoantigen in the autoimmune-mediated skin disease of Scurfy mice and patients with the "immune dysregulation polyendocrinopathy, enteropathy, and X-linked" syndrome. OBJECTIVES: To examine whether K14 is a target protein in autoimmune skin diseases (ASD), we analyzed the expression pattern of K14 in lesional skin of patients with lichen ruber, cutaneous lupus erythematosus, dermatomyositis, graft-versus-host disease, psoriasis, and pemphigus vulgaris, and evaluated the reactivity of patient sera with recombinantly expressed and epidermis-derived K14...
June 2016: International Journal of Dermatology
D Wilsmann-Theis, J Wagenpfeil, D Holzinger, J Roth, S Koch, S Schnautz, T Bieber, J Wenzel
BACKGROUND: Psoriasis is a chronic skin disease with deregulation of proteins in the immune system. These proteins include members of the heterogeneous S100 family, which have been discussed as potential biomarkers for disease severity. OBJECTIVE: The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease. PATIENTS AND METHODS: S100A7, S100A8, S100A9 and S100A12 mRNA expression was determined in the skin of patients with psoriasis and controls (N = 341) by gene expression analyses...
July 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Martina Gatzka, Karin Scharffetter-Kochanek
Nach dem Konzept der T-Zellplastizität können periphere T-Zellen - sobald sie sich in eine spezifische T-Zell-Untergruppe differenziert haben - in Reaktion auf neue Umweltfaktoren oder veränderte Signale den Phänotyp einer anderen Helferzell-Untergruppe in Bezug auf Zytokinproduktion und regulatorische Funktionen annehmen. Die T-Zellplastizität - besonders die Umwandlung regulatorischer T-Zellen (Tregs) zu IL-17-produzierenden Entzündungszellen - wurde in jüngster Zeit bei verschiedenen T-Zell-vermittelten entzündlichen Erkrankungen wie rheumatoider Arthritis, Multipler Sklerose, entzündlichen Darmerkrankungen und Psoriasis als wichtiger Pathomechanismus, der an der Verschlimmerung von Entzündungssymptomen und der Chronifizierung der Krankheit beteiligt ist, beschrieben...
July 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Gian-Piero Ghisu, Daniel Fink
Vuval pathologies manifested by allodynia and burning sensations can be due to infection, inflammatory dermatoses or other causes. Infective as well as certain inflammatory diseases, e.g. drug eruptions, allergic eczemas, irritative dermatitis/vulvitis, Behcet's Syndrome and pemphigus/pemphigoid usually respond well to conservative treatment. The category of inflammatory diseases also contains pathologies that in certain circumstances do require a surgical intervention, e.g. Lichen ruber planus/Lichen sclerosus, Condyloma, scars, premalignant lesions (VIN, genital M...
June 17, 2015: Praxis
Pilvi Maliniemi, Michelle Vincendeau, Jens Mayer, Oliver Frank, Sonja Hahtola, Leena Karenko, Emilia Carlsson, Francois Mallet, Wolfgang Seifarth, Christine Leib-Mösch, Annamari Ranki
The pathomechanism of mycosis fungoides (MF), the most common type of primary cutaneous T-cell lymphomas (CTCLs) and a malignancy of non-recirculating, skin-resident T-cells, is unknown albeit underlying viral infections have been sought for. Human endogenous retroviruses (HERVs) are ancient retroviral sequences in the human genome and their transcription is often deregulated in cancers. We explored the transcriptional activity of HERV sequences in a total of 34 samples comprising MF and psoriasis skin lesions, as well as corresponding non-malignant skin using a retrovirus-specific microarray and quantitative RT-PCR...
2013: PloS One
Antonios G A Kolios, Ewerton Marques Maggio, Christoph Gubler, Antonio Cozzio, Reinhard Dummer, Lars E French, Alexander A Navarini
BACKGROUND: Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. OBJECTIVE: We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate and pimecrolimus, intramuscular triamcinolone acetonide); because of systemic side effects the patient did not tolerate systemic acitretin dosed up to 25 mg daily...
2013: Dermatology: International Journal for Clinical and Investigative Dermatology
H S Füessl, P Stiefelhagen
No abstract text is available yet for this article.
February 7, 2013: MMW Fortschritte der Medizin
Domenico Autieri, Antonio Luigi Pastore, Luigi Silvestri, Antonino Leto, Andrea Ripoli, Giovanni Palleschi, Natale Porta, Vincenzo Petrozza, Antonio Carbone
We present a case of retroperitoneal schwannoma incidentally diagnosed in a patient undergoing surgical drainage of a pelvic abscess as a complication of a prostatic biopsy. A 50-year-old male, suffering from lymphatic leukemia, came to our observation due to lichen ruber planus and ejaculatory pain. The patient underwent a trans-perineal ultrasound-guided biopsy of the right seminal vesicle and of a hypoechoic area documented by ultrasonography. 48 hours after the procedure, the patient had developed: cold sores, shortness of breath with dyspnea, and high fever (40°C)...
December 30, 2012: Urologia
A A Shakhnovich, L S Kruglova
The combination of narrow-band range UV-A (311 nm) and middle/broad-band UV-B (320-400 nm) irradiation was shown to significantly reduce manifestations of objective and subjective symptoms in the patients presenting with lichen ruber planus. Moreover, it promoted elimination ofdisbalance between characteristics of congenital immunity and normalization of HBD-2 and TLR-2 gene expression.
May 2011: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
J Sepić, S Ristić, O Perković, V Brinar, J Lipozencić, M Crnić-Martinović, N Starcević Cizmarević, D Janko Labinac, M Kapović, B Peterlin
Multiple sclerosis and lichen ruber planus are clinically and histologically distinct complex disorders of putative autoimmune aetiology that are fairly commonly observed in isolation but rarely found in combination. Only two previous reports have described lichen skin disorders in association with multiple sclerosis. The present report describes the case of a 51-year-old Caucasian woman exhibiting both familial multiple sclerosis and lichen ruber planus. This combination may have occurred by chance or it might imply that these disorders share common mechanisms in their pathogenesis...
September 2010: Journal of International Medical Research
C Goldnau, A Köninger, R Kimmig
Symptoms of diseases of the female external genitalia are often expressed in pruritus and burning pain. To accomplish a targeted differential diagnosis an exact knowledge of anatomy is essential. An accurate anamnesis, a detailed inspection, and conducting a biopsy or microbiological smear lead to the correct diagnosis. Lichen sclerosus et atrophicus is the most common non-neoplastic disease of the vulva. This should be distinguished from amongst others lichen ruber planus, psoriasis, contact dermatitis of the vulva, or infectious diseases like condylomata acuminata, herpes genitalis, or mycosis...
December 2010: Der Urologe. Ausg. A
No abstract text is available yet for this article.
January 1946: Acta Dermato-venereologica
No abstract text is available yet for this article.
October 1946: Archives of Dermatology and Syphilology
P B Mumford, H W Barber
No abstract text is available yet for this article.
April 1943: Proceedings of the Royal Society of Medicine
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