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Haksan Jeong, Woo-Ram Myung, Yong-Gue Sung, Kyung-Yeol Kim, Seung-Boo Jung
Microstructures and mechanical property of Sn-3.0Ag-0.5Cu (SAC305) and epoxy Sn-3.0Ag-0.5Cu (epoxy SAC) solder joints were investigated with various surface finishes; organic solderability preservative (OSP), electroless nickel immersion gold (ENIG) and electroless nickel electroless palladium immersion gold (ENEPIG). Bending property of solder joints was evaluated by 3-point bend test method. Microstructure and chemical composition of solder joints was characterized by scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDX), respectively...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Kyung-Yeol Kim, Woo-Ram Myung, Haksan Jeong, Yong-Gue Sung, Seung-Boo Jung
The ball-grid array (BGA) is widely used to reduce component size and it had advantages such as high I/O pins and fine pitch. Typical Sn-Ag-Cu (SAC) solder alloys are used for formation of BGA because SAC solder has excellent characteristics among lead-free solders. However, the electronic components assembled by SAC solder were easily damaged by heat during manufacture process because SAC solder had high melting point of 220 °C. To prevent these thermal damages, SAC305 BGA component assembled by Sn-58Bi solder paste has been studied because Sn-58Bi solder had low melting point of 139 °C...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Jérémie Prévost, Jonathan Richard, Halima Medjahed, Audrey Alexander, Jennifer Jones, John C Kappes, Christina Ochsenbauer, Andrés Finzi
HIV-1 infected cells expressing envelope glycoproteins (Env) in the CD4-bound conformation on their surface are targeted by antibody-dependent cellular cytotoxicity (ADCC) mediated by CD4-induced (CD4i) antibodies and HIV+ sera. By downregulating the surface expression of CD4, Nef prevents Env-CD4 interaction thus protecting HIV-1-infected cells from ADCC. HIV-1 infectious molecular clones (IMC) are widely used to measure ADCC. In order to facilitate the identification of infected cells and high-throughput ADCC analysis, reporter genes (e...
April 18, 2018: Journal of Virology
Yuan-Wei Chang, Chia-Chia Hu, Hsin-Ying Peng, Yu-Chun Liang, Chih Chen, Tao-Chih Chang, Chau-Jie Zhan, Jing-Ye Juang
Microbumps in three-dimensional integrated circuit now becomes essential technology to reach higher packaging density. However, the small volume of microbumps dramatically changes the characteristics from the flip-chip (FC) solder joints. For a 20 µm diameter microbump, the cross-section area and the volume are only 1/25 and 1/125 of a 100 µm diameter FC joint. The small area significantly enlarges the current density although the current crowding effect was reduced at the same time. The small volume of solder can be fully transformed into the intermetallic compounds (IMCs) very easily, and the IMCs are usually stronger under electromigration (EM)...
April 12, 2018: Scientific Reports
Gioacchini Giorgia, Ciani Elia, Pessina Andrea, Cecchini Cinzia, Silvi Stefania, Rodiles Ana, Merrifield L Daniel, Olivotto Ike, Carnevali Oliana
In the present study, Nile tilapia Oreochromis niloticus was used as experimental model to study the molecular effects of a new probiotic preparation, Lactogen 13 (Lactobacillus rhamnosus IMC 501® encapsulated with vegetable fat matrices by spray chilling and further indicated as probiotic microgranules), on growth and appetite during larval development. Probiotic microgranules were administered for 30 days to tilapia larvae starting from first feeding. Molecular analysis using high-throughput sequencing revealed that the probiotic could populate the gastrointestinal tract and modulate the microbial communities by significantly increasing the proportion of Lactobacillus as well as reducing the proportion of potential pathogens such as members of the Family Microbacteriaceae, Legionellaceae, and Weeksellaceae...
April 4, 2018: Microbial Ecology
Li-Yan Zhao, Jie Li, Xiong-Qing Huang, Guo-Hao Wang, Xiao-Fei Lv, Wei-Feng Meng, Wen-Liang Chen, Ji-Yan Pang, Yong-Cheng Lin, Hong-Shuo Sun, Guan-Lei Wang, Yao-Min Du
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central and peripheral arteries and plays an important role in blood pressure control. In this study, we examined whether Xyl-B exerted an antihypertensive effect in a hypertensive rat model, and further explored the possible mechanisms underlying its antihypertensive action...
March 29, 2018: Acta Pharmacologica Sinica
Gokoulakrichenane Loganadane, Zhen Xi, Hao Ping Xu, Noemie Grellier Adedjouma, Louis Bazire, Alain Fourquet, Youlia M Kirova
Purpose: To evaluate loco regional control and describe the patterns of loco regional failure in women with breast cancer irradiated by a previously described post-mastectomy highly conformal electron beam radiotherapy technique. Materials and methods: We included all women irradiated by PMERT for non-metastatic breast cancer (BC) between 2007 and 2011 in our department. All cases of bilateral BC were excluded. All patients who experienced loco regional recurrence have been studied...
June 2017: Clinical and Translational Radiation Oncology
Nailu Li, Anle Mu, Xiyun Yang, Kaman T Magar, Chao Liu
The optimal tuning of adaptive flap controller can improve adaptive flap control performance on uncertain operating environments, but the optimization process is usually time-consuming and it is difficult to design proper optimal tuning strategy for the flap control system (FCS). To solve this problem, a novel adaptive flap controller is designed based on a high-efficient differential evolution (DE) identification technique and composite adaptive internal model control (CAIMC) strategy. The optimal tuning can be easily obtained by DE identified inverse of the FCS via CAIMC structure...
March 22, 2018: ISA Transactions
Kevin M Gildea, Christy R Hileman, Paul Rogers, Guillermo J Salazar, Lawrence N Paskoff
BACKGROUND: Research indicates that first-generation antihistamine usage may impair pilot performance by increasing the likelihood of vestibular illusions, spatial disorientation, and/or cognitive impairment. Second- and third-generation antihistamines generally have fewer impairing side effects and are approved for pilot use. We hypothesized that toxicological findings positive for second- and third-generation antihistamines are less likely to be associated with pilots involved in fatal mishaps than first-generation antihistamines...
April 1, 2018: Aerospace Medicine and Human Performance
Hao Bai, Rong Zhu, Hao An, Guoya Zhou, Hui Huang, Hongqiang Ren, Yan Zhang
Although the properties of municipal wastewater sludge play key roles in the electro-osmosis dewatering process, it is still controversial which properties have the greatest effect on the dewatering performance. In this study, multiple regression models with Group Lasso method were used to investigate the relationship between the final moisture content (FMC) and the sludge properties, including pH, electrical conductivity (EC), volatile solids content (VS), zeta potential (ζ), initial moisture content (IMC), extracellular polymeric substances (EPS), proteins of EPS (EPSPr), polysaccharides of EPS (EPSPo) and the ratio of EPSPr and EPSPo (EPSR)...
March 20, 2018: Environmental Technology
Amirhossein Meisami, Jivan Deglise-Hawkinson, Mark E Cowen, Mark P Van Oyen
The decision of whether to admit a patient to a critical care unit is a crucial operational problem that has significant influence on both hospital performance and patient outcomes. Hospitals currently lack a methodology to selectively admit patients to these units in a way that patient health risk metrics can be incorporated while considering the congestion that will occur. The hospital is modeled as a complex loss queueing network with a stochastic model of how long risk-stratified patients spend time in particular units and how they transition between units...
March 13, 2018: Health Care Management Science
Priscila B Zanella, Camila C Àvila, Carolina G de Souza
OBJECTIVE: The objective of this study was to investigate the anthropometric and functional status in patients with pulmonary hypertension (PH) and its relationship with pulmonary circulation parameters and functional performance. METHODS: The study is cross-sectional with 34 subjects, who were evaluated in terms of anthropometric measurements, physical performance, pulmonary circulation, and regular physical activity. RESULTS: Subjects had a mean age of 47...
March 13, 2018: Journal of the American College of Nutrition
Tianqi Liu, Xin Peng, Ya-Nan Chen, Qing-Wen Bai, Cong Shang, Lin Zhang, Huiliang Wang
A novel type of polymeric material with tunable mechanical properties is fabricated from polymers and small molecules that can form hydrogen-bonded intermolecular complexes (IMCs). In this work, poly(vinyl alcohol) (PVA)-glycerol hydrogels are first prepared, and then they are dried to form IMCs. The tensile strengths and moduli of IMCs decrease dramatically with increasing glycerol content, while the elongations increase gradually. The mechanical properties are comparable with or even superior to those of common engineering plastics and rubbers...
March 13, 2018: Macromolecular Rapid Communications
Agnes-Laurence Chenine, Melanie Merbah, Lindsay Wieczorek, Sebastian Molnar, Brendan Mann, Jenica Lee, Anne Marie O'Sullivan, Meera Bose, Eric Sanders-Buell, Gustavo H Kijak, Carolina Herrera, Robert McLinden, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Jerome H Kim, Victoria R Polonis, Sodsai Tovanabutra
BACKGROUND: HIV-1 CRF01_AE is dominant in Thailand where RV144 vaccine trial was conducted. To study immune correlates of protection in ongoing trials, CRF01_AE derived reagents are essential. Here we present a panel of 14 HIV-1 infectious molecular clones (IMC) identified from different stages of infection, and characterization of their neutralization sensitivity using two standard assays. METHODS: One full-length IMC was constructed using a transmitted-founder virus to express Renilla luciferase (LucR) reporter gene and full-length envelopes (envs) of exogenous HIV-1...
March 8, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Prashanthi N Thota, Zubin Arora, John A Dumot, Gary Falk, Tanmayee Benjamin, John Goldblum, Sunguk Jang, Rocio Lopez, John J Vargo
BACKGROUND AND AIMS: Endoscopic ablation therapy has become the mainstay of treatment of Barrett's associated dysplasia and intramucosal cancer (IMC). The widely available techniques for ablation are radiofrequency ablation (RFA) and cryotherapy. Our aim was to compare eradication rates of metaplasia and dysplasia with both these modalities. PATIENTS AND METHODS: Retrospective review of prospectively collected database of patients who underwent endoscopic therapy for Barrett's dysplasia or IMC from 2006 to 2011 was performed...
May 2018: Digestive Diseases and Sciences
Anthony B El-Khoueiry, Robert O'Donnell, Thomas J Semrad, Philip Mack, Suzette Blanchard, Nathan Bahary, Yixing Jiang, Yun Yen, John Wright, Helen Chen, Heinz-Josef Lenz, David R Gandara
PURPOSE: The insulin-like growth factor (IGF) pathway is activated in hepatocarcinogenesis. Cixutumumab is a monoclonal antibody against human insulin-like growth factor-1 receptor (IGF-1R). Given the cross-talk between the IGF and VEGF pathways, we performed a phase I study of the combination of cixutumumab and sorafenib in hepatocellular cancer (HCC). METHODS: Eligible patients with no prior systemic therapy for advanced HCC and Child-Pugh A to B7 were treated with sorafenib 400 mg BID and escalating doses of cixutumumab (2, 4, or 6 mg/kg IV weekly) in a 3 + 3 design...
March 8, 2018: Cancer Chemotherapy and Pharmacology
Raef F A Hafez, Magad S Morgan, Osama M Fahmy, Hamdy T Hassan
OBJECTIVE: This study aims to report and confirm long-term effectiveness and safety of stereotactic Gamma Knife Surgery as a primary sole treatment in the management of 40 glomus jagulare tumors patients. PATIENTS AND METHODS: Retrospective analysis of clinical and radiological outcomes of 40 GJTs consecutive patients treated with GKS as primary sole treatment at International Medical Center (IMC), Cairo-Egypt from the beginning of 2005 till the end of 2014,with mean follow-up period of 84 months (range 36-156 months), mean tumor volume was 6...
February 26, 2018: Clinical Neurology and Neurosurgery
Inês Santos Ferreira, Judith Kikhney, Laura Kursawe, Stefanie Kasper, Lídia M D Gonçalves, Andrej Trampuz, Annette Moter, Ana Francisca Bettencourt, António J Almeida
Eradication of Gram-positive biofilms is a critical aspect in implant-associated infection treatment. Although antibiotic-containing particulate carriers may be a promising strategy for overcoming biofilm tolerance, the assessment of their interaction with biofilms has not been fully explored. In the present work, the antibiofilm activity of daptomycin- and vancomycin-loaded poly(methyl methacrylate) (PMMA) and PMMA-Eudragit RL 100 (EUD) microparticles against methicillin-resistant Staphylococcus aureus (MRSA) and polysaccharide intercellular adhesin-positive S...
February 27, 2018: AAPS PharmSciTech
A Ranger, A Dunlop, K Hutchinson, H Convery, M K Maclennan, H Chantler, N Twyman, C Rose, D McQuaid, R A Amos, C Griffin, N M deSouza, E Donovan, E Harris, C E Coles, A Kirby
AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be minimised. This dosimetry study compared the ability of three-dimensional conformal radiotherapy, arc therapy and proton beam therapy (PBT) techniques with and without breath-hold to achieve target volume constraints while minimising dose to organs at risk (OARs). MATERIALS AND METHODS: In 14 patients' datasets, seven IMC radiotherapy techniques were compared: wide tangent (WT) three-dimensional conformal radiotherapy, volumetric-modulated arc therapy (VMAT) and PBT, each in voluntary deep inspiratory breath-hold (vDIBH) and free breathing (FB), and tomotherapy in FB only...
February 23, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
De-Ming Rao, Shi-Tong Zhang, Chang-Ming Li, Yu-Di Chen, Min Pu, Hong Yan, Min Wei
Intermetallic compounds (IMCs) have shown excellent catalytic performance toward the selective hydrogenation of acetylene, but the theoretical understanding on this reaction over Ni-based IMCs is rather limited. In this work, the adsorptions of the C2 species, Bader charge, projected density of states (PDOS) and the reaction pathways were calculated by the density functional theory (DFT) method to investigate the mechanism and selectivity for the acetylene hydrogenation on the (111) surface of Nin Ga (n = 1, 3) IMCs, with a comparative study on the pristine Ni(111) surface...
February 26, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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