keyword
MENU ▼
Read by QxMD icon Read
search

Imc

keyword
https://www.readbyqxmd.com/read/29220097/invasive-mucinous-carcinoma-of-the-breast-and-response-patterns-after-neoadjuvant-chemotherapy-nac
#1
Susan Fineberg, Rosemarie Didonato, Nella Shapiro, Tova Koenigsberg, Timothy D'Alfonso, Shabnam Jaffer
AIMS: Neoadjuvant chemotherapy (NAC) is often used to treat localized invasive breast cancer. Invasive mucinous carcinoma (IMC) is considered to be an indolent form of invasive breast cancer and is rarely treated with NAC. We report the largest series of IMC treated with NAC, and report a characteristic, but not well recognized, pattern of pathologic response. METHODS AND RESULTS: Our series included 7 patients with IMC treated with NAC. Three patients presented with locally advanced disease, three patients had tumors that were Her/2Neu positive, and four patients had tumors with admixed mucinous and micropapillary features...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29200911/dual-control-of-the-vestibulosympathetic-reflex-following-hypotension-in-rats
#2
Sang Eon Park, Yuan-Zhe Jin, Byung Rim Park
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29197758/uv-filters-and-musk-fragrances-in-seafood-commercialized-in-europe-union-occurrence-risk-and-exposure-assessment
#3
S C Cunha, L Trabalón, S Jacobs, M Castro, M Fernandez-Tejedor, K Granby, W Verbeke, C Kwadijk, F Ferrari, J Robbens, I Sioen, E Pocurull, A Marques, J O Fernandes, J L Domingo
In the framework of the FP7 ECsafeSeafood project, 62 seafood samples commercialized in Europe Union from several representative species - mackerel, tuna, salmon, seabream, cod, monkfish, crab, shrimp, octopus, perch and plaice - were analysed for residues of 21 personal care products (PCPs), including 11 UV-filters (UV-Fs) and 10 musk fragrances (musks). PCPs analysis were performed by Quick, Easy, Cheap, Effective Rugged, Safe (QuEChERS), combined with liquid-liquid extraction (LLE) or dispersive solid-phase extraction (dSPE), followed by gas chromatography-tandem mass spectrometry (GC-MS/MS)...
November 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/29191969/olaratumab-exerts-anti-tumor-activity-in-preclinical-models-of-pediatric-bone-and-soft-tissue-tumors-through-inhibition-of-platelet-derived-growth-factor-receptor-alpha
#4
Caitlin D Lowery, Wayne Blosser, Michele Dowless, Shelby Knoche, Jennifer Stephens, Huiling Li, David Surguladze, Nick Loizos, Debra Luffer-Atlas, Gerard Joseph Oakley, Qianxu Guo, Seema Iyer, Brian P Rubin, Louis F Stancato
PURPOSE: Platelet-derived growth factor receptor alpha (PDGFRα) is implicated in several adult and pediatric malignancies, where activated signaling in tumor cells and/or cells within the microenvironment drive tumorigenesis and disease progression. Olaratumab (LY3012207/IMC-3G3) is a human monoclonal antibody that exclusively binds to PDGFRα and recently received accelerated FDA approval and conditional EMA approval for treatment of advanced adult sarcoma patients in combination with doxorubicin...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29168726/nutrient-modeling-for-a-semi-intensive-imc-pond-an-ms-excel-approach
#5
Lala I P Ray, B C Mal, S Moulick
Semi-intensive Indian Major Carp (IMC) culture was practised in polythene lined dugout ponds at the Aquacultural Farm of Indian Institute of Technology, Kharagpur, West Bengal for 3 consecutive years at three different stocking densities (S.D), viz., 20,000, 35,000 and 50,000 numbers of fingerlings per hectare of water spread area. Fingerlings of Catla, Rohu and Mrigal were raised at a stocking ratio of 4:3:3. Total ammonia nitrogen (TAN) value along with other fishpond water quality parameters was monitored at 1 day intervals to ensure a good water ecosystem for a better fish growth...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29167705/comparative-analysis-of-impacted-upper-canines-panoramic-radiograph-vs-cone-beam-computed-tomography
#6
Catarina-Luís-Vicente-Rodrigues Pico, Francisco-José-Fernandes do Vale, Francisco-José-Santiago-Fernandes-Amado Caramelo, Ana Corte-Real, Sónia-Margarida-Alves Pereira
Background: The use of CBCT exam in the study of IMC is not new. However, it's still not known in what specific aspects CBCT exam shows a better result than then conventional exams. The aim of this study was to compare and conclude in what way the opinion regarding upper canine impaction differed when observing a panoramic image compared to the observation of a set of CBCT reconstructions. Material and Methods: Twenty patients (10 males and 10 females) with a total of 28 impacted maxillary canines were identified from the database of the Department of Dentistry, Faculty of Medicine, University of Coimbra...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29157658/continuous-ambulatory-hand-force-monitoring-during-manual-materials-handling-using-instrumented-force-shoes-and-an-inertial-motion-capture-suit
#7
G S Faber, A S Koopman, I Kingma, C C Chang, J T Dennerlein, J H van Dieën
Hand forces (HFs) are commonly measured during biomechanical assessment of manual materials handling; however, it is often a challenge to directly measure HFs in field studies. Therefore, in a previous study we proposed a HF estimation method based on ground reaction forces (GRFs) and body segment accelerations and tested it with laboratory equipment: GFRs were measured with force plates (FPs) and segment accelerations were measured using optical motion capture (OMC). In the current study, we evaluated the HF estimation method based on an ambulatory measurement system, consisting of inertial motion capture (IMC) and instrumented force shoes (FSs)...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29150518/molecular-characterization-of-an-endozoicomonas-like-organism-causing-infection-in-king-scallop-pecten-maximus-l
#8
Irene Cano, Ronny van Aerle, Stuart Ross, David W Verner-Jeffreys, Richard K Paley, Georgina Rimmer, David Ryder, Patrick Hooper, David Stone, Stephen W Feist
One of the fastest growing fisheries in the UK is the king scallop Pecten maximus L., also currently rated as the second most valuable. Mass mortality events in scallops have been reported world-wide, often with the causative agent(s) remaining uncharacterized. In May 2013 and 2014, two mass mortality events affecting king scallops were recorded in the Lyme Bay Marine Protected Area (MPA), in South West England. Histopathological examination showed gill epithelial tissues infected with intracellular microcolonies of bacteria (IMC), resembling rickettsia-like organisms (RLOs), often with bacteria released in vascular spaces...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29138437/photosensitized-ina-labelled-protein-1-phil1-is-novel-component-of-the-inner-membrane-complex-and-is-required-for-plasmodium-parasite-development
#9
Ekta Saini, Mohammad Zeeshan, Declan Brady, Rajan Pandey, Gesine Kaiser, Ludek Koreny, Pradeep Kumar, Vandana Thakur, Shreyansh Tatiya, Nicholas J Katris, Rebecca Stanway Limenitakis, Inderjeet Kaur, Judith L Green, Andrew R Bottrill, David S Guttery, Ross F Waller, Volker Heussler, Anthony A Holder, Asif Mohmmed, Pawan Malhotra, Rita Tewari
Plasmodium parasites, the causative agents of malaria, possess a distinctive membranous structure of flattened alveolar vesicles supported by a proteinaceous network, and referred to as the inner membrane complex (IMC). The IMC has a role in actomyosin-mediated motility and host cell invasion. Here, we examine the location, protein interactome and function of PhIL1, an IMC-associated protein on the motile and invasive stages of both human and rodent parasites. We show that PhIL1 is located in the IMC in all three invasive (merozoite, ookinete-, and sporozoite) stages of development, as well as in the male gametocyte and locates both at the apical and basal ends of ookinete and sporozoite stages...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125764/selective-acceleration-of-crystal-growth-of-indomethacin-polymorphs-by-low-concentration-poly-ethylene-oxide
#10
Qin Shi, Jie Zhang, Chen Zhang, Jing Jiang, Jun Tao, Dongshan Zhou, Ting Cai
Physical stability of pharmaceutical amorphous solid dispersions is one of the critical attributes to the successful development of the formulation. Herein, we studied the impact of low-concentration poly(ethylene oxide) (PEO) on the crystallization rates of three polymorphs of indomethacin (IMC, γ-, α-, and δ-form). We observed that the addition of 3% w/w PEO significantly increased the crystal growth rates of γ-form and α-form of IMC, but had a negligible effect on the δ-form. The reduction of the activation energy for the crystal growth of IMC polymorphs after adding the PEO follows the order γ-form > α-form > δ-form, which is consistent with the trend toward the accelerating effects of PEO on the crystal growth rates of three polymorphs...
November 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29123495/likability-s-effect-on-interpersonal-motor-coordination-exploring-natural-gaze-direction
#11
Zhong Zhao, Robin N Salesse, Ludovic Marin, Mathieu Gueugnon, Benoît G Bardy
Although existing studies indicate a positive effect of interpersonal motor coordination (IMC) on likability, no consensus has been reached as for the effect of likability back onto IMC. The present study specifically investigated the causal effect of likability on IMC and explored, by tracking the natural gaze direction, the possible underlying mechanisms. Twenty-two participants were engaged in an interpersonal finger-tapping task with a confederate in three likability conditions (baseline, likable, and unlikable), while wearing an eye tracker...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29111765/nanostructures-and-dynamics-of-isochorically-confined-amorphous-drug-mediated-by-cooling-rate-interfacial-and-intermolecular-interactions
#12
Chen Zhang, Ye Sha, Yue Zhang, Ting Cai, Linling Li, Dongshan Zhou, Xiaoliang Wang, Gi Xue
The production and stabilization of amorphous drugs by the nanoconfinement effect has recently become a research hotspot in pharmaceutical sciences. Herein, two guest/host systems, indomethacin (IMC) and griseofulvin (GSF) confined in anodic aluminum oxide (AAO) templates with different pore diameters (25-250 nm) are investigated by differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS). The crystallization of the confined drugs is suppressed, and their glass transition temperatures show an evident pore-size dependency...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29094998/-nutritional-and-functional-state-of-patients-with-chronic-obstructive-pulmonary-disease-effects-of-oral-nutritional-supplementation-ofos-study
#13
Maria Del Pilar Benito Martínez, Jorge Estanislao La Serna Infantes, Marta Guarro Riba, Mireia Morera Inglès, Diego Marco Camere Colarossi, Marco Antonio Camere Torrealva
INTRODUCTION: Weight loss and malnutrition are associated with a worse prognosis of chronic obstructive pulmonary disease (COPD). OBJECTIVE: The main objective of the OFOS study was to assess the efficacy and tolerability of a new nutritional oral formula in adults with COPD with weight loss or malnutrition. METHODS: Prospective, single-centre, randomized, open-label and controlled trial conducted in Lima (Peru). A total of 99 outpatients of both sexes were included (control [GC]: 49; supplement [GS]: 50), aged from 18 to 80 years old, who had been diagnosed with COPD and that suffered from malnutrition or involuntary weight loss during the last months...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29065705/effects-of-a-probiotic-slab51%C3%A2-on-clinical-and-histologic-variables-and-microbiota-of-cats-with-chronic-constipation-megacolon-a-pilot-study
#14
G Rossi, A Jergens, M Cerquetella, S Berardi, E Di Cicco, G Bassotti, G Pengo, J S Suchodolski
Chronic constipation (CC) and idiopathic megacolon (IMC) occur frequently in cats. The aim of the study was to investigate the effects of a multi-strain probiotic (SLAB51™) in constipated cats (n=7) and in patients with megacolon and constipation (n=3). Ten pet cats with a diagnosis of chronic constipation, non-responsive to medical management received orally 2×10(11) bacteria daily for 90 days. For microbiota analysis, selected bacterial groups were analysed by qPCR. Histological samples in megacolons were evaluated for interstitial cells of Cajal (ICC), enteric neurons, and neuronal apoptosis...
October 25, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29062899/differential-roles-for-inner-membrane-complex-proteins-across-toxoplasma-gondii-and-sarcocystis-neurona-development
#15
Rashmi Dubey, Brooke Harrison, Sriveny Dangoudoubiyam, Giulia Bandini, Katherine Cheng, Aziz Kosber, Carolina Agop-Nersesian, Daniel K Howe, John Samuelson, David J P Ferguson, Marc-Jan Gubbels
The inner membrane complex (IMC) of apicomplexan parasites contains a network of intermediate filament-like proteins. The 14 alveolin domain-containing IMC proteins in Toxoplasma gondii fall into different groups defined by their distinct spatiotemporal dynamics during the internal budding process of tachyzoites. Here, we analyzed representatives of different IMC protein groups across all stages of the Toxoplasma life cycle and during Sarcocystis neurona asexual development. We found that across asexually dividing Toxoplasma stages, IMC7 is present exclusively in the mother's cytoskeleton, whereas IMC1 and IMC3 are both present in mother and daughter cytoskeletons (IMC3 is strongly enriched in daughter buds)...
September 2017: MSphere
https://www.readbyqxmd.com/read/29057024/intermetallic-compounds-in-3d-integrated-circuits-technology-a-brief-review
#16
REVIEW
Syahira Annuar, Reza Mahmoodian, Mohd Hamdi, King-Ning Tu
The high performance and downsizing technology of three-dimensional integrated circuits (3D-ICs) for mobile consumer electronic products have gained much attention in the microelectronics industry. This has been driven by the utilization of chip stacking by through-Si-via and solder microbumps. Pb-free solder microbumps are intended to replace conventional Pb-containing solder joints due to the rising awareness of environmental preservation. The use of low-volume solder microbumps has led to crucial constraints that cause several reliability issues, including excessive intermetallic compounds (IMCs) formation and solder microbump embrittlement due to IMCs growth...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/29054609/estimating-the-l5s1-flexion-extension-moment-in-symmetrical-lifting-using-a-simplified-ambulatory-measurement-system
#17
Axel S Koopman, Idsart Kingma, Gert S Faber, Jonas Bornmann, Jaap H van Dieën
Mechanical loading of the spine has been shown to be an important risk factor for the development of low-back pain. Inertial motion capture (IMC) systems might allow measuring lumbar moments in realistic working conditions, and thus support evaluation of measures to reduce mechanical loading. As the number of sensors limits applicability, the objective of this study was to investigate the effect of the number of sensors on estimates of L5S1 moments. Hand forces, ground reaction forces (GRF) and full-body kinematics were measured using a gold standard (GS) laboratory setup...
October 12, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29037225/yap-transcriptionally-regulates-cox-2-expression-and-gccsysm-4-g-4-a-dual-yap-cox-2-inhibitor-overcomes-drug-resistance-in-colorectal-cancer
#18
Wei Li, Yuanyuan Cao, Jinling Xu, Ying Wang, Weijie Li, Qian Wang, Ziwei Hu, Yaping Hao, Li Hu, Yawen Sun, Guanglin Xu, Guizhen Ao
BACKGROUND: Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations identifying new modulators of COX-2 pathway and searching for new chemicals targeting these valid resistant biomarkers are still greatly needed. METHODS: HCT15, HCT-116, HT-29, COLO205, FHC, IMCE, SW480 cell lines were used to detect the expression of YAP and COX-2...
October 16, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29023506/exopolysaccharides-regulate-calcium-flow-in-cariogenic-biofilms
#19
Monika Astasov-Frauenhoffer, Muth M Varenganayil, Alan W Decho, Tuomas Waltimo, Olivier Braissant
Caries-associated biofilms induce loss of calcium from tooth surfaces in the presence of dietary carbohydrates. Exopolysaccharides (EPS) provide a matrix scaffold and an abundance of primary binding sites within biofilms. The role of EPS in binding calcium in cariogenic biofilms is only partially understood. Thus, the aim of the present study is to investigate the relationship between the calcium dissolution rates and calcium tolerance of caries-associated bacteria and yeast as well as to examine the properties of EPS to quantify its binding affinity for dissolved calcium...
2017: PloS One
https://www.readbyqxmd.com/read/29022389/the-composition-and-metabolism-of-faecal-microbiota-is-specifically-modulated-by-different-dietary-polysaccharides-and-mucin-an-isothermal-microcalorimetry-study
#20
K Adamberg, K Kolk, M Jaagura, R Vilu, S Adamberg
The metabolic activity of colon microbiota is specifically affected by fibres with various monomer compositions, degree of polymerisation and branching. The supply of a variety of dietary fibres assures the diversity of gut microbial communities considered important for the well-being of the host. The aim of this study was to compare the impact of different oligo- and polysaccharides (galacto- and fructooligosaccharides, resistant starch, levan, inulin, arabinogalactan, xylan, pectin and chitin), and a glycoprotein mucin on the growth and metabolism of faecal microbiota in vitro by using isothermal microcalorimetry (IMC)...
October 12, 2017: Beneficial Microbes
keyword
keyword
74056
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"