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https://www.readbyqxmd.com/read/29468422/molecular-profiling-and-comprehensive-genome-wide-analysis-of-somatic-copy-number-alterations-in-gastric-intramucosal-neoplasias-based-on-microsatellite-status
#1
Tamotsu Sugai, Makoto Eizuka, Noriyuki Arakawa, Mitsumasa Osakabe, Wataru Habano, Yasuko Fujita, Eiichiro Yamamoto, Hiroo Yamano, Masaki Endoh, Takayuki Matsumoto, Hiromu Suzuki
BACKGROUND: We attempted to identify the molecular profiles of gastric intramucosal neoplasia (IMN; low-grade dysplasia, LGD; high-grade dysplasia, HGD; intramucosal cancer, IMC) by assessing somatic copy number alterations (SCNAs) stratified by microsatellite status (microsatellite stable, MSS; microsatellite instable, MSI). Thus, microsatellite status was determined in 84 tumors with MSS status and 16 tumors with MSI status. METHODS: One hundred differentiated type IMNs were examined using SCNAs...
February 21, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29464409/solid-state-nmr-investigation-of-drug-excipient-interactions-and-phase-behavior-in-indomethacin-eudragit-e-amorphous-solid-dispersions
#2
Joseph W Lubach, Jonathan Hau
PURPOSE: To investigate the nature of drug-excipient interactions between indomethacin (IMC) and methacrylate copolymer Eudragit® E (EE) in the amorphous state, and evaluate the effects on formulation and stability of these amorphous systems. METHODS: Amorphous solid dispersions containing IMC and EE were spray dried with drug loadings from 20% to 90%. PXRD was used to confirm the amorphous nature of the dispersions, and DSC was used to measure glass transition temperatures (Tg )...
February 20, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29458591/asymmetric-low-temperature-bonding-structure-with-thin-solder-layers-using-ultra-thin-buffer-layer
#3
Ting-Yang Yu, Hao-Wen Liang, Yao-Jen Chang, Kuan-Neng Chen
Asymmetric Cu to In/Sn bonding structure with Ni ultrathin buffer layer (UBL) on Cu side is investigated in this research. The usage of Ni UBL slows down intermetallic compound (IMC) formation during bonding. Asymmetric structure can separate electrical isolation and solder process to avoid interaction, which can prevent IMC formation during polymer curing. A well-bonded asymmetric structure can be achieved with submicron solder by 150 °C bonding for 15 min. The structure shows the potential for low temperature hybrid bonding technology in high-density three-dimensional (3D) integration...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29458583/nanostructured-layered-terbium-hydroxide-containing-nasids-in-vitro-physicochemical-and-biological-evaluations
#4
Qing-Yang Gu, Xiao Qiu, Jing-Jing Liu, Min Fu, Jian-Ping Chao, Rui-Jun Ju, Xue-Tao Li
Diclofenac sodium (abrr. DS) and indomethacin (abrr. IMC) have been intercalated into the layered terbium hydroxide (LTbH) by anion exchange method. Chemical compositions, thermostability, morphology, luminescence property, release behaviors and cytotoxic effects have been investigated. The DS molecules may embed between layers with a bilayered arrangement and the IMC may correspond to a monolayered arrangement. The Tb3+ luminescence in DS-LTbH and IMC-LTbH composites were enhanced compared with LTbH precusor and the luminescence intensity increases with the deprotonation degree...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29452867/deep-inspiration-breath-hold-level-variability-and-deformation-in-locoregional-breast-irradiation
#5
Leigh Conroy, Sarah Quirk, Elizabeth Watt, Gillian Ecclestone, Jessica L Conway, Ivo A Olivotto, Tien Phan, Wendy L Smith
PURPOSE: The purpose of this study was to evaluate the dosimetric effect of breath hold level variability and deformation on breast, chest wall, internal mammary chain (IMC) nodes, and heart. METHODS AND MATERIALS: Left-sided post-lumpectomy (n = 12) and postmastectomy (n = 3) patients underwent deep inspiration breath hold (DIBH) and exhale breath hold (EBH) computed tomography (CT) scans. Forward-planned locoregional breast plans were created on the DIBH scan...
February 13, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29452285/risk-factors-for-perioperative-morbidity-in-spine-surgeries-of-different-complexities-a-multivariate-analysis-of-1009-consecutive-patients
#6
M Farshad, D E Bauer, C Wechsler, C Gerber, A Aichmair
BACKGROUND CONTEXT: There is a broad spectrum of complications during or after surgical procedures, with differing incidences reported in the published literature. Heterogeneity can be explained by the lack of an established evidence-based classification system for documentation and classification of complications in a standardized manner. PURPOSE: To identify predictive risk factors for peri- and early post-operative morbidities in spine surgeries of different complexities in a large cohort of consecutive patients...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29451286/addressing-the-temperature-transferability-of-structure-based-coarse-graining-models
#7
David Rosenberger, Nico F A van der Vegt
Systematically derived coarse grained (CG) models for molecular liquids do not inherently guarantee transferability to a state point different from its reference, especially when derived on the basis of structure based CG methods like Inverse Monte Carlo (IMC). Several efforts made in the past years to improve the transferability of these models focused on including thermodynamic constraints or on the application of multistate parametrization. Das and Andersen (DA) [Das et al., J. Chem. Phys., 2010, 132, 164106...
February 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29448730/effects-of-fragmented-fe-intermetallic-compounds-on-ductility-in-al-si-mg-alloys
#8
JaeHwang Kim, DaeHwan Kim
Fe is intentionally added in order to form the Fe intermetallic compounds (Fe-IMCs) during casting. Field emission scanning electron microscope with energy dispersive spectrometer (EDS) was conducted to understand microstructural changes and chemical composition analyses. The needlelike Fe-IMCs based on two dimensional observation with hundreds of micro size are modified to fragmented particles with the minimum size of 300 nm through clod rolling with 80% thickness reduction. The ratio of Fe:Si on the fragmented Fe-IMCs after 80% reduction is close to 1:1, representing the β-Al5FeSi...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448192/impact-of-enzymatic-hydrolysis-on-the-quantification-of-total-urinary-concentrations-of-chemical-biomarkers
#9
Prabha Dwivedi, Xiaoliu Zhou, Tolar G Powell, Antonia M Calafat, Xiaoyun Ye
Human exposure to consumer and personal care products chemicals such as phenols, including parabens and other antimicrobial agents, can be assessed through biomonitoring by quantifying urinary concentrations of the parent chemical or its metabolites, often after hydrolysis of phase II conjugates. Developing suitable analytical methods for the concurrent quantification of multiple exposure biomarkers is challenging because optimal conditions for the hydrolysis of such conjugates (e.g., O-glucuronides, N-glucuronides, sulfates) may differ depending on the biomarker...
February 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29429685/homogeneous-cu-ni-6sn5-intermetallic-compound-joints-rapidly-formed-in-asymmetrical-ni-sn-cu-system-using-ultrasound-induced-transient-liquid-phase-soldering-process
#10
Z L Li, H J Dong, X G Song, H Y Zhao, H Tian, J H Liu, J C Feng, J C Yan
Homogeneous (Cu, Ni)6Sn5 intermetallic compound (IMC) joints were rapidly formed in asymmetrical Ni/Sn/Cu system by an ultrasound-induced transient liquid phase (TLP) soldering process. In the traditional TLP soldering process, the intermetallic joints formed in Ni/Sn/Cu system consisted of major (Cu, Ni)6Sn5 and minor Cu3Sn IMCs, and the grain morphology of (Cu, Ni)6Sn5 IMCs subsequently exhibited fine rounded, needlelike and coarse rounded shapes from the Ni side to the Cu side, which was highly in accordance with the Ni concentration gradient across the joints...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29412381/obese-with-higher-fndc5-irisin-levels-have-a-better-metabolic-profile-lower-lipopolysaccharide-levels-and-type-2-diabetes-risk
#11
Ivan Luiz Padilha Bonfante, Mara Patricia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Alexandre Gabarra Oliveira, Tiago Gomes Araujo, Mario Jose Abdalla Saad, Cláudia Regina Cavaglieri
OBJECTIVE: Thus, the aim of this study was to compare if higher or smaller fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are associated with inflammatory and metabolic markers, caloric/macronutrient intake, physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged men, and also to correlate all variables analyzed with FNDC5/irisin. SUBJECTS AND METHODS: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 ± 1...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29380074/surface-enrichment-and-depletion-of-the-active-ingredient-in-spray-dried-amorphous-solid-dispersions
#12
Zhen Chen, Kuan Yang, Chengbin Huang, Alan Zhu, Lian Yu, Feng Qian
PURPOSE: To study the effects of physicochemical properties of drug and polymer, as well as the drug-polymer interactions, on the surface composition of SDDs. METHODS: Ethanol solutions containing a model drug (IMC, NMP or FCZ) and a model polymer (PVPK12, PVPK30 or PVP-VA) were spray dried, and the surface composition of SDDs was analyzed by XPS. The surface tensions of pure components and their solutions were measured using Wilhelmy plate and/or calculated using ACD/Labs...
January 29, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29373737/il-1%C3%AE-promotes-pathogenic-immature-myeloid-cells-and-il-1%C3%AE-favors-protective-mature-myeloid-cells-during-acute-lung-infection
#13
Sivakumar Periasamy, Jonathan A Harton
Bacterial pneumonia is a common risk factor for acute lung injury and sepsis-mediated death, but the mechanisms underlying the overt inflammation and accompanying pathology are unclear. Infiltration of immature myeloid cells (IMC) and necrotizing inflammation mediate severe pathology and death during pulmonary infection with Francisella tularensis. However, eliciting mature myeloid cells provides protection. Yet, the host factors responsible for this pathologic IMC response are unknown. Here, we report that while the influx of both mature and immature is strictly MyD88-dependent, the IL-1R receptor mediates an important dual function via its ligands IL-1α and IL-1β...
January 24, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29345852/cadmium-and-cadmium-tolerant-soil-bacteria-in-cacao-crops-from-northeastern-colombia
#14
Daniel Bravo, Sergio Pardo-Díaz, Javier Benavides-Erazo, Gersain Rengifo-Estrada, Olivier Braissant, Clara Leon-Moreno
AIMS: This research aims to assess total-cadmium soil content and microbiological aspects to understand the dynamics of culturable cadmium-tolerant bacteria (CdtB) in cacao soils from northeastern Colombia. METHODS AND RESULTS: An integration of inverted dish plating, Cd determination and a microcalorimetry assay (IMC) was carried out. A farm in Boyacá showed the highest level of total soil Cd (3.74 mg kg-1 ) followed by farms in Santander and Arauca (2.76 and 1...
January 18, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29330624/functional-transcriptomic-annotation-and-protein-protein-interaction-network-analysis-identify-nek2-birc5-and-top2a-as-potential-targets-in-obese-patients-with-luminal-a-breast-cancer
#15
Miriam Nuncia-Cantarero, Sandra Martinez-Canales, Fernando Andrés-Pretel, Gabriel Santpere, Alberto Ocaña, Eva Maria Galan-Moya
PURPOSE: Although obesity is a risk factor for breast cancer, little effort has been made in the identification of druggable molecular alterations in obese-breast cancer patients. Tumors are controlled by their surrounding microenvironment, in which the adipose tissue is a main component. In this work, we intended to describe molecular alterations at a transcriptomic and protein-protein interaction (PPI) level between obese and non-obese patients. METHODS AND RESULTS: Gene expression data of 269 primary breast tumors were compared between normal-weight (BMI < 25, n = 130) and obese (IMC > 30, n = 139) patients...
January 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29316625/interfacial-reaction-and-imc-growth-of-an-ultrasonically-soldered-cu-sac305-cu-structure-during-isothermal-aging
#16
Yulong Li, Weifeng Long, Xiaowu Hu, Yanshu Fu
In order to accelerate the growth of interfacial intermetallic compound (IMC) layers in a soldering structure, Cu/SAC305/Cu was first ultrasonically spot soldered and then subjected to isothermal aging. Relatively short vibration times, i.e., 400 ms and 800 ms, were used for the ultrasonic soldering. The isothermal aging was conducted at 150 °C for 0, 120, 240, and 360 h. The evolution of microstructure, the IMC layer growth mechanism during aging, and the shear strength of the joints after aging were systemically investigated...
January 6, 2018: Materials
https://www.readbyqxmd.com/read/29305664/effect-of-formulation-and-process-parameters-on-the-disproportionation-of-indomethacin-sodium-in-buffered-lyophilized-formulations
#17
Sampada Koranne, Seema Thakral, Raj Suryanarayanan
PURPOSE: (i) To investigate buffer salt crystallization and the consequent pH shifts during the freezing stage of the lyophilization of indomethacin sodium (IMCNa) in aqueous sodium phosphate buffer. (ii) To determine the effect of pH shift on the disproportionation of IMCNa in lyophilized formulations. METHODS: Prelyophilization solutions containing IMCNa in sodium phosphate buffer, at initial buffer concentrations ranging from 10 to 100 mM (pH 7.0), and at IMCNa concentrations of 5, 10 & 15 mg/ml, were investigated...
January 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29297358/stable-solution-to-l-2-1-based-robust-inductive-matrix-completion-and-its-application-in-linking-long-noncoding-rnas-to-human-diseases
#18
Ashis Kumer Biswas, Dongchul Kim, Mingon Kang, Chris Ding, Jean X Gao
BACKGROUNDS: A large number of long intergenic non-coding RNAs (lincRNAs) are linked to a broad spectrum of human diseases. The disease association with many other lincRNAs still remain as puzzle. Validation of such links between the two entities through biological experiments are expensive. However, a plethora lincRNA-data are available now, thanks to the High Throughput Sequencing (HTS) platforms, Genome Wide Association Studies (GWAS), etc, which opens the opportunity for cutting-edge machine learning and data mining approaches to extract meaningful relationships among lincRNAs and diseases...
December 28, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29285338/treatment-of-maxillary-retained-canine-with-implants-new-perspectives
#19
E El Haddad, R Calcaterra, G El Haddad, V Candotto, D Lauritano
Purpose: The surgical-orthodontic treatment of impacted maxillary canine (IMC) remains a challenge to today's clinicians. The aim of the present paper is to describe an unconventional treatment of IMC with insertion of implant into the retained canine and 3 years follow-up. Case report: A 55-year-old female patient attended to rehabilitate her maxillary left canine site. An unconventional approach was proposed to the patient. A large diameter tapered implant (Ø 5 × 18 mm) was inserted (Nobel Active, Kolten, Swisse)...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29246438/nano-scale-and-molecular-level-understanding-of-wet-milled-indomethacin-poloxamer-407-nanosuspension-with-tem-suspended-state-nmr-and-raman-measurements
#20
Yosuke Kuroiwa, Kenjirou Higashi, Keisuke Ueda, Keiji Yamamoto, Kunikazu Moribe
We investigated the formation and stabilization mechanisms of indomethacin (IMC)/poloxamer 407 nanosuspensions. Stable nanosuspensions were prepared via 24 h wet-milling of three IMC forms (γ form, α form, and amorphous) with poloxamer 407. Cryogenic-transmission electron microscopy images of nanoparticles obtained using γ-form IMC indicated a rhombic-plate shape. In contrast, needle-like nanoparticles were observed in the nanosuspensions of α-form and amorphous IMC. Suspended-state cross polarization 13C NMR and Raman measurements directly detected the molecular states of IMC in nanosuspensions...
December 12, 2017: International Journal of Pharmaceutics
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