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Lara Tânia de Assumpção Domingues Gonçalves de Oliveira, Camila Pontes da Silva, Maria das Vitorias Guedes, Ana Célia de Oliveira Sousa, Flávio Sarno
Objectives: To describe indicators and processes developed and implemented for pharmaceutical assistance at the Einstein Program at Paraisópolis Community pharmacy. Methods: This was a descriptive study of retrospective data from January 2012 to December 2015. Data were obtained from spreadsheets developed for monitoring the productivity and care quality provided at the pharmacy. The evaluated variables were pharmaceutical assistance to prescription, pharmaceutical intervention, orientation (standard and pharmaceutical) and pharmaceutical orientation rate...
July 2016: Einstein
Tatiane Fernandes Farias, Karina da Silva Aguiar, Inajara Rotta, Klezia Morais da Silva Belletti, Juliane Carlotto
Objective: To implement a clinical pharmacy service focused on the comprehensive review of antineoplastic drugs used in therapy of hematological diseases. Methods: An interventional study was conducted in a Brazilian tertiary teaching hospital in two different periods, with and without a clinical pharmacy service, respectively. This service consisted of an antineoplastic prescription validation (analysis of patients' characteristics, laboratory tests, compliance with the therapeutic protocol and with pharmacotechnical parameters)...
July 2016: Einstein
Lívia Falcão Lima, Bruna Cristina Cardoso Martins, Francisco Roberto Pereira de Oliveira, Rafaela Michele de Andrade Cavalcante, Vanessa Pinto Magalhães, Paulo Yuri Milen Firmino, Liana Silveira Adriano, Adriano Monteiro da Silva, Maria Jose Nascimento Flor, Eugenie Desirée Rabelo Néri
Objective: To describe and analyze the pharmaceutical orientation given at hospital discharge of transplant patients. Methods: This was a cross-sectional, descriptive and retrospective study that used records of orientation given by the clinical pharmacist in the inpatients unit of the Kidney and Liver Transplant Department, at Hospital Universitário Walter Cantídio, in the city of Fortaleza (CE), Brazil, from January to July, 2014. The following variables recorded at the Clinical Pharmacy Database were analyzed according to their significance and clinical outcomes: pharmaceutical orientation at hospital discharge, drug-related problems and negative outcomes associated with medication, and pharmaceutical interventions performed...
July 2016: Einstein
A Alsius-Serra, M Ballbé-Anglada, M L López-Yeste, M Buxeda-Figuerola, E Guillén-Campuzano, L Juan-Pereira, C Colomé-Mallolas, I Caballé-Martín
OBJECTIVE: To describe the study of the comparability of the measurements levels of biological tests processed in biochemistry in Catlab's 4 laboratories. MATERIAL AND METHODS: Quality requirements, coefficients of variation and total error (CV% and TE %) were established. Controls were verified with the precision requirements (CV%) in each test and each individual laboratory analyser. Fresh serum samples were used for the comparability study. The differences were analysed using a Microsoft Access® application that produces modified Bland-Altman plots...
November 2015: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
Jorge F Elgart, Lorena González, Enzo Rucci, Juan J Gagliardino
Although test strips for self-monitoring of blood glucose (SMBG) represent around 50% of diabetes treatment cost in Argentina, little is known about their current use and relationship with different types of treatment. We therefore aimed to estimate the current use of test strips and identify the major use drivers and the percentage they represent of total prescription costs in 2 entities of the social security system (SSS) of Argentina. Observational retrospective study measuring test strip prescriptions delivered by pharmacies from the province of Buenos Aires (8115 records collected during 3 months provided by the Colegio de Farmacéuticos de la Provincia de Buenos Aires) of affiliates with type 2 diabetes (T2DM) from 2 large entities of the SSS system...
November 2014: Journal of Diabetes Science and Technology
Javier Cremades, Mario Gonzalo, Isabel Arrebola
UNLABELLED: Drug interactions may represent an iatrogenic risk that should be controlled in community pharmacies at the dispensing level. AIM: We analyzed the association between potential drug-drug interactions (DDIs) and negative clinical outcomes. METHODS: WE USED DISPENSING DATA FROM TWO COMMUNITY PHARMACIES: instances where drug dispensing was associated with a potential DDI and a comparison group of randomized dispensing operations with no potential DDI...
January 2009: Pharmacy Practice
Marlom Silva Rolim, Magali Romero Sá
The article analyzes two periodicals published by the chemical and pharmaceutical company Bayer - as they played into scientific relations between Brazil and Germany. At the close of World War I, a number of countries, including Brazil, broke off political, economic, and scientific relations with Germany. Germany's medical and scientific community moved to implement a policy of disseminating Germanism through science and medicine, aimed above all at Latin America. Germany's chemical and pharmaceutical industry was impacted by this policy, as it both supported and was a beneficiary of the endeavor to disseminate German science and to promote international scientific exchange, which opened new markets...
March 2013: História, Ciências, Saúde—Manguinhos
José P H Patrício, Cristina Santos, Rui Cerdeira
BACKGROUND: Current scientific evidence indicates that anemia in pregnancy, regardless of severity, is associated with an increased risk of maternal and fetal mortality. There is little published information about the bioavailability and bioequivalence of formulations containing both iron and folic acid. However, in vitro dissolution studies can provide important information on the likely relative bioavailability of various formulations. AIM: The objective of our study was to compare the in vitro dissolution of two similar commercially available formulations of iron- and folic acid-containing supplements, Folifer® (Bialport - Produtos Farmacêuticos, S...
March 1, 2012: Drugs in R&D
Raúl Rodríquez Nozal
The pharmaceutical industry associations, as it happened with other businesses, had a significant rise during the dictatorship of Primo de Rivera and II Republic. The 'Cámara Nacional de Industrias Químicas', in Barcelona, represented the national chemical industry to its ultimate assimilation by the 'Organización Sindical' in 1939. In this association, matters relating to pharmaceutical products -- which we will especially deal with in this work -- were managed by the 'Unión Nacional de Laboratorios Químico-Farmacéuticos', which defended the interests of pharmaceutical companies in the presence of government authorities, using the resources and mechanisms also managed by business pressure groups...
2011: Asclepio; Archivo Iberoamericano de Historia de la Medicina y Antropología Médica
Gustavo Duarte Mendes, André Arruda, Lu Shi Chen, José Cássio de Almeida Magalhães, Khalid M Alkharfy, Gilberto De Nucci
A rapid, sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane (70/30; v/v) solvent. After removing and drying the organic phase, the extracts were reconstituted with a fixed volume of acetonitrile/water (50/50 v/v)+0.1% of acetic acid. The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry (LC-MS/MS)...
January 2012: Biomedical Chromatography: BMC
G Marcelín-Jiménez, A C P Angeles, A García, M Morales, L Rivera, A Martín-Del-Campo
OBJECTIVE: To evaluate the bioequivalence between two 250 mg-tablets of lysine clonixinate, Dorixina Forte (Siegfried Rhein, México) as reference product, and Prestodol (Farmaceúticos Rayere, S.A., México) as test formulation. METHODS: 26 healthy adult female Mexican volunteers received a single oral dose of 250-mg lysine clonixinate under fasting conditions. The drug was administered following a randomized, two-period, two-sequence, cross-over design. Twelve serial blood samples were collected up to 8 h after dosing, and clonixin (CLX) was measured by ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry...
May 2010: International Journal of Clinical Pharmacology and Therapeutics
An Baeyens, Tom Goffin
No abstract text is available yet for this article.
May 2008: European Journal of Health Law
E Martí-Bonmatí, M P Ortega-García, P Cervera-Casino, C Lacasa, J L Llop, J L Villalobos, L de la Morena et al.
OBJECTIVE: The aim of this cross-sectional national multicentric study was to determine the prevalence of hyperglycemia in patients with parenteral nutrition and to assess other clinical factors associated with this complication. METHOD: All Spanish hospital pharmacy services were invited to participate in the study. RESULTS: Twenty eight (28) pharmacy services agreed to participate. The study included 442 patients. The prevalence of hyperglycemia (plasma levels > 200 mg/dL) was 26...
January 2006: Farmacia Hospitalaria
José Carlos Saraiva Gonçalves, Tânia Maria Monteiro, Claúdia Silvana de Miranda Neves, Karla Regina da Silva Gram, Nádia Maria Volpato, Vivian A Silva, Ricardo Caminha, Maria do Rocio Bencke Gonçalves, Fábio Monteiro Dos Santos, Gabriel Estolano da Silveira, François Noël
A validated method for on-line solid-phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry (SPE-HPLC-MS-MS) is described for the quantification of bromazepam in human plasma. The method involves a dilution of 300 muL of plasma with 100 muL of carbamazepine (2.5 ng/mL), used as internal standard, vortex-mixing, centrifugation, and injection of 100 muL of the supernate. The analytes were ionized using positive electrospray mass spectrometry then detected by multiple reaction monitoring (MRM)...
October 2005: Therapeutic Drug Monitoring
Beatriz Elena Parra, Luz Mariela Manjarrés, Alba Lucía Gómez, Dora María Alzate, María Clemencia Jaramillo
INTRODUCTION: Iron and folic acid deficiencies are the major causes of health problems among pregnant women and children, with a significant negative impact on economic and social development. OBJECTIVE: From April 2002 to April 2003 at the Gilberto Mejía Mejía Hospital (Rionegro, Antioquia), the prenatal program was assessed for its impact on a cohort of pregnant women concerning knowledge of the following nutritional parameters: iron and folic acid functions, their source foods and bioavailability, supplement intake and tolerance, and globular indexes...
June 2005: Biomédica: Revista del Instituto Nacional de Salud
Ney Carter do Carmo Borges, Gustavo Duarte Mendes, Diogo de Oliveira Silva, Vinicius Marcondes Rezende, Rafael Eliseo Barrientos-Astigarraga, Gilberto De Nucci
A rapid, sensitive and specific method to quantify carvedilol in human plasma using metoprolol as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether solvent. After removed and dried the organic phase, the extracts were reconstituted with a fixed volume of acetonitrile-water (50/50; v/v). The extracts were analyzed by a high performance liquid chromatography coupled to electrospray tandem mass spectrometry (HPLC-MS/MS)...
August 5, 2005: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
No abstract text is available yet for this article.
January 1950: Giornale di Medicina Militare
G Marcelín-Jiménez, José Hernández, Alionka P Angeles, L Contreras, M Hinojosa, L Rivera, L Martínez-Rossier, O Amancio, A Fernández
A randomized, crossover study was conducted in 24 healthy female volunteers to compare the bioavailability of two brands of ketoconazole (200 mg) tablets; Onofin-K (Farmacéuticos Rayere S.A., Mexico) as the test and Nizoral (Janssen-Cilag, Mexico) as the reference products. The study was performed at the Clinical Pharmacology Research Center of the Hospital General de Mexico in Mexico City. Two tablets (400 mg) were administered as a single dose with 250 ml of water after a 12 h overnight fast on two treatment days separated by a 1 week washout period...
July 2004: Biopharmaceutics & Drug Disposition
Tiago L Laurito, Gustavo D Mendes, Vincenzo Santagada, Giuseppe Caliendo, Maria Elisabete A de Moraes, Gilberto De Nucci
A rapid, sensitive and specific method to quantify bromazepam in human plasma using diazepam as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid-liquid extraction using diethyl ether-hexane (80 : 20, v/v). The extracts were analyzed by high-performance liquid chromatography (HPLC) coupled to electrospray tandem mass spectrometry (MS/MS). Chromatography was performed isocratically on a Genesis C(18) analytical column (100 x 2.1 mm i.d., film thickness 4 microm)...
February 2004: Journal of Mass Spectrometry: JMS
No abstract text is available yet for this article.
January 1965: Annali di Medicina Navale
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