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Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
Victoria Bell, João Rui Pita, Ana Leonor Pereira
Portugal did not participate in World War II but was one of the first countries in the world to receive penicillin for civilian use. The Portuguese Red Cross began to import the antibiotic from the United States of America in 1944 and appointed a controlling committee to oversee its distribution, due to the small amount available. In 1945, as world production increased, penicillin began to be distributed through the normal channels. An important role in its regulation was played by the official department responsible for controlling pharmaceutical and chemical products in Portugal, the Comissão Reguladora dos Produtos Químicos e Farmacêuticos (Regulatory Committee for Chemical and Pharmaceutical Products)...
2017: Dynamis
Julia Álvarez Hernández
The Scientific Committee of the Sociedad Española de Nutrición Parenteral y Enteral (SENPE) and the Nutricia Advanced Medical Nutrition company began this Course some years ago, and now, it is a referent course in the multidisciplinary training of Clinical Nutrition. With this issue we review the advances in Clinical Nutrition in different situations and, this year, the topic is the malnutrition in chronic complex patients.
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ane Elisa Paim, Eliane Regina Pereira do Nascimento, Kátia Cilene Godinho Bertoncello, Karla Gomes Sifroni, Nadia Chiodelli Salum, Keyla Cristiane do Nascimento
Objective: to validate the content of a Standard Operational Procedure, regarding nursing interventions in emergency patients treated with vasoactive drugs. Method: methodological study, carried out from December 2015 to January 2016. Content validity was determined by 16 experts (13 nurses, 2 pharmacists and one biomedical scientist), who judged it through a four-point Likert scale. The items were evaluated in terms of: feasibility, objectivity, simplicity, clearness, pertinence and accuracy...
May 2017: Revista Brasileira de Enfermagem
Dinesh Abrol, T Sundararaman, Harilal Madhavan, K J Joseph
This article presents an overview of the changes that are taking place within the public and private health innovation systems in India including delivery of medical care, pharmaceutical products, medical devices, and Indian traditional medicine. The nature of the flaws that exist in the health innovation system is pinpointed. The response by the government, the health, technology and medical institutions, and the evolving industry is addressed on a national level. The article also discusses how the alignment of policies and institutions was developed within the scope of national health innovation systems, and how the government and the industry are dealing with the challenges to integrate health system, industry, and social policy development processes...
November 3, 2016: Cadernos de Saúde Pública
Lara Tânia de Assumpção Domingues Gonçalves de Oliveira, Camila Pontes da Silva, Maria das Vitorias Guedes, Ana Célia de Oliveira Sousa, Flávio Sarno
Objectives: To describe indicators and processes developed and implemented for pharmaceutical assistance at the Einstein Program at Paraisópolis Community pharmacy. Methods: This was a descriptive study of retrospective data from January 2012 to December 2015. Data were obtained from spreadsheets developed for monitoring the productivity and care quality provided at the pharmacy. The evaluated variables were pharmaceutical assistance to prescription, pharmaceutical intervention, orientation (standard and pharmaceutical) and pharmaceutical orientation rate...
July 2016: Einstein
Tatiane Fernandes Farias, Karina da Silva Aguiar, Inajara Rotta, Klezia Morais da Silva Belletti, Juliane Carlotto
Objective: To implement a clinical pharmacy service focused on the comprehensive review of antineoplastic drugs used in therapy of hematological diseases. Methods: An interventional study was conducted in a Brazilian tertiary teaching hospital in two different periods, with and without a clinical pharmacy service, respectively. This service consisted of an antineoplastic prescription validation (analysis of patients' characteristics, laboratory tests, compliance with the therapeutic protocol and with pharmacotechnical parameters)...
July 2016: Einstein
Lívia Falcão Lima, Bruna Cristina Cardoso Martins, Francisco Roberto Pereira de Oliveira, Rafaela Michele de Andrade Cavalcante, Vanessa Pinto Magalhães, Paulo Yuri Milen Firmino, Liana Silveira Adriano, Adriano Monteiro da Silva, Maria Jose Nascimento Flor, Eugenie Desirée Rabelo Néri
Objective: To describe and analyze the pharmaceutical orientation given at hospital discharge of transplant patients. Methods: This was a cross-sectional, descriptive and retrospective study that used records of orientation given by the clinical pharmacist in the inpatients unit of the Kidney and Liver Transplant Department, at Hospital Universitário Walter Cantídio, in the city of Fortaleza (CE), Brazil, from January to July, 2014. The following variables recorded at the Clinical Pharmacy Database were analyzed according to their significance and clinical outcomes: pharmaceutical orientation at hospital discharge, drug-related problems and negative outcomes associated with medication, and pharmaceutical interventions performed...
July 2016: Einstein
A Alsius-Serra, M Ballbé-Anglada, M L López-Yeste, M Buxeda-Figuerola, E Guillén-Campuzano, L Juan-Pereira, C Colomé-Mallolas, I Caballé-Martín
OBJECTIVE: To describe the study of the comparability of the measurements levels of biological tests processed in biochemistry in Catlab's 4 laboratories. MATERIAL AND METHODS: Quality requirements, coefficients of variation and total error (CV% and TE %) were established. Controls were verified with the precision requirements (CV%) in each test and each individual laboratory analyser. Fresh serum samples were used for the comparability study. The differences were analysed using a Microsoft Access® application that produces modified Bland-Altman plots...
November 2015: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
Jorge F Elgart, Lorena González, Enzo Rucci, Juan J Gagliardino
Although test strips for self-monitoring of blood glucose (SMBG) represent around 50% of diabetes treatment cost in Argentina, little is known about their current use and relationship with different types of treatment. We therefore aimed to estimate the current use of test strips and identify the major use drivers and the percentage they represent of total prescription costs in 2 entities of the social security system (SSS) of Argentina. Observational retrospective study measuring test strip prescriptions delivered by pharmacies from the province of Buenos Aires (8115 records collected during 3 months provided by the Colegio de Farmacéuticos de la Provincia de Buenos Aires) of affiliates with type 2 diabetes (T2DM) from 2 large entities of the SSS system...
November 2014: Journal of Diabetes Science and Technology
Javier Cremades, Mario Gonzalo, Isabel Arrebola
UNLABELLED: Drug interactions may represent an iatrogenic risk that should be controlled in community pharmacies at the dispensing level. AIM: We analyzed the association between potential drug-drug interactions (DDIs) and negative clinical outcomes. METHODS: WE USED DISPENSING DATA FROM TWO COMMUNITY PHARMACIES: instances where drug dispensing was associated with a potential DDI and a comparison group of randomized dispensing operations with no potential DDI...
January 2009: Pharmacy Practice
Marlom Silva Rolim, Magali Romero Sá
The article analyzes two periodicals published by the chemical and pharmaceutical company Bayer - as they played into scientific relations between Brazil and Germany. At the close of World War I, a number of countries, including Brazil, broke off political, economic, and scientific relations with Germany. Germany's medical and scientific community moved to implement a policy of disseminating Germanism through science and medicine, aimed above all at Latin America. Germany's chemical and pharmaceutical industry was impacted by this policy, as it both supported and was a beneficiary of the endeavor to disseminate German science and to promote international scientific exchange, which opened new markets...
March 2013: História, Ciências, Saúde—Manguinhos
José P H Patrício, Cristina Santos, Rui Cerdeira
BACKGROUND: Current scientific evidence indicates that anemia in pregnancy, regardless of severity, is associated with an increased risk of maternal and fetal mortality. There is little published information about the bioavailability and bioequivalence of formulations containing both iron and folic acid. However, in vitro dissolution studies can provide important information on the likely relative bioavailability of various formulations. AIM: The objective of our study was to compare the in vitro dissolution of two similar commercially available formulations of iron- and folic acid-containing supplements, Folifer® (Bialport - Produtos Farmacêuticos, S...
March 1, 2012: Drugs in R&D
Raúl Rodríquez Nozal
The pharmaceutical industry associations, as it happened with other businesses, had a significant rise during the dictatorship of Primo de Rivera and II Republic. The 'Cámara Nacional de Industrias Químicas', in Barcelona, represented the national chemical industry to its ultimate assimilation by the 'Organización Sindical' in 1939. In this association, matters relating to pharmaceutical products -- which we will especially deal with in this work -- were managed by the 'Unión Nacional de Laboratorios Químico-Farmacéuticos', which defended the interests of pharmaceutical companies in the presence of government authorities, using the resources and mechanisms also managed by business pressure groups...
2011: Asclepio; Archivo Iberoamericano de Historia de la Medicina y Antropología Médica
Gustavo Duarte Mendes, André Arruda, Lu Shi Chen, José Cássio de Almeida Magalhães, Khalid M Alkharfy, Gilberto De Nucci
A rapid, sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane (70/30; v/v) solvent. After removing and drying the organic phase, the extracts were reconstituted with a fixed volume of acetonitrile/water (50/50 v/v)+0.1% of acetic acid. The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry (LC-MS/MS)...
January 2012: Biomedical Chromatography: BMC
G Marcelín-Jiménez, A C P Angeles, A García, M Morales, L Rivera, A Martín-Del-Campo
OBJECTIVE: To evaluate the bioequivalence between two 250 mg-tablets of lysine clonixinate, Dorixina Forte (Siegfried Rhein, México) as reference product, and Prestodol (Farmaceúticos Rayere, S.A., México) as test formulation. METHODS: 26 healthy adult female Mexican volunteers received a single oral dose of 250-mg lysine clonixinate under fasting conditions. The drug was administered following a randomized, two-period, two-sequence, cross-over design. Twelve serial blood samples were collected up to 8 h after dosing, and clonixin (CLX) was measured by ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry...
May 2010: International Journal of Clinical Pharmacology and Therapeutics
An Baeyens, Tom Goffin
No abstract text is available yet for this article.
May 2008: European Journal of Health Law
E Martí-Bonmatí, M P Ortega-García, P Cervera-Casino, C Lacasa, J L Llop, J L Villalobos, L de la Morena et al.
OBJECTIVE: The aim of this cross-sectional national multicentric study was to determine the prevalence of hyperglycemia in patients with parenteral nutrition and to assess other clinical factors associated with this complication. METHOD: All Spanish hospital pharmacy services were invited to participate in the study. RESULTS: Twenty eight (28) pharmacy services agreed to participate. The study included 442 patients. The prevalence of hyperglycemia (plasma levels > 200 mg/dL) was 26...
January 2006: Farmacia Hospitalaria
José Carlos Saraiva Gonçalves, Tânia Maria Monteiro, Claúdia Silvana de Miranda Neves, Karla Regina da Silva Gram, Nádia Maria Volpato, Vivian A Silva, Ricardo Caminha, Maria do Rocio Bencke Gonçalves, Fábio Monteiro Dos Santos, Gabriel Estolano da Silveira, François Noël
A validated method for on-line solid-phase extraction coupled with high-performance liquid chromatography tandem mass spectrometry (SPE-HPLC-MS-MS) is described for the quantification of bromazepam in human plasma. The method involves a dilution of 300 muL of plasma with 100 muL of carbamazepine (2.5 ng/mL), used as internal standard, vortex-mixing, centrifugation, and injection of 100 muL of the supernate. The analytes were ionized using positive electrospray mass spectrometry then detected by multiple reaction monitoring (MRM)...
October 2005: Therapeutic Drug Monitoring
Beatriz Elena Parra, Luz Mariela Manjarrés, Alba Lucía Gómez, Dora María Alzate, María Clemencia Jaramillo
INTRODUCTION: Iron and folic acid deficiencies are the major causes of health problems among pregnant women and children, with a significant negative impact on economic and social development. OBJECTIVE: From April 2002 to April 2003 at the Gilberto Mejía Mejía Hospital (Rionegro, Antioquia), the prenatal program was assessed for its impact on a cohort of pregnant women concerning knowledge of the following nutritional parameters: iron and folic acid functions, their source foods and bioavailability, supplement intake and tolerance, and globular indexes...
June 2005: Biomédica: Revista del Instituto Nacional de Salud
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