Dragana Zanini, Nikola Todorovic, Darinka Korovljev, Valdemar Stajer, Jelena Ostojic, Jelena Purac, Danijela Kojic, Elvira Vukasinovic, Srdjana Djordjievski, Miron Sopic, Azra Guzonjic, Ana Ninic, Sanja Erceg, Sergej M Ostojic
In this randomized controlled pilot trial, we investigated the effects of a 6-month intake of hydrogen-rich water (HRW) on several molecular and phenotypic biomarkers of aging in older adults aged 70 years and over. Forty older adults (20 women) were randomly allocated in a parallel-group design to receive 0.5 L per day of HRW (15 ppm of hydrogen) or control drink (0 ppm of hydrogen) during a 6-month intervention period. The biomarkers assessed at baseline and 6-month follow up were molecular markers in the blood (DNA and chromosomes, nutrient sensing, protein, and lipid metabolism, oxidative stress and mitochondria, cell senescence, inflammation), brain metabolism, cognitive functioning, physical function and body composition, resting blood pressure, facial skin features, sleep outcomes, and health-related quality of life...
November 2021: Experimental Gerontology