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sleep and telomere length

Kyung Soo Kim, Jin Wook Kwak, Su Jin Lim, Yong Kyun Park, Hoon Shik Yang, Hyun Jik Kim
The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length shortening is a characteristic feature that can assess oxidative stress levels. We used quantitative PCR to measure telomere length using peripheral blood genomic DNA...
October 2016: Aging and Disease
Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt, Sergio Tufik
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction...
September 27, 2016: Oncotarget
Kyung-Mee Choi, Robert J Thomas, Dai Wui Yoon, Seung Ku Lee, Inkyung Baik, Chol Shin
STUDY OBJECTIVES: Age-related brain white matter changes (WMC) have been associated separately with obstructive sleep apnea (OSA) and short telomere length (TL). No studies have examined their interaction effect on WMC. METHODS: This is a cross-sectional study with a community-based sample of 420 participants (mean age, 61.3 ± 7.2) from the Korean Genome and Epidemiology Study during 2011-2012. An overnight fasted blood sample was taken to determine glucose and blood lipid levels at the sleep laboratory of Korea University Ansan Hospital...
September 1, 2016: Sleep
Laurent Boyer, Etienne Audureau, Laurent Margarit, Elisabeth Marcos, Emilie Bizard, Philippe Le Corvoisier, Isabelle Macquin-Mavier, Geneviève Derumeaux, Thibaud Damy, Xavier Drouot, Ala Covali-Noroc, Jorge Boczkowski, Sylvie Bastuji-Garin, Serge Adnot
RATIONALE: Sleep disorders may lead to stress-induced premature aging and telomere shortening. OBJECTIVES: To determine whether obstructive sleep apnea syndrome causing intermittent hypoxemic episodes was associated with telomere shortening independently from the comorbidities associated with this syndrome. METHODS: We conducted a cross-sectional study in 161prospectivelly enrolled, untreated, middle-aged men free of known comorbidities related or unrelated to sleep apnea...
July 2016: Annals of the American Thoracic Society
Dóra Révész, Yuri Milaneschi, Erik M Terpstra, Brenda W J H Penninx
BACKGROUND: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study. MATERIAL AND METHODS: Leukocyte TL was measured (baseline N=2936; 6-year follow-up N=1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included sociodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers...
May 2016: Psychoneuroendocrinology
Judith E Carroll, Stephanie Esquivel, Alyssa Goldberg, Teresa E Seeman, Rita B Effros, Jeffrey Dock, Richard Olmstead, Elizabeth C Breen, Michael R Irwin
STUDY OBJECTIVES: Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. METHODS: A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls)...
March 1, 2016: Sleep
Chol Shin, Chang-Ho Yun, Dae Wui Yoon, Inkyung Baik
STUDY OBJECTIVES: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. METHODS: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013...
April 1, 2016: Sleep
Priscila F Tempaku, Diego R Mazzotti, Sergio Tufik
The identification of biological markers that allow the early diagnosis, or even the prevention of age-related diseases, is an important goal that is being actively pursued in the research community. Sleep is one of the physiological processes that is most affected by aging, and there is a strong relationship between age-related sleep alterations and diseases. Changes in cellular senescence and the linked changes in telomere length might be potential markers of age-related sleep changes. In this review, we present some of the most recent evidence showing that telomere length has been associated with sleep loss and sleep disturbances in cross-sectional and case-control studies...
May 2015: Sleep Medicine
Amy M Kwon, Inkyung Baik, Robert J Thomas, Chol Shin
PURPOSE: The purpose of the study is to examine the objective association between sleep stability and leukocyte telomere lengths (LTL) using cardiopulmonary coupling (CPC) analysis, which is an electrocardiogram (ECG)-based technique to quantify physiologic sleep stability. METHODS: Three hundred eighty-one healthy subjects were recruited from a community-based cohort study from the Korean Genome and Epidemiology Study (KoGES), and the associations between LTL and total quantities of different frequency coupling bands were examined using generalized linear model (GLM) with adjustment of significant covariates...
September 2015: Sleep & Breathing, Schlaf & Atmung
Aric A Prather, Blake Gurfein, Patricia Moran, Jennifer Daubenmier, Michael Acree, Peter Bacchetti, Elizabeth Sinclair, Jue Lin, Elizabeth Blackburn, Frederick M Hecht, Elissa S Epel
Poor sleep quality and short sleep duration are associated with increased incidence and progression of a number of chronic health conditions observed at greater frequency among the obese and those experiencing high levels of stress. Accelerated cellular aging, as indexed by telomere attrition in immune cells, is a plausible pathway linking sleep and disease risk. Prior studies linking sleep and telomere length are mixed. One factor may be reliance on leukocytes, which are composed of varied immune cell types, as the sole measure of telomere length...
July 2015: Brain, Behavior, and Immunity
Hamisu M Salihu, Lindsey King, Priyanshi Patel, Arnut Paothong, Anupam Pradhan, Judette Louis, Eknath Naik, Phillip J Marty, Valerie Whiteman
STUDY OBJECTIVES: Our investigation aims to assess the impact of symptoms of maternal sleep-disordered breathing, specifically sleep apnea risk and daytime sleepiness, on fetal leukocyte telomere length. PARTICIPANTS AND SETTING: Pregnant women were recruited upon hospital delivery admission. INTERVENTIONS: Sleep exposure outcomes were measured using the Berlin Questionnaire to quantify sleep apnea and the Epworth Sleepiness Scale to measure daytime sleepiness...
April 2015: Sleep
Sheila N Garland, Christina Palmer, Michelle Donelson, Philip Gehrman, F Brad Johnson, Jun J Mao
The ability to achieve sufficient restorative sleep is important in the maintenance of physical and mental health; however, disturbed sleep and insomnia symptoms are a common experience among women with breast cancer. In non-cancer populations, insufficient sleep quantity and quality has been associated with shortened telomere length (TL), a measure of accumulated cellular damage and human aging. This feasibility study compared TL in women previously diagnosed with breast cancer with clinically significant insomnia symptoms (n=70) to an age- and body mass index (BMI)-matched comparison group (n=70) of breast cancer survivors...
October 2014: Rejuvenation Research
E Puterman, J Lin, J Krauss, E H Blackburn, E S Epel
Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress and health behaviors. Cross-sectionally, highly stressed postmenopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors, including diet, exercise, and sleep. Here we followed healthy women over 1 year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect...
April 2015: Molecular Psychiatry
Kathryn A Lee, Caryl Gay, Janice Humphreys, Carmen J Portillo, Clive R Pullinger, Bradley E Aouizerat
BACKGROUND AND STUDY OBJECTIVE: Telomere length provides an estimate of cellular aging and is influenced by oxidative stress and health behaviors such as diet and exercise. This article describes relationships between telomere length and sleep parameters that included total sleep time (TST), wake after sleep onset (WASO), and self-reported sleep quality in a sample of adults with chronic illness. DESIGN AND PARTICIPANTS: Cross-sectional study of 283 adults (74% male, 42% Caucasian) infected with human immunodeficiency virus (HIV) while living in the San Francisco Bay area, CA, USA...
January 1, 2014: Sleep
Matthew R Cribbet, McKenzie Carlisle, Richard M Cawthon, Bert N Uchino, Paula G Williams, Timothy W Smith, Heather E Gunn, Kathleen C Light
STUDY OBJECTIVES: To examine whether subjective sleep quality and sleep duration moderate the association between age and telomere length (TL). DESIGN: Participants completed a demographic and sleep quality questionnaire, followed by a blood draw. SETTING: Social Neuroscience Laboratory. PARTICIPANTS: One hundred fifty-four middle-aged to older adults (age 45-77 y) participated. Participants were excluded if they were on immunosuppressive treatment and/or had a disease with a clear immunologic (e...
January 2014: Sleep
Katri Savolainen, Johan G Eriksson, Eero Kajantie, Marius Lahti, Katri Räikkönen
OBJECTIVES: Sleep apnea poses an elevated risk for chronic age-related diseases. Leukocyte telomere length (LTL), a biomarker and factor associated with accelerated cellular aging processes, may serve as a novel mechanism underlying these disease risks. We investigated if a history of clinician-diagnosed sleep apnea or primary snoring was associated with LTL in later adulthood. METHODS: Data on sleep apnea, primary snoring and LTL, were available for 1948 participants from the Helsinki Birth Cohort Study...
February 2014: Sleep Medicine
Angela R Starkweather, Areej A Alhaeeri, Alison Montpetit, Jenni Brumelle, Kristin Filler, Marty Montpetit, Lathika Mohanraj, Debra E Lyon, Colleen K Jackson-Cook
BACKGROUND: Although telomere shortening occurs as a natural part of aging, there is now a robust body of research that suggests that there is a relationship between psychosocial, environmental, and behavioral factors and changes in telomere length. These factors need to be considered when integrating telomere measurement in biobehavioral research studies. OBJECTIVES: This article provides a brief summary of the known facts about telomere biology and an integrative review of current human research studies that assessed relationships between psychosocial, environmental, or behavioral factors and telomere length...
January 2014: Nursing Research
Eli Puterman, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, James J Gross, Mary A Whooley, Beth E Cohen
Major depressive disorder (MDD) has been associated with reduced leukocyte telomere length (LTL). It is not known, however, whether psychosocial and behavioral protective factors moderate this association. In the current study, we examine whether multisystem resiliency--defined by healthy emotion regulation, strong social connections, and health behaviors (sleep and exercise)--predicts LTL and mitigates previously demonstrated associations between depression diagnosis and LTL. LTL was measured, using a quantitative PCR assay, in 954 patients with stable cardiovascular disease in the Heart and Soul Study...
October 2013: Brain, Behavior, and Immunity
Sourindra N Maiti, Helen Huls, Harjeet Singh, Margaret Dawson, Matthew Figliola, Simon Olivares, Pullavathi Rao, Yi Jue Zhao, Asha Multani, Ge Yang, Ling Zhang, Denise Crossland, Sonny Ang, Hiroki Torikai, Brian Rabinovich, Dean A Lee, Partow Kebriaei, Perry Hackett, Richard E Champlin, Laurence J N Cooper
The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB system for human application and generated T cells expressing a chimeric antigen receptor (CAR) specific for CD19. Electrotransfer of CD19-specific SB DNA plasmids in peripheral blood mononuclear cells and propagation on CD19 artificial antigen presenting cells was used to numerically expand CD3 T cells expressing CAR. By day 28 of coculture, >90% of expanded CD3 T cells expressed CAR...
February 2013: Journal of Immunotherapy
Marta Jackowska, Mark Hamer, Livia A Carvalho, Jorge D Erusalimsky, Lee Butcher, Andrew Steptoe
BACKGROUND: Shorter telomere length and poor sleep are more prevalent at older ages, but their relationship is uncertain. This study explored associations between sleep duration and telomere length in a sample of healthy middle and early old age people. METHODS: Participants were 434 men and women aged 63.3 years on average drawn from the Whitehall II cohort study. Sleep duration was measured by self-report. RESULTS: There was a linear association between sleep duration and leukocyte telomere length in men but not in women (P = 0...
2012: PloS One
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