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sleep and telomere length

Isabel Cristina Ribas Werlang, Monique Cabral Hahn, Juliana Rombaldi Bernardi, Martha Nast, Marcelo Zubaran Goldani, Mariana Bohns Michalowski
OBJECTIVE: Studies focusing on telomere attrition in newborns and what factors could be involved in this issue are sparse; most reports have been in adult populations. Thereby, the aim of this study was to present an overview of what is currently known about the relationship between environmental exposure of the fetus during pregnancy and telomere length outcomes in early life. METHODS: The MEDLINE (via PubMed) and Bireme databases were searched for studies published until 1 June, 2016...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
Sarah Oerther, Rebecca Lorenz
Telomere biology shows promise as an integrative biomarker of exposures and increased occurrence of chronic disease and early mortality. This integrative review examined the state of the science regarding toxicokinetic risks and maternal factors in humans and in vivo models that are correlated with telomere length during the first 1,000 days of life. The Preferred Reporting Items of Systematic Reviews and Meta-Analyses framework assisted in guiding this integrative by aiding researchers in identifying, selecting, and critically appraising the literature...
March 1, 2018: Western Journal of Nursing Research
Nathalie K Zgheib, Fatima Sleiman, Lara Nasreddine, Mona Nasrallah, Nancy Nakhoul, Hussain Isma'eel, Hani Tamim
In Lebanon, data stemming from national cross-sectional surveys indicated significant increasing trends in the prevalence of cardiovascular diseases and associated behavioral and age-related risk factors. To our knowledge, no data are available on relative telomere length (RTL) as a potential biomarker for age-related diseases in a Lebanese population. The aim of this study was to evaluate whether there is an association between RTL and demographic characteristics, lifestyle habits and diseases in the Lebanese...
February 2018: Aging and Disease
Hua Zhao, Lixia Han, David Chang, Yuanqing Ye, Jie Shen, Carrie R Daniel, Jian Gu, Wong-Ho Chow, Xifeng Wu
In the current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight gain, and RTL, among 12,792 Mexican Americans aged 20 to 85 years in the Mano-A-Mano, the Mexican American Cohort. As expected, RTL was inversely correlated with age ( ρ =-0.15, ρ <0.001). In the multivariate analysis, we found that RTL was positively correlated with levels of education ( ρ =0...
November 14, 2017: Oncotarget
Katarzyna Polonis, Virend K Somers, Christiane Becari, Naima Covassin, Phillip J Schulte, Brooke R Druliner, Ruth A Johnson, Krzysztof Narkiewicz, Lisa A Boardman, Prachi Singh
Obstructive sleep apnea (OSA) is associated with cardiometabolic diseases. Telomere shortening is linked to hypertension, diabetes mellitus, and cardiovascular diseases. Because these conditions are highly prevalent in OSA, we hypothesized that telomere length (TL) would be reduced in OSA patients. We identified 106 OSA and 104 non-OSA subjects who underwent polysomnography evaluation. Quantitative PCR was used to measure telomere length in genomic DNA isolated from peripheral blood samples. The association between OSA and TL was determined using unadjusted and adjusted linear models...
November 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
H F Liu, F Li, Y H Wang, J H Chen, D X Peng, J Chen, L H Tan, X Mi, B H Zhao
Objective: To understand the association between peripheral leukocytes telomere length (TL) and sleep in middle-aged and old adults. Methods: A total of 176 middle-aged and old adults were investigated by using the Pittsburgh Sleep Quality Index and questionnaire. TL was measured by fluorescence quantitative PCR. The correlation and regression analysis between sleep and telomere length was performed. Results: TL had a mean T/S ratio of 0.995±0.23. There was a negative correlation between TL and age (r=-0.241, P=0...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Sarah James, Sara McLanahan, Jeanne Brooks-Gunn, Colter Mitchell, Lisa Schneper, Brandon Wagner, Daniel A Notterman
OBJECTIVE: To test the association between sleep duration and telomere length in a pediatric population. STUDY DESIGN: We analyzed cross-sectional data for 1567 children from the age 9 study wave of the Fragile Families and Child Wellbeing Study, a population-based birth cohort of children born between 1998 and 2000 in large American cities (population >200 000). We measured telomere length using quantitative polymerase chain reaction, and children's typical nightly sleep duration was reported by their primary caregivers...
August 2017: Journal of Pediatrics
Jenny Q Ouyang, Maaike de Jong, Roy H A van Grunsven, Kevin D Matson, Mark F Haussmann, Peter Meerlo, Marcel E Visser, Kamiel Spoelstra
The natural nighttime environment is increasingly polluted by artificial light. Several studies have linked artificial light at night to negative impacts on human health. In free-living animals, light pollution is associated with changes in circadian, reproductive, and social behavior, but whether these animals also suffer from physiologic costs remains unknown. To fill this gap, we made use of a unique network of field sites which are either completely unlit (control), or are artificially illuminated with white, green, or red light...
November 2017: Global Change Biology
Linda E Carlson, Erin L Zelinski, Michael Speca, Lynda G Balneaves, Jennifer M Jones, Daniel Santa Mina, Peter M Wayne, Tavis S Campbell, Janine Giese-Davis, Peter Faris, Jennifer Zwicker, Kamala Patel, Tara L Beattie, Steve Cole, Kirsti Toivonen, Jill Nation, Philip Peng, Bruce Thong, Raimond Wong, Sunita Vohra
PURPOSE: A growing number of cancer survivors suffer high levels of distress, depression and stress, as well as sleep disturbance, pain and fatigue. Two different mind-body interventions helpful for treating these problems are Mindfulness-Based Cancer Recovery (MBCR) and Tai Chi/Qigong (TCQ). However, while both interventions show efficacy compared to usual care, they have never been evaluated in the same study or directly compared. This study will be the first to incorporate innovative design features including patient choice while evaluating two interventions to treat distressed cancer survivors...
August 2017: Contemporary Clinical Trials
Valerie E Whiteman, Anjali Goswami, Hamisu M Salihu
We sought to synthesize a comprehensive literature review comprising recent research linking fetal programming to fetal telomere length. We also explored the potential effects fetal telomere length shortening has on fetal phenotypes. Utilizing the PubMed database as our primary search engine, we retrieved and reviewed 165 articles of published research. The inclusion criteria limited the articles to those that appeared within the last ten years, were pertinent to humans, and without restriction to language of publication...
May 2017: American Journal of Reproductive Immunology: AJRI
Kyung Soo Kim, Jin Wook Kwak, Su Jin Lim, Yong Kyun Park, Hoon Shik Yang, Hyun Jik Kim
The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length shortening is a characteristic feature that can assess oxidative stress levels. We used quantitative PCR to measure telomere length using peripheral blood genomic DNA...
October 2016: Aging and Disease
Priscila Farias Tempaku, Diego Robles Mazzotti, Camila Hirotsu, Monica Levy Andersen, Gabriela Xavier, Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Elisa Brietzke, Sintia Iole Belangero, Lia Bittencourt, Sergio Tufik
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction...
October 25, 2016: Oncotarget
Kyung-Mee Choi, Robert J Thomas, Dai Wui Yoon, Seung Ku Lee, Inkyung Baik, Chol Shin
STUDY OBJECTIVES: Age-related brain white matter changes (WMC) have been associated separately with obstructive sleep apnea (OSA) and short telomere length (TL). No studies have examined their interaction effect on WMC. METHODS: This is a cross-sectional study with a community-based sample of 420 participants (mean age, 61.3 ± 7.2) from the Korean Genome and Epidemiology Study during 2011-2012. An overnight fasted blood sample was taken to determine glucose and blood lipid levels at the sleep laboratory of Korea University Ansan Hospital...
September 1, 2016: Sleep
Laurent Boyer, Etienne Audureau, Laurent Margarit, Elisabeth Marcos, Emilie Bizard, Philippe Le Corvoisier, Isabelle Macquin-Mavier, Geneviève Derumeaux, Thibaud Damy, Xavier Drouot, Ala Covali-Noroc, Jorge Boczkowski, Sylvie Bastuji-Garin, Serge Adnot
RATIONALE: Sleep disorders may lead to stress-induced premature aging and telomere shortening. OBJECTIVES: To determine whether obstructive sleep apnea syndrome causing intermittent hypoxemic episodes was associated with telomere shortening independently from the comorbidities associated with this syndrome. METHODS: We conducted a cross-sectional study in 161prospectivelly enrolled, untreated, middle-aged men free of known comorbidities related or unrelated to sleep apnea...
July 2016: Annals of the American Thoracic Society
Dóra Révész, Yuri Milaneschi, Erik M Terpstra, Brenda W J H Penninx
BACKGROUND: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study. MATERIAL AND METHODS: Leukocyte TL was measured (baseline N=2936; 6-year follow-up N=1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included sociodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers...
May 2016: Psychoneuroendocrinology
Judith E Carroll, Stephanie Esquivel, Alyssa Goldberg, Teresa E Seeman, Rita B Effros, Jeffrey Dock, Richard Olmstead, Elizabeth C Breen, Michael R Irwin
STUDY OBJECTIVES: Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. METHODS: A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls)...
March 1, 2016: Sleep
Chol Shin, Chang-Ho Yun, Dae Wui Yoon, Inkyung Baik
STUDY OBJECTIVES: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomere length (LTL) using PSG and a questionnaire. METHODS: A cross-sectional PSG study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2010-2013...
April 1, 2016: Sleep
Priscila F Tempaku, Diego R Mazzotti, Sergio Tufik
The identification of biological markers that allow the early diagnosis, or even the prevention of age-related diseases, is an important goal that is being actively pursued in the research community. Sleep is one of the physiological processes that is most affected by aging, and there is a strong relationship between age-related sleep alterations and diseases. Changes in cellular senescence and the linked changes in telomere length might be potential markers of age-related sleep changes. In this review, we present some of the most recent evidence showing that telomere length has been associated with sleep loss and sleep disturbances in cross-sectional and case-control studies...
May 2015: Sleep Medicine
Amy M Kwon, Inkyung Baik, Robert J Thomas, Chol Shin
PURPOSE: The purpose of the study is to examine the objective association between sleep stability and leukocyte telomere lengths (LTL) using cardiopulmonary coupling (CPC) analysis, which is an electrocardiogram (ECG)-based technique to quantify physiologic sleep stability. METHODS: Three hundred eighty-one healthy subjects were recruited from a community-based cohort study from the Korean Genome and Epidemiology Study (KoGES), and the associations between LTL and total quantities of different frequency coupling bands were examined using generalized linear model (GLM) with adjustment of significant covariates...
September 2015: Sleep & Breathing, Schlaf & Atmung
Aric A Prather, Blake Gurfein, Patricia Moran, Jennifer Daubenmier, Michael Acree, Peter Bacchetti, Elizabeth Sinclair, Jue Lin, Elizabeth Blackburn, Frederick M Hecht, Elissa S Epel
Poor sleep quality and short sleep duration are associated with increased incidence and progression of a number of chronic health conditions observed at greater frequency among the obese and those experiencing high levels of stress. Accelerated cellular aging, as indexed by telomere attrition in immune cells, is a plausible pathway linking sleep and disease risk. Prior studies linking sleep and telomere length are mixed. One factor may be reliance on leukocytes, which are composed of varied immune cell types, as the sole measure of telomere length...
July 2015: Brain, Behavior, and Immunity
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