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sleep performance model

Yang Ye, Cun-Zhi Liu, Rui Wang, Yu-Wei Zhang, Bo Zhang, Yu Cui, Xue-Wei Liu, Shu-Ming Huang
Previous small animal models for menopausal transition are mainly performed to mimic the biochemical changes of patients with menopausal transition. The psychological symptoms in animal models are often overlooked. To mimic clinical situation, we developed a new mouse model of menopausal transition: the combination of bilateral ovariectomy (OVX) and empty bottle stimulation (EBS). After OVX and 21 days of EBS, behavioral test and pentobarbital-induced sleep test were carried out. Then all the animals were euthanized for further investigations...
March 16, 2018: Gynecological Endocrinology
Qihong Zou, Shuqin Zhou, Jing Xu, Zihui Su, Yuezhen Li, Yundong Ma, Hongqiang Sun, Changwei W Wu, Jia-Hong Gao
Rapid eye movement (REM) sleep has been frequently associated with dreaming. However, mounting evidence obtained from behavioral, pharmacological, and brain imaging studies suggests that REM sleep is not indicative of the dream report and may originate from diverse neural substrates in brain functionality. The aim of the current study was to investigate the functional systems associated with inter-individual differences in dream recall and REM sleep through assessments of the resting-state functional connectivity...
March 12, 2018: NeuroImage
Tristan Martin, Antoine Gauthier, Zhang Ying, Nicolas Benguigui, Sebastien Moussay, Jan Bulla, Damien Davenne, Nicolas Bessot
The aim of the study was to test the effect of total sleep deprivation on performance and time-of-day pattern of Subjective Visual Vertical (SVV) and postural control. Nineteen healthy young participants (4 females and 15 males 21.9 {plus minus} 1.2 years) were engaged in two counterbalanced experimental sessions with or without total sleep deprivation. Oral temperature, Karolinska sleepiness scale and visual analogic scale for fatigue, postural control and SVV were randomly measured every 4h, from 6:00 h to 22:00 h...
March 15, 2018: Journal of Applied Physiology
H Andersson, L Sonnesen
AIMS: This was to compare sleepiness, occlusion, dental arch and palatal dimensions between children with attention deficit hyperactivity disorders (ADHD) and healthy children (control group). METHODS: 15 children with ADHD (10 boys, 5 girls, mean age 10.98 years) and 36 healthy age matched children (21 boys, 15 girls, mean age 10.60 years) were included. Intra-oral three-dimensional scans of the teeth and palate were performed to evaluate the occlusion, dental arch and palatal dimensions...
March 14, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Michelle R Zeidler, Jennifer L Martin, Eric C Kleerup, Hartmut Schneider, Michael N Mitchell, Nadia N Hansel, Krishna Sundar, Helena Schotland, Robert C Basner, James Wells, Jerry A Krishnan, Gerard J Criner, Stephanie Cristenson, Samuel Krachman, M Safwan Badr
Study Objectives: Sleep quality is poor among patients with COPD, and studies show sleep disturbance is associated with low overall quality of life in this population. We evaluated the impact of patient-reported sleep quality and sleep apnea risk on disease-specific and overall quality of life within COPD patients enrolled in the SPIROMICS study, after accounting for demographics and COPD disease severity. Methods: Baseline data from 1,341 participants [892 mild/moderate COPD (FEV1≥50% predicted); 449 severe COPD (FEV1<50%)], were used to perform three nested (blocks) regression models to predict quality of life (Short Form-12 mental and physical components and St...
March 9, 2018: Sleep
Michael C Mullarkey, Igor Marchetti, Christopher G Beevers
Experiencing depression symptoms, even at mild to moderate levels, is associated with maladaptive outcomes for adolescents. We used network analysis to evaluate which symptoms (and associations between symptoms) are most central to adolescent depression. Participants were part of a large, diverse community sample (N = 1,409) of adolescents between 13 and 19 years of age. Network analysis was used to identify the most central symptoms (nodes) and associations between symptoms (edges) assessed by the Children's Depression Inventory...
March 13, 2018: Journal of Clinical Child and Adolescent Psychology
A Kesintha, L Rampal, M S Sherina, T Kalaiselvam
INTRODUCTION: Poor sleep quality among adolescents is becoming a major worldwide concern and is widely recognized as a significant public health issue. OBJECTIVES: To determine the prevalence and predictors of poor sleep quality among secondary school students in Gombak District, Selangor. METHODS: A cross-sectional study was conducted in Gombak District. The sample size was 1,092 based on two group comparison formula. Students were selected using sampling with probability to proportionate to size...
February 2018: Medical Journal of Malaysia
P E Vonk, A M E H Beelen, N de Vries
PURPOSE: To evaluate the effect of different passive maneuvers on upper airway patency during drug-induced sleep endoscopy (DISE) compared to recent literature on treatment outcomes of positional therapy (PT), oral appliance therapy (OAT), and combined treatment in obstructive sleep apnea (OSA) patients. METHODS: A retrospective, single-center cohort study including a consecutive series of 200 OSA patients. All patients underwent DISE with and without manually performed jaw thrust and lateral head rotation by using the VOTE classification...
March 9, 2018: Sleep & Breathing, Schlaf & Atmung
Huina Zhang, Fan Yang, Yichen Guo, Li Wang, Fang Fang, Hao Wu, Shaoping Nie, Yifan Wang, Man-Lung Fung, Yu Huang, Haiteng Deng, Yanwen Qin, Xinliang Ma, Yongxiang Wei
OBJECTIVE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for many clinical complications. However, how OSAHS cause multiple organ injury and initiate inter-organ communication remains unclear. Moreover, despite it is well-recognized that chronic intermittent hypoxia (CIH) is a main feature of OSAHS, specific contribution of CIH to overall OSAHS-initiated pathological complications remains unclear. This study aimed to use an unbiased proteomic approach to determine whether OSAHS alters protein profiles of serum extracellular microvesicles (SEMVs) and how CIH contributes to such alterations...
March 6, 2018: Metabolism: Clinical and Experimental
Alexis Roman, Soraya Meftah, Sébastien Arthaud, Pierre-Hervé Luppi, Christelle Peyron
Narcolepsy type 1 is a disabling disorder with four primary symptoms: excessive-daytime-sleepiness, cataplexy, hypnagogic hallucinations and sleep paralysis. The three latter symptoms together with a short REM sleep latency have suggested impairment in REM sleep homeostatic regulation with an enhanced propensity for (i.e. tendency to enter) REM sleep. To test this hypothesis, we challenged REM sleep homeostatic regulation in a recognized model of narcolepsy, the orexin knock-out (Orex-KO) mice and their wild-type (WT) littermates...
March 7, 2018: Sleep
Suzanne M Bertisch, Benjamin D Pollock, Murray A Mittleman, Daniel J Buysse, Lydia A Bazzano, Daniel J Gottlieb, Susan Redline
Study Objectives: To quantify the association between insomnia/poor sleep with objective short sleep and incident cardiovascular disease (CVD) and mortality in the general population. Methods: We conducted a time-to-event analysis of Sleep Heart Health Study data. Questionnaires and at-home polysomnography were performed between 1994 -1998. Participants were followed for a median 11.4 years (Q1-Q3, 8.8-12.4 years) until death or last contact. The primary exposure was insomnia or poor sleep with short sleep defined as: difficulty falling asleep, difficulty returning to sleep, early morning awakenings, or sleeping pill use, 16-30 nights/month; and total sleep <6 hours on polysomnography (PSG)...
March 7, 2018: Sleep
Udaya Seneviratne, Ray C Boston, Mark J Cook, Wendyl J D'Souza
We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. We used K-means cluster analysis and finite mixture modeling to quantify and characterize the groups of ED duration and IDI...
2018: Frontiers in Neurology
F Santamaria-Martos, I Benítez, C Girón, F Barbé, M A Martínez-García, L Hernández, J M Montserrat, E Nagore, A Martorell-Calatayud, F Campos-Rodriguez, J Corral, V Cabriada, J Abad, O Mediano, M F Troncoso, I Cano-Pumarega, A M Fortuna Gutierrez, T Diaz-Cambriles, M Somoza-Gonzalez, I Almendros, R Farre, D Gozal, M Sánchez-de-la-Torre
The goal of this study was to assess the relationship between the severity of OSA and the levels of carcinogenesis- and tumour growth-related biomarkers, in patients with cutaneous melanoma (CM).This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI); 0-5 events/h), mild-OSA (AHI; 5-15 events/h), and moderate to severe OSA (AHI>15 events/h). Enzyme-linked immunosorbent assays (ELISAs) were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (VEGF, IL8, ICAM-1, VCAM-1), and markers of tumour aggressiveness (S100B, MIA)...
March 9, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Alexander Malafeev, Ximena Omlin, Aleksandra Wierzbicka, Adam Wichniak, Wojciech Jernajczyk, Robert Riener, Peter Achermann
Quantitative electroencephalogram analysis (e.g. spectral analysis) has become an important tool in sleep research and sleep medicine. However, reliable results are only obtained if artefacts are removed or excluded. Artefact detection is often performed manually during sleep stage scoring, which is time consuming and prevents application to large datasets. We aimed to test the performance of mostly simple algorithms of artefact detection in polysomnographic recordings, derive optimal parameters and test their generalization capacity...
March 8, 2018: Journal of Sleep Research
Qian Han, Guihua Li, Mary SiuMan Ip, Yuelin Zhang, Zhe Zhen, Judith ChoiWo Mak, Nuofu Zhang
Obstructive sleep apnoea (OSA) characterized by intermittent hypoxia (IH) is closely associated with cardiovascular diseases. IH confers cardiac injury via accelerating cardiomyocyte apoptosis, whereas the underlying mechanism has remained largely enigmatic. This study aimed to explore the potential mechanisms involved in the IH-induced cardiac damage performed with the IH-exposed cell and animal models and to investigate the protective effects of haemin, a potent haeme oxygenase-1 (HO-1) activator, on the cardiac injury induced by IH...
March 7, 2018: Journal of Cellular and Molecular Medicine
Belma Kalaycı, Yunus Turgay Erten, Tunahan Akgün, Turgut Karabag, Furuzan Kokturk
BACKGROUNDS: Charlson Comorbidity index (CCI) is a scoring system to predict prognosis and mortality. It exhibits better utility when combined with age, age-adjusted Charlson Comorbidity Index (ACCI). The aim of this study was to evaluate the relationship between ACCI and diurnal variation of blood pressure parameters in hypertensive patients and normotensive patients. METHODS: We enrolled 236 patients. All patients underwent a 24-h ambulatory blood pressure monitoring (ABPM) for evaluation of dipper or non-dipper pattern...
March 5, 2018: Clinical and Experimental Hypertension: CHE
Salema B Abul Khair, Nisha R Dhanushkodi, Mustafa T Ardah, Wenfeng Chen, Yufeng Yang, M Emdadul Haque
Background: Mutations in glucocerebrosidase (GBA), a lysosomal enzyme are the most common genetic risk factor for developing Parkinson's disease (PD). We studied how reduced GCase activity affects α-synuclein (α-syn) and its mutants (A30P and A53T) aggregation, neurodegeneration, sleep and locomotor behavior in a fly model of PD. Methods: We developed drosophila with GBA gene knockdown (RNAi) (with reduced GCase activity) that simultaneously expresses either wildtype (WT) or mutants such as A30P or A53T α-syn...
2018: Frontiers in Neuroscience
Adrian Svingos, Sarah Greif, Brittany Bailey, Shelley Heaton
Children with conditions affecting cognitive processes experience high levels of sleep disturbance, which may further compound the cognitive ramifications of their disorders. Despite this, existing studies in this area have been primarily confined to only particular diagnostic groups and/or a limited scope of sleep and cognitive parameters. The current study characterized the nature of sleep problems and examined the relationship between a wide range of sleep-related problems and cognitive functioning in a large ( N = 103) diagnostically heterogeneous sample of youth (aged 6-16) referred for neuropsychological assessment...
February 28, 2018: Children
Xiaojuan Dong, Haixia Qin, Taoyu Wu, Hua Hu, Keren Liao, Fei Cheng, Dong Gao, Xu Lei
Introduction: One classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting-state large-scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large-scale brain networks in patients with insomnia disorder (ID) during resting state. Methods: In the present study, the resting-state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs)...
February 2018: Brain and Behavior
Mollie McDermott, Devin L Brown, Chengwei Li, Nelda M Garcia, Erin Case, Ronald D Chervin, Lewis B Morgenstern, Lynda D Lisabeth
OBJECTIVE/BACKGROUND: Sleep-disordered breathing (SDB), an independent risk factor for stroke, is associated with worse post-stroke outcomes. Differences in the relationship between SDB and stroke may exist for women versus men. In this population-based study, we compared the prevalence of both pre- and post-stroke SDB by sex. We also explored whether menopausal status is related to post-stroke SDB. PATIENTS/METHODS: We performed a cross-sectional study of subjects enrolled in the Brain Attack Surveillance in Corpus Christi (BASIC) project...
March 2018: Sleep Medicine
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