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https://www.readbyqxmd.com/read/29346627/severe-and-protracted-sleep-disruptions-in-mouse-model-of-post-traumatic-stress-disorder
#1
Rishi Sharma, Pradeep Sahota, Mahesh M Thakkar
Increasing evidences suggest that the predator threat model is a valid animal model of post-traumatic stress disorder (PTSD). However, sleep has never been examined in this model. Since sleep disturbances, including insomnia and excessive daytime sleepiness, are severe and protracted symptoms of PTSD, we hypothesized that mice exposed to predator odor trauma (POT) will display contextual fear conditioning along with severe and protracted sleep disruptions.Adult male C57BL/6J mice, instrumented with wire electrodes [to record hippocampal field potentials (LFP) and nuchal muscle (EMG) activity], were exposed to contextual conditioning using soiled cat litter as unconditional stimulus (US)...
January 13, 2018: Sleep
https://www.readbyqxmd.com/read/29335916/association-between-obstructive-sleep-apnea-and-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#2
REVIEW
Shanshan Jin, Suwen Jiang, Airong Hu
The relationship between obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) has been an issue of great concern. The primary purpose of this study was to determine the influence of OSA on the levels of liver enzymes including alanine transaminase (ALT) and aspartate transaminase (AST). The secondary purpose was to estimate the effect of OSA on the histological lesions of NAFLD, such as steatosis, lobular inflammation, ballooning degeneration, fibrosis, as well as NAFLD activity score (NAS)...
January 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29330768/comorbid-insomnia-symptoms-predict-lower-6-month-adherence-to-cpap-in-us-veterans-with-obstructive-sleep-apnea
#3
Douglas M Wallace, A M Sawyer, S Shafazand
PURPOSE: There is limited information on the association between pre-treatment insomnia symptoms and dysfunctional sleep beliefs with continuous positive airway pressure (CPAP) adherence in veterans with obstructive sleep apnea (OSA). Our aims were to describe demographic and sleep characteristics of veterans with and without comorbid insomnia and determine whether pre-treatment insomnia symptoms and dysfunctional sleep beliefs predict CPAP use after 6 months of therapy. METHODS: Hispanic veterans attending the Miami VA sleep clinic were recruited and completed the insomnia severity index, the dysfunctional sleep belief and attitude scale (DBAS), and other questionnaires...
January 4, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29329416/automatic-ecg-based-detection-of-autonomic-arousals-and-their-association-with-cortical-arousals-leg-movements-and-respiratory-events-in-sleep
#4
Mads Olsen, Logan Douglas Schneider, Joseph Cheung, Paul E Peppard, Poul J Jennum, Emmanuel Mignot, Helge Bjarup Dissing Sorensen
Study objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in isolation in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals...
January 10, 2018: Sleep
https://www.readbyqxmd.com/read/29325164/sleep-duration-in-the-united-states-2003-2016-first-signs-of-success-in-the-fight-against-sleep-deficiency
#5
Mathias Basner, David F Dinges
Study Objectives: The high prevalence of chronic insufficient sleep in the population has been a concern due to the associated health and safety risks. We evaluated secular trends in sleep duration over the most recent 14-year period. Methods: The American Time Use Survey (ATUS), representative of US residents ≥15 years, was used to investigate trends in self-reported sleep duration and waking activities for the period 2003-2016 (N=181,335 respondents). Results: Sleep duration increased across survey years both on weekdays (+1...
January 8, 2018: Sleep
https://www.readbyqxmd.com/read/29325109/estimating-adolescent-sleep-need-using-dose-response-modelling
#6
Michelle A Short, Nathan Weber, Chelsea Reynolds, Scott Coussens, Mary A Carskadon
Study Objectives: This study will, (a) estimate the nightly sleep need of human adolescents, (b) determine the time course and severity of sleep-related deficits when sleep is reduced below this optimal quantity, and (c) determine whether sleep restriction perturbs the circadian system as well as the sleep homeostat. Methods: Thirty-four adolescents aged 15 to 17 years spent 10 days and 9 nights in the sleep laboratory. Between two baseline nights and two recovery nights with 10-hours' time in bed (TIB) per night, participants experienced either severe sleep restriction (5-hr TIB), moderate sleep restriction (7...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29315132/self-help-cognitive-behavior-therapy-for-working-women-with-problematic-hot-flushes-and-night-sweats-menos-work-a-multicenter-randomized-controlled-trial
#7
Claire Hardy, Amanda Griffiths, Sam Norton, Myra S Hunter
OBJECTIVE: The aim of the study was to examine the efficacy of an unguided, self-help cognitive behavior therapy (SH-CBT) booklet on hot flush and night sweat (HFNS) problem rating, delivered in a work setting. METHODS: Women aged 45 to 60 years, having 10 or more problematic HFNS a week, were recruited to a multicenter randomized controlled trial, via the occupational health/human resources departments of eight organizations. Participants were 1:1 randomized to SH-CBT or no treatment waitlist control (NTWC)...
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29304152/combination-of-near-infrared-and-thermal-imaging-techniques-for-the-remote-and-simultaneous-measurements-of-breathing-and-heart-rates-under-sleep-situation
#8
Menghan Hu, Guangtao Zhai, Duo Li, Yezhao Fan, Huiyu Duan, Wenhan Zhu, Xiaokang Yang
To achieve the simultaneous and unobtrusive breathing rate (BR) and heart rate (HR) measurements during nighttime, we leverage a far-infrared imager and an infrared camera equipped with IR-Cut lens and an infrared lighting array to develop a dual-camera imaging system. A custom-built cascade face classifier, containing the conventional Adaboost model and fully convolutional network trained by 32K images, was used to detect the face region in registered infrared images. The region of interest (ROI) inclusive of mouth and nose regions was afterwards confirmed by the discriminative regression and coordinate conversions of three selected landmarks...
2018: PloS One
https://www.readbyqxmd.com/read/29302618/time-restricted-feeding-improves-circadian-dysfunction-as-well-as-motor-symptoms-in-the-q175-mouse-model-of-huntington-s-disease
#9
Huei-Bin Wang, Dawn H Loh, Daniel S Whittaker, Tamara Cutler, David Howland, Christopher S Colwell
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep/wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and fatigue during the day. The heterozygous Q175 mouse model of HD has been shown to phenocopy many HD core symptoms including circadian dysfunctions. Because circadian dysfunction manifests early in the disease in both patients and mouse models, we sought to determine if early intervention that improve circadian rhythmicity can benefit HD and delay disease progression...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29298404/predictors-of-obstructive-sleep-apnea-in-consecutive-patients-with-metabolic-syndrome
#10
Rodrigo P Pedrosa, Cristiane Maki-Nunes, Thiago Midlej-Brito, Heno F Lopes, Lunara S Freitas, Ivani C Trombetta, Edgar Toschi-Dias, Maria Janieire N N Alves, Raffael F Fraga, Maria U Rondon, Carlos E Negrão, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
BACKGROUND: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. METHODS: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements...
January 3, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29297761/an-improved-model-to-predict-performance-under-mental-fatigue
#11
Henry T Peng, Fethi Bouak, Wenbi Wang, Renee Chow, Oshin Vartanian
Fatigue has become an increasing problem in our modern society. Using MATLAB as a generic modelling tool, a fatigue model was developed based on an existing one and compared with a commercial fatigue software for prediction of cognitive performance under total and partial sleep deprivation. The flexibility of our fatigue model allowed additions of new algorithms and mechanisms for non-sleep factors and countermeasures and thus improved model predictions and usability for both civilian and military applications...
January 8, 2018: Ergonomics
https://www.readbyqxmd.com/read/29295853/is-blood-pressure-improving-in-children-with-chronic-kidney-disease-a-period-analysis
#12
Gina-Marie Barletta, Christopher Pierce, Mark Mitsnefes, Joshua Samuels, Bradley A Warady, Susan Furth, Joseph Flynn
Uncontrolled hypertension in children with chronic kidney disease (CKD) has been identified as one of the main factors contributing to progression of CKD and increased risk for cardiovascular disease. Recent efforts to achieve better blood pressure (BP) control have been recommended. The primary objective of this analysis was to compare BP control over 2 time periods among participants enrolled in the CKiD study (Chronic Kidney Disease in Children). Casual BP and 24-hour ambulatory BP monitor data were compared among 851 participants during 2 time periods: January 1, 2005, through July 1, 2008 (period 1, n=345), and July 1, 2010, through December 31, 2013 (period 2, n=506)...
January 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29287793/the-protective-effect-of-20-s-protopanaxadiol-ppd-against-chronic-sleep-deprivation-csd-induced-memory-impairments-in-mice
#13
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
Sleep deprivation (SD) is associated with oxidative stress that causes learning and memory impairment. 20(S)-Protopanaxadiol (PPD), one of the protopanaxadiol-type saponins, has antioxidant and neuroprotective effect. This study was designed to research the protective effect of PPD against cognitive deficits induced by chronic sleep deprivation (CSD) in mice. The CSD model was induced by subjecting the mice to our self-made Sleep Interruption Apparatus (SIA) continuously for 14 days. The memory enhancing effects of PPD were evaluated by behavioral tests and the related mechanism was further explored by observing the oxidative stress changes in the cortex and hippocampus of mice...
December 26, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29280659/prevalence-of-hypovitaminosis-d-and-associated-factors-in-adolescent-students-of-a-capital-of-northeastern-brazil
#14
Euarda Pontes Dos Santos Araújo, Dayanna Joyce Marques Queiroz, Juliana Padilha Ramos Neves, Lavoisiana Mateus de Lacerda, Maria Da Conceição Rodrigues Gonçalves, Alice Teles de Carvalho
BACKGROUND: Hypovitaminosis D is a frequent problem in the world and can be influenced by several factors. OBJECTIVE: To estimate the prevalence of hypovitaminosis D and associated factors in adolescent students of a capital city of northeastern Brazil. METHODS: Cross-sectional epidemiological study assessing 220 school adolescents of both sexes aged 15 to 19 years. A questionnaire was applied to assess sociodemographic (skin color, mother's education and receiving social benefits) and behavioral data (number of hours of sleep per day, sun exposure, physical activity and dietary vitamin D intake)...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29258977/estimation-of-symptom-severity-during-chemotherapy-from-passively-sensed-data-exploratory-study
#15
Carissa A Low, Anind K Dey, Denzil Ferreira, Thomas Kamarck, Weijing Sun, Sangwon Bae, Afsaneh Doryab
BACKGROUND: Physical and psychological symptoms are common during chemotherapy in cancer patients, and real-time monitoring of these symptoms can improve patient outcomes. Sensors embedded in mobile phones and wearable activity trackers could be potentially useful in monitoring symptoms passively, with minimal patient burden. OBJECTIVE: The aim of this study was to explore whether passively sensed mobile phone and Fitbit data could be used to estimate daily symptom burden during chemotherapy...
December 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29250775/most-impactful-factors-on-the-health-related-quality-of-life-of-a-geriatric-population-with-cancer
#16
Maria Pisu, Andres Azuero, Karina I Halilova, Courtney P Williams, Kelly M Kenzik, Elizabeth A Kvale, Grant R Williams, Karen Meneses, Margaret Sullivan, Supriya Kumar Yagnik, Hans-Peter Goertz, Gabrielle B Rocque
BACKGROUND: As the population of older adults with cancer continues to grow, the most important factors contributing to their health-related quality of life (HRQOL) remain unclear. METHODS: A total of 1457 older adults (aged ≥65 years) with cancer participated in a telephone survey. Outcomes were measured using the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the 12-Item Short Form Survey (SF-12) from the Medical Outcomes Study (version 2)...
December 18, 2017: Cancer
https://www.readbyqxmd.com/read/29248975/a-meta-analysis-of-obstructive-sleep-apnea-in-patients-with-cerebrovascular-disease
#17
Zesheng Wu, Fanghui Chen, Fan Yu, Yi Wang, Zhidong Guo
BACKGROUND: There is increasing evidence that there is a direct relationship between obstructive sleep apnea (OSA) and cerebrovascular (CV) disease. This meta-analysis includes prospective cohorts and cross-sectional studies. It determines the prevalence of OSA among patients with CV disease and also looks for the risk o f cerebrovascular events among patients with OSA. METHOD: We conducted a computerized literature search in the databases of Medline, Embase, Wanfang, CNKI, Wiley Online Library, and CINAHL (date till April 2017)...
December 16, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29247105/association-of-sleep-duration-and-quality-with-blood-lipids-a-systematic-review-and-meta-analysis-of-prospective-studies
#18
Marlot Kruisbrink, Wendy Robertson, Chen Ji, Michelle A Miller, Johanna M Geleijnse, Francesco P Cappuccio
OBJECTIVES: To assess the longitudinal evidence of the relationships between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships. SETTING: Systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. METHODS: We performed a systematic search of PubMed and Embase (up to 9 September 2017), complemented with manual searches, of prospective population studies describing the association between sleep duration and quality and the incidence of dyslipidaemias...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29233240/sleep-on-long-haul-layovers-and-pilot-fatigue-at-the-start-of-the-next-duty-period
#19
Jan Cosgrave, Lora J Wu, Margo van den Berg, T Leigh Signal, Philippa H Gander
INTRODUCTION: Layovers are critical for pilot recovery between flights and minimum layover durations are required by regulation. However, research on the factors affecting layover sleep and safety performance indicators (SPIs) before subsequent flights is relatively sparse. The present project combined data from 6 studies, including 8 long-range and 5 ultra-long range out-and-back trips across a range of different layover destinations (299 pilots in 4-person crews, 410 layovers, 1-3 d layover duration)...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29228820/associations-between-depressive-symptomatology-and-neurocognitive-impairment-in-hiv-aids
#20
Sarah Tymchuk, Daniela Gomez, Noshin Koenig, M John Gill, Esther Fujiwara, Christopher Power
OBJECTIVE: Mood disorders and neurocognitive impairments are debilitating conditions among patients with HIV/AIDS. How these comorbidities interact and their relationships to systemic factors remain uncertain. Herein, we investigated factors contributing to depressive symptomatology (DS) in a prospective cohort of patients with HIV/AIDS in active care that included neuropsychological assessment. METHODS: Among patients with HIV/AIDS receiving combination antiretroviral therapy (cART) and ongoing clinical assessments including measures of sleep, health-related quality of life (HQoL), neuropsychological testing, and mood evaluation (Patient Health Questionnaire-9 [PHQ-9]) were performed...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
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