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https://www.readbyqxmd.com/read/29783161/candidate-gene-analysis-in-the-s%C3%A3-o-paulo-epidemiologic-sleep-study-episono-shows-an-association-of-variant-in-pde4d-and-sleepiness
#1
Victoria M Pak, Diego R Mazzotti, Brendan T Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I Pack, Sergio Tufik
INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA), and Phosphodiesterase 4D (PDE4D)...
January 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29782961/baclofen-induced-encephalopathy-in-overdose-modeling-of-the-electroencephalographic-effect-concentration-relationships-and-contribution-of-tolerance-in-the-rat
#2
Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard
Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. We designed a rat study to characterize baclofen-induced encephalopathy, correlate its severity with plasma concentrations and investigate the contribution of tolerance...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29782311/the-independent-associations-of-physical-activity-and-sleep-with-cognitive-function-in-older-adults
#3
Ryan S Falck, John R Best, Jennifer C Davis, Teresa Liu-Ambrose
BACKGROUND: Current evidence suggests physical activity (PA) and sleep are important for cognitive health; however, few studies examining the role of PA and sleep for cognitive health have measured these behaviors objectively. OBJECTIVE: We cross-sectionally examined whether 1) higher PA is associated with better cognitive performance independently of sleep quality; 2) higher sleep quality is associated with better cognitive performance independently of PA; and 3) whether higher PA is associated with better sleep quality...
May 15, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781824/symptom-experience-and-self-rated-physical-functioning-in-patients-with-ovarian-cancer-receiving-chemotherapy-a-longitudinal-study
#4
Ingvild Vistad, Milada Cvancarova, Guro Lindviksmoen Astrup, Tone Rustøen, Astrid H Liavaag
OBJECTIVES: In this longitudinal study, we investigated occurrence of multiple symptoms during chemotherapy in patients with ovarian cancer. We also evaluated whether self-rated physical functioning, selected demographic, and clinical variables were associated with symptom burden over time. METHODS AND MATERIALS: In total, 82 patients provided longitudinal data (4 time points) by completing questionnaires including the Memorial Symptom Assessment Scale, the Karnofsky Performance Status Scale, and the Self-Administered Comorbidity Questionnaire...
May 18, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29781654/is-fatigue-a-disease-specific-or-generic-symptom-in-chronic-medical-conditions
#5
Juliane Menting, Cees J Tack, Gijs Bleijenberg, Rogier Donders, Hal A Droogleever Fortuyn, Jaap Fransen, Martine M Goedendorp, Joke S Kalkman, Riet Strik-Albers, Nens van Alfen, Sieberen P van der Werf, Nicol C Voermans, Baziel G van Engelen, Hans Knoop
OBJECTIVE: Severe fatigue is highly prevalent in various chronic diseases. Disease-specific fatigue models have been developed, but it is possible that fatigue-related factors in these models are similar across diseases. The purpose of the current study was to determine the amount of variance in fatigue severity explained by: (a) the specific disease, (b) factors associated with fatigue across different chronic diseases (transdiagnostic factors), and (c) the interactions between these factors and specific diseases...
June 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29781634/household-chaos-and-family-sleep-during-infants-first-year
#6
Corey J Whitesell, Brian Crosby, Thomas F Anders, Douglas M Teti
Household chaos has been linked with dysregulated family and individual processes. The present study investigated linkages between household chaos and infant and parent sleep, a self-regulated process impacted by individual, social, and environmental factors. Studies of relations between household chaos and child sleep have focused on older children and teenagers, with little attention given to infants or parent sleep. This study examines these relationships using objective measures of household chaos and sleep while controlling for, respectively, maternal emotional availability at bedtime and martial adjustment, in infant and parent sleep...
May 21, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29781511/prevalence-and-risk-indicators-of-pain-related-temporomandibular-disorders-among-indonesian-children-and-adolescents
#7
Carolina Marpaung, Maurits K A van Selms, Frank Lobbezoo
OBJECTIVES: To assess the prevalence of pain-related temporomandibular disorders (TMDs) among Indonesian children and adolescents, and to investigate which risk indicators are associated with it. METHODS: In this cross-sectional study, 1,800 questionnaires were distributed among pupils of schools in the greater Jakarta area. This was done for 2 samples: children with ages ranging from 7 to 12 years (parental report) and adolescents aged 13-18 years (self-report)...
May 21, 2018: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29780978/i-ll-be-back-on-the-multiple-lives-of-users-of-a-mobile-activity-tracking-application
#8
Zhiyuan Lin, Tim Althoff, Jure Leskovec
Mobile health applications that track activities, such as exercise, sleep, and diet, are becoming widely used. While these activity tracking applications have the potential to improve our health, user engagement and retention are critical factors for their success. However, long-term user engagement patterns in real-world activity tracking applications are not yet well understood. Here we study user engagement patterns within a mobile physical activity tracking application consisting of 115 million logged activities taken by over a million users over 31 months...
April 2018: Proceedings of the International World-Wide Web Conference
https://www.readbyqxmd.com/read/29780977/modeling-interdependent-and-periodic-real-world-action-sequences
#9
Takeshi Kurashima, Tim Althoff, Jure Leskovec
Mobile health applications, including those that track activities such as exercise, sleep, and diet, are becoming widely used. Accurately predicting human actions in the real world is essential for targeted recommendations that could improve our health and for personalization of these applications. However, making such predictions is extremely difficult due to the complexities of human behavior, which consists of a large number of potential actions that vary over time, depend on each other, and are periodic...
April 2018: Proceedings of the International World-Wide Web Conference
https://www.readbyqxmd.com/read/29780880/circadian-and-brain-state-modulation-of-network-hyperexcitability-in-alzheimer-s-disease
#10
Rosalind Brown, Alice D Lam, Alfredo Gonzalez-Sulser, Andrew Ying, Mary Jones, Robert Chang-Chih Chou, Makis Tzioras, Crispin Y Jordan, Izabela Jedrasiak-Cape, Anne-Laure Hemonnot, Maurice Abou Jaoude, Andrew J Cole, Sydney S Cash, Takashi Saito, Takaomi Saido, Richard R Ribchester, Kevan Hashemi, Iris Oren
Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APPNL/F )...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29779564/effects-of-alertness-management-training-on-sleepiness-among-long-haul-truck-drivers-a-randomized-controlled-trial
#11
M Pylkkönen, A Tolvanen, C Hublin, J Kaartinen, K Karhula, S Puttonen, M Sihvola, M Sallinen
Education is a frequently recommended remedy for driver sleepiness in occupational settings, although not many studies have examined its usefulness. To date, there are no previous on-road randomized controlled trials investigating the benefits of training on sleepiness among employees working in road transport. To examine the effects of an educational intervention on long-haul truck drivers' sleepiness at the wheel, amount of sleep between work shifts, and use of efficient sleepiness countermeasures (SCM) in association with night and non-night shift, a total of 53 truck drivers operating from southern Finland were allocated into an intervention and a control group using a stratified randomization method (allocation ratio for intervention and control groups 32:21, respectively)...
May 18, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29778684/modeled-and-perceived-rf-emf-noise-and-air-pollution-and-symptoms-in-a-population-cohort-is-perception-key-in-predicting-symptoms
#12
Astrid L Martens, Marije Reedijk, Tjabe Smid, Anke Huss, Danielle Timmermans, Maciej Strak, Wim Swart, Virissa Lenters, Hans Kromhout, Robert Verheij, Pauline Slottje, Roel C H Vermeulen
BACKGROUND: Psychosocial research has shown that perceived exposure can influence symptom reporting, regardless of actual exposure. The impact of this phenomenon on the interpretation of results from epidemiological research on environmental determinants of symptoms is unclear. OBJECTIVE: Our aim was to compare associations between modeled exposures, the perceived level of these exposures and reported symptoms (non-specific symptoms, sleep disturbances, and respiratory symptoms) for three different environmental exposures (radiofrequency electromagnetic fields (RF-EMF), noise, and air pollution)...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29777969/multicontextual-correlates-of-adolescent-sugar-sweetened-beverage-intake
#13
Allison W Watts, Jon Miller, Nicole I Larson, Marla E Eisenberg, Mary T Story, Dianne Neumark-Sztainer
PURPOSE: To examine personal, home, peer, school, neighborhood, and media correlates of sugar-sweetened beverage (SSB) intake in a diverse sample of adolescents. METHODS: Cross-sectional, population-based study (EAT 2010: Eating and Activity in Teens) of 2793 adolescents (54% female, mean age [SD] = 14.5 [2.0], 80% nonwhite) attending public secondary schools in Minneapolis-St. Paul, Minnesota. Adolescents completed a food frequency questionnaire and answered survey questions about their diet/health perceptions and behaviors...
May 1, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29776774/association-of-disrupted-circadian-rhythmicity-with-mood-disorders-subjective-wellbeing-and-cognitive-function-a-cross-sectional-study-of-91-105-participants-from-the-uk-biobank
#14
Laura M Lyall, Cathy A Wyse, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Carlos A Celis Morales, Stephany M Biello, Daniel Mackay, Joey Ward, Rona J Strawbridge, Jason M R Gill, Mark E S Bailey, Jill P Pell, Daniel J Smith
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder...
May 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29776626/insomnia-symptoms-and-their-association-with-workplace-productivity-cross-sectional-and-pre-post-intervention-analyses-from-a-large-multinational-manufacturing-company
#15
Colin A Espie, Brent Pawlecki, Dickon Waterfield, Kit Fitton, Michael Radocchia, Annemarie I Luik
BACKGROUND: Symptoms of insomnia are common and might impact work productivity. We investigated the relationship between insomnia symptoms and workplace productivity in a global manufacturing company. METHODS: Within an uncontrolled, cross-sectional study, employees from a US-based company were invited to participate in an online evaluation comprising the Sleep Condition Indicator (SCI) measuring symptoms of insomnia (high score indicating better sleep), 2 items of the Work Productivity and Impairment Index (WPAI) measuring 'presenteeism' and 'absenteeism' (high score indicating loss of work productivity) and 1 item of the Perceived Stress Scale (PSS) from January 2015 onwards...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29776622/sleep-deficiency-among-native-hawaiian-pacific-islander-black-and-white-americans-and-the-association-with-cardiometabolic-diseases-analysis-of-the-national-health-interview-survey-data
#16
Ellyn E Matthews, Chenghui Li, Christopher R Long, Marie-Rachelle Narcisse, Bradley C Martin, Pearl Anna McElfish
PURPOSE: Examine sleep deficiency, factors, and associations with cardiometabolic diseases in United States Native Hawaiian/Pacific Islanders (NHPI), Blacks, and Whites. DESIGN: Data from the 2014 National Health Interview Survey and NHPI National Health Interview Survey household interviews of adults were analyzed. PARTICIPANTS: Of 31,724 participants, 7% were NHPI, 14% were Black, and 79% were White. METHODS: Habitual sleep duration and quality, sociodemographic/economic covariates, health behaviors, psychological distress, and chronic diseases were self-reported...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29776620/physical-neighborhood-and-social-environment-beliefs-about-sleep-sleep-hygiene-behaviors-and-sleep-quality-among-african-americans
#17
Soohyun Nam, Robin Whittemore, Sunyoung Jung, Carl Latkin, Trace Kershaw, Nancy S Redeker
OBJECTIVES: African Americans (AAs) have a higher prevalence of sleep disorders than other racial/ethnic groups. However, little is known about the relationships among individual and neighborhood factors related to sleep quality in AAs. The purposes of this study were to (1) describe beliefs about sleep, sleep hygiene behaviors, and sleep quality among AAs; and (2) examine the relationships among sociodemographic characteristics, neighborhood environment, beliefs about sleep, sleep hygiene behaviors, and sleep quality...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29776467/how-memory-replay-in-sleep-boosts-creative-problem-solving
#18
REVIEW
Penelope A Lewis, Günther Knoblich, Gina Poe
Creative thought relies on the reorganisation of existing knowledge. Sleep is known to be important for creative thinking, but there is a debate about which sleep stage is most relevant, and why. We address this issue by proposing that rapid eye movement sleep, or 'REM', and non-REM sleep facilitate creativity in different ways. Memory replay mechanisms in non-REM can abstract rules from corpuses of learned information, while replay in REM may promote novel associations. We propose that the iterative interleaving of REM and non-REM across a night boosts the formation of complex knowledge frameworks, and allows these frameworks to be restructured, thus facilitating creative thought...
June 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29775702/abnormal-sleep-architecture-and-hippocampal-circuit-dysfunction-in-a-mouse-model-of-fragile-x-syndrome
#19
Christine E Boone, Heydar Davoudi, Jon B Harrold, David J Foster
Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and single-gene cause of autism spectrum disorder. The Fmr1 null mouse models much of the human disease including hyperarousal, sensory hypersensitivity, seizure activity, and hippocampus-dependent cognitive impairment. Sleep architecture is disorganized in FXS patients, but has not been examined in Fmr1 knockout (Fmr1-KO) mice. Hippocampal neural activity during sleep, which is implicated in memory processing, also remains uninvestigated in Fmr1-KO mice...
May 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29775401/electroencephalographic-signals-during-anesthesia-recorded-from-surface-and-depth-electrodes
#20
Ville Jäntti, Tuomo Ylinen, Narayan Puthanmadam Subramaniyam, Kotoe Kamata, Arvi Yli-Hankala, Pasi Kauppinen, Eila Sonkajärvi
Purpose - Anesthesiologists have increasingly started to use EEG based indexes to estimate the level and type of unconsciousness. However, the physiology and biophysics are poorly understood in anesthesiological literature. Methods - EEG was recorded from electrodes on the surface of head, including scalp, as well as DBS (deep brain stimulation) electrodes implanted deep in the brain. Mathematical modeling with a realistic head model was performed to create illustrative images of the sensitivity of electrode montages...
May 18, 2018: International Journal of Radiation Biology
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