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https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#1
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909432/pharmacokinetics-of-a-novel-sildenafil-orodispersible-film-administered-by-the-supralingual-and-the-sublingual-route-to-healthy-men
#2
Luca Loprete, Chiara Leuratti, Valeria Frangione, Milko Radicioni
BACKGROUND: Sildenafil was the first selective drug available on the market as oral therapy for erectile dysfunction (ED). A novel sildenafil orodispersible film (ODF) for ED treatment, containing sildenafil citrate, has recently been marketed. OBJECTIVES: Study objective was to investigate sildenafil bioavailability of the novel ODF formulation after sublingual and supralingual administration. METHODS: In this randomised, two-way cross-over study, 12 healthy male volunteers received a single 50 mg sildenafil dose by the sublingual and supralingual administration routes...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909264/tamoxifen-versus-clomiphene-citrate-for-ovulation-induction-in-infertile-women
#3
REVIEW
Li Jie, Deng Li, Chen Yang, Zhang Haiying
This systematic review aimed to compare the clinical efficacy of tamoxifen with that of clomiphene citrate (CC) in anovulatory patients. The PubMed, EMBASE, and CNKI databases were searched up to October 2016 for literature comparing tamoxifen with CC in anovulatory women. The pooled risk ratios (RR) or standardized mean differences (SMD) with 95% confidence intervals (CIs) were subjected to statistical analysis. Twelve studies involving 1302 patients with 2030 ovulation-induction cycles were summarized. There were no statistically significant differences for the ovulation and pregnancy rates in the tamoxifen comparing to the CC group in the pooled analysis...
June 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908775/insulin-resistance-is-associated-with-depression-risk-in-polycystic-ovary-syndrome
#4
Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddleston
OBJECTIVE: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). DESIGN: Secondary analysis of data from a multicenter randomized trial. SETTING: Multicenter university-based clinical practices. PATIENT(S): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908374/clomiphene-citrate-increases-nitric-oxide-interleukin-10-and-reduces-matrix-metalloproteinase-9-in-women-with-polycystic-ovary-syndrome
#5
Angel Mercy Sylus, Hanumanthappa Nandeesha, Magadi Gopalakrishna Sridhar, Thyagaraju Chitra, Karli Sreenivasulu
OBJECTIVES: Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in PCOS, the effect of clomiphene citrate on them has not been studied till date. The present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9, nitric oxide and interleukin-10 levels in women with PCOS. STUDY DESIGN: 72 women diagnosed with PCOS were enrolled in the study...
June 8, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908003/molecular-cloning-of-tamate2-homoeologues-potentially-related-to-aluminium-tolerance-in-bread-wheat-triticum-aestivum-l
#6
Ana Luísa Garcia-Oliveira, César Benito, Henrique Guedes-Pinto, Paula Martins-Lopes
Recently, members of MATE family have been implicated in aluminium (Al) tolerance by facilitating citrate efflux in plants. The aim of the present work was to perform a molecular characterisation of the MATE2 gene in bread wheat. Here, we cloned a member of the MATE gene family in bread wheat and named TaMATE2, which showed the typical secondary structure of MATE-type transporters maintaining all the 12 transmembrane domains. The amplification in Chinese Spring nulli-tetrasomic and ditelosomic lines revealed that TaMATE2 is located on the long arm of homoeologous group 1 chromosomes...
June 15, 2018: Plant Biology
https://www.readbyqxmd.com/read/29907844/insulin-suppression-of-fatty-acid-skeletal-muscle-enzyme-activity-in-postmenopausal-women-and-improvements-in-metabolic-flexibility-and-lipoprotein-lipase-with-aerobic-exercise-and-weight-loss
#7
Alice S Ryan, Heidi K Ortmeyer
BACKGROUND: Obesity and insulin resistance are characterized by metabolic inflexibility, a condition described as an inability to switch from fat oxidation during fasting to carbohydrate oxidation during hyperinsulinemia. The purpose of this study was to examine predictors of metabolic flexibility in 103 obese (37-59% fat), sedentary (VO2 max: 19.4 ± 0.5 ml/kg/min), postmenopausal (45-76 years) women, and changes in metabolic flexibility with exercise and weight loss interventions...
June 15, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29906757/transport-of-oxaliplatin-species-in-water-saturated-natural-soil
#8
Natalia Goykhman, Ishai Dror, Brian Berkowitz
This study reports the transport characteristics of the organometallic anticancer compound oxaliplatin and its derivatives in natural soil-water environments. Although pharmaceuticals and their derivatives have for many years been detected in water resources, and linked to toxicological impacts on ecological systems, their transport in soil and groundwater is not fully understood. Specifically, studies that describe transport of organometallic pharmaceuticals in porous media are rare, and the transport characteristics of platinum complexes have received little attention...
June 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29904332/citrate-usage-in-the-leading-causes-of-blindness-new-possibilities-for-the-old-metabolite
#9
REVIEW
Marta Michalczuk, Beata Urban, Tadeusz Porowski, Anna Wasilewska, Alina Bakunowicz-Łazarczyk
Introduction: Citrate is an old metabolite which is best known for the role in the Krebs cycle. Citrate is widely used in many branches of medicine. In ophthalmology citrate is considered as a therapeutic agent and an useful diagnostic tool-biomarker. Objectives: To summarize the published literature on citrate usage in the leading causes of blindness and highlight the new possibilities for this old metabolite. Methods: We conducted a systematic search of the scientific literature about citrate usage in ophthalmology up to January 2018...
2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29903508/rapid-thrombelastography-compared-to-kaolin-and-native-rapid-and-efficient
#10
Julia R Coleman, Ernest E Moore, Michael P Chapman, Anirban Banerjee, Christopher C Silliman, Arsen Ghasabyan, James Chandler, Jason M Samuels, Angela Sauaia
BACKGROUND: Several thrombelastography functional assays have been developed to guide transfusion in injured patients, but how this acceleration of thrombelastography affects its ability to predict massive transfusion is unknown. The objective of this study is to compare citrated native, citrated kaolin, and citrated rapid thromboelastographies for their prediction of massive transfusion after trauma. We hypothesized that citrated native thrombelastography best predicts massive transfusion...
June 11, 2018: Surgery
https://www.readbyqxmd.com/read/29902680/oil-biosynthesis-and-transcriptome-profiles-in-developing-endosperm-and-oil-characteristic-analyses-in-paeonia-ostii-var-lishizhenii
#11
Yu Xiu, Guodong Wu, Wensi Tang, Zhengfeng Peng, Xiangpan Bu, Longjun Chao, Xue Yin, Jiannan Xiong, Haiwu Zhang, Xiaoqing Zhao, Jing Ding, Lvyi Ma, Huafang Wang, Johannes van Staden
Paeonia ostii var. lishizhenii, a well-known medicinal and horticultural plant, is indigenous to China. Recent studies have shown that its seed has a high oil content, and it was approved as a novel resource of edible oil with a high level of α-linolenic acid by the Chinese Government. This study measured the seed oil contents and fatty acid components of P. ostii var. lishizhenii and six other peonies, P. suffruticosa, P. ludlowii, P. decomposita, P. rockii, and P. lactiflora Pall. 'Heze' and 'Gansu'. The results show that P...
June 4, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29902250/inhibition-of-mitochondrial-respiration-under-hypoxia-and-increased-antioxidant-activity-after-reoxygenation-of-tribolium-castaneum
#12
Lei Wang, Sufen Cui, Zhicheng Liu, Yong Ping, Jiangping Qiu, Xueqing Geng
Regulating the air in low-oxygen environments protects hermetically stored grains from storage pests damage. However, pests that can tolerate hypoxic stress pose a huge challenge in terms of grain storage. We used various biological approaches to determine the fundamental mechanisms of Tribolium castaneum to cope with hypoxia. Our results indicated that limiting the available oxygen to T. castaneum increased glycolysis and inhibited the Krebs cycle, and that accumulated pyruvic acid was preferentially converted to lactic acid via anaerobic metabolism...
2018: PloS One
https://www.readbyqxmd.com/read/29902242/effects-of-low-dose-silver-nanoparticle-treatment-on-the-structure-and-community-composition-of-bacterial-freshwater-biofilms
#13
Alexandra Y Grün, Constantin B App, Andreas Breidenbach, Jutta Meier, George Metreveli, Gabriele E Schaumann, Werner Manz
The application of engineered silver nanoparticles (AgNPs) in a considerable amount of registered commercial products inevitably will result in the continuous release of AgNPs into the natural aquatic environment. Therefore, native biofilms, as the prominent life form of microorganisms in almost all known ecosystems, will be subjected to AgNP exposure. Despite the exponentially growing research activities worldwide, it is still difficult to assess nanoparticle-mediated toxicity in natural environments. In order to obtain an ecotoxicologically relevant exposure scenario, we performed experiments with artificial stream mesocosm systems approaching low dose AgNP concentrations close to predicted environmental concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29902105/characterization-and-transcriptome-analysis-of-acinetobacter-baumannii-persister-cells
#14
Rashad Alkasir, Yanan Ma, Fei Liu, Jing Li, Na Lv, Yong Xue, Yongfei Hu, Baoli Zhu
Acinetobacter baumannii is a nonfermenting Gram-negative bacillus. A. baumannii resistance is a significant obstacle to clinical infection treatment. The existence of persister cells (persisters) might represent the reason for therapy failure and relapse, and such cells may be the driving force behind rising resistance rates. In this study, A. baumannii ATCC 19606 was used as a target to explore the essential features of A. baumannii persisters. Antibiotic treatment of A. baumannii cultures at 50-fold the minimum inhibitory concentration resulted in a distinct plateau of surviving drug-tolerant persisters...
June 14, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29901147/antioxidants-retard-the-ageing-of-mouse-oocytes
#15
Yexing Xian, Lifeng Liang, Shutao Qi, Yingjun Xie, Bing Song, Shuming Ouyang, Yuhuan Xie, Xiaofang Sun, Weihua Wang
The aim of the present study was to verify the effects of heavy metal coupling agents (sodium citrate and EDTA) and antioxidants (acetyl carnitine and lipoic acid) on the number of oocytes, as well as the ageing of mitochondria, chromosomes and spindles in mice. C57BL/6 female mice were randomly classified into four groups (n=12 per group): i) Heavy metal coupling agent; ii) antioxidant; iii) mixed group; and iv) the normal control group. For the treatments, heavy metal coupling agents and antioxidants were added to the drinking water provided to the mice...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901145/weighted-gene-co%C3%A2-expression-network-analysis-in-identification-of-key-genes-and-networks-for-ischemic%C3%A2-reperfusion-remodeling-myocardium
#16
Nan Guo, Nan Zhang, Liqiu Yan, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Xufen Cao
Acute myocardial infarction induces ventricular remodeling, which is implicated in dilated heart and heart failure. The pathogenical mechanism of myocardium remodeling remains to be elucidated. The aim of the present study was to identify key genes and networks for myocardium remodeling following ischemia‑reperfusion (IR). First, the mRNA expression data from the National Center for Biotechnology Information database were downloaded to identify differences in mRNA expression of the IR heart at days 2 and 7...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900660/a-sensitive-sers-quantitative-analysis-method-for-ni-2-by-the-dimethylglyoxime-reaction-regulating-a-graphene-oxide-nanoribbon-catalytic-gold-nanoreaction
#17
Aihui Liang, Xin Li, Xinghui Zhang, Guiqing Wen, Zhiliang Jiang
The nanogold reaction between HAuCl4 and trisodium citrate (TCA) proceeded very slowly at 60°C in a water bath. The as-prepared graphene oxide nanoribbons (GONRs) exhibited strong catalysis during the reaction to form gold nanoparticles (Au NPs) and appeared as a strong surface-enhanced Raman scattering (SERS) peak at 1616 cm-1 in the presence of the molecular probe Victoria blue 4R (VB4r). With increase in GONR concentration, the SERS peak increased due to increased formation of Au NPs. Upon addition of dimethylglyoxime (DMG) ligand, which was adsorbed onto the GONR surface to inhibit GONR catalysis, the SERS peak decreased...
June 13, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29899443/structural-basis-for-regulation-of-human-acetyl-coa-carboxylase
#18
Moritz Hunkeler, Anna Hagmann, Edward Stuttfeld, Mohamed Chami, Yakir Guri, Henning Stahlberg, Timm Maier
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2 . Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the outer mitochondrial membrane and controls fatty acid β-oxidation1,3 . ACC1 is regulated by a complex interplay of phosphorylation, binding of allosteric regulators and protein-protein interactions, which is further linked to filament formation1,4-8 ...
June 13, 2018: Nature
https://www.readbyqxmd.com/read/29898699/rapid-calcium-loss-may-cause-arrhythmia-in-hemofiltration-with-regional-citrate-anticoagulation-a-case-report
#19
Buyun Wu, Jing Wang, Guang Yang, Changying Xing, Huijuan Mao
BACKGROUND: Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to induce arrhythmia caused by rapid calcium loss. We report a case of arrhythmia associated with rapid calcium loss during RCA-RRT. CASE PRESENTATION: A 51-year-old man with hypercalcemia, primary hyperparathyroidism, and acute kidney injury was treated by predilutional-RCA-hemofiltration at a rate of 4...
June 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29898003/influence-of-citrate-concentration-on-the-activation-of-blood-cells-in-an-in-vitro-dialysis-setup
#20
Jakob Gubensek, Karin Strobl, Stephan Harm, Rene Weiss, Tanja Eichhorn, Jadranka Buturovic-Ponikvar, Viktoria Weber, Jens Hartmann
BACKGROUND: Regional citrate anticoagulation has been associated with enhanced biocompatibility in hemodialysis, but the optimal dose of citrate remains to be established. Here, we compared parameters related to cellular activation during in vitro dialysis, using two doses of citrate. METHODS: Human whole blood, anticoagulated with either 3 mM or 4 mM of citrate, was recirculated in an in vitro miniaturized dialysis setup. Complement (C3a-desArg), soluble platelet factor 4 (PF4), thromboxane B2 (TXB2), myeloperoxidase (MPO), as well as platelet- and red blood cell-derived extracellular vesicles (EV) were quantified during recirculation...
2018: PloS One
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