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Mobilization with movement

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https://www.readbyqxmd.com/read/28733144/the-spliceosome-a-protein-directed-metalloribozyme
#1
REVIEW
Yigong Shi
Pre-mRNA splicing is executed by the ribonucleoprotein machinery spliceosome. Nearly forty years after the discovery of pre-mRNA splicing, the atomic structure of the spliceosome has finally come to light. Four distinct conformational states of the yeast spliceosome have been captured at atomic or near-atomic resolutions. Two catalytic metal ions at the active site are specifically coordinated by the U6 small nuclear RNA (snRNA) and catalyze both the branching reaction and the exon ligation. Of the three snRNAs in the fully-assembled spliceosome, U5 and U6, along with 30 contiguous nucleotides of U2 at its 5'-end, remain structurally rigid throughout the splicing reaction...
July 18, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28733130/a-pilot-randomized-controlled-trial-on-the-effects-of-a-progressive-exercise-program-on-the-range-of-motion-and-upper-extremity-grip-strength-in-young-adults-with-breast-cancer
#2
Marize Ibrahim, Thierry Muanza, Nadia Smirnow, Warren Sateren, Beatrice Fournier, Petr Kavan, Michael Palumbo, Richard Dalfen, Mary-Ann Dalzell
BACKGROUND: The diagnosis of breast cancer in young women (aged 18-45 years) has been increasing. Women are commonly left coping with treatment-related disabilities of the upper limb that can persist for > 2 years postoperatively. PATIENTS AND METHODS: A total of 59 young breast cancer patients (29 in the intervention group and 30 in the control group) participated in a pilot prospective randomized controlled trial to determine whether a 12-week postradiation exercise program would improve long-term arm mobility, pain, and handgrip strength...
June 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28729234/mobile-phone-supported-physiotherapy-for-frozen-shoulder-feasibility-assessment-based-on-a-usability-study
#3
Thomas Stütz, Gerlinde Emsenhuber, Daniela Huber, Michael Domhardt, Martin Tiefengrabner, Gertie Janneke Oostingh, Ulrike Fötschl, Nicholas Matis, Simon Ginzinger
BACKGROUND: Patients with frozen shoulder show limited shoulder mobility often accompanied by pain. Common treatment methods include physiotherapy, pain medication, administration of corticosteroids, and surgical capsulotomy. Frozen shoulder often lasts from months to years and mostly affects persons in the age group of 40 to 70 years. It severely reduces the quality of life and the ability to work. OBJECTIVE: The objective of this study was to evaluate the feasibility of a mobile health (mHealth) intervention that supports patients affected by "stage two" frozen shoulder...
July 20, 2017: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/28727585/closed-continuous-irrigation-with-lidocaine-and-immediate-mobilization-for-treatment-of-pyogenic-tenosynovitis
#4
Rebecca Knackstedt, Joyce Tyler, Steven Bernard
Pyogenic flexor tenosynovitis treatment consists of either closed continuous irrigation with sterile saline or antibiotic solution, or open debridement and irrigation. These treatment approaches serve to resolve the infection, but are extremely painful and residual stiffness can be devastating to the patient. We describe herein our approach to managing pyogenic flexor tenosynovitis. To provide continuous irrigation, a butterfly catheter with needle removed is utilized with irrigation holes cut into the tubing...
July 19, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28719842/spatiotemporal-gait-changes-with-use-of-an-arm-swing-cueing-device-in-people-with-parkinson-s-disease
#5
Elizabeth Thompson, Peter Agada, W Geoffrey Wright, Hendrik Reimann, John Jeka
Impaired arm swing is a common motor symptom of Parkinson's disease (PD), and correlates with other gait impairments and increased risk of falls. Studies suggest that arm swing is not merely a passive consequence of trunk rotation during walking, but an active component of gait. Thus, techniques to enhance arm swing may improve gait characteristics. There is currently no portable device to measure arm swing and deliver immediate cues for larger movement. Here we test report pilot testing of such a device, ArmSense (patented), using a crossover repeated-measures design...
July 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28713049/patient-reported-outcomes-after-surgical-stabilization-of-spinal-tumors-symptom-based-validation-of-the-spinal-instability-neoplastic-score-sins-and-surgery
#6
Ibrahim Hussain, Ori Barzilai, Anne S Reiner, Natalie DiStefano, Lily McLaughlin, Shahiba Ogilvie, Mark Bilsky, Ilya Laufer
BACKGROUND CONTEXT: Neoplastic spinal instability is movement-related pain or neurologic compromise under physiologic loads with the Spinal Instability Neoplastic Score (SINS) developed to facilitate diagnosis. There is a paucity of evidence that mechanical instability correlates with patient-reported symptoms and that surgical stabilization significantly improves these patient-reported outcomes (PRO). PURPOSE: The objective of this study was to determine if SINS correlates with patient-reported preoperative pain and disability and if surgical stabilization significantly improves PRO...
July 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28712014/do-you-see-what-i-see-mobile-eye-tracker-contextual-analysis-and-inter-rater-reliability
#7
S Stuart, D Hunt, J Nell, A Godfrey, J M Hausdorff, L Rochester, L Alcock
Mobile eye-trackers are currently used during real-world tasks (e.g. gait) to monitor visual and cognitive processes, particularly in ageing and Parkinson's disease (PD). However, contextual analysis involving fixation locations during such tasks is rarely performed due to its complexity. This study adapted a validated algorithm and developed a classification method to semi-automate contextual analysis of mobile eye-tracking data. We further assessed inter-rater reliability of the proposed classification method...
July 15, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28710064/time-course-analysis-of-early-meiotic-prophase-events-informs-mechanisms-of-homolog-pairing-and-synapsis-in-caenorhabditis-elegans
#8
Susanna Mlynarczyk-Evans, Anne M Villeneuve
Segregation of homologous chromosomes during meiosis depends on their ability to reorganize within the nucleus, discriminate among potential partners, and stabilize pairwise associations through assembly of the synaptonemal complex (SC). Here we report a high-resolution time-course analysis of these key early events during Caenorhabditis elegans meiosis. Labeled nucleotides are incorporated specifically into the X chromosomes during the last two hours of S phase, a property we exploit to identify a highly synchronous cohort of nuclei...
July 14, 2017: Genetics
https://www.readbyqxmd.com/read/28704626/the-effectiveness-of-neural-mobilization-for-neuro-musculoskeletal-conditions-a-systematic-review-and-meta-analysis
#9
Annalie Basson, Benita Olivier, Richard Ellis, Michel Coppieters, Aimee Stewart, Witness Mudzi
Study Design Systematic review with meta-analysis. Background Neural mobilization (NM) or neurodynamics is a movement-based intervention aimed at restoring the homeostasis in and around the nervous system. The current level of evidence for NM is largely unknown. Objectives To determine the efficacy of NM for musculoskeletal conditions with a neuropathic component. Methods Databases were searched for randomised trials investigating the effect of NM for neuro-musculoskeletal conditions. Standard methods for article identification, selection and quality appraisal were used...
July 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28701917/distinct-features-of-doublecortin-as-a-marker-of-neuronal-migration-and-its-implications-in-cancer-cell-mobility
#10
REVIEW
Abiola A Ayanlaja, Ye Xiong, Yue Gao, GuangQuan Ji, Chuanxi Tang, Zamzam Abdikani Abdullah, DianShuai Gao
Neuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in this protein impairs neuronal migration leading to several pathological conditions. Although, DCX is capable of modulating and stabilizing microtubules (MTs) to ensure effective migration, the mechanisms involved in executing these functions remain poorly understood...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28697382/bacterial-mobilization-and-transport-through-manure-enriched-soils-experiment-and-modeling
#11
N Sepehrnia, L Memarianfard, A A Moosavi, J Bachmann, G Guggenberger, F Rezanezhad
A precise evaluation of bacteria transport and mathematical investigations are useful for best management practices in agroecosystems. In this study, using laboratory experiments and modeling approaches, we assess the transport of bacteria released from three types of manure (cow, sheep, and poultry) to find the importance of the common manures in agricultural activities in soil and water pollution. Thirty six intact soil columns with different textures (sandy, loamy, and silty clay loam) were sampled. Fecal coliform leaching from layers of the manures on the soil surface was conducted under steady-state saturated flow conditions at 20 °C for up to four Pore Volumes (PVs)...
July 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28694267/mobility-of-us-rural-primary-care-physicians-during-2000-2014
#12
Matthew R McGrail, Peter M Wingrove, Stephen M Petterson, Andrew W Bazemore
PURPOSE: Despite considerable investment in increasing the number of primary care physicians in rural shortage areas, little is known about their movement rates and factors influencing their mobility. We aimed to characterize geographic mobility among rural primary care physicians, and to identify location and individual factors that influence such mobility. METHODS: Using data from the American Medical Association Physician Masterfile for each clinically active US physician, we created seven 2-year (biennial) mobility periods during 2000-2014...
July 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28692785/can-a-time-fractional-derivative-model-capture-scale-dependent-dispersion-in-saturated-soils
#13
Rhiannon M Garrard, Yong Zhang, Song Wei, HongGuang Sun, Jiazhong Qian
Time nonlocal transport models such as the time fractional advection-dispersion equation (t-fADE) were proposed to capture well-documented non-Fickian dynamics for conservative solutes transport in heterogeneous media, with the underlying assumption that the time nonlocality (which means that the current concentration change is affected by previous concentration load) embedded in the physical models can release the effective dispersion coefficient from scale dependency. This assumption, however, has never been systematically examined using real data...
July 10, 2017: Ground Water
https://www.readbyqxmd.com/read/28690497/high-amplitude-eeg-motor-potential-during-repetitive-foot-movement-possible-use-and-challenges-for-futuristic-bcis-that-restore-mobility-after-spinal-cord-injury
#14
Aljoscha Thomschewski, Yvonne Höller, Peter Höller, Stefan Leis, Eugen Trinka
Recent advances in neuroprostheses provide us with promising ideas of how to improve the quality of life in people suffering from impaired motor functioning of upper and lower limbs. Especially for patients after spinal cord injury (SCI), futuristic devices that are controlled by thought via brain-computer interfaces (BCIs) might be of tremendous help in managing daily tasks and restoring at least some mobility. However, there are certain problems arising when trying to implement BCI technology especially in such a heterogenous patient group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28690439/grasshopper-dcmd-an-undergraduate-electrophysiology-lab-for-investigating-single-unit-responses-to-behaviorally-relevant-stimuli
#15
Dieu My T Nguyen, Mark Roper, Stanislav Mircic, Robert M Olberg, Gregory J Gage
Avoiding capture from a fast-approaching predator is an important survival skill shared by many animals. Investigating the neural circuits that give rise to this escape behavior can provide a tractable demonstration of systems-level neuroscience research for undergraduate laboratories. In this paper, we describe three related hands-on exercises using the grasshopper and affordable technology to bring neurophysiology, neuroethology, and neural computation to life and enhance student understanding and interest...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28685669/understanding-how-domestic-health-policy-is-integrated-into-foreign-policy-in-south-africa-a-case-for-accelerating-access-to-antiretroviral-medicines
#16
Simon Moeketsi Modisenyane, Stephen James Heinrich Hendricks, Harvey Fineberg
BACKGROUND: South Africa, as an emerging middle-income country, is becoming increasingly influential in global health diplomacy (GHD). However, little empirical research has been conducted to inform arguments for the integration of domestic health into foreign policy by state and non-state actors. This study seeks to address this knowledge gap. It takes the form of an empirical case study which analyses how South Africa integrates domestic health into its foreign policy, using the lens of access to antiretroviral (ARV) medicines...
2017: Global Health Action
https://www.readbyqxmd.com/read/28684744/learning-new-movements-after-paralysis-results-from-a-home-based-study
#17
Camilla Pierella, Farnaz Abdollahi, Elias Thorp, Ali Farshchiansadegh, Jessica Pedersen, Ismael Seáñez-González, Ferdinando A Mussa-Ivaldi, Maura Casadio
Body-machine interfaces (BMIs) decode upper-body motion for operating devices, such as computers and wheelchairs. We developed a low-cost portable BMI for survivors of cervical spinal cord injury and investigated it as a means to support personalized assistance and therapy within the home environment. Depending on the specific impairment of each participant, we modified the interface gains to restore a higher level of upper body mobility. The use of the BMI over one month led to increased range of motion and force at the shoulders in chronic survivors...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684075/achieved-chin-position-after-genioplasty-follows-the-planned-horizontal-change-better-than-the-planned-vertical-change
#18
Jimoh Olubanwo Agbaje, Yi Sun, Ahmed S Salem, Zhaokai Li, Kelvin Osei Adu, Constantinus Politis
PURPOSE: The soft-tissue pogonion closely follows changes of the bony pogonion, but it is unknown how often an augmented bony pogonion reaches the intended position. Here we assessed the agreement between planned surgical changes and achieved results in chin surgery. MATERIALS AND METHODS: Surgical treatment was planned based on clinical examination, cast model analysis, and cephalometric image analysis. The mobile chin segment was stabilized using one chin plate...
July 3, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28679381/does-genetic-structure-reflect-differences-in-non-breeding-movements-a-case-study-in-small-highly-mobile-seabirds
#19
Petra Quillfeldt, Yoshan Moodley, Henri Weimerskirch, Yves Cherel, Karine Delord, Richard A Phillips, Joan Navarro, Luciano Calderón, Juan F Masello
BACKGROUND: In seabirds, the extent of population genetic and phylogeographic structure varies extensively among species. Genetic structure is lacking in some species, but present in others despite the absence of obvious physical barriers (landmarks), suggesting that other mechanisms restrict gene flow. It has been proposed that the extent of genetic structure in seabirds is best explained by relative overlap in non-breeding distributions of birds from different populations. We used results from the analysis of microsatellite DNA variation and geolocation (tracking) data to test this hypothesis...
July 5, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28676090/clustering-patient-mobility-patterns-to-assess-effectiveness-of-health-service-delivery
#20
Selman Delil, Rahmi Nurhan Çelik, Sayın San, Murat Dundar
BACKGROUND: Analysis of patient mobility in a country not only gives an idea of how the health-care system works, but also can be a guideline to determine the quality of health care and health disparity among regions. Even though determination of patient movement is important, it is not often realized that patient mobility could have a unique pattern beyond health-related endowments (e.g., facilities, medical staff). This study therefore addresses the following research question: Is there a way to identify regions with similar patterns using spatio-temporal distribution of patient mobility? The aim of the paper is to answer this question and improve a classification method that is useful for populous countries like Turkey that have many administrative areas...
July 4, 2017: BMC Health Services Research
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