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https://www.readbyqxmd.com/read/28475656/nmr-based-metabolomic-analysis-for-the-effects-of-creatine-supplementation-on-mouse-myoblast-cell-line-c2c12
#1
Wenqi Xu, Donghai Lin, Caihua Huang
Creatine (Cr) supplementation has drawn much attention from researchers owing to its widespread efficacy in sports, and more recently, in therapeutic fields. However, the underlying molecular mechanisms remain elusive. Here, we performed nuclear magnetic resonance-based metabolomic analysis to address the metabolic profile of aqueous extracts from the mouse myoblast cell line C2C12 exposed to 2 mM Cr for 24 h (the Cr-treated group). Results showed that Cr supplementation facilitated the proliferation of C2C12 myoblasts...
May 5, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28432552/subchronic-nandrolone-administration-reduces-cardiac-oxidative-markers-during-restraint-stress-by-modulating-protein-expression-patterns
#2
Barbara Pergolizzi, Vitina Carriero, Giuliana Abbadessa, Claudia Penna, Paola Berchialla, Silvia De Francia, Enrico Bracco, Silvia Racca
Nandrolone decanoate (ND), an anabolic-androgenic steroid prohibited in collegiate and professional sports, is associated with detrimental cardiovascular effects through redox-dependent mechanisms. We previously observed that high-dose short-term ND administration (15 mg/kg for 2 weeks) did not induce left heart ventricular hypertrophy and, paradoxically, improved postischemic response, whereas chronic ND treatment (5 mg/kg twice a week for 10 weeks) significantly reduced the cardioprotective effect of postconditioning, with an increase in infarct size and a decrease in cardiac performance...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28277983/l-arginine-supplementation-improves-rats-antioxidant-system-and-exercise-performance
#3
E P Silva, L S Borges, C Mendes-da-Silva, S M Hirabara, R H Lambertucci
Reactive species have great importance in sports performance, once they can directly regulate energy production, muscular contraction, inflammation, and fatigue. Therefore, the redox control is essential for athletes' performance. Studies demonstrated that l-arginine has an important role in the synthesis of urea, cell growth and production of nitric oxide, moreover, there are indications that it is also able to induce benefits to muscle antioxidant system through the upregulation of some antioxidant enzymes, and by inhibiting some pathways of reactive species production...
March 22, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28102488/performance-and-side-effects-of-supplementation-with-n-acetylcysteine-a-systematic-review-and-meta-analysis
#4
REVIEW
Kate Rhodes, Andrea Braakhuis
BACKGROUND: N-Acetylcysteine (NAC) is a promising antioxidant supplement with potential as an acute strategy to enhance performance in elite sport, but there are concerns about its side effects with high doses. OBJECTIVE: To review the current literature and evaluate the effects of NAC supplementation on sport performance and the risk of adverse effects. METHODS: The literature up to May 2016 was searched on MEDLINE (PubMed), EMBASE, SPORTDiscus, Google Scholar and Scopus databases to identify all studies investigating the effects of NAC supplementation on exercise performance and/or side effects experienced...
January 19, 2017: Sports Medicine
https://www.readbyqxmd.com/read/27855498/mitochondria-targeted-nutraceuticals-in-sports-medicine-a-new-perspective
#5
Sergej M Ostojic
Since mitochondria have been recognized as the cells' key organelles involved in the energy utilization during exercise, targeting the organelle with specifically designed compounds (mitochondria-targeted nutraceuticals, MTNs) may have a great promise in the prevention and treatment of heavy exercise-related mitochondrial dysfunction. In vitro studies suggested that MTNs have antioxidant effects at the molecular level, and might boost mitochondrial biogenesis and organelle bioenergetics, with both processes are known to positively affect exercise performance and recovery...
January 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/27761888/a-lifelong-competitive-training-practice-attenuates-age-related-lipid-peroxidation
#6
COMPARATIVE STUDY
Yaira Barranco-Ruiz, Antonio Martínez-Amat, Cristina Casals, Jerónimo Aragón-Vela, Silvia Rosillo, Silvana N Gomes, Ana Rivas-García, Rafael Guisado, Jesús R Huertas
The effect of exercise-induced oxidative stress on health and aging is not clearly explained. This study examined the effects of habitual sport practice, age, and submaximal exercise on the blood markers of oxidative stress, muscle damage, and antioxidant response. Seventy-two healthy men were grouped by their habitual sport practice: inactive (<1.5 h/week), recreational (3-8 h/week), and trained athletes (>8 h/week), and further divided by age: young (18-25 years), adult (40-55 years), and senior (>55 years)...
February 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27747795/oxidative-stress-in-female-athletes-using-combined-oral-contraceptives
#7
Sabina Cauci, Cinzia Buligan, Micaela Marangone, Maria Pia Francescato
BACKGROUND: Oxidative stress in female athletes is understudied. We investigated oxidative stress in sportswomen of different disciplines according to combined oral contraceptive (OC) use and lifestyle/alimentary habits. METHODS: Italian sportswomen (n = 144; mean age 23.4 ± 4.2 years; body mass index 21.2 ± 2.2 kg m(-2); sport activity 9.2 ± 4.1 h week(-1)) were analyzed; 48 % were volleyball players, 12.5 % soccer players, 10.4 % track-and-field sports, and followed by other disciplines' athletes...
December 2016: Sports Medicine—Open
https://www.readbyqxmd.com/read/27732910/sesame-oil-improves-functional-recovery-by-attenuating-nerve-oxidative-stress-in-a-mouse-model-of-acute-peripheral-nerve-injury-role-of-nrf-2
#8
Che-Chia Hsu, Hui-Cheng Huang, Po-Ting Wu, Ta-Wei Tai, I-Ming Jou
Peripheral nervous injury (PNI) is a common form of trauma in modern society, especially in sport players. Despite the advance of therapy for PNI, the recovery of function can never reach the preinjury level after treatments. Recently, inhibiting neural oxidative stress shows a beneficial effect in improving functional recovery after PNI. In addition, sesame oil has been reported to possess the excellent antioxidative properties. However, whether sesame oil can improve the functional recovery after PNI by its antioxidative effect has never been investigated...
September 14, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27729185/control-of-antioxidant-supplementation-through-interview-is-not-appropriate-in-oxidative-stress-sport-studies-analytical-confirmation-should-be-required
#9
Yaira Barranco-Ruiz, Jeronimo Aragón-Vela, Cristina Casals, Antonio Martínez-Amat, Rafael A Casuso, Jesus R Huertas
OBJECTIVE: Controlling antioxidant supplementation in athletes involved in studies related to oxidative stress and muscle damage is the key to ensure results. The aim of this study was to confirm through high-performance liquid chromatography (HPLC) analysis whether well-trained individuals lied during a personal interview when asked if they were taking supplements with antioxidants, and how this could affect oxidative stress, muscle damage, and antioxidant response. METHODS: A total of 94 men, well trained in endurance sports, volunteered in this study...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27579626/regulation-of-adipogenesis-through-differential-modulation-of-ros-and-kinase-signaling-pathways-by-3-4-dihydroxyflavone-treatment
#10
Jihae Han, Hye Yeon Choi, Ahmed Abdal Dayem, Kyeongseok Kim, Gwangmo Yang, Jihye Won, Sun Hee Do, Jin-Hoi Kim, Kyu-Shik Jeong, Ssang-Goo Cho
Studies on adipogenesis may be important for regulating human and/or animal obesity, which causes several complications such as, type II diabetes, hypertension, and cardiovascular disease, thus giving rise to increased economic burden in many countries. Previous reports revealed that various flavonoids have anti-apoptotic, antioxidant, and cell differentiation-regulating activities with a number of physiological benefits, including protection from cardiovascular disease, cancers, and oxidative stress. As we found that the hydroxylation patterns of the flavonoid B ring are known to play a critical role in their function, we screened several flavonoids containing different numbers and positions of OH substitutions in B ring for their modulatory property on adipogenesis...
May 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27497636/protective-effects-of-the-roots-of-angelica-sinensis-on-strenuous-exercise-induced-sports-anemia-in-rats
#11
Chih-Wei Chang, Yi-Ming Chen, Yi-Ju Hsu, Chi-Chang Huang, Yu-Tse Wu, Mei-Chich Hsu
ETHNOPHARMACOLOGICAL RELEVANCE: Sports anemia is a persistent and severe problem in athletes owing to strenuous exercise-induced oxidative stress and hepcidin upregulation. The roots of Angelica sinensis (AS), a familiar traditional Chinese medicine, has been used for replenishing blood since antiquity. AIM OF THE STUDY: To evaluate the effects of ethanolic AS extract in a 4-week study on sports anemia in female Wistar rats. MATERIALS AND METHODS: To induce anemia, a strenuous exercise protocol consisting of running and swimming was employed with increasing intensity...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27470373/-effects-of-recombinant-human-erythropoietin-high-mimicking-abuse-doses-on-oxidative-stress-processes-in-rats
#12
Sara Bianchi, Jonathan Fusi, Ferdinando Franzoni, Luca Giovannini, Fabio Galetta, Claudio Mannari, Emanuele Guidotti, Leonardo Tocchini, Gino Santoro
Although many studies highlight how long-term moderate dose of Recombinant Human Erythropoietin (rHuEPO) treatments result in beneficial and antioxidants effects, few studies take into account the effects that short-term high doses of rHuEPO (mimicking abuse conditions) might have on the oxidative stress processes. Thus, the aim of this study was to investigate the in vivo antioxidant activity of rHuEPO, administered for a short time and at high doses to mimic its sports abuse as doping. Male Wistar healthy rats (n=36) were recruited for the study and were treated with three different concentrations of rHuEPO: 7...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27374568/black-bean-coats-new-source-of-anthocyanins-stabilized-by-%C3%AE-cyclodextrin-copigmentation-in-a-sport-beverage
#13
Yolanda Aguilera, Luis Mojica, Miguel Rebollo-Hernanz, Mark Berhow, Elvira González de Mejía, María A Martín-Cabrejas
Anthocyanin-rich powders and aqueous extracts, with high antioxidant activities, were obtained from black bean seed coats and applied to colour a sport beverage. Idaho and Otomi bean coats were extracted in water-citric acid 2% (1/50, w/v), stirring for 4h at 40°C. Anthocyanins from Idaho and Otomi extracts (1.83mg and 1.02mg C3G/g, respectively) were applied to a commercially available sport beverage, with and without 2% β-cyclodextrin (βCD) under light and darkness conditions for 10days, and stored at 4°C and 25°C for 6weeks...
December 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27367679/fernblock-polypodium-leucotomos-extract-molecular-mechanisms-and-pleiotropic-effects-in-light-related-skin-conditions-photoaging-and-skin-cancers-a-review
#14
REVIEW
Concepcion Parrado, Marta Mascaraque, Yolanda Gilaberte, Angeles Juarranz, Salvador Gonzalez
Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock(®), IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds...
June 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27348226/ergogenic-aids-and-supplements
#15
Marisa Porrini, Cristian Del Boʼ
Great interest is currently shown for the contribution of nutrition to optimize training and athletic performance, and a considerable debate exists about the potential ergogenic value of several dietary supplements. However, most of the products used by athletes do not provide sufficient scientific evidence regarding their efficacy in enhancing physical performance as well as their specificity of action and safety. For this reason, sport nutrition professionals need skills in evaluating the scientific value of papers and advertisements on ergogenic aids and supplements in order to support athletes in their choice...
2016: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/27255146/platelet-rich-plasma-reduces-the-oxidative-damage-determined-by-a-skeletal-muscle-contusion-in-rats
#16
Rodrigo Pereira Martins, Diane Duarte Hartmann, Jefferson Potiguara de Moraes, Felix Alexandre Antunes Soares, Gustavo Orione Puntel
Platelet-rich plasma (PRP) has received increasing attention and is widely used in clinical practice in order to stimulate human tissue healing. Contusions are very common injuries observed in sports and affect the function of the musculoskeletal system. This study investigated the effects of PRP on the oxidative damage determined by a contusion induced in gastrocnemius muscle of rats. PRP was injected intramuscularly immediately after injury and every 48 h, and the biochemical analysis was performed 1, 3, 5, or 7 days after the contusion onset in order to evaluate the changes characteristics of the healing process...
December 2016: Platelets
https://www.readbyqxmd.com/read/27191691/effect-of-time-of-day-on-biochemical-markers-in-response-to-physical-exercise
#17
REVIEW
Achraf Ammar, Hamdi Chtourou, Nizar Souissi
Ammar, A, Chtourou, H, and Souissi, N. Effect of time-of-day on biochemical markers in response to physical exercise. J Strength Cond Res 31(1): 272-282, 2017-It is well established that many physiological functions are time-of-day (TOD) dependent, and their circadian rhythms are well documented in healthy populations at resting state. In fact, greater rate of oxidative stress, white blood cell, homocysteine, and muscle damage markers were shown in the early evening (≈18:00 hours), and more efficient antioxidant activity was observed in the early morning (≈06:00 hours)...
January 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27164174/the-importance-of-vitaminsfor-soccer-players
#18
Günay Eskici
Soccer is one of the most widely played and complex sports in the world, where success depends on technical, tactical and physical skills of the players. Studies to improve performance in soccer have often focused on technique and tactics. However, nutrition is one of the most important factors influencing athletic performance of the players. The duration of matches is long and the training is intense. This leads to increased requirements for energy and nutrients, as well as increased reactive oxygen radicals and hence increased muscle damage...
May 10, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27082964/red-and-infrared-low-level-laser-therapy-prior-to-injury-with-or-without-administration-after-injury-modulate-oxidative-stress-during-the-muscle-repair-process
#19
Beatriz Guimarães Ribeiro, Agnelo Neves Alves, Lucas Andreo Dias Dos Santos, Tatiane Matarazzo Cantero, Kristianne Porta Santos Fernandes, Danielle da Silva Dias, Nathalia Bernardes, Kátia De Angelis, Raquel Agnelli Mesquita-Ferrari
INTRODUCTION: Muscle injury is common among athletes and amateur practitioners of sports. Following an injury, the production of reactive oxygen species (ROS) occurs, which can harm healthy muscle fibers (secondary damage) and delay the repair process. Low-level laser therapy (LLLT) administered prior to or following an injury has demonstrated positive and protective effects on muscle repair, but the combination of both administration times together has not been clarified. AIM: To evaluate the effect of LLLT (660 nm and 780 nm, 10 J/cm², 40 mW, 3...
2016: PloS One
https://www.readbyqxmd.com/read/26882488/active-paraplegics-are-protected-against-exercise-induced-oxidative-damage-through-the-induction-of-antioxidant-enzymes
#20
M Inglés, P Serra-Añó, J Gambini, F Abu-Sharif, M Dromant, R Garcia-Valles, H Pareja-Galeano, C Garcia-Lucerga, M C Gomez-Cabrera
STUDY DESIGN: Experimental study. OBJECTIVES: Exercise improves functional capacity in spinal cord injury (SCI). However, exhaustive exercise, especially when sporadic, is linked to the production of reactive oxygen species that may have a detrimental effect on SCI. We aimed to study the effect of a single bout of exhaustive exercise on systemic oxidative stress parameters and on the expression of antioxidant enzymes in individuals with paraplegia. SETTING: The study was conducted in the Physical Therapy department and the Physical Education and Sports department of the University of Valencia...
October 2016: Spinal Cord
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