keyword
https://read.qxmd.com/read/38417346/identification-of-glucagon-like-peptide-1-glp-1-in-mice-stomach
#1
JOURNAL ARTICLE
Manami Otsuka, Jin Huang, Toru Tanaka, Ichiro Sakata
Glucagon like peptide-1 (GLP-1) is a peptide hormone encoded by the pre-proglucagon gene that serves multiple physiological functions, including incretin action. While GLP-1 is primarily synthesized in the L cells of the lower intestine, recent findings indicate its presence in the stomachs of both rats and humans. However, the role of gastric GLP-1 in other species remains unclear. In this study, we aimed to identify GLP-1-producing cells and examine the localization of GLP-1 production in the mouse stomach...
February 21, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/37927592/enteroendocrine-cells-and-gut-hormones-as-potential-targets-in-the-crossroad-of-the-gut-kidney-axis-communication
#2
REVIEW
José Arimatéa de Oliveira Nery Neto, Victor Yuji Yariwake, Niels Olsen Saraiva Câmara, Vinicius Andrade-Oliveira
Recent studies suggest that disruptions in intestinal homeostasis, such as changes in gut microbiota composition, infection, and inflammatory-related gut diseases, can be associated with kidney diseases. For instance, genomic investigations highlight how susceptibility genes linked to IgA nephropathy are also correlated with the risk of inflammatory bowel disease. Conversely, investigations demonstrate that the use of short-chain fatty acids, produced through fermentation by intestinal bacteria, protects kidney function in models of acute and chronic kidney diseases...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37905754/-effect-of-somatostatin-on-gastrointestinal-hormone-levels-and-clinical-outcomes-in-critically-ill-infants-after-gastrointestinal-surgery-a-prospective-randomized-controlled-study
#3
JOURNAL ARTICLE
Bo-Xiang Qi, Zhi Liu, Lei Zhu, Li-Ping Sheng, Shuang-Shuang Hu, Na-Na Wen, Tong Qian
OBJECTIVES: To explore the effects of somatostatin on the levels of gastrointestinal hormones and clinical outcomes in critically ill infants after gastrointestinal surgery. METHODS: Using a random number table method, critically ill infants after gastrointestinal surgery who were admitted to the Intensive Care Unit of Xuzhou Children's Hospital from June 2019 to June 2021 were randomly divided into an observation group (29 cases) and a control group (30 cases)...
October 15, 2023: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/36755506/weight-loss-by-calorie-restriction-does-not-alter-appetite-regulating-gut-hormone-responses-from-perfused-rat-small-intestine
#4
JOURNAL ARTICLE
Marina K Gerstenberg, Daniel B Andersen, Lola Torz, Carlos M Castorena, Angie L Bookout, Bolette Hartmann, Jens F Rehfeld, Natalia Petersen, Jens J Holst, Rune E Kuhre
Postprandial secretion of the appetite-inhibiting hormones, glucagon-like peptide-1 (GLP-1) and peptide YY, are reduced with obesity. It is unclear if the reduced secretion persists following weight loss (WL), if other appetite-inhibiting hormones are also reduced, and if so whether reduced secretion results from intrinsic changes in the gut. To address whether WL may restore secretion of GLP-1 and other appetite inhibiting hormones, we performed a gut perfusion study of the small intestine in diet-induced obese (DIO) rats after WL...
February 8, 2023: Acta Physiologica
https://read.qxmd.com/read/36521797/four-sidenotes-about-glucagon-peptides
#5
JOURNAL ARTICLE
Jens F Rehfeld
Century old glucagon is a classic pancreatic hormone. But today we also know that the glucagon gene is expressed at high levels at extrapancreatic sites - particularly so in the gut. Major hormonal glucagon gene products in the digestive tract are the two glucagon-like peptides (GLP-1 and -2). Of these, truncated GLP-1 has in recent decades attracted massive interest due to its incretin effect, and the subsequent GLP-1 derived design of potent diabetes and obesity drugs. Truncated GLP-1 has consequently become an important contributor to gastrointestinal endocrinology...
December 12, 2022: Peptides
https://read.qxmd.com/read/36207281/time-restricted-feeding-affects-transcriptomic-profiling-of-hypothalamus-in-pigs-through-regulating-aromatic-amino-acids-metabolism
#6
JOURNAL ARTICLE
Hongyu Wang, Pengke Xia, Zhiyang Lu, Yong Su, Weiyun Zhu
BACKGROUND: Time-restricted feeding (TRF) is an effective means that can efficiently administer the metabolism and health of animal and humans. However, the effect of TRF on hypothalamic function remains unclear yet. RESULTS: Results showed that TRF significantly increased the activities of digestive enzymes lipase, maltase in the duodenum and lipase, trypsin in the pancreas whereas significantly decreased serum gastrointestinal hormones gastrin, GLP-1, CCK, PYY, and ghrelin...
October 7, 2022: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/35484823/a-glp-1-glucagon-cck-2-receptors-tri-agonist-provides-new-therapy-for-obesity-and-diabetes
#7
JOURNAL ARTICLE
Songfeng Zhao, Zhiming Yan, Yue Du, Zeyun Li, Chunli Tang, Lin Jing, Lidan Sun, Qimeng Yang, Xueling Tang, Yongliang Yuan, Jing Han, Neng Jiang
BACKGROUND AND PURPOSE: Glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) dual agonists have exerted promising therapeutic effects for the treatment of obesity and diabetes in clinical development. Moreover, GLP-1R and cholecystokinin 2 receptor (CCK-2R) dual agonists have been shown to restore pancreas function and improve glycemic control in many preclinical studies. In the present study, we describe for the first time that the beneficial effects of GLP-1R/GCGR and GLP-1R/CCK-2R dual agonists can be integrated into one peptide, resulting in significant anti-diabetes and anti-obesity effectiveness...
April 28, 2022: British Journal of Pharmacology
https://read.qxmd.com/read/34562330/amplifying-the-antidiabetic-actions-of-glucagon-like-peptide-1-potential-benefits-of-new-adjunct-therapies
#8
REVIEW
Neil Tanday, Peter R Flatt, Nigel Irwin
Clinically approved for the treatment of diabetes and obesity, glucagon-like peptide-1 (GLP-1) receptor agonists display prominent glucose- and weight-lowering effects as well as positive cardioprotective and neuroprotective actions. Despite these benefits, bariatric surgery remains superior in producing robust and sustained weight loss alongside improvements in metabolic control with possible diabetes remission. The current review considers the potential for adjunct therapies to augment the therapeutic actions of GLP-1 receptor agonists...
September 25, 2021: Diabetic Medicine: a Journal of the British Diabetic Association
https://read.qxmd.com/read/34479813/the-effect-of-sleeve-ablation-of-gastric-mucosa-on-body-weight-and-glucose-homeostasis-in-sprague-dawley-rat-model
#9
JOURNAL ARTICLE
Ponnie Robertlee Dolo, Libin Yao, Yong Shao, Jason Widjaja, Chao Li, Xiaocheng Zhu
BACKGROUND: The gastric mucosa is an important endocrine organ, most of which is resected in sleeve gastrectomy (SG). The effect of removing most of the gastric mucosa has not been studied. OBJECTIVE: To assess the effect of ablating the gastric mucosa (an area proportional to that in SG), on obesity and diabetes in a rat model. SETTING: The Affiliated Hospital of Xuzhou Medical University in Xuzhou Jiangsu, P. R. China. METHODS: Among 34 fatty Sprague-Dawley rats, 26 randomly received low-dose streptozotocin (STZ) to induce diabetes and then were randomly assigned to gastric mucosa ablation (GMA, n = 10), sleeve gastrectomy (SG, n = 8), and sham (n = 8) groups...
December 2021: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/34479362/entero-pancreatic-hormone-secretion-gastric-emptying-and-glucose-absorption-after-frequently-sampled-meal-tests
#10
JOURNAL ARTICLE
Simon Veedfald, Jens Frederik Rehfeld, Gerrit van Hall, Lars Bo Svendsen, Jens Juul Holst
CONTEXT: Entero-pancreatic hormone secretion has been reported during the pre-absorptive cephalic and gastric meal phases, but never with a blood sampling frequency providing a temporal resolution that allows close scrutiny and correlations with gastric emptying and glucose-absorption. OBJECTIVE: We hypothesized that entero-pancreatic hormone secretion after nutrient ingestion would be rapid and correlate with gastric emptying and glucose absorption. DESIGN AND SETTING: Two visits in a clinical research facility...
August 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33921209/nfat5-is-involved-in-grp-enhanced-secretion-of-glp-1-by-sodium
#11
JOURNAL ARTICLE
Caini Fan, Laureano D Asico, Van Anthony M Villar, Jessica Hunt, Santiago Cuevas, Ines Armando, Pedro A Jose, Prasad R Konkalmatt
Gastrin, secreted by G-cells, and glucagon-like peptide-1 (GLP-1), secreted by L-cells, may participate in the regulation of sodium balance. We studied the effect of sodium in mice in vivo and mouse ileum and human L-cells, on GLP-1 secretion, and the role of NFAT5 and gastrin-releasing peptide receptor (GRPR) in this process. A high-sodium diet increases serum GLP-1 levels in mice. Increasing sodium concentration stimulates GLP-1 secretion from mouse ileum and L-cells. GRP enhances the high sodium-induced increase in GLP-1 secretion...
April 12, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33852195/acute-ketosis-inhibits-appetite-and-decreases-plasma-concentrations-of-acyl-ghrelin-in-healthy-humans
#12
JOURNAL ARTICLE
Esben Thyssen Vestergaard, Natasa Brkovic Zubanovic, Nikolaj Rittig, Niels Møller, Rune Ehrenreich Kuhre, Jens J Holst, Jens F Rehfeld, Henrik Holm Thomsen
CONTEXT: Ketosis appears to decrease appetite and facilitate weight loss. Potential underlying mechanisms include decreases in plasma levels of the orexigenic hormone ghrelin and increases in appetite-inhibiting glucagon-like peptide-1 (GLP-1) levels. The effect of acute ketosis as compared to an isocaloric and isovolumetric beverage on both acyl ghrelin and total GLP-1 plasma concentrations has not been previously measured. OBJECTIVE: We aimed to investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG), and GLP-1 secretion and to compare responses to those elicited by isocaloric glucose administration...
April 14, 2021: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/33795544/high-fat-diet-enhances-gastric-contractility-but-abolishes-nesfatin-1-induced-inhibition-of-gastric-emptying
#13
JOURNAL ARTICLE
Zarife N Özdemir-Kumral, Türkan Koyuncuoğlu, Sevil Arabacı-Tamer, Özlem T Çilingir-Kaya, Ayça K Köroğlu, Meral Yüksel, Berrak Ç Yeğen
Background/Aims: Gastrointestinal motility changes contribute to development and maintenance of obesity. Nesfatin-1 (NES-1) is involved in central appetite control. The aim is to elucidate effects of NES-1 and high-fat diet (HFD) on gastrointestinal motility and to explore myenteric neuron expressions of tyrosine hydroxylase (TH), vasoactive intestinal peptide (VIP), and neuronal nitric oxide synthase (nNOS) in HFDinduced oxidative injury. Methods: Sprague-Dawley rats were fed with normal diet (ND) or HFD...
April 30, 2021: Journal of Neurogastroenterology and Motility
https://read.qxmd.com/read/33125843/stapled-and-xenopus-glucagon-like-peptide-1-glp-1-based-dual-glp-1-gastrin-receptor-agonists-with-improved-metabolic-benefits-in-rodent-models-of-obesity-and-diabetes
#14
JOURNAL ARTICLE
Xinyu Chen, Junjie Fu, Feng Zhou, Qimeng Yang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Xuelin Tang, Neng Jiang, Jian Yin, Jing Han
Diabetes is characterized by pancreas dysfunction and is commonly associated with obesity. Hypoglycemic agents capable of improving β-cell function and reducing body weight therefore are gaining increasing interest. Though glucagon-like peptide 1 receptor (GLP-1R)/cholecystokinin 2 receptor (CCK-2R) dual agonist ZP3022 potently increases β-cell mass and improves glycemic control in diabetic db/db mice, the in vivo half-life ( t 1/2 ) is short, and its body weight reducing activity is limited. Here, we report the discovery of a series of novel GLP-1R/CCK-2R dual agonists...
October 30, 2020: Journal of Medicinal Chemistry
https://read.qxmd.com/read/32770661/increased-oral-sodium-chloride-intake-in-humans-amplifies-selectively-postprandial-glp-1-but-not-gip-cck-and-gastrin-in-plasma
#15
RANDOMIZED CONTROLLED TRIAL
Ali Asmar, Per K Cramon, Meena Asmar, Lene Simonsen, Charlotte M Sorensen, Sten Madsbad, Cedric Moro, Bolette Hartmann, Jens F Rehfeld, Jens J Holst, Peter Hovind, Boye L Jensen, Jens Bülow
Human studies have demonstrated that physiologically relevant changes in circulating glucagon-like peptide-1 (GLP-1) elicit a rapid increase in renal sodium excretion when combined with expansion of the extracellular fluid volume. Other studies support the involvement of various gastrointestinal hormones, e.g., gastrin and cholecystokinin (CCK) in a gut-kidney axis, responsible for a rapid-acting feed-forward natriuretic mechanism. This study was designed to investigate the hypothesis that the postprandial GLP-1 plasma concentration is sensitive to the sodium content in the meal...
August 2020: Physiological Reports
https://read.qxmd.com/read/31984675/cck-1-and-cck-2-receptor-agonism-do-not-stimulate-glp-1-and-neurotensin-secretion-in-the-isolated-perfused-rat-small-intestine-or-glp-1-and-pyy-secretion-in-the-rat-colon
#16
JOURNAL ARTICLE
Ida M Modvig, Charlotte B Christiansen, Jens F Rehfeld, Jens J Holst, Simon Veedfald
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI-H716) and gastrin receptor expression in proglucagon-expressing cells from the rat colon, suggested that gastrin could be a regulator of glucagon-like peptide-1 (GLP-1) secretion. To investigate these findings, we studied the acute effects of CCK-8 (a CCK1/CCK2 (gastrin) receptor agonist) and gastrin-17 (a CCK2(gastrin) receptor agonist) in robust ex vivo models: the isolated perfused rat small intestine and the isolated perfused rat colon...
January 2020: Physiological Reports
https://read.qxmd.com/read/31983660/resection-of-the-duodenum-causes-long-term-endocrine-and-exocrine-dysfunction-after-whipple-procedure-for-benign-tumors-results-of-a-systematic-review-and-meta-analysis
#17
REVIEW
Hans G Beger, Benjamin Mayer, Bertram Poch
BACKGROUND: Metabolic dysfunctions after pancreatoduodenectomy (PD) need to be considered when pancreatic head resection is likely to lead to long-term survival. METHODS: Medline, Embase and Cochrane Library were searched for studies reporting measured data of metabolic function after PD and duodenum-sparing total pancreatic head resection (DPPHR). Data from 23 cohort studies comprising 1019 patients were eligible; 594 and 910 patients were involved in systematic review and meta-analysis, respectively...
June 2020: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/31725337/gastrin-secretion-in-normal-subjects-and-diabetes-patients-is-inhibited-by-glucagon-like-peptide-1-a-role-in-the-gastric-side-effects-of-glp-1-derived-drugs
#18
JOURNAL ARTICLE
Jens F Rehfeld, Filip K Knop, Meena Asmar
Background: Randomized and controlled trials of glucagon-like peptide-1 (GLP-1) derived drugs have shown that the most frequent adverse symptoms are gastrointestinal. Some of the side effects such as dyspepsia, nausea and upper abdominal pain may well be of gastric origin. Since the antral hormone gastrin regulates gastric secretion of acid and enzymes and contributes to the regulation of gastric motility, we examined the effect of GLP-1 on the secretion of gastrin in normal subjects and diabetes patients. Method: Plasma was sampled from ten healthy subjects and ten patients with diabetes mellitus type 1 with glucose clamped between 6 and 9 mM...
December 2019: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/31670611/the-physiology-of-the-gastric-parietal-cell
#19
REVIEW
Amy C Engevik, Izumi Kaji, James R Goldenring
Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food, absorption of minerals, and control of harmful bacteria. However, a fine balance of activators and inhibitors of parietal cell-mediated acid secretion is required to ensure proper digestion of food, while preventing damage to the gastric and duodenal mucosa. As a result, parietal cell secretion is highly regulated through numerous mechanisms including the vagus nerve, gastrin, histamine, ghrelin, somatostatin, glucagon-like peptide 1, and other agonists and antagonists...
April 1, 2020: Physiological Reviews
https://read.qxmd.com/read/31630290/distal-gastric-mucosa-ablation-induces-significant-weight-loss-and-improved-glycemic-control-in-type-2-diabetes-sprague-dawley-rat-model
#20
JOURNAL ARTICLE
Ponnie Robertlee Dolo, Ke Huang, Jason Widjaja, Chao Li, Xiaocheng Zhu, Libin Yao, Jian Hong
BACKGROUND: Excluding the foregut (distal stomach and duodenum) from food transit in RYGB normalizes glucose tolerance. Excluding/removing the duodenal mucosa partly improves glycemic control. So far, the effect of excluding/removing the gastric mucosa remains unknown. OBJECTIVE: To observe the effect of removing the distal gastric mucosa on glucose tolerance. METHOD: Thirty fatty Sprague-Dawley rats received low-dose streptozotocin (STZ) to induce type 2 diabetes (T2D), then randomly assigned to Roux-en-Y gastric bypass (RYGB, n = 8), distal gastric mucosa removal (DGMR, n = 8), duodenal-jejunal bypass (DJB, n = 8), and Sham (n = 6) groups...
October 2020: Surgical Endoscopy
keyword
keyword
74028
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.