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portal vein hypertension

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https://www.readbyqxmd.com/read/29472420/budd-chiari-syndrome-in-a-patient-with-ulcerative-colitis
#1
Gopal Krishana Bohra, Vivek Chhabra, Naresh Midha, Binit Sureka
We report a case of 26-year-old man who was admitted on our ward for the evaluation of ascites. He was a known case of inflammatory bowel disease(ulcerative colitis) and was on regular mesalamine therapy. On evaluation, he was having high serum ascites albumin gradient. CT scan of the abdomen revealed features of portal hypertension and non-visualisation of right and middle hepatic veins along with thrombus in inferior vena cava, suggesting a diagnosis of Budd-Chiari syndrome (BCS). There are only few case reports available showing association of BCS with UC...
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29470153/structured-reporting-of-multiphasic-ct-for-hepatocellular-carcinoma-effect-on-staging-and-suitability-for-transplant
#2
Peter D Poullos, Joseph J Tseng, Marc L Melcher, Waldo Concepcion, Andreas M Loening, Jarrett Rosenberg, Jüergen K Willmann
OBJECTIVE: The purpose of this study is to evaluate whether use of a standardized radiology report template would improve the ability of liver transplant surgeons to diagnose stage T2 hepatocellular carcinoma (HCC) and determine patient suitability to undergo orthotopic liver transplant (OLT). MATERIALS AND METHODS: In this retrospective study, a standardized template was devised, and its use was mandated for reporting of liver CT findings for patients with cirrhosis and HCC...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29469530/-percutaneous-transsplenic-varices-embolization-in-treatment-of-upper-gastrointestinal-hemorrhage-of-schistosomiasis-cirrhosis
#3
Ji Chang-Xue, Li Ying, Ju Shuai, Qiang Jin-Wei
OBJECTIVE: To evaluate the application value of percutaneous transsplenic varices embolization (PTSVE) in the treatment of upper gastrointestinal hemorrhage in patients with schistosomiasis cirrhosis. METHODS: Sixteen schistosomiasis cirrhosis patients (12 males and 4 females) with portal hypertension complicated with esophageal and upper gastrointestinal hemorrhage were selected as the investigation subjects, all the patients had been treated by esophageal vein ligation and sclerotherapy, but with bleeding again post-operation...
March 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29465601/postoperative-hemorrhage-caused-by-portal-hypertension-associated-with-autoimmune-pancreatitis-a-case-report
#4
Puzi Wang, Rongli Xie, Zhifeng Zhao, Jiajun Ren, Jian Fei
RATIONALE: Autoimmune pancreatitis is a form of chronic pancreatitis, characterized by diffused enlargement of the pancreas and irregular narrowing of the main pancreatic duct. The theory that portal hypertension is associated with autoimmune pancreatitis has not been emphasized. In addition, only a few studies report that the gastrointestinal tract hemorrhage caused by portal hypertension is associated with autoimmune pancreatitis. PATIENT CONCERNS: The patient was a 61-year-old male with pancreas occupying lesion detected in a physical examination...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465591/a-study-on-risk-factors-and-diagnostic-efficiency-of-posthepatectomy-liver-failure-in-the-nonobstructive-jaundice
#5
He Wang, Shi-Chun Lu, Lei He, Jia-Hong Dong
Liver failure remains as the most common complication and cause of death after hepatectomy, and continues to be a challenge for doctors.t test and χ test were used for single factor analysis of data-related variables, then results were introduced into the model to undergo the multiple factors logistic regression analysis. Pearson correlation analysis was performed for related postoperative indexes, and a diagnostic evaluation was performed using the receiver operating characteristic (ROC) of postoperative indexes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465472/a-new-prognostic-score-can-predict-survival-after-hepatocellular-carcinoma-treatment-in-a-cohort-of-1302-egyptian-hepatocellular-carcinoma-patients
#6
Ashraf O Abdelaziz, Hend I Shousha, Ahmed H Abdelmaksoud, Yasmin Saad, Tamer M Elbaz, Zeinab A Soliman, Ayman Salah, Rania Lithy, Mona Ahmed, Mohamed M Nabil
INTRODUCTION: Survival of hepatocellular carcinoma (HCC) differs between regions and countries according to the different underlying factors and the degree of standard of care that enables early diagnosis and management. Our aim was to identify the most potent predictive factors of survival in Egyptian HCC patients receiving curative or palliative treatments. PATIENTS AND METHODS: This retrospective study included 1302 HCC patients attending the HCC multidisciplinary clinic, Cairo University, between February 2009 and December 2016...
February 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29464506/idiopathic-portal-hypertension-and-extrahepatic-portal-venous-obstruction
#7
REVIEW
Rajeev Khanna, Shiv Kumar Sarin
BACKGROUND: Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are non-cirrhotic vascular causes of portal hypertension (PHT). Variceal bleed and splenomegaly are the commonest presentations. AIM: The present review is intended to provide the existing literature on etiopathogenesis, clinical profile, diagnosis, natural history and management of IPH and EHPVO. RESULTS: IPH and EHPVO are both characterized by normal hepatic venous pressure gradient, moderate to massive splenomegaly with preserved liver synthetic functions...
February 20, 2018: Hepatology International
https://www.readbyqxmd.com/read/29462027/transjugular-intrahepatic-portosystemic-shunt-creation-for-cirrhotic-portal-hypertension-is-well-tolerated-among-patients-with-portal-vein-thrombosis
#8
Jonathan Merola, Brett E Fortune, Yanhong Deng, Maria Ciarleglio, Smbat Amirbekian, Noami Chaudhary, Alampady Shanbhogue, Rajasekhara Ayyagari, Manuel I Rodriguez-Davalos, Lewis Teperman, Hearns W Charles, Samuel H Sigal
BACKGROUND: Portal vein thrombosis (PVT) develops in cirrhotic patients because of stagnation of blood flow. Transjugular intrahepatic portosystemic shunt (TIPS) creates a low-resistance conduit that restores portal venous patency and blood flow. AIM: The effect of PVT on transplant-free survival in cirrhotic patients undergoing TIPS creation was evaluated. PATIENTS AND METHODS: A multicenter, retrospective cohort study of patients who underwent TIPS creation for cirrhotic portal hypertension was carried out...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29443759/a-traumatic-hepatic-artery-pseudoaneurysm-and-arterioportal-fistula-with-severe-diarrhea-as-the-first-symptom-a-case-report-and-review-of-the-literature
#9
Ping Han, Lan Yang, Xiao-Wei Huang, Xiu-Qin Zhu, Li Chen, Nan Wang, Zhen Li, De-An Tian, Hua Qin
RATIONALE: Hepaticarterioportal fistula (APF) is a rare cause of portal hypertension and gastrointestinal hemorrhage, and presents as abnormal communication between the hepatic artery and portal vein. Percutaneous liver biopsy is a main iatrogenic cause of AFP. However, non-iatrogenic, abdominal, trauma-related APF is rarely reported. PATIENT CONCERNS: A 29-year-old man presenting with severe, watery diarrhea was transferred to our hospital, and his condition was suspected to be acute gastroenteritis because he ate expired food and suffered a penetrating abdominal stab wound 5 years ago...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29434696/tmem16a-regulates-portal-vein-smooth-muscle-cell-proliferation-in-portal-hypertension
#10
Xi Zeng, Ping Huang, Mingkai Chen, Shiqian Liu, Nannan Wu, Fang Wang, Jing Zhang
The aim of the present study was to elucidate the effect of transmembrane protein 16A (TMEM16A) on portal vein smooth muscle cell (PVSMC) proliferation associated with portal vein remodeling in portal hypertension (PHT). Sprague-Dawley rats were subjected to bile duct ligation to establish a rat model of liver cirrhosis and PHT. Sham-operated animals served as controls. At 8 weeks after bile duct ligation, the extent of liver fibrosis and the portal vein wall thickness were assessed using hematoxylin-eosin staining...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433850/lenvatinib-versus-sorafenib-in-first-line-treatment-of-patients-with-unresectable-hepatocellular-carcinoma-a-randomised-phase-3-non-inferiority-trial
#11
Masatoshi Kudo, Richard S Finn, Shukui Qin, Kwang-Hyub Han, Kenji Ikeda, Fabio Piscaglia, Ari Baron, Joong-Won Park, Guohong Han, Jacek Jassem, Jean Frederic Blanc, Arndt Vogel, Dmitry Komov, T R Jeffry Evans, Carlos Lopez, Corina Dutcus, Matthew Guo, Kenichi Saito, Silvija Kraljevic, Toshiyuki Tamai, Min Ren, Ann-Lii Cheng
BACKGROUND: In a phase 2 trial, lenvatinib, an inhibitor of VEGF receptors 1-3, FGF receptors 1-4, PDGF receptor α, RET, and KIT, showed activity in hepatocellular carcinoma. We aimed to compare overall survival in patients treated with lenvatinib versus sorafenib as a first-line treatment for unresectable hepatocellular carcinoma. METHODS: This was an open-label, phase 3, multicentre, non-inferiority trial that recruited patients with unresectable hepatocellular carcinoma, who had not received treatment for advanced disease, at 154 sites in 20 countries throughout the Asia-Pacific, European, and North American regions...
February 9, 2018: Lancet
https://www.readbyqxmd.com/read/29432256/portal-vein-thrombosis-yes-or-no-on-anticoagulation-therapy
#12
Fanny Turon, Virginia Hernández-Gea, Juan Carlos García-Pagán
PURPOSE OF REVIEW: To describe portal vein thrombosis (PVT) in the setting of cirrhosis especially in relation to its potential impact on liver transplantation. In addition, the safety and efficacy of anticoagulation is reviewed. RECENT FINDINGS: PVT in cirrhosis occurs in up to 26% of patients awaiting liver transplantation. Different studies have suggested that PVT impacts negatively post-liver transplantation survival, particularly in first year post-liver transplantation and when PVT is complete involving the porto-mesenteric confluence and not allowing physiological anastomosis...
February 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29429910/natural-history-of-patients-with-non-cirrhotic-portal-hypertension-comparison-with-patients-with-compensated-cirrhosis
#13
Stefania Gioia, Silvia Nardelli, Chiara Pasquale, Ilaria Pentassuglio, Valeria Nicoletti, Francesca Aprile, Manuela Merli, Oliviero Riggio
BACKGROUND: The knowledge of natural history of patients with portal hypertension (PH) not due to cirrhosis is less well known than that of cirrhotic patients. AIM: To describe the clinical presentation and the outcomes of 89 patients with non-cirrhotic PH (25 with non-cirrhotic portal hypertension, INCPH, and 64 with chronic portal vein thrombosis, PVT) in comparison with 77 patients with Child A cirrhosis. METHODS: The patients were submitted to a standardized clinical, laboratory, ultrasonographic and endoscopic follow-up...
January 31, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29404482/nonalcoholic-fatty-liver-with-a-hepatic-arterial-buffer-response-strongly-associated-with-future-metabolic-disease
#14
Masashi Hirooka, Yohei Koizumi, Teruki Miyake, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Atsushi Yukimoto, Yoshiko Nakamura, Yusuke Imai, Masanori Abe, Yoichi Hiasa
A change in hepatic blood flow caused by the hepatic arterial buffer response (HABR) occurs as fatty liver disease progress. The aim of this longitudinal cohort study was to investigate whether fatty liver with the HABR induces metabolic disorders. In 2009 and 2010, 494 (89.5%) participants were enrolled. The median follow-up duration was 5.0 (interquartile range, 3.9-6.0) years. The hazard ratios of fatty liver with the HABR for incident metabolic disorders were assessed by Cox proportional hazard models. A non-fatty liver group (non-FL group, hepatorenal echo intensity ratio <1...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29396900/effects-of-early-antiplatelet-therapy-after-splenectomy-with-gastro-oesophageal-devascularization
#15
Jin-Bao Zhou, Bao-Yang Luo, Chi-Wen Liu, Feng Zhu
BACKGROUND: This study aimed to explore the effects of early antiplatelet therapy (APT) for portal vein thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy with gastro-oesophageal devascularization. METHODS: We retrospectively analysed 139 patients who underwent splenectomy with gastro-oesophageal devascularization for portal hypertension due to cirrhosis between April 2010 and December 2016. Based on the post-operative platelet values, we used two different APT regimens: APT was started when platelet counts were increased to 200 × 109 /L or above (group A, n = 64) or 300 × 109 /L or above (group B, n = 75)...
February 3, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29389083/are-we-any-closer-to-treating-liver-fibrosis-and-if-no-why-not
#16
REVIEW
Rilu Feng, Xiaodong Yuan, Chen Shao, Huiguo Ding, Roman Liebe, Hong-Lei Weng
This review provides a personal view on anti-fibrosis therapy in liver. The worst clinical consequence of liver fibrosis is the development of liver cirrhosis and portal hypertension. Etiology is a decisive factor which determines patterns of fibrous septa and subsequent vascular remodeling, which is essential for the development of portal hypertension. Removing or controlling the disease-causing agent, i.e. anti-viral treatment for hepatitis, is the essential first step for treating chronic liver diseases and can reverse fibrosis in some settings...
February 1, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29381977/bleeding-from-isolated-gastric-varices-as-complication-of-a-mucinous-cystic-neoplasm-of-the-pancreas-a-case-report
#17
Corina Lupascu-Ursulescu, Ana-Maria Trofin, Mihai Zabara, Alexandra Vornicu, Ramona Cadar, Oana Apopei, Gabriela Stefanescu, Cristian Lupascu
INTRODUCTION: Bleeding from isolated gastric varices, though uncommon, may be life threatening and may occur as a consequence of splenic vein thrombosis by tumoral compression and subsequent left-sided portal hypertension. CASE OVERVIEW: We report the case of a 37-year old woman, previously diagnosed with a benign pancreatic cyst, who presented with severe gastric variceal bleeding. DIAGNOSIS, THERAPEUTICS INTERVENTIONS, AND OUTCOMES: Abdominal ultrasound (US) and computed-tomography (CT) revealed enlargement and changed morphology of the cystic tumor located on the body of the pancreas...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377486/liver-atrophy-and-regeneration-in-non-cirrhotic-portal-vein-thrombosis-effect-of-surgical-shunts
#18
Abdulrhman S Elnaggar, Adam D Griesemer, Stuart Bentley-Hibbert, Robert S Brown, Mercedes Martinez, Steven J Lobritto, Tomoaki Kato, Jean C Emond
OBJECTIVE: To characterize the relationship between portal vein thrombosis (PVT) and hepatic atrophy in the non-cirrhotic patients and the effect of various types of surgical shunts on liver regeneration and splenomegaly. BACKGROUND: Non-cirrhotic patients with PVT suffer from presinusoidal portal hypertension and often hepatic atrophy, a topic that has received little attention. We hypothesized that patients with PVT have decreased liver volumes, and shunts that preserve intrahepatic portal flow enhance liver regeneration...
January 29, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29373208/predictors-of-shunt-dysfunction-and-overall-survival-in-patients-with-variceal-bleeding-treated-with-transjugular-portosystemic-shunt-creation-using-the-fluency-stent-graft
#19
Yue-Meng Wan, Yu-Hua Li, Ying Xu, Hua-Mei Wu, Ying-Chun Li, Xi-Nan Wu, Jin-Hui Yang
RATIONALE AND OBJECTIVES: Transjugular intrahepatic portosystemic shunt (TIPS) is an established method for portal hypertension. This study was to investigate the long-term safety, technical success, and patency of TIPS, and to determine the risk factors and clinical impacts of shunt dysfunction. MATERIALS AND METHODS: A total of 154 consecutive patients undergoing embolotherapy of gastric coronary vein and/or short gastric vein and TIPS creation were prospectively studied...
January 16, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29360462/association-between-portosystemic-shunts-and-increased-complications-and-mortality-in-patients-with-cirrhosis
#20
Macarena Simón-Talero, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Michael Praktiknjo, Martin H Maurer, Alexander Zipprich, Michela Triolo, Guillaume Vangrinsven, Rita Garcia-Martinez, Annette Dam, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G Abraldes, Marta Lopez, Guido Kukuk, Aleksander Krag, Rafael Bañares, Wim Laleman, Vincenzo La Mura, Cristina Ripoll, Annalisa Berzigotti, Jonel Trebicka, Jose Luis Calleja, Puneeta Tandon, Virginia Hernandez-Gea, Thomas Reiberger, Agustín Albillos, Emmanuel A Tsochatzis, Salvador Augustin, Joan Genescà, Sergi Quiroga, Dominic Yu, Mattias Mandorfer, Juan Carlos Garcia-Pagan, Claudia Berbel, Jose Ferrusquia, Michel Ble, Mari Angeles Garcia-Criado, Ernest Belmonte, Michael Ney, Cristina Margini, Stefania Casu, Giuseppe Murgia, Christiane Ludwig, Martin Rönsch, Dietrich Stoevesandt, Laura Carrion, Enrique Ramón Botella
BACKGROUND & AIMS: Spontaneous portosystemic shunts (SPSSs) have been associated with hepatic encephalopathy (HE). Little is known about their prevalence among patients with cirrhosis or clinical effects. We investigated the prevalence and characteristics of SPSSs in patients with cirrhosis and their outcomes. METHODS: We performed a retrospective study of 1729 patients with cirrhosis who underwent abdominal computed tomography or magnetic resonance imaging analysis from 2010 through 2015 at 14 centers in Canada and Europe...
January 20, 2018: Gastroenterology
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