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https://www.readbyqxmd.com/read/28071845/influence-of-age-sex-and-seriousness-on-reporting-of-adverse-drug-reactions-in-sweden
#1
Lennart Holm, Elisabet Ekman, Kerstin Jorsäter Blomgren
PURPOSE: To investigate how reporting of adverse drug reactions (ADRs) among adults in Sweden is associated to age and sex, in addition to seriousness of the reaction and drug utilisation. METHODS: Individual case safety reports (ICSRs) reported by healthcare professionals to the national pharmacovigilance database 2008-2011 were related to defined daily dose (DDD) in the Swedish Prescribed Drug Register (SPDR) for individual's ≥20 years. Data were stratified into five age groups...
January 10, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28063135/cost-effectiveness-of-insulin-degludec-plus-liraglutide-ideglira-in-a-fixed-combination-for-uncontrolled-type-2-diabetes-mellitus-in-sweden
#2
Åsa Ericsson, Adam Lundqvist
BACKGROUND: Patients with uncontrolled type 2 diabetes mellitus (T2DM) are a priority group for intensified therapy without weight gain and with low risk of hypoglycaemia. OBJECTIVE: This study evaluates the cost effectiveness of insulin degludec plus liraglutide (IDegLira, Xultophy(®)) compared with six potential intensification treatment options for patients with T2DM that is uncontrolled with basal insulin. METHODS: The Swedish Institute for Health Economics (IHE) Cohort Model of Type 2 Diabetes was used with Swedish input data, a 40-year time frame and a societal perspective...
January 6, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28060450/effects-of-increased-alcohol-availability-during-adolescence-on-the-risk-of-all-cause-and-cause-specific-disability-pension-a-natural-experiment
#3
Emelie Thern, Jeroen de Munter, Tomas Hemmingsson, George Davey Smith, Mats Ramstedt, Per Tynelius, Finn Rasmussen
AIM: To test if being exposed to increased alcohol availability during adolescence is associated with an increased risk of receiving disability pension due to all-cause, alcohol use disorders and mental disorders. DESIGN: Register-based population-based study using a natural experiment setting, the alcohol policy change in Sweden (1967-1968), with increased access to strong beer in a narrow time window and geographical area. The individuals exposed to the policy change were compared with non-exposed individuals living in the rest of Sweden, excluding a border area...
January 6, 2017: Addiction
https://www.readbyqxmd.com/read/28028147/cannabis-tobacco-alcohol-use-and-the-risk-of-early-stroke-a-population-based-cohort-study-of-45-000-swedish-men
#4
Daniel Falkstedt, Valerie Wolff, Peter Allebeck, Tomas Hemmingsson, Anna-Karin Danielsson
BACKGROUND AND PURPOSE: Current knowledge on cannabis use in relation to stroke is based almost exclusively on clinical reports. By using a population-based cohort, we aimed to find out whether there was an association between cannabis use and early-onset stroke, when accounting for the use of tobacco and alcohol. METHODS: The cohort comprises 49 321 Swedish men, born between 1949 and 1951, who were conscripted into compulsory military service between the ages of 18 and 20...
December 27, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28006863/concordant-and-discordant-familial-cancer-familial-risks-proportions-and-population-impact
#5
Christoph Frank, Jan Sundquist, Hongyao Yu, Akseli Hemminki, Kari Hemminki
Relatives of cancer patients are at an increased risk of the same (concordant) cancer but whether they are at a risk for different (discordant) cancers is largely unknown - beyond well characterized hereditary cancer syndromes - but would be of major scientific and clinical interest. We therefore decided to resolve the issue by analyzing familial risks when family members were diagnosed with any discordant cancers. We compared the population impact of concordant to discordant familial cancer. The Swedish Family-Cancer Database (FCD) was used to calculate familial relative risks (RRs) for family members of cancer patients, for the 27 most common cancers...
December 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27991826/relationship-between-breastfeeding-and-early-childhood-obesity-results-of-a-prospective-longitudinal-study-from-birth-to-4-years
#6
Thomas Wallby, Dagmar Lagerberg, Margaretha Magnusson
AIM: To study a potential link between breastfeeding in infancy and obesity at age 4. MATERIALS AND METHODS: A total of 30,508 infants born during 2002-2007 from the databases of the Preventive Child Health Services in two Swedish counties and from national registers were studied. The outcome variable was obesity at age 4. Analyses were conducted by logistic regression models using the methodology of generalized estimating equations. Analyses were adjusted for child sex and maternal anthropometric and sociodemographic variables...
December 19, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27990607/family-history-of-venous-thromboembolism-and-mortality-after-venous-thromboembolism-a-swedish-population-based-cohort-study
#7
Bengt Zöller, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist
Studies on whether family history (FH) of venous thromboembolism (VTE) affects long-term mortality after VTE are missing. The aim of this study was to determine whether FH of VTE affects long-term mortality after a first episode of VTE. Using Swedish medical databases, we conducted a 30-year nationwide cohort study of 49,159 adult Swedish born patients included in the multi-generation register (born 1932 or later) with a first-time VTE (1981-2010). Using Cox regression, we assessed mortality Hazard ratios (HRs) with 95% confidence intervals (CIs)...
December 19, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27971420/retrospective-database-study-describing-patient-characteristics-and-resource-use-in-swedish-patients-receiving-second-generation-long-acting-injection-antipsychotics
#8
E Hernlund, E Landfeldt, L A Lombard, A Tockhorn-Heidenreich, C Bushe, V Porsdal, J Eriksson, J Berg
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27955647/comparisons-between-comorbid-conditions-and-health-care-consumption-in-rheumatoid-arthritis-patients-with-or-without-biological-disease-modifying-anti-rheumatic-drugs-a-register-based-study
#9
Karin Bengtsson, Lennart T H Jacobsson, Barbro Rydberg, Göran Kvist, Tomas Torstenson, Mats Dehlin, Elisabet Hilme, Anna Lindhé, Susanna Maria Wallerstedt, Helena Forsblad-d'Elia
BACKGROUND: Symptoms and prognosis of patients with rheumatoid arthritis (RA) have improved with more intensive therapy, including the biological disease-modifying anti-rheumatic drugs (bDMARDs). Real life data concerning how comorbidities are distributed among patients treated or not treated with bDMARDs are scarce. Our objective was to investigate differences in comorbidity and health care consumption in RA patients, with and without bDMARDs. METHODS: This cross-sectional study was performed in the Southwestern part of Sweden...
December 12, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27940275/nurses-experiences-of-working-in-organizations-undergoing-restructuring-a-metasynthesis-of-qualitative-research-studies
#10
Anne Sofie Bøtcher Jensen, Dorthe Sørensen
BACKGROUND: Health care organizations worldwide undergo continual reconfiguration and structural changes in order to optimize the use of resources, reduce costs, and improve the quality of treatment. OBJECTIVE: The objective of this study was to synthesize qualitative studies of how nurses experience working in organizations undergoing structural changes. DESIGN: The review is designed as a metasynthesis and follows the guidelines put forth by Sandelowski and Barroso for synthesizing qualitative research...
December 5, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27931605/bariatric-surgery-and-the-risk-of-new-onset-atrial-fibrillation-in-swedish%C3%A2-obese-subjects
#11
Shabbar Jamaly, Lena Carlsson, Markku Peltonen, Peter Jacobson, Lars Sjöström, Kristjan Karason
BACKGROUND: Obesity is a risk factor for atrial fibrillation, which in turn is associated with stroke, heart failure, and increased all-cause mortality. OBJECTIVES: The authors investigated whether weight loss through bariatric surgery may reduce the risk of new-onset atrial fibrillation. METHODS: SOS (Swedish Obese Subjects) is a prospective matched cohort study conducted at 25 surgical departments and 480 primary healthcare centers in Sweden...
December 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27931268/an-epidemiological-analysis-of-equine-welfare-data-from-regulatory-inspections-by-the-official-competent-authorities
#12
P L Hitchens, J Hultgren, J Frössling, U Emanuelson, L J Keeling
Determining welfare status in a population is the first step in efforts to improve welfare. The primary objective of this study was to explore a new epidemiological approach for analysis of data from official competent authorities that pertain to compliance with animal welfare legislation. We reviewed data already routinely collected as part of Swedish official animal welfare inspections for 2010-13, using a checklist containing 45 checkpoints (CPs). These covered animal-, resource- and management-based measures of equine welfare...
December 9, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27889699/comparison-of-clinical-factors-between-patients-with-angiotensin-converting-enzyme-inhibitor-induced-angioedema-and-cough
#13
Pär Hallberg, Julia Nagy, Malgorzata Karawajczyk, Leif Nordang, Gunilla Islander, Pia Norling, Hans-Erik Johansson, Mary Kämpe, Svante Hugosson, Qun-Ying Yue, Mia Wadelius
BACKGROUND: Angioedema is a rare and serious adverse drug reaction (ADR) to angiotensin-converting enzyme (ACE) inhibitor treatment. Dry cough is a common side effect of ACE inhibitors and has been identified as a possible risk factor for angioedema. OBJECTIVE: We compared characteristics between patients with ACE inhibitor-induced angioedema and cough with the aim of identifying risk factors that differ between these adverse events. METHODS: Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians...
November 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27887585/reduction-in-antibiotic-prescribing-for-respiratory-tract-infections-in-swedish-primary-care-a-retrospective-study-of-electronic-patient-records
#14
Mia Tyrstrup, Anders Beckman, Sigvard Mölstad, Sven Engström, Christina Lannering, Eva Melander, Katarina Hedin
BACKGROUND: Swedish studies on antibiotic use in primary care have been based on one-week registrations of infections. In order to study adherence to guidelines, analyses based on large databases that provide information on diagnosis linked prescriptions, are needed. This study describes trends in management of infections in Swedish primary care particularly with regards to antibiotic prescribing and adherence to national guidelines. METHODS: A descriptive study of Sweden's largest database regarding diagnosis linked antibiotic prescription data, the Primary care Record of Infections in Sweden (PRIS), for the years 2008, 2010 and 2013...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27859103/traits-of-riparian-woody-plants-responding-to-hydrological-and-hydraulic-conditions-a%C3%A2-northern-swedish-database
#15
María Dolores Bejarano, Judit Maroto, Christer Nilsson, Francisca Constança Aguiar
The main goal of this study was to create a database that ultimately serves further studies on riparian vegetation and flow response guilds in the boreal region and on transferability of results across different regions. To achieve this aim, we compiled traits for all woody riparian species in northern Sweden which, directly or indirectly, underlie their responses to hydrological and hydraulic conditions, between October 2012 and April 2015. Consulted sources of information were diverse, ranging from scientific to informative and whose accuracy might or might not be verified...
October 2016: Ecology
https://www.readbyqxmd.com/read/27843375/polymyalgia-rheumatica-and-cancer-risk-the-importance-of-the-diagnostic-set
#16
Ciro Manzo, Maria Natale
In the last few years, the relationship between polymyalgia rheumatica (PMR) and cancer has been considered with very different conclusions. In particular, in 2010, Ji et al examined the overall and specific cancer risks among Swedish subjects following hospitalization for PMR and giant cell arteritis and noted that the risk of cancer was highest in the first year after hospitalization (of 3941 total cancer diagnoses, 783 [19.1%] were in the first year). In 2013, Muller et al, using data from General Practice Research Database, highlighted that elderly patients with a PMR diagnosis were significantly more likely to receive a cancer diagnosis in the year after PMR diagnosis (313/667 cancer cases [69%])...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27836904/the-effect-of-socioeconomic-status-on-the-choice-of-treatment-for-patients-with-cruciate-ligament-injuries-in-the-knee-a-population-based-cohort-study
#17
Richard Nordenvall, Alejandro I Marcano, Johanna Adami, Mårten Palme, Ville M Mattila, Shahram Bahmanyar, Li Felländer-Tsai
BACKGROUND: The socioeconomic status (SES) of patients has been widely recognized as playing an important role in many health-related conditions, including orthopaedic conditions, in which a higher SES has been associated with a higher utilization of more advanced medical treatments such as drugs, diagnostics, and surgery. However, the association between SES and cruciate ligament surgery has not been thoroughly investigated. PURPOSE: To evaluate the association between SES and choice of treatment in patients with a cruciate ligament injury...
November 11, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27832745/the-burden-of-chickenpox-disease-in-sweden
#18
Katarina Widgren, Johan Giesecke, Lars Lindquist, Anders Tegnell
BACKGROUND: Chickenpox vaccine is not included in the routine childhood vaccination programme in Sweden. The aim of this study was to estimate the baseline of national chickenpox disease burden, as comprehensive studies, required for an assessment regarding vaccine introduction, are lacking. METHODS: We used available health care registers and databases; the death register, hospitalisations register, communicable disease notifications database, Stockholm County registers on consultations in specialist and primary care, temporary parental benefit to care for a sick child, and searches on the health care system's website...
November 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27821670/identification-of-patients-with-non-metastatic-colorectal-cancer-in-primary-care-a-case-control-study
#19
Marcela Ewing, Peter Naredi, Chenyang Zhang, Jörgen Månsson
BACKGROUND: Colorectal cancer is the third most common cancer worldwide and second most common in Europe. Despite screening, it is often diagnosed at an unfavourable stage. AIM: To identify and quantify features of non-metastatic colorectal cancer in primary care to enable earlier diagnosis by GPs. DESIGN AND SETTING: A case-control study was conducted using diagnostic codes from national and regional healthcare databases in Sweden. METHOD: A total of 542 patients diagnosed with non-metastatic colorectal cancer in 2011 and 2139 matched controls were selected from the Swedish Cancer Register (SCR) and a regional healthcare database respectively...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27803195/an-integrated-metagenomics-pipeline-for-strain-profiling-reveals-novel-patterns-of-bacterial-transmission-and-biogeography
#20
Stephen Nayfach, Beltran Rodriguez-Mueller, Nandita Garud, Katherine S Pollard
We present the Metagenomic Intra-species Diversity Analysis System (MIDAS), which is an integrated computational pipeline for quantifying bacterial species abundance and strain-level genomic variation, including gene content and single-nucleotide polymorphisms (SNPs), from shotgun metagenomes. Our method leverages a database of more than 30,000 bacterial reference genomes that we clustered into species groups. These cover the majority of abundant species in the human microbiome but only a small proportion of microbes in other environments, including soil and seawater...
November 2016: Genome Research
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