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Aortic sclerosis

Elena Bartoloni, Giacomo Pucci, Francesca Cannarile, Francesca Battista, Alessia Alunno, Marco Giuliani, Giacomo Cafaro, Roberto Gerli, Giuseppe Schillaci
Although microvascular disease is a hallmark of systemic sclerosis (SSc), a higher prevalence of macrovascular disease and a poorer related prognosis have been reported in SSc than in the general population. The simultaneous assessment of prognostically relevant functional properties of larger and smaller arteries, and their effects on central hemodynamics, has never been performed in SSc using the state-of-the-art techniques. Thirty-four women with SSc (aged 61±15 years, disease duration 17±12 years, and blood pressure 123/70±18/11 mm Hg) and 34 healthy women individually matched by age and mean arterial pressure underwent the determination of carotid-femoral (aortic) and carotid-radial (upper limb) pulse wave velocity (a direct measure of arterial stiffness), aortic augmentation (a measure of the contribution of reflected wave to central pulse pressure), and aortobrachial pulse pressure amplification (brachial/aortic pulse pressure) through applanation tonometry (SphygmoCor)...
October 17, 2016: Hypertension
Charline Estublier, Roland Chapurlat, Pawel Szulc
OBJECTIVE: Data on the relationship between disc degeneration (DD) and fragility fractures in men are limited. The aim of this study was to prospectively analyse the risk of vertebral and non-vertebral fractures in men with thoracolumbar DD according to the severity of its radiological signs: disc space narrowing (DSN), osteophytes and endplate sclerosis. METHODS: Men >50 years of age (n = 765) had lateral spine radiographs and DXA and were monitored prospectively...
October 3, 2016: Rheumatology
P Dueppers, M Duran, K Grabitz, H Schelzig
BACKGROUND: Abdominal aortic aneurysms (AAA) are a very rare in pediatric patients and can rarely be associated with tuberous sclerosis (TS). Open surgery is the first-line-therapy. We report our experience added by a review on current literature. REPORT: A 9-year old boy with TS and history of two earlier open repairs for AAA presented to our department with a recurrent juxtarenal aortic aneurysm. We performed a PTFE patch plasty. Postoperative course was uneventful...
September 22, 2016: Annals of Vascular Surgery
George P Karamanolis, Stylianos Panopoulos, Konstantinos Denaxas, Anastasios Karlaftis, Alexandra Zorbala, Dimitrios Kamberoglou, Spiros D Ladas, Petros P Sfikakis
BACKGROUND: Acute administration of the oral 5-HT1A receptor agonist buspirone, which is commonly used as an anxiolytic drug, may improve compromised lower esophageal sphincter function. In an open-label trial we assessed the effects of buspirone on esophageal motor function and symptoms in patients with esophageal involvement associated with systemic sclerosis (SSc). METHODS: Thirty consecutive patients with SSc and symptomatic esophageal involvement, despite treatment with proton pump inhibitors, underwent high resolution manometry and chest computed tomography for assessment of motor function and esophageal dilatation, respectively...
2016: Arthritis Research & Therapy
Tuomas Peltonen, Pauli Ohukainen, Heikki Ruskoaho, Jaana Rysä
Calcific aortic valve disease (CAVD) represents a spectrum of disease spanning from milder degrees of calcification of valve leaflets, i.e. aortic sclerosis, to severe calcification i.e. aortic stenosis (AS) with hemodynamic instability. The prevalence of CAVD is increasing rapidly due to the aging of the population, being up to 2,8% among patients over 75 years of age. Even without significant aortic valve stenosis, aortic sclerosis is associated with a 50% increased risk of myocardial infarction and death from cardiovascular causes...
September 1, 2016: Annals of Medicine
Matteo Nicola Dario Di Minno, Alessandro Di Minno, Paola Songia, Pasquale Ambrosino, Paola Gripari, Alessio Ravani, Mauro Pepi, Paolo Osvaldo Rubba, Emanuela Medda, Elena Tremoli, Damiano Baldassarre, Paolo Poggio
OBJECTIVE: Growing evidence suggested an association between aortic valve sclerosis (AVSc) and cardiovascular (CV) events. However, little is known about the association of AVSc with major markers of subclinical atherosclerosis. We performed a meta-analysis of literature studies to address this issue. METHODS: Studies on the relationship between AVSc and common carotid artery intima-media thickness (IMT), prevalence of carotid plaques (CPs), flow-mediated dilation (FMD), aortic pulse wave velocity (PWV) and augmentation index (AIx) were systematically searched in electronic databases...
November 15, 2016: International Journal of Cardiology
Jonathan L Eliason, Dawn M Coleman, Enrique Criado, James C Stanley
OBJECTIVE: Pediatric abdominal aortic aneurysms (AAAs) are rare. The intent of this report was to review the presentation and surgical management of AAAs in infancy and early childhood. METHODS: The clinical courses of young children undergoing AAA surgery were subjected to a retrospective review and analysis. RESULTS: Eleven children, nine boys and two girls, ranging in age from 2 weeks to 6 years, underwent surgical treatment of AAA at the University of Michigan from 2002 to 2014...
July 18, 2016: Journal of Vascular Surgery
Chang-Yi Li, Yi-He Chen, Qian Wang, Jian-Wen Hou, Hong Wang, Yue-Peng Wang, Yi-Gang Li
BACKGROUND: Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. Upregulated ALK4 expression and activated ALK4-small mother against decapentaplegic (Smad)2/3 signaling have been reported to play a pivotal role in tumorigenesis and in the development of systemic sclerosis. However, the role of ALK4-Smad2/3 pathway in the pathogenesis of cardiac hypertrophy and cardiac fibrosis remains unknown...
September 2016: Journal of Hypertension
Joanna L d'Arcy, Sean Coffey, Margaret A Loudon, Andrew Kennedy, Jonathan Pearson-Stuttard, Jacqueline Birks, Eleni Frangou, Andrew J Farmer, David Mant, Jo Wilson, Saul G Myerson, Bernard D Prendergast
BACKGROUND: Valvular heart disease (VHD) is expected to become more common as the population ages. However, current estimates of its natural history and prevalence are based on historical studies with potential sources of bias. We conducted a cross-sectional analysis of the clinical and epidemiological characteristics of VHD identified at recruitment of a large cohort of older people. METHODS AND RESULTS: We enrolled 2500 individuals aged ≥65 years from a primary care population and screened for undiagnosed VHD using transthoracic echocardiography...
June 26, 2016: European Heart Journal
Shigeo Horinaka, Hiroshi Yagi, Hiromichi Fukushima, Yoshimasa Shibata, Hiroshi Takeshima, Toshihiko Ishimitsu
Aortic pulse wave velocity (PWV) has been accepted as the gold standard for arterial stiffness measurement. However, PWV depends on blood pressure (BP). To eliminate the BP dependency of PWV, the cardio-ankle vascular index (CAVI) was developed. This study aimed to define the relationship between CAVI and aortic atherosclerosis or structure on multidetector computed tomography (MDCT). Patients with (n = 49) or without (n = 49) coronary artery disease were studied. The lumen and vessel diameters and wall thickness were calculated from the cross-sectional area at the pulmonary bifurcation level by 64-slice MDCT...
June 22, 2016: Angiology
C Doutrelon, S Skopinski, C Boulon, J Constans
PURPOSE: Systemic sclerosis is characterized by cutaneous sclerosis, vascular disease and immunological dysfunction. The prevalence of macrovascular disease remains controversial. PATIENTS AND METHODS: This was a descriptive prospective single-center study conducted in the vascular medicine department of the University Hospital of Bordeaux from July 1 to September 1, 2015. All inpatients followed for systemic scleroderma were included. Each patient had a Doppler ultrasound of the supra-aortic, upper and lower limb, and digital arteries as well as the aorta...
July 2016: Journal des Maladies Vasculaires
Sarfaraz Memon, Harsha V Ganga, Shihab Masrur, Paul D Thompson
The risk factors and pathology for the development and progression of aortic stenosis are similar to those for arterial atherosclerosis. Statin therapy has been hypothesized to delay progression of aortic stenosis, but studies evaluating this hypothesis report conflicting results. We performed a systematic search and review of statin clinical trials of aortic stenosis progression to determine why there are apparent differences in trial results. We identified 137 reports related to clinical trials of statin therapy and aortic stenosis, 14 of which qualified for analysis...
March 2016: Connecticut Medicine
Matteo Nicola Dario Di Minno, Alessandro Di Minno, Pasquale Ambrosino, Paola Songia, Elena Tremoli, Paolo Poggio
BACKGROUND: Nowadays, aortic valve sclerosis (AVSc) might be considered an atherosclerosis-like process due to significant association with age, male gender and some major features of metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) has been recognized as a clinical expression of the metabolic syndrome and as a predictor of cardiovascular events. We aim, with this meta-analysis, to evaluate the correlation between NAFLD and AVSc; this finding might suggest new insights and interactions among NAFLD, AVSc and the atherosclerotic process...
August 15, 2016: International Journal of Cardiology
Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo, Antonio Pinto
BACKGROUND: IgG4-related disease is a rare, clinical and pathologic disease entity of unknown etiology. Its main features are increased serum concentrations of IgG4 > 1,35 g/l, lymphocyte and IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation of IgG4-RSD is pancreatitis which is combined with the involvement of biliary ducts in 74 percent of patients. Extrapancreatic manifestations include: abdominal or mediastinal lymphadenopathy; the involvement of salivary glands and lacrimal glands, kidneys, lung, retroperitoneum...
May 10, 2016: Current Pharmaceutical Design
D Luke Glancy, Koteswara R Pothineni
There is a sinus P wave in front of each QRS, and the rate is 122 beats/min. The QRS voltage is large and meets many criteria for left ventricular hypertrophy: RI > 13 mm (1.3 mV); RaVF > 19 mm; SaVR > 14 mm; SV1 > 24 mm; SV2 > 30 mm; RV6 > 26 mm; RV6 > RV5; SV1 + RV5 or RV6 > 35 mm; SV2 + RV5 or RV6 > 45 mm; RaVL + SV3 > 20 mm in a woman.1 In addition, there are two non-voltage criteria for LVH: QRS duration = 0.11 s and typical repolarization changes: J-point depression with a downsloping ST segment into an inverted T wave and a more rapid upslope back to the baseline...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
D Luke Glancy Md, Koteswara R Pothineni Md
There is a sinus P wave in front of each QRS, and the rate is 122 beats/min. The QRS voltage is large and meets many criteria for left ventricular hypertrophy: RI > 13 mm (1.3 mV); RaVF > 19 mm; SaVR > 14 mm; SV1 > 24 mm; SV2 > 30 mm; RV6 > 26 mm; RV6 > RV5; SV1 + RV5 or RV6 > 35 mm; SV2 + RV5 or RV6 > 45 mm; RaVL + SV3 > 20 mm in a woman.1 In addition, there are two non-voltage criteria for LVH: QRS duration = 0.11 s and typical repolarization changes: J-point depression with a downsloping ST segment into an inverted T wave and a more rapid upslope back to the baseline...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
Y I Zeng, Rongrong Sun, Xianchi Li, Min Liu, Shuang Chen, Peiying Zhang
Valvular heart disease (VHD) is caused by either damage or defect in one of the four heart valves, aortic, mitral, tricuspid or pulmonary. Defects in these valves can be congenital or acquired. Age, gender, tobacco use, hypercholesterolemia, hypertension, and type II diabetes contribute to the risk of disease. VHD is an escalating health issue with a prevalence of 2.5% in the United States alone. Considering the likely increase of the aging population worldwide, the incidence of acquired VHD is expected to increase...
April 2016: Experimental and Therapeutic Medicine
Cyndi R Morales, Dan L Li, Zully Pedrozo, Herman I May, Nan Jiang, Viktoriia Kyrychenko, Geoffrey W Cho, Soo Young Kim, Zhao V Wang, David Rotter, Beverly A Rothermel, Jay W Schneider, Sergio Lavandero, Thomas G Gillette, Joseph A Hill
Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition of class I histone deacetylases (HDACs), a group of chromatin remodeling enzymes, has been successful in blocking the growth of some cancer cell types. These inhibitors also attenuate the pathogenesis of pathological cardiac remodeling by blunting and even reversing pathological hypertrophy...
April 5, 2016: Science Signaling
Jaana Rysä
Calcific aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening (i.e. aortic sclerosis) to severe calcification of valves (i.e. aortic stenosis). Gene expression profiling analysis of non-calcified controls, sclerotic, and calcified aortic valves was performed to better understand the progression of calcific aortic valve disease. The complementary information related to processing and statistical analysis of the DNA microarray data is provided in this article. Interpretation of this data can be found in a research article entitled "MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease" [1]...
March 2016: Genomics Data
Alessandra Bitto, Gian Luca Bagnato, Gabriele Pizzino, William Neal Roberts, Natasha Irrera, Letteria Minutoli, Giuseppina Russo, Francesco Squadrito, Antonino Saitta, Gian Filippo Bagnato, Domenica Altavilla
Aims Systemic sclerosis (SSc) is characterized by vasculopathy and organ fibrosis. Although microvascular alterations are very well characterized, structural and functional abnormalities of large vessels are not well defined. Therefore, we evaluated the effect of simvastatin administration on aortic and small renal arteries thickening, and on myofibroblasts differentiation in a murine model of SSc. Methods and results SSc was induced in BALB/c mice by daily subcutaneous injections of hypochlorous acid (HOCl, 100 μl) for 6 weeks...
2016: Free Radical Research
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