Maddalena Conte, Paolo Poggio, Maria Monti, Laura Petraglia, Serena Cabaro, Dario Bruzzese, Giuseppe Comentale, Aurelio Caruso, Mariagabriella Grimaldi, Emilia Zampella, Annarita Gencarelli, Maria Rosaria Cervasio, Flora Cozzolino, Vittoria Monaco, Veronika Myasoedova, Vincenza Valerio, Adele Ferro, Luigi Insabato, Michele Bellino, Gennaro Galasso, Francesca Graziani, Pietro Pucci, Pietro Formisano, Emanuele Pilato, Alberto Cuocolo, Pasquale Perrone Filardi, Dario Leosco, Valentina Parisi
Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls)...
January 18, 2024: International Journal of Molecular Sciences