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Adaptive RT

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https://www.readbyqxmd.com/read/28327925/abvd-chemotherapy-with-reduced-radiation-therapy-rates-in-children-adolescents-and-young-adults-with-all-stages-of-hodgkin-lymphoma
#1
K C Marr, J M Connors, K J Savage, K J Goddard, R J Deyell
Background: We adopted ABVD chemotherapy with risk-adapted radiation therapy (RT) as first-line therapy for children, adolescents and young adults with Hodgkin lymphoma (HL) in British Columbia (BC) in 2004. Patients and Methods: Patients ≤ 25 years diagnosed from 2004 to 2013 with all stages of HL who received ABVD as initial therapy were included. Results: Among 55 children (age < 18 y) and 154 young adults (18-25 y) there were no significant differences between age groups for sex, histologic subtype, tumour bulk, B symptoms, prognostic risk groups or treatment received...
March 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28325943/a-parameterized-model-for-mean-urinary-inflow-rate-and-its-preliminary-application-in-radiotherapy-for-cervical-cancer
#2
Fu Jin, Huan-Li Luo, Juan Zhou, Ding-Yi Yang, Li Yin, Xiao-Qing Yang, Ya-Nan He, Xian-Feng Liu, Da Qiu, Ming-Song Zhong, Han Yang, Chao Li, Qi-Cheng Li, Guang-Lei He, Ying Wang
Forty-nine patients with stage IIb cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P age), water consumption (P wat ), and body mass index (BMI, P bmi ) on the mean urinary inflow rate (v tot ) were analysed. The bladder volume (BV) increased linearly over time. A large variation in v tot among individuals was observed, ranging from 0.19 to 5.13 ml/min. The v tot was correlated with P age (R = -0...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320832/g-csf-receptor-blockade-ameliorates-arthritic-pain-and-disease
#3
Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook
G-CSF or CSF-3, originally defined as a regulator of granulocyte lineage development via its cell surface receptor (G-CSFR), can play a role in inflammation, and hence in many pathologies, due to its effects on mature lineage populations. Given this, and because pain is an extremely important arthritis symptom, the efficacy of an anti-G-CSFR mAb for arthritic pain and disease was compared with that of a neutrophil-depleting mAb, anti-Ly6G, in both adaptive and innate immune-mediated murine models. Pain and disease were ameliorated in Ag-induced arthritis, zymosan-induced arthritis, and methylated BSA/IL-1 arthritis by both prophylactic and therapeutic anti-G-CSFR mAb treatment, whereas only prophylactic anti-Ly6G mAb treatment was effective...
March 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28317152/-68-ga-psma-pet-for-radiation-treatment-planning-in-prostate-cancer-recurrences-after-surgery-individualized-medicine-or-new-standard-in-salvage-treatment
#4
Gregor Habl, Katharina Sauter, Kilian Schiller, Sabrina Dewes, Tobias Maurer, Matthias Eiber, Stephanie E Combs
BACKGROUND: (68) Ga-PSMA-PET imaging is a novel promising diagnostic tool to locate early biochemical failure after radical prostatectomy (RP) in prostate cancer (PC) patients. Exact knowledge of the relapse location may result in changes of the therapy concept aside from changes to the TNM stage. To gain data for this approach, we evaluated PC patients receiving (68) Ga-PSMA-PET imaging before salvage radiotherapy (RT). METHODS AND MATERIALS: In this study, 100 patients with biochemical failure after RP± prior RT who underwent (68) Ga-PSMA PET/CT or PET/MRI were evaluated undergoing salvage RT in our department...
March 20, 2017: Prostate
https://www.readbyqxmd.com/read/28294424/therapeutic-regulation-of-systemic-inflammation-in-xenograft-recipients
#5
Hayato Iwase, Hong Liu, Tao Li, Zhongquiang Zhang, Bingsi Gao, Hidetaka Hara, Martin Wijkstrom, Cassandra Long, Ryan Saari, David Ayares, David K C Cooper, Mohamed B Ezzelarab
Inflammation is known to preclude tolerance after transplantation. We have previously shown that systemic inflammation in xenograft recipients (SIXR) precedes activation of coagulation in the absence of T cell responses. Accordingly, SIXR may amplify innate and adaptive immune responses against xenografts after pig-to-primate xenotransplantation, even with efficient immunosuppressive therapy. We evaluated the impact of anti-inflammatory agents on pro-inflammatory cytokines and chemokines in pig artery patch and heart xenograft recipients...
March 12, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28290295/amino-acid-decarboxylase-dependent-acid-tolerance-selected-phenotypic-and-virulence-gene-expression-responses-of-salmonella-enterica-serovar-heidelberg
#6
Jiamei Liu, Ligong Zhai, Wenjun Lu, Zhaoxin Lu, Xiaomei Bie
Salmonella enterica serovar Heidelberg (S. Heidelberg) is one of the pathogens most frequently detected in recent years in food products from animals; here, we examine the acid tolerance of this strain. Mild acid (pH5.5-5.0) induced a strong acid resistance in S. Heidelberg; the induced acid resistance improved within 0.5-6h and resulted in >95% cell survival following challenge in pH3.0 medium. Addition of lysine or arginine to pH2.5 acid challenge medium significantly improved the survival of S. Heidelberg; lysine induced the largest increase in survival...
February 2017: Food Research International
https://www.readbyqxmd.com/read/28290067/expert-system-classifier-for-adaptive-radiation-therapy-in-prostate-cancer
#7
Gabriele Guidi, Nicola Maffei, Claudio Vecchi, Giovanni Gottardi, Alberto Ciarmatori, Grazia Maria Mistretta, Ercole Mazzeo, Patrizia Giacobazzi, Frank Lohr, Tiziana Costi
A classifier-based expert system was developed to compare delivered and planned radiation therapy in prostate cancer patients. Its aim is to automatically identify patients that can benefit from an adaptive treatment strategy. The study predominantly addresses dosimetric uncertainties and critical issues caused by motion of hollow organs. 1200 MVCT images of 38 prostate adenocarcinoma cases were analyzed. An automatic daily re-contouring of structures (i.e. rectum, bladder and femoral heads), rigid/deformable registration and dose warping was carried out to simulate dose and volume variations during therapy...
March 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28286236/5-hydroxytyrosol-inhibits-hiv-1-replication-in-primary-cells-of-the-lower-and-upper-female-reproductive-tract
#8
Elisa Saba, Paola Panina-Bordignon, Isabel Pagani, Massimo Origoni, Massimo Candiani, Claudio Doglioni, Gianluca Taccagni, Silvia Ghezzi, José Alcami, Elisa Vicenzi, Guido Poli
We investigated the potential anti-HIV-1 activity of the candidate microbicide 5-hydroxytyrosol (5-HT) both in primary human cervical tissue explants (CTE), established from tissues of women undergoing histerectomy, and in endometrium-associated leukocytes (EAL). CTE were exposed to either the laboratory-adapted HIV-1BaL or to primary viral isolates in the presence or absence of 5-HT or 3TC/lamivudine as control and were then monitored for 12 days in terms of HIV-1 p24 Gag antigen production in culture supernatants...
March 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28280927/cuticle-ultrastructure-cuticular-lipid-composition-and-gene-expression-in-hypoxia-stressed-arabidopsis-stems-and-leaves
#9
Hyojin Kim, Dongsu Choi, Mi Chung Suh
An increased permeability of the cuticle is closely associated with downregulation of genes involved in cuticular lipid synthesis in hypoxia-stressed Arabidopsis and may allow plants to cope with oxygen deficiency. The hydrophobic cuticle layer consisting of cutin polyester and cuticular wax is the first barrier to protect the aerial parts of land plants from environmental stresses. In the present study, we investigated the role of cuticle membrane in Arabidopsis responses to oxygen deficiency. TEM analysis showed that the epidermal cells of hypoxia-treated Arabidopsis stems and leaves possessed a thinner electron-translucent cuticle proper and a more electron-dense cuticular layer...
March 9, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28280617/identifying-prognostic-intratumor-heterogeneity-using-pre-and-post-radiotherapy-18f-fdg-pet-images-for-pancreatic-cancer-patients
#10
Yong Yue, Arsen Osipov, Benedick Fraass, Howard Sandler, Xiao Zhang, Nicholas Nissen, Andrew Hendifar, Richard Tuli
BACKGROUND: To stratify risks of pancreatic adenocarcinoma (PA) patients using pre- and post-radiotherapy (RT) PET/CT images, and to assess the prognostic value of texture variations in predicting therapy response of patients. METHODS: Twenty-six PA patients treated with RT from 2011-2013 with pre- and post-treatment 18F-FDG-PET/CT scans were identified. Tumor locoregional texture was calculated using 3D kernel-based approach, and texture variations were identified by fitting discrepancies of texture maps of pre- and post-treatment images...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28280462/the-role-of-glia-in-the-peripheral-and-central-auditory-system-following-noise-overexposure-contribution-of-tnf-%C3%AE-and-il-1%C3%AE-to-the-pathogenesis-of-hearing-loss
#11
Verónica Fuentes-Santamaría, Juan Carlos Alvarado, Pedro Melgar-Rojas, María C Gabaldón-Ull, Josef M Miller, José M Juiz
Repeated noise exposure induces inflammation and cellular adaptations in the peripheral and central auditory system resulting in pathophysiology of hearing loss. In this study, we analyzed the mechanisms by which noise-induced inflammatory-related events in the cochlea activate glial-mediated cellular responses in the cochlear nucleus (CN), the first relay station of the auditory pathway. The auditory function, glial activation, modifications in gene expression and protein levels of inflammatory mediators and ultrastructural changes in glial-neuronal interactions were assessed in rats exposed to broadband noise (0...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28273480/enhanced-protein-translation-underlies-improved-metabolic-and-physical-adaptations-to-different-exercise-training-modes-in-young-and-old-humans
#12
Matthew M Robinson, Surendra Dasari, Adam R Konopka, Matthew L Johnson, S Manjunatha, Raul Ruiz Esponda, Rickey E Carter, Ian R Lanza, K Sreekumaran Nair
The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic capacity and skeletal muscle mitochondrial respiration. HIIT revealed a more robust increase in gene transcripts than other exercise modalities, particularly in older adults, although little overlap with corresponding individual protein abundance was noted...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28271402/cortical-bilateral-adaptations-in-rats-submitted-to-focal-cerebral-ischemia-emphasis-on-glial-metabolism
#13
Yasmine Nonose, Pedro E Gewehr, Roberto F Almeida, Jussemara S da Silva, Bruna Bellaver, Leo A M Martins, Eduardo R Zimmer, Samuel Greggio, Gianina T Venturin, Jaderson C Da Costa, André Quincozes-Santos, Luc Pellerin, Diogo O de Souza, Adriano M de Assis
This study was performed to evaluate the bilateral effects of focal permanent ischemia (FPI) on glial metabolism in the cerebral cortex. Two and 9 days after FPI induction, we analyze [(18)F]FDG metabolism by micro-PET, astrocyte morphology and reactivity by immunohistochemistry, cytokines and trophic factors by ELISA, glutamate transporters by RT-PCR, monocarboxylate transporters (MCTs) by western blot, and substrate uptake and oxidation by ex vivo slices model. The FPI was induced surgically by thermocoagulation of the blood in the pial vessels of the motor and sensorimotor cortices in adult (90 days old) male Wistar rats...
March 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28270856/resistance-training-to-improve-type-2-diabetes-working-toward-a-prescription-for-the-future
#14
REVIEW
Dominik H Pesta, Renata L S Goncalves, Anila K Madiraju, Barbara Strasser, Lauren M Sparks
The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to manage and prevent this disease are urgently needed. Resistance training (RT) promotes health benefits through increased skeletal muscle mass and qualitative adaptations, such as enhanced glucose transport and mitochondrial oxidative capacity. In particular, mitochondrial adaptations triggered by RT provide evidence for this type of exercise as a feasible lifestyle recommendation to combat T2D, a disease typically characterized by altered muscle mitochondrial function...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28259993/glycometabolic-adaptation-mediates-the-insensitivity-of-drug-resistant-k562-adm-leukaemia-cells-to-adriamycin-via-the-akt-mtor-c-myc-signalling-pathway
#15
Xueyan Zhang, Ziying Ai, Jing Chen, Juan Yi, Zhuan Liu, Huaishun Zhao, Hulai Wei
In human leukaemia, resistance to chemotherapy leads to treatment ineffectiveness or failure. Previous studies have indicated that cancers with increased levels of aerobic glycolysis are insensitive to numerous forms of chemotherapy and respond poorly to radiotherapy. Whether glycolysis serves a key role in drug resistance of leukaemia cells remains unclear. The present study systematically investigated aerobic glycolytic alterations and regulation in K562/adriamycin (ADM) multidrug‑resistant (MDR) and ADM‑sensitive K562 leukaemia cells in normoxia, and the association between drug resistance and improper glycometabolism...
February 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28256563/the-alr-groel1-operon-in-mycobacterium-tuberculosis-an-interplay-of-multiple-regulatory-elements
#16
Aadil H Bhat, Deepika Pathak, Alka Rao
Threonylcarbamoyladenosine is a universally conserved essential modification of tRNA that ensures translational fidelity in cellular milieu. TsaD, TsaB and TsaE are identified as tRNA-A37-threonylcarbamoyl (t(6)A)-transferase enzymes that have been reconstituted in vitro, in few bacteria recently. However, transcriptional organization and regulation of these genes are not known in any of these organisms. This study describes the intricate architecture of a complex multicistronic alr-groEL1 operon, harboring essential genes, namely tsaD, tsaB, tsaE, groES, groEL1, and alr (required for cell wall synthesis), and rimI encoding an N-α- acetyltransferase in Mycobacterium tuberculosis...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254685/molecular-and-antigenic-traits-on-hemagglutinin-gene-of-avian-influenza-h9n2-viruses-evidence-of-a-new-escape-mutant-in-egypt-adapted-in-quails
#17
Amany Adel, Abdelsatar Arafa, Hussein A Hussein, Ahmed A El-Sanousi
The LPAI viruses of H9N2 subtype became widely distributed in Middle Eastern countries, causing great economic losses in poultry industry especially when complicated with other pathogens. The H9N2 viruses in Egypt have a wide spread nature since its first occurrence in 2011. In this study, we collected cloacal and tracheal samples from 19 flocks for detection and propagation of H9N2 virus using real-time RT-PCR and egg inoculation. We studied the molecular evolution of the Hemagglutinin gene of H9N2 viruses by full HA gene sequencing, then the antigenic characterization was implemented using the cross HI assay and analyzed using 3D Bioinformatics cartography software...
February 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28254371/the-important-functionality-of-14-3-3-isoforms-in-rice-roots-revealed-by-affinity-chromatography
#18
Zhixing Zhang, Yiping Zhang, Hong Zhao, Fenglian Huang, Zefeng Zhang, Wenxiong Lin
Plant 14-3-3 proteins belong to a large family of proteins involved in numerous physiological processes, and function by binding to phosphorylated client proteins to regulate their function. However, little is known about their regulatory mechanisms in rice root growth. In this study, four 14-3-3 isoforms (GF14b, GF14c, GF14e, GF14f) exhibiting prominent expression profiles in rice roots, were selected for further investigation. Through a pull-down assay using four 14-3-3 isoforms in rice roots, 87 client proteins were identified that are involved in metabolism, protein synthesis and trafficking, energy metabolism, cell structure and growth, and other cellular processes...
February 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28253929/reducing-radiation-dose-to-normal-brain-through-a-risk-adapted-dose-reduction-protocol-for-patients-with-favourable-subtype-anaplastic-glioma
#19
M Back, M LeMottee, C Crasta, D Bailey, H Wheeler, L Guo, T Eade
AIM: In patients with isocitrate dehydrogenase (IDH) mutated anaplastic glioma determine the dosimetric benefits of delivering radiation therapy using a PET guided integrated boost IMRT technique (ib-IMRT) compared with standard IMRT (s-IMRT) in reducing dose to normal brain. METHODS: Ten patients with anaplastic glioma, identified as a favourable molecular subgroup through presence of IDH mutation, and managed with radiation therapy using an ib-IMRT were enrolled into a dosimetric study comparing two RT techniques: s-IMRT to 59...
March 2, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28249771/effects-of-the-copy-number-of-ribosomal-genes-genes-for-rrna-on-viability-of-subjects-with-chromosomal-abnormalities
#20
N A Lyapunova, L N Porokhovnik, N V Kosyakova, I A Mandron, T G Tsvetkova
The number of active ribosomal genes (AcRG) was evaluated in 172 carriers of chromosomal abnormalities (CA) such as Down's syndrome (DS), Robertsonian translocations (RT), Klinefelter's and Turner's syndromes, trisomy Х, disomy Y, and various structural CA. In controls (n=318), AcRG dosage varied from 119 to 190 copies with a mean of 151 copies per diploid genome. In CA carriers, except for DS newborns, AcRG dosage was not beyond these limits. As shown previously, only within these limits cellular homeostasis and organism's viability can be supported, while genomes beyond these limits are eliminated by embryonic loss...
February 26, 2017: Gene
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