Jun Yin, Hsueh-Ling Chen, Anna Grigsby-Brown, Yi He, Myriam L Cotten, Jacob Short, Aidan Dermady, Jingce Lei, Mary Gibbs, Ethan S Cheng, Dean Zhang, Caixia Long, Lele Xu, Tiffany Zhong, Rinat Abzalimov, Mariam Haider, Rong Sun, Ye He, Qiangjun Zhou, Nico Tjandra, Quan Yuan
Glia derived secretory factors play diverse roles in supporting the development, physiology, and stress responses of the central nervous system (CNS). Through transcriptomics and imaging analyses, we have identified Obp44a as one of the most abundantly produced secretory proteins from Drosophila CNS glia. Protein structure homology modeling and Nuclear Magnetic Resonance (NMR) experiments reveal Obp44a as a fatty acid binding protein (FABP) with a high affinity towards long-chain fatty acids in both native and oxidized forms...
April 11, 2024: bioRxiv