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https://www.readbyqxmd.com/read/28214983/pooled-analysis-of-four-non-interventional-studies-effectiveness-and-tolerability-of-the-antidepressant-agomelatine-in-daily-practice
#1
Gerd Laux, Bettina Barthel, Göran Hajak, Matthias Lemke, Hans-Peter Volz
INTRODUCTION: Meta-analyses are useful to increase knowledge and strengthen evidence about antidepressant treatment supplementary to individual studies. METHODS: A pooled analysis of four multicenter, open-label, prospective, non-interventional studies (2009-2013) was performed to provide further evidence about the antidepressant effectiveness and tolerability of agomelatine (25-50 mg/day) in a large number of non-selected German outpatients with major depressive disorder...
February 18, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28214871/restraint-stress-during-pregnancy-rapidly-raises-kynurenic-acid-levels-in-mouse-placenta-and-fetal-brain
#2
Francesca M Notarangelo, Robert Schwarcz
Stressful events during pregnancy adversely affect brain development and may increase the risk of psychiatric disorders later in life. Early changes in the kynurenine (KYN) pathway (KP) of tryptophan (TRP) degradation, which contains several neuroactive metabolites, including kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN), may constitute a molecular link between prenatal stress and delayed pathological consequences. To begin testing this hypothesis experimentally, we examined the effects of a 2-h restraint stress on KP metabolism in pregnant FVB/N mice on gestational day 17...
February 18, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28214781/cannabis-use-and-the-course-and-outcome-of-major-depressive-disorder-a-population-based-longitudinal-study
#3
Daniel Feingold, Jürgen Rehm, Shaul Lev-Ran
Cannabis use has been reported to affect the course of various psychiatric disorders, however its effect on the course of major depressive disorder (MDD) is not yet clear. We used data from Wave 1 and Wave 2 of the National Epidemiologic survey on Alcohol and Related Conditions (NESARC). Individuals with baseline MDD (N=2,348) were included in the study. Cannabis users without a Cannabis Use Disorder (CUDs) and individuals with a CUD were compared to nonusers using linear and logistic regression analyses controlling for sociodemographics, psychiatric disorders and substance use disorders at baseline...
February 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214777/utility-of-long-term-video-eeg-monitoring-for-children-with-staring
#4
Anup D Patel, Babitha Haridas, Zachary M Grinspan, Jack Stevens
OBJECTIVE: Staring spells are a common reason for referral to overnight epilepsy monitoring unit (EMU) evaluation. However, inpatient EMU admissions are expensive and time consuming. This study determined what percentage of those referred for staring had a confirmed epileptic seizure on long-term video-EEG monitoring (LTM) and developed a scoring system to help prioritize which patients should undergo this procedure. METHODS: We performed a four-year retrospective chart review of all children at a tertiary pediatric hospital who received LTM (long-term monitoring) for the purposes of characterizing staring...
February 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28214752/metabolic-syndrome-and-cardiovascular-risk-among-institutionalized-patients-with-schizophrenia-receiving-long-term-tertiary-care
#5
Lee Seng Esmond Seow, Siow Ann Chong, Peizhi Wang, Saleha Shafie, Hui Lin Ong, Mythily Subramaniam
BACKGROUND: Metabolic syndrome (MetS) and cardiovascular risk are highly prevalent among individuals with schizophrenia. This study aimed to determine the cardiometabolic profile and the associated risk factors in a group of institutionalized patients with schizophrenia or schizoaffective disorder receiving prolonged hospital care in the only tertiary psychiatric institution in Singapore. METHODS: Patients residing in long stay wards who were hospitalized for a minimum period of 1year were recruited...
February 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28214643/family-history-of-suicide-and-high-motor-impulsivity-distinguish-suicide-attempters-from-suicide-ideators-among-college-students
#6
Yong-Guang Wang, Shen Chen, Zhi-Ming Xu, Zhi-Hua Shen, Yi-Quan Wang, Xiao-Yan He, Ri-Fang Cao, David L Roberts, Jian-Fei Shi, Yi-Qiang Wang
Suicide in college students has become an important public health issue in China. The aim of this study was to identify the differences between suicide attempters and suicide ideators based on a cross-sectional survey. Our results indicate that although female gender, positive screening for psychiatric illness, positive family history of suicide, elevated overall impulsivity, and elevated motor impulsivity were correlated with suicidal ideation, only positive family history of suicide and high motor impulsivity could differentiate suicide attempters from suicidal ideators...
February 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28214634/a-systematic-review-of-help-seeking-and-mental-health-service-utilization-among-military-service-members
#7
REVIEW
Melanie A Hom, Ian H Stanley, Matthew E Schneider, Thomas E Joiner
Research has demonstrated that military service members are at elevated risk for a range of psychiatric problems, and mental health services use is a conduit to symptom reduction and remission. Nonetheless, there is a notable underutilization of mental health services in this population. This systematic review aimed to identify and critically examine: (1) rates of service use; (2) barriers and facilitators to care; and (3) programs and interventions designed to enhance willingness to seek care and increase help-seeking behaviors among current military personnel (e...
February 4, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28214436/impact-of-child-maltreatment-on-meaning-in-life-in-psychiatric-patients
#8
Sébastien Weibel, Sonia Vidal, Emilie Olié, Roland Hasler, Catherine Torriani, Paco Prada, Philippe Courtet, Sébastien Guillaume, Nader Perroud, Philippe Huguelet
Child maltreatment (CM) worsens prognosis and quality of life in several psychiatric conditions. Meaning in life is a construct which relates to the sense of purpose that one can perceive in life, and is a key aspect of recovery in psychiatric patients. The lasting impact of CM on meaning in life and its mediating variables have not been studied in patients with chronic persistent psychiatric conditions. One hundred and sixty-six patients with bipolar disorder (N=35), psychotic disorder (N=73), anorexia nervosa (N=30) or borderline personality disorder (N=28) were assessed for meaning in life (revised version of the Life Regard Index (LRI-R)), for CM (Childhood Trauma Questionnaire (CTQ)) and for internalized/externalized psychopathology...
February 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28214349/the-educational-value-of-inpatient-psychiatric-training-in-undergraduate-medical-education
#9
Noah Capurso, Kirsten Wilkins
No abstract text is available yet for this article.
February 18, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28214183/-misuse-and-dependence-on-prescription-opioids-prevention-identification-and-treatment
#10
B Rolland, D Bouhassira, N Authier, M Auriacombe, V Martinez, P Polomeni, G Brousse, R Schwan, P Lack, J Bachellier, S Rostaing, P Bendimerad, P Vergne-Salle, M Dematteis, S Perrot
Since the 1990s, the use of prescription opioids has largely spread, which has brought a real progress in the treatment of pain. The long-term use of prescription opioid is sometimes required, and may lead to pharmacological tolerance and withdrawal symptoms, i.e. pharmacological dependence on prescription opioids. Occasionally, this may also lead to misuse of prescription opioids (MPO). MPO preferentially occurs in vulnerable individuals, i.e., those with a young age, history of other addictive or psychiatric disorders, especially anxious and depressive disorders...
February 14, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28213339/classifying-empirically-valid-and-clinically-meaningful-change-in-eating-disorders-using-the-eating-disorders-inventory-version-2-edi-2
#11
David Clinton, Andreas Birgegård
The study examined the ability of the EDI-2 to classify empirically valid and clinically meaningful change using clinical significance and the Reliable Change Index (CS/RCI), and compared CS/RCI to classification based on diagnostic change. Eating disorder (ED) patients (N=363) were assessed at intake and after 36months on measures of ED and psychiatric symptoms, self-image, interpersonal relationships, treatment satisfaction and general outcome. Patients were categorized using a four-way classification scheme as "Deteriorated", "Unchanged", "Improved" or "No ED"; and using a two-way classification scheme as either in remission or not in remission...
February 9, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28213305/risk-of-suicide-according-to-the-level-of-psychiatric-contact-in-the-older-people-analysis-of-national-health-insurance-databases-in-taiwan
#12
Shin-Ting Yeh, Yee-Yung Ng, Shiao-Chi Wu
PURPOSE: Suicide in the older people is a serious problem worldwide; however the effect of psychiatric contact on the risk of suicide has not been fully explored. The aim of this study was to investigate the relationship between psychiatric contact and suicide in the older people in Taiwan. METHODS: A population-based database was used in this national case-control study. Propensity score matching was used to match older people who did and did not commit suicide from 2010 to 2012 by calendar year, gender, age, and area of residence...
February 1, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28213123/risk-of-depression-in-patients-with-uterine-leiomyoma-a-nationwide-population-based-cohort-study
#13
Te-Chun Shen, Chih-Yi Yang, Yu-Jhen Huang, Cheng-Li Lin, Fung-Chang Sung
BACKGROUND: Population-based cohort study investigating the depression risk for patients with uterine leiomyoma (UL) is unavailable. This study investigated the subsequent risk of depression among patients with UL in an Asian population. METHODS: Using data from the National Health Insurance Research Database of Taiwan, we established a cohort with 21,168 patients diagnosed with UL between 2000 and 2010, and a non-UL cohort of 82,108 women without UL matched by age and year of diagnosis...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28213064/juvenile-treatment-with-a-novel-mglur2-agonist-mglur3-antagonist-compound-ly395756-reverses-learning-deficits-and-cognitive-flexibility-impairments-in-adults-in-a-neurodevelopmental-model-of-schizophrenia
#14
Meng-Lin Li, Yelena Gulchina, Sarah A Monaco, Bo Xing, Brielle R Ferguson, Yan-Chun Li, Feng Li, Xi-Quan Hu, Wen-Jun Gao
Schizophrenia (SCZ) is a neurodevelopmental psychiatric disorder, in which cognitive function becomes disrupted at early stages of the disease. Although the mechanisms underlying cognitive impairments remain unclear, N-methyl-D-aspartate receptors (NMDAR) hypofunctioning in the prefrontal cortex (PFC) has been implicated. Moreover, cognitive symptoms in SCZ are usually unresponsive to treatment with current antipsychotics and by onset, disruption of the dopamine system, not NMDAR hypofunctioning, dominates the symptoms...
February 14, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28212873/temperament-and-character-personality-dimensions-in-nitrate-tilt-induced-vasovagal-syncope-patients
#15
Vincenzo Russo, Ahmed AlTurki, Anna Rago, Riccardo Proietti, Guillaume Chaussé, Alessio Maria Monteleone, Pasquale Scognamiglio, Palmiero Monteleone, Gerardo Nigro
INTRODUCTION: Vasovagal syncope (VVS) is a clinical syndrome characterized by transient loss of consciousness and postural tone that is due to a temporary and spontaneously self-terminating global cerebral hypoperfusion. It is known that personality modulates the individual's sensitivity to stressors, and emotional arousal and psychologic uncertainty are conditions contributing to vasodepressor syncope. Therefore it is postulated that personality characteristics of VVS patients could have a role in the pathophysiology of VVS...
February 14, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28212663/isolation-of-primary-microglia-from-the-human-post-mortem-brain-effects-of-ante-and-post-mortem-variables
#16
Mark R Mizee, Suzanne S M Miedema, Marlijn van der Poel, Adelia, Karianne G Schuurman, Miriam E van Strien, Jeroen Melief, Joost Smolders, Debbie A Hendrickx, Kirstin M Heutinck, Jörg Hamann, Inge Huitinga
Microglia are key players in the central nervous system in health and disease. Much pioneering research on microglia function has been carried out in vivo with the use of genetic animal models. However, to fully understand the role of microglia in neurological and psychiatric disorders, it is crucial to study primary human microglia from brain donors. We have developed a rapid procedure for the isolation of pure human microglia from autopsy tissue using density gradient centrifugation followed by CD11b-specific cell selection...
February 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28212579/suicidal-ideation-among-chinese-cancer-inpatients-of-general-hospitals-prevalence-and-correlates
#17
Bao-Liang Zhong, Si-Heng Li, Shu-Yan Lv, Shun-Li Tian, Zhi-Dong Liu, Xu-Bin Li, Hong-Qing Zhuang, Ran Tao, Wei Zhang, Chuan-Jun Zhuo
Cancer patients are at high risk for suicide, particularly when they are informed about the cancer diagnosis or hospitalized for cancer treatment. Therefore, oncology healthcare settings such as large general hospitals in China, may represent an ideal setting to identify and treat suicidality in cancer patients. However, the clinical epidemiology of suicidality of Chinese cancer patients remains largely unknown. This study examined the prevalence and correlates of suicidal ideation among Chinese cancer inpatients of large general hospitals...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212507/higher-severity-of-cocaine-addiction-is-associated-with-tactile-and-somatic-hallucinations
#18
C Roncero, L Grau-López, R F Palma-Álvarez, L Rodriguez-Cintas, E Ros-Cucurull, A Esojo, C Daigre
BACKGROUND: The aim of this study is to describe the features of cocaine-dependent patients who have had cocaine-induced tactile/somatic hallucinations (CITSH), and to analyze the association with addiction-related variables and psychiatric comorbidity, comparing patients with CITSH, patients with cocaine psychotic symptoms (CIP) and no CITSH, and patients without any psychotic symptom. METHOD: A cross-sectional study was conducted in 767 cocaine-dependent patients in an outpatient treatment center for addictions...
December 1, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28212496/antipsychotic-use-in-dementia
#19
Julia Kirkham, Chelsea Sherman, Clive Velkers, Colleen Maxwell, Sudeep Gill, Paula Rochon, Dallas Seitz
Antipsychotics are necessary for many older adults to treat major mental illnesses or reduce distressing psychiatric symptoms. Current controversy exists over the role of antipsychotics in the management of neuropsychiatric symptoms (NPS) in persons with dementia. Although some NPS may be appropriately and safely treated with antipsychotics, a fine balance must be achieved between the benefits of these medications, which are often modest, and adverse events, which may have significant consequences. Approximately one-third of all persons with dementia are currently prescribed antipsychotic medications, and there is significant variation in the use of antipsychotics across care settings and providers...
March 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28212441/depressive-disorder-and-gastrointestinal-dysfunction-after-myocardial-infarct-are-associated-with-abnormal-tryptophan-5-hydroxytryptamine-metabolism-in-rats
#20
Xiaofang Lu, Yuefen Wang, Chunyan Liu, Yangang Wang
In this study, we investigated the relationship between tryptophan-5-hydroxytryptamine metabolism, depressive disorder, and gastrointestinal dysfunction in rats after myocardial infarction. Our goal was to elucidate the physiopathologic bases of somatic/psychiatric depression symptoms after myocardial infarction. A myocardial infarction model was established by permanent occlusion of the left anterior descending coronary artery. Depression-like behavior was evaluated using the sucrose preference test, open field test, and forced swim test...
2017: PloS One
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