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https://www.readbyqxmd.com/read/29710635/dual-role-of-dom-in-a-scenario-of-global-change-on-photosynthesis-and-structure-of-coastal-phytoplankton-from-the-south-atlantic-ocean
#1
Virginia E Villafañe, Joanna Paczkowska, Agneta Andersson, Cristina Durán Romero, Macarena S Valiñas, E Walter Helbling
We evaluated the dual role of DOM (i.e., as a source of inorganic nutrients and as an absorber of solar radiation) on a phytoplankton community of the western South Atlantic Ocean. Using a combination of microcosms and a cluster approach, we simulated the future conditions of some variables that are highly influenced by global change in the region. We increased nutrients (i.e., anthropogenic input) and dissolved organic matter (DOM), and we decreased the pH, to assess their combined impact on growth rates (μ), species composition/abundance and size structure, and photosynthesis (considering in this later also the effects of light quality i...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29609378/dynamic-strain-measurement-with-khz-level-repetition-rate-and-centimeter-level-spatial-resolution-based-on-brillouin-optical-correlation-domain-analysis
#2
Bin Wang, Xinyu Fan, Yuanxiu Fu, Zuyuan He
In this paper, we propose and demonstrate an ultrahigh-speed Brillouin optical correlation domain analysis (BOCDA) with a single-position sampling rate of 200 kS/s and a spatial resolution of 8 cm. The Brillouin gain spectrum (BGS) is obtained by using a data subtraction scheme rather than the conventional lock-in amplifier (LIA) detection configuration, thus removing the limitation of measurement speed imposed by the LIA. Meanwhile, a voltage controlled oscillator (VCO) is used to sweep the frequency interval between the pump and the probe rapidly...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29527514/fucosylated-antigens-in-cancer-an-alliance-toward-tumor-progression-metastasis-and-resistance-to-chemotherapy
#3
REVIEW
Athanasios Blanas, Neha M Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J van Vliet
Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa , Lewisb , and sialyl Lewisa ) and type II (H2, Lewisx , Lewisy , and sialyl Lewisx ) Lewis antigens, frequently occurs on the cancer cell surface and is mainly attributed to upregulated expression of pertinent fucosyltransferases (FUTs). Nevertheless, the impact of fucose-containing moieties on tumor cell biology is not fully elucidated yet. Here, we review the relevance of tumor-overexpressed FUTs and their respective synthesized Lewis determinants in critical aspects associated with cancer progression, such as increased cell survival and proliferation, tissue invasion and metastasis, endothelial to mesenchymal transition, endothelial and immune cell interaction, angiogenesis, multidrug resistance, and cancer stemness...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29486531/establishment-and-identification-of-cell-lines-from-type-o-blood-korean-native-pigs-and-their-efficiency-in-supporting-embryonic-development-via-somatic-cell-nuclear-transfer
#4
Anukul Taweechaipaisankul, Geon A Kim, Jun-Xue Jin, Su Cheong Yeom, Byeong Chun Lee
Due to their close similarities with humans in anatomy, physiology and genetics and handling advantages, miniature pigs are becoming a very attractive model for biomedical research. The purpose of this study was to establish and evaluate blood type O cells derived from Korean native pig (KNP), a typical miniature pig breed in Korea. Total 10 cell lines derived from 8 KNP piglets, adult KNP female pig (kidney and ear tissues) were established. To confirm the blood type O, genomic DNA, fucosyltransferase (FUT) expression and immunofluorescence staining were examined...
February 27, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29228607/clinical-significance-and-biological-function-of-fucosyltransferase-2-in-lung-adenocarcinoma
#5
Wenyuan Zhou, Huijun Ma, Guoqing Deng, Lili Tang, Jianxin Lu, Xiaoming Chen
Fucosylation, which is catalyzed by fucosyltransferases (FUTs), is one of the most important glycosylation events involved in cancer. Studies have shown that fucosyltransferase 8 (FUT8) is overexpressed in NSCLC and promotes lung cancer progression. However, there are no reports about the pathological role of fucosyltransferase 2 (FUT2) in lung cancer. To identify FUT2 associated with lung cancer, the expression and clinical significance of FUT2 in lung cancer was investigated by Real-Time PCR, Immunohistochemistry and Western Blot...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176924/novel-phonotactic-learning-tracking-syllable-position-and-co-occurrence-constraints
#6
Amélie Bernard
Are syllable-level and co-occurrence representations simultaneously available when one learns novel phonotactics? After training on word-medial consonant restrictions (e.g., word-medial onsets P/Z, codas D/F, and cross-syllable consonant clusters FP/DZ in items like baF.Pev, tiD.Zek), adults falsely recognized novel items containing restricted consonants with the same co-occurrences (e.g., FP) more often than those with different co-occurrences (e.g., FZ) when syllable-position information was kept constant (e...
October 2017: Journal of Memory and Language
https://www.readbyqxmd.com/read/28977906/trypsin-protease-activated-receptor-2-signaling-contributes-to-pancreatic-cancer-pain
#7
Jiao Zhu, Xue-Rong Miao, Kun-Ming Tao, Hai Zhu, Zhi-Yun Liu, Da-Wei Yu, Qian-Bo Chen, Hai-Bo Qiu, Zhi-Jie Lu
Pain treatment is a critical aspect of pancreatic cancer patient clinical care. This study investigated the role of trypsin-protease activated receptor-2 (PAR-2) in pancreatic cancer pain. Pancreatic tissue samples were collected from pancreatic cancer (n=22) and control patients (n=22). Immunofluorescence analyses confirmed colocalization of PAR-2 and neuronal markers in pancreatic cancer tissues. Trypsin levels and protease activities were higher in pancreatic cancer tissue specimens than in the controls...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28973293/nf%C3%AE%C2%BAb-mediated-activation-of-the-cellular-fut3-5-and-6-gene-cluster-by-herpes-simplex-virus-type-1
#8
Rickard Nordén, Ebba Samuelsson, Kristina Nyström
Herpes simplex virus type 1 has the ability to induce expression of a human gene cluster located on chromosome 19 upon infection. This gene cluster contains three fucosyltransferases (encoded by FUT3, FUT5 and FUT6) with the ability to add a fucose to an N-acetylglucosamine residue. Little is known regarding the transcriptional activation of these three genes in human cells. Intriguingly, herpes simplex virus type 1 activates all three genes simultaneously during infection, a situation not observed in uninfected tissue, pointing towards a virus specific mechanism for transcriptional activation...
September 4, 2017: Glycobiology
https://www.readbyqxmd.com/read/28946534/the-effects-of-balance-and-postural-stability-exercises-on-spa-based-rehabilitation-programme-in-patients-with-ankylosing-spondylitis
#9
Selim M Gunay, Ilke Keser, Zemzem T Bicer
BACKGROUND: Ankylosing spondylitis (AS) can cause severe functional disorders that lead to loss of balance. OBJECTIVE: The aim of this study was to investigate the effects of balance and postural stability exercises on spa based rehabilitation programme in AS subjects. METHODS: Twenty-one participants were randomized to the study (n= 11) and control groups (n= 10). Patients balance and stability were assessed with the Berg Balance Scale (BBS), Timed Up and Go (TUG) Test, Single Leg Stance Test (SLST) and Functional Reach Test (FRT)...
September 8, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28828091/fundamental-tactical-principles-of-soccer-a-comparison-of-different-age-groups
#10
Paulo Henrique Borges, José Guilherme, Leandro Rechenchosky, Luciane Cristina Arantes da Costa, Wilson Rinadi
The fundamental tactical principles of the game of soccer represent a set of action rules that guide behaviours related to the management of game space. The aim of this study was to compare the performance of fundamental offensive and defensive tactical principles among youth soccer players from 12 to 17 years old. The sample consisted of 3689 tactical actions performed by 48 soccer players in three age categories: under 13 (U-13), under 15 (U-15), and under 17 (U-17). Tactical performance was measured using the System of Tactical Assessment in Soccer (FUT-SAT)...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28771224/mir-125a-3p-fut5-fut6-axis-mediates-colorectal-cancer-cell-proliferation-migration-invasion-and-pathological-angiogenesis-via-pi3k-akt-pathway
#11
Leilei Liang, Chengshun Gao, Yang Li, Mingming Sun, Jingchao Xu, Huairui Li, Li Jia, Yongfu Zhao
The fucosyltransferase (FUT) family produces glycans, a fundamental event in several cancers, including colorectal cancer (CRC). miR-125a-3p is a non-coding RNA that can reduce cell proliferation and migration in cancer. In this study, we explored the levels of miR-125a-3p and FUT expression in human CRC tissues and two human CRC cell lines by qPCR. The results showed that miR-125a-3p, FUT5 and FUT6 are differentially expressed in normal and tumour tissues. On the basis of our previous research, FUT can be regulated by miRNA, which influences the proliferation and invasion of breast and hepatocellular cancer cells...
August 3, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28700339/trypsin-protease-activated-receptor-2-signaling-contributes-to-pancreatic-cancer-pain
#12
Jiao Zhu, Xue-Rong Miao, Kun-Ming Tao, Hai Zhu, Zhi-Yun Liu, Da-Wei Yu, Qian-Bo Chen, Hai-Bo Qiu, Zhi-Jie Lu
Pain treatment is a critical aspect of pancreatic cancer patient clinical care. This study investigated the role of trypsin-protease activated receptor-2 (PAR-2) in pancreatic cancer pain. Pancreatic tissue samples were collected from pancreatic cancer (n=22) and control patients (n=22). Immunofluorescence analyses confirmed colocalization of PAR-2 and neuronal markers in pancreatic cancer tissues. Trypsin levels and protease activities were higher in pancreatic cancer tissue specimens than in the controls...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28694438/stress-induces-more-serious-barrier-dysfunction-in-follicle-associated-epithelium-than-villus-epithelium-involving-mast-cells-and-protease-activated-receptor-2
#13
Lei Zhang, Jun Song, Tao Bai, Wei Qian, Xiao-Hua Hou
Psychological stress has been associated with intestinal epithelial hyperpermeability, the basic process in various functional and organic bowel diseases. In the present study, we aimed to clarify the differences and underlining mechanisms in stress-induced barrier disruption in functionally and structurally distinct epitheliums, including the villus epithelium (VE) and follicle-associated epithelium (FAE), a specialized epithelium overlaid the domes of Peyer's lymphoid follicles. Employing an Ussing Chamber system, the epithelial permeability was assessed in rats following water avoidance stress (WAS) in vivo and in mucosa tissues exposed to corticotropin-releasing factor (CRF) ex vivo...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587215/the-use-of-flexible-ultrasound-transducers-for-the-detection-of-laser-induced-guided-waves-on-curved-surfaces-at-elevated-temperatures
#14
Tai Chieh Wu, Makiko Kobayashi, Masayuki Tanabe, Che Hua Yang
In this study, a flexible ultrasonic transducer (FUT) was applied in a laser ultrasonic technique (LUT) for non-destructive characterization of metallic pipes at high temperatures of up to 176 °C. Compared with normal ultrasound transducers, a FUT is a piezoelectric film made of a PZT/PZT sol-gel composite which has advantages due to its high sensitivity, curved surface adaptability and high temperature durability. By operating a pulsed laser in B-scan mode along with the integration of FUT and LUT, a multi-mode dispersion spectrum of a stainless steel pipe at high temperature can be measured...
June 4, 2017: Sensors
https://www.readbyqxmd.com/read/28558796/systems-based-approach-to-examine-the-cytokine-responses-in-primary-mouse-lung-macrophages-infected-with-low-pathogenic-avian-influenza-virus-circulating-in-south-east-asia
#15
Biruhalem Taye, Hui Chen, Myint Zu Myaing, Boon Huan Tan, Sebastian Maurer-Stroh, Richard J Sugrue
BACKGROUND: Influenza A virus (IAV) is a major public health concern, being responsible for the death of approximately half a million people each year. Zoonotic transmissions of the virus from swine and avian origin have occurred in the past, and can potentially lead to the emgergence of new IAV stains in future pandemics. Pulmonary macrophages have been implicated in disease severity in the lower airway, and understanding the host response of macrophages infected with avian influenza viruses should provide new therapeutic strategies...
May 30, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28483047/follicular-unit-extraction-for-hair-transplantation-an-update
#16
F Jiménez-Acosta, I Ponce-Rodríguez
Follicular unit extraction (FUE) is a hair transplantation technique that uses small punches (0.8-1 mm in diameter) to extract the follicular units (FUs). Though initially the technique was not widely accepted because of the difficulty of extracting intact follicular units with such small punches, it has since gained in popularity due mainly to rising patient demand, the availability of better instrumentation and greater surgical skill acquired from experience. It is now a recognised alternative to follicular unit transplantation (FUT), a technique based on harvesting the FUs from a strip of tissue...
July 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28440416/fuca1-is-induced-by-wild-type-p53-and-expressed-at-different-levels-in-thyroid-cancers-depending-on-p53-status
#17
Nobuo Tsuchida, Masa-Aki Ikeda, Υoshizumu Ιshino, Michele Grieco, Giancarlo Vecchio
Fucose residues of cell surface glycans, which play important roles in growth, invasion and metastasis, are added by fucosyltransferases (FUTs) and removed by α-L-fucosidases (FUCAs). By the differential display method, we isolated a 3' non-coding region of α-L-fucosidase-1 (FUCA1) (a gene coding for the lysosomal fucosidase-1 enzyme) as a wild-type p53-inducible gene: 18S and 20S FUCA1 mRNA species were induced in Saos-2 cells transfected with a temperature-sensitive p53 mutant at the permissive temperature...
June 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28437995/single-measurement-digital-optical-frequency-comb-based-phase-detection-brillouin-optical-time-domain-analyzer
#18
Chao Jin, Liang Wang, Yuli Chen, Nan Guo, Wenghong Chung, Hoyin Au, Zhaohui Li, Hwa-Yaw Tam, Chao Lu
A single-measurement sweep-free distributed Brillouin optical time domain analyzer (BOTDA) sensor based on phase detection is proposed and experimentally demonstrated employing digital optical frequency comb (DOFC) probe signal. Brillouin Phase Spectrum (BPS) of DOFC probe induced by Brillouin interaction is measured using coherent detection in a single acquisition, without any frequency scanning and data averaging. Single-measurement BOTDA sensor based on BPS in 10km long fiber is demonstrated with a response time of 100 μs, which is limited only by the fiber length...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28374503/tryptase-potentiates-enteric-nerve-activation-by-histamine-and-serotonin-relevance-for-the-effects-of-mucosal-biopsy-supernatants-from-irritable-bowel-syndrome-patients
#19
D Ostertag, A Annahazi, D Krueger, K Michel, I E Demir, G O Ceyhan, F Zeller, M Schemann
BACKGROUND: We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons. METHODS: Calcium-imaging was performed using the calcium-sensitive dye Fluo-4 AM in human submucous plexus preparations from 45 individuals...
September 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28321052/saline-infusion-test-highly-associated-with-the-incidence-of-cardio-and-cerebrovascular-events-in-primary-aldosteronism
#20
Reiko Hayashi, Daisuke Tamada, Masahiko Murata, Kosuke Mukai, Tetsuhiro Kitamura, Michio Otsuki, Iichiro Shimomura
Primary aldosteronism (PA) is caused by excess secretion of aldosterone and is an independent risk factor for cardio-cerebro-vascular (CCV) events. The goal of treatment of PA should include prevention of CCV events. A definitive diagnosis of PA is established by confirmatory tests [saline infusion test (SIT), furosemide upright test (FUT) and captopril challenge test (CCT)]. However, there is no information on whether the hormone levels measured by these confirmatory tests are associated with CCV events. The aim of this retrospective study was to elucidate the relationship between the results of the above confirmatory tests and prevalence of CCV disease in patients with PA...
March 18, 2017: Endocrine Journal
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