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D Ostertag, A Annahazi, D Krueger, K Michel, I E Demir, G O Ceyhan, F Zeller, M Schemann
BACKGROUND: We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons. METHODS: Calcium-imaging was performed using the calcium-sensitive dye Fluo-4 AM in human submucous plexus preparations from 45 individuals...
April 4, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Reiko Hayashi, Daisuke Tamada, Masahiko Murata, Kosuke Mukai, Tetsuhiro Kitamura, Michio Otsuki, Iichiro Shimomura
Primary aldosteronism (PA) is caused by excess secretion of aldosterone and is an independent risk factor for cardio-cerebro-vascular (CCV) events. The goal of treatment of PA should include prevention of CCV events. A definitive diagnosis of PA is established by confirmatory tests [saline infusion test (SIT), furosemide upright test (FUT) and captopril challenge test (CCT)]. However, there is no information on whether the hormone levels measured by these confirmatory tests are associated with CCV events. The aim of this retrospective study was to elucidate the relationship between the results of the above confirmatory tests and prevalence of CCV disease in patients with PA...
March 18, 2017: Endocrine Journal
Sing Wan Wong, Brian Chun Ho Cheung, Bruce Tak Keung Pang, Ateline Kwong, Anna Chung, Kenneth Ka Ho Lee, Arthur Fut Tak Mak
Deep tissue pressure ulcers, a serious clinical challenge originating in the muscle layer, are hardly detectable at the beginning. The challenge apparently occurs in aged subjects more frequently. As the ulcer propagates to the skin surface, it becomes very difficult to manage and can lead to fatal complications. Preventive measures are thus highly desirable. Although the complex pathological mechanisms have not been fully understood, prolonged and excessive physical challenges and oxidative stress are believed to be involved in the ulcer development...
April 11, 2017: Journal of Biomechanics
Louise E Arve, Ole Mathis Opstad Kruse, Karen K Tanino, Jorunn E Olsen, Cecilia Futsæther, Sissel Torre
Previous studies have shown that plants developed under high relative air humidity (RH>85%) develop malfunctioning stomata and therefor have increased transpiration and reduced desiccation tolerance when transferred to lower RH conditions and darkness. In this study, plants developed at high RH were exposed to daily VPD fluctuations created by changes in temperature and/or RH to evaluate the potential improvements in stomatal functioning. Daily periods with an 11°C temperature increase and consequently a VPD increase (vpd: 0...
April 2017: Journal of Plant Physiology
Stefan Mittermayr, Giao N Lê, Colin Clarke, Silvia Millán Martín, Anne-Marie Larkin, Peter O'Gorman, Jonathan Bones
The pathological progression from benign monoclonal gammopathy of undetermined significance (MGUS) to smoldering myeloma (SMM) and finally to active myeloma (MM) is poorly understood. Abnormal immunoglobulin G (IgG) glycosylation in myeloma has been reported. Using a glycomic platform composed of hydrophilic interaction UPLC, exoglycosidase digestions, weak anion-exchange chromatography, and mass spectrometry, polyclonal IgG N-glycosylation profiles from 35 patients [MGUS (n = 8), SMM (n = 5), MM (n = 8), complete-response (CR) post-treatment (n = 5), relapse (n = 4), healthy age-matched control (n = 5)] were characterized to map glycan structures in distinct disease phases of multiple myeloma...
December 12, 2016: Journal of Proteome Research
Reindert W Emmens, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Hans W M Niessen, Paul A J Krijnen
The complement system plays an important role in the inflammatory response subsequent to acute myocardial infarction (AMI). The aim of this study is to create a systematic overview of studies that have investigated therapeutic administration of complement inhibitors in both AMI animal models and human clinical trials. To enable extrapolation of observations from included animal studies toward post-AMI clinical trials, ex vivo studies on isolated hearts and proof-of-principle studies on inhibitor administration before experimental AMI induction were excluded...
October 14, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
Olga De Castro, Antonietta Di Maio, Mirko Di Febbraro, Gennaro Imparato, Michele Innangi, Errol Véla, Bruno Menale
The Mediterranean coastline is a dynamic and complex system which owes its complexity to its past and present vicissitudes, e.g. complex tectonic history, climatic fluctuations, and prolonged coexistence with human activities. A plant species that is widespread in this habitat is the sea daffodil, Pancratium maritimum (Amaryllidaceae), which is a perennial clonal geophyte of the coastal sands of the Mediterranean and neighbouring areas, well adapted to the stressful conditions of sand dune environments. In this study, an integrated approach was used, combining genetic and environmental data with a niche modelling approach, aimed to investigate: (1) the effect of climate change on the geographic range of this species at different times {past (last inter-glacial, LIG; and last glacial maximum, LGM), present (CURR), near-future (FUT)} and (2) the possible influence of environmental variables on the genetic structure of this species in the current period...
2016: PloS One
Ayako Moriya, Masaaki Yamamoto, Shunsuke Kobayashi, Tomoko Nagamine, Naomi Takeichi-Hattori, Mototsugu Nagao, Taro Harada, Kyoko Tanimura-Inagaki, Shiro Onozawa, Satoru Murata, Hideki Tamura, Izumi Fukuda, Shinichi Oikawa, Hitoshi Sugihara
The diagnostic steps for primary aldosteronism (PA) include case screening tests, confirmatory tests, and localization. The aim of this study was to identify useful confirmatory tests and their cut-off values for differentiating the subtype of primary aldosteronism, especially in unilateral PA, such as aldosterone-producing adenoma, and bilateral PA, such as idiopathic hyperaldosteronism. Seventy-six patients who underwent all four confirmatory tests, the captopril-challenge test (CCT), furosemide upright test (FUT), saline infusion test (SIT), and ACTH stimulation test (AST), and who were confirmed to have an aldosterone excess by adrenal venous sampling (AVS) were recruited...
January 30, 2017: Endocrine Journal
Lei Cheng, Shuhang Gao, Xiaobo Song, Weijie Dong, Huimin Zhou, Lifen Zhao, Li Jia
Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating fucosylation. Mass spectrometry (MS) analysis showed pronounced differences of the N-glycosylation patterns and fucosylated N-glycans between the adjacent and tumor tissues...
September 20, 2016: Oncotarget
Nana Li, Yuejian Liu, Yuan Miao, Lifen Zhao, Huimin Zhou, Li Jia
It is demonstrated that the maladjustment of microRNA (miRNA) plays significant roles in the occurrence and development of tumors. MicroRNA-106b-5p (miR-106b), a carcinogenic miRNA, is identified as a dysregulated miRNA in human breast cancer. In this article, the expression levels of miR-106b were discovered to be particularly higher in breast cancer tissues than that in the corresponding adjacent tissues. Accordingly, miR-106b was higher expressed in the breast cancer cell lines compared with that in the normal breast cell lines...
September 2016: IUBMB Life
P Roman, G Budziński, A Suszka-Świtek, A Caban, G Oczkowicz, R Wiaderkiewicz, F Ryszka, Z Smorąg, L Cierpka
BACKGROUND: Transgenic animals may serve as organ donors in human organ transplantation. However, the number of the studies addressing all doubts related to this issue is currently insufficient for the clinical application of this approach. The aim of this study was to analyze the hepatic tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) synthesis during a 24-hour cold preservation of the transgenic pig liver, depending on the type of transgenesis. MATERIALS AND METHODS: The study was carried out on wild-type and transgenic pig livers with transferred human α1,2-fucosyltransferase (FUT) and/or α-galactosidase (GAL) gene (four groups; n = 6)...
June 2016: Transplantation Proceedings
Roberto Cejuela, Miguel García-Jaén, Juan M Cortell-Tormo, Sergio Sellés-Pérez, Iván Chulvi-Medrano, Juan Tortosa-Martínez, Tamara Rial
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Miguel García-Jaén, Juan M Cortell-Tormo, Sergio Sellés-Pérez, Iván Chulvi-Medrano, Roberto Cejuela, Juan Tortosa-Martínez, Tamara Rial
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Bruce Curtis
The modest literature on the history of Canadian Sociology takes the appearance of a named academic discipline as its object. Canadian Sociology is held to have had some precursors in the 1880s, but really to appear only in the 1920s. It is described as a foreign import and as an activity first of intellectual speculation and moral reform. Observational and analytic practice are absent before 1880. The activities of state agents and government departments in the social field are not discussed. This article offers a richer account through an examination of the larger field from which Sociology was extracted, "the social science," which was practiced actively in colonial Canada from the early nineteenth century...
May 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
Andreas Wannhoff, Trine Folseraas, Maik Brune, Christian Rupp, Kilian Friedrich, Johannes Knierim, Karl Heinz Weiss, Peter Sauer, Christa Flechtenmacher, Peter Schirmacher, Wolfgang Stremmel, Johannes R Hov, Daniel N Gotthardt
BACKGROUND: Primary sclerosing cholangitis (PSC) patients are at increased risk of biliary tract cancer, and carcinoembryonic antigen (CEA) serum levels might be used for screening. OBJECTIVE: To examine cancer screening with CEA in PSC patients and analyse how serum CEA levels are affected by genetic variants of fucosyltransferase (FUT) 2 and 3. METHODS: In a retrospective cohort analysis we evaluated CEA levels in 226 PSC patients, including 19 with biliary malignancy, and investigated how FUT2 and FUT3 SNPs affected CEA levels...
February 2016: United European Gastroenterology Journal
M Kherbouche, D Bendaoud, R Bali, F Mouassaoui, A Meziane Tani
OBJECTIFS: Nous exposons un recueil de 2 cas cliniques montrant les différences de thérapeutiques entre un syndrome d'apnée du sommeil avec Hypertension artérielle systémique seule versus un autre cas de syndrome d'apnée du sommeil avec à la fois une hypertension artérielle systémique et une hypertension pulmonaire. le suivi tant clinique qu'écho-cardiographique du syndrome d'apnée du sommeil bien que parait simple, cache de multiples pièges qu'il faut savoir les rechercher d'une façon méthodique...
December 2015: Annales de Cardiologie et D'angéiologie
F Saada, S Talbi, F Atrouz, S Ouanoughi
OBJECTIFS: Le lien entre hypertension artérielle (HTA) et maladie rénale en général, fût établit par Richard Bright en 1837. L'hypertension artérielle est particulièrement fréquente dans les néphropathies glomérulaires primitives et cette fréquence dépend d'une part de la nature histologique de la lésion et d'autre part du débit de la filtration glomérulaire. l'objectif principal de notre étude est de déterminer la fréquence de l'hypertension artérielle chez des patients présentant des néphropathies glomérulaires primitives et d'en préciser le mécanisme physiopathologique selon les différentes lésions anatomopathologiques...
December 2015: Annales de Cardiologie et D'angéiologie
D Batouche, M A Djazouli, L Sadaoui, W Berrached, N Benatta
OBJECTIFS: La cardiomyopathie idiopathique du péripartum (CIPP) est une affection rare de cause inconnue, dont l'évolution est grevée par de nombreuses complications hémodynamiques, thrombo - emboliques et rythmiques. L'objectif de ce travail rétrospectif est de décrire les aspects cliniques, paracliniques, évolutifs. MéTHODES: Nous avons mené une étude dans le Service de Gynécologie du CHU d'Oran, portant sur 12 patientes atteintes de CIPP, de septembre 2010 à septembre 2014...
December 2015: Annales de Cardiologie et D'angéiologie
Parul Thakur, S Sacchidanand, H V Nataraj, A S Savitha
BACKGROUND: Repigmentation of vitiligo is closely related to hair follicles. Hence, replenishing melanocytes in vitiliginous patches utilizing undifferentiated stem cells of the hair follicles using follicular unit transplantation (FUT) is a possible treatment option. OBJECTIVES OF THE STUDY: To study the efficacy of FUT in cases of segmental/stabilized vitiligo as a treatment option for leukotrichia. MATERIALS AND METHODS: Fifty patients with 63 lesions of stable vitiligo over nonglabrous areas were treated with follicular unit grafts...
October 2015: Journal of Cutaneous and Aesthetic Surgery
Dingyuan Hu, Daguan Zhang, Shuzi Zheng, Maodong Guo, Xinxin Lin, Yi Jiang
OBJECTIVES: Dysbiosis of intestinal microbiota has been implicated in ulcerative colitis (UC). Fucosyltransferase (FUT) 2 and FUT3 determine expression of histo-blood group antigens in the gut and may affect the intestinal microbiota. We investigated the association between FUT2 and FUT3 polymorphisms and UC in Chinese patients. METHODS: We genotyped FUT2 (rs281377, rs1047781 and rs601338) and FUT3 (rs28362459, rs3745635 and rs3894326) in 485 UC patients and 580 healthy controls using SNaPshot...
2016: PloS One
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