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https://www.readbyqxmd.com/read/27810412/on-the-value-of-therapeutic-interventions-targeting-the-complement-system-in-acute-myocardial-infarction
#1
REVIEW
Reindert W Emmens, Diana Wouters, Sacha Zeerleder, S Marieke van Ham, Hans W M Niessen, Paul A J Krijnen
The complement system plays an important role in the inflammatory response subsequent to acute myocardial infarction (AMI). The aim of this study is to create a systematic overview of studies that have investigated therapeutic administration of complement inhibitors in both AMI animal models and human clinical trials. To enable extrapolation of observations from included animal studies toward post-AMI clinical trials, ex vivo studies on isolated hearts and proof-of-principle studies on inhibitor administration before experimental AMI induction were excluded...
October 14, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27749920/a-multi-faceted-approach-to-analyse-the-effects-of-environmental-variables-on-geographic-range-and-genetic-structure-of-a-perennial-psammophilous-geophyte-the-case-of-the-sea-daffodil-pancratium-maritimum-l-in-the-mediterranean-basin
#2
Olga De Castro, Antonietta Di Maio, Mirko Di Febbraro, Gennaro Imparato, Michele Innangi, Errol Véla, Bruno Menale
The Mediterranean coastline is a dynamic and complex system which owes its complexity to its past and present vicissitudes, e.g. complex tectonic history, climatic fluctuations, and prolonged coexistence with human activities. A plant species that is widespread in this habitat is the sea daffodil, Pancratium maritimum (Amaryllidaceae), which is a perennial clonal geophyte of the coastal sands of the Mediterranean and neighbouring areas, well adapted to the stressful conditions of sand dune environments. In this study, an integrated approach was used, combining genetic and environmental data with a niche modelling approach, aimed to investigate: (1) the effect of climate change on the geographic range of this species at different times {past (last inter-glacial, LIG; and last glacial maximum, LGM), present (CURR), near-future (FUT)} and (2) the possible influence of environmental variables on the genetic structure of this species in the current period...
2016: PloS One
https://www.readbyqxmd.com/read/27725373/acth-stimulation-test-and-computed-tomography-are-useful-for-differentiating-the-subtype-of-primary-aldosteronism
#3
Ayako Moriya, Masaaki Yamamoto, Shunsuke Kobayashi, Tomoko Nagamine, Naomi Takeichi-Hattori, Mototsugu Nagao, Taro Harada, Kyoko Tanimura-Inagaki, Shiro Onozawa, Satoru Murata, Hideki Tamura, Izumi Fukuda, Shinichi Oikawa, Hitoshi Sugihara
The diagnostic steps for primary aldosteronism (PA) include case screening tests, confirmatory tests, and localization. The aim of this study was to identify useful confirmatory tests and their cut-off values for differentiating the subtype of primary aldosteronism, especially in unilateral PA, such as aldosterone-producing adenoma, and bilateral PA, such as idiopathic hyperaldosteronism. Seventy-six patients who underwent all four confirmatory tests, the captopril-challenge test (CCT), furosemide upright test (FUT), saline infusion test (SIT), and ACTH stimulation test (AST), and who were confirmed to have an aldosterone excess by adrenal venous sampling (AVS) were recruited...
October 1, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27533464/comprehensive-n-glycan-profiles-of-hepatocellular-carcinoma-reveal-association-of-fucosylation-with-tumor-progression-and-regulation-of-fut8-by-micrornas
#4
Lei Cheng, Shuhang Gao, Xiaobo Song, Weijie Dong, Huimin Zhou, Lifen Zhao, Li Jia
Glycosylation has significant effects on cancer progression. Fucosylation is one of the most important glycosylation events involved in hepatocellular carcinoma (HCC). Here, we compared N-glycan profiles of liver tumor tissues and adjacent tissues of 27 HCC patients to reveal the association between fucosylation and HCC progression, as well as verified the potential role of miRNA in regulating fucosylation. Mass spectrometry (MS) analysis showed pronounced differences of the N-glycosylation patterns and fucosylated N-glycans between the adjacent and tumor tissues...
August 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27519168/microrna-106b-targets-fut6-to-promote-cell-migration-invasion-and-proliferation-in-human-breast-cancer
#5
Nana Li, Yuejian Liu, Yuan Miao, Lifen Zhao, Huimin Zhou, Li Jia
It is demonstrated that the maladjustment of microRNA (miRNA) plays significant roles in the occurrence and development of tumors. MicroRNA-106b-5p (miR-106b), a carcinogenic miRNA, is identified as a dysregulated miRNA in human breast cancer. In this article, the expression levels of miR-106b were discovered to be particularly higher in breast cancer tissues than that in the corresponding adjacent tissues. Accordingly, miR-106b was higher expressed in the breast cancer cell lines compared with that in the normal breast cell lines...
September 2016: IUBMB Life
https://www.readbyqxmd.com/read/27496504/concentration-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-in-isolated-porcine-liver-depending-on-type-of-transgenesis
#6
P Roman, G Budziński, A Suszka-Świtek, A Caban, G Oczkowicz, R Wiaderkiewicz, F Ryszka, Z Smorąg, L Cierpka
BACKGROUND: Transgenic animals may serve as organ donors in human organ transplantation. However, the number of the studies addressing all doubts related to this issue is currently insufficient for the clinical application of this approach. The aim of this study was to analyze the hepatic tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) synthesis during a 24-hour cold preservation of the transgenic pig liver, depending on the type of transgenesis. MATERIALS AND METHODS: The study was carried out on wild-type and transgenic pig livers with transferred human α1,2-fucosyltransferase (FUT) and/or α-galactosidase (GAL) gene (four groups; n = 6)...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27362113/acute-physiological-responses-of-performance-of-choy-lee-fut-forms-in-amateur-practitioners-3747-board-186-june-4-9-30-am-11-00-am
#7
Roberto Cejuela, Miguel García-Jaén, Juan M Cortell-Tormo, Sergio Sellés-Pérez, Iván Chulvi-Medrano, Juan Tortosa-Martínez, Tamara Rial
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27362112/comparative-acute-responses-of-choy-lee-fut-air-and-heavy-bag-forms-in-amateur-practitioners-3746-board-185-june-4-9-30-am-11-00-am
#8
Miguel García-Jaén, Juan M Cortell-Tormo, Sergio Sellés-Pérez, Iván Chulvi-Medrano, Roberto Cejuela, Juan Tortosa-Martínez, Tamara Rial
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27183965/the-missing-memory-of-canadian-sociology-reflexive-government-and-the-social-science
#9
Bruce Curtis
The modest literature on the history of Canadian Sociology takes the appearance of a named academic discipline as its object. Canadian Sociology is held to have had some precursors in the 1880s, but really to appear only in the 1920s. It is described as a foreign import and as an activity first of intellectual speculation and moral reform. Observational and analytic practice are absent before 1880. The activities of state agents and government departments in the social field are not discussed. This article offers a richer account through an examination of the larger field from which Sociology was extracted, "the social science," which was practiced actively in colonial Canada from the early nineteenth century...
May 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/26966527/a-common-genetic-variant-of-fucosyltransferase-2-correlates-with-serum-carcinoembryonic-antigen-levels-and-affects-cancer-screening-in-patients-with-primary-sclerosing-cholangitis
#10
Andreas Wannhoff, Trine Folseraas, Maik Brune, Christian Rupp, Kilian Friedrich, Johannes Knierim, Karl Heinz Weiss, Peter Sauer, Christa Flechtenmacher, Peter Schirmacher, Wolfgang Stremmel, Johannes R Hov, Daniel N Gotthardt
BACKGROUND: Primary sclerosing cholangitis (PSC) patients are at increased risk of biliary tract cancer, and carcinoembryonic antigen (CEA) serum levels might be used for screening. OBJECTIVE: To examine cancer screening with CEA in PSC patients and analyse how serum CEA levels are affected by genetic variants of fucosyltransferase (FUT) 2 and 3. METHODS: In a retrospective cohort analysis we evaluated CEA levels in 226 PSC patients, including 19 with biliary malignancy, and investigated how FUT2 and FUT3 SNPs affected CEA levels...
February 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26877534/p-225-the-sleep-apnea-syndrome-from-the-high-blood-pressure-to-the-high-pulmonary-pressure
#11
M Kherbouche, D Bendaoud, R Bali, F Mouassaoui, A Meziane Tani
OBJECTIFS: Nous exposons un recueil de 2 cas cliniques montrant les différences de thérapeutiques entre un syndrome d'apnée du sommeil avec Hypertension artérielle systémique seule versus un autre cas de syndrome d'apnée du sommeil avec à la fois une hypertension artérielle systémique et une hypertension pulmonaire. le suivi tant clinique qu'écho-cardiographique du syndrome d'apnée du sommeil bien que parait simple, cache de multiples pièges qu'il faut savoir les rechercher d'une façon méthodique...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877497/p-188-blood-pressure-control-in-primary-glomerulonephritis-about-153-cases
#12
F Saada, S Talbi, F Atrouz, S Ouanoughi
OBJECTIFS: Le lien entre hypertension artérielle (HTA) et maladie rénale en général, fût établit par Richard Bright en 1837. L'hypertension artérielle est particulièrement fréquente dans les néphropathies glomérulaires primitives et cette fréquence dépend d'une part de la nature histologique de la lésion et d'autre part du débit de la filtration glomérulaire. l'objectif principal de notre étude est de déterminer la fréquence de l'hypertension artérielle chez des patients présentant des néphropathies glomérulaires primitives et d'en préciser le mécanisme physiopathologique selon les différentes lésions anatomopathologiques...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26877362/p-062-peripartum-cardiomyopathy-diagnosis-and-outcome-aspects
#13
D Batouche, M A Djazouli, L Sadaoui, W Berrached, N Benatta
OBJECTIFS: La cardiomyopathie idiopathique du péripartum (CIPP) est une affection rare de cause inconnue, dont l'évolution est grevée par de nombreuses complications hémodynamiques, thrombo - emboliques et rythmiques. L'objectif de ce travail rétrospectif est de décrire les aspects cliniques, paracliniques, évolutifs. MéTHODES: Nous avons mené une étude dans le Service de Gynécologie du CHU d'Oran, portant sur 12 patientes atteintes de CIPP, de septembre 2010 à septembre 2014...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26865785/a-study-of-hair-follicular-transplantation-as-a-treatment-option-for-vitiligo
#14
Parul Thakur, S Sacchidanand, H V Nataraj, A S Savitha
BACKGROUND: Repigmentation of vitiligo is closely related to hair follicles. Hence, replenishing melanocytes in vitiliginous patches utilizing undifferentiated stem cells of the hair follicles using follicular unit transplantation (FUT) is a possible treatment option. OBJECTIVES OF THE STUDY: To study the efficacy of FUT in cases of segmental/stabilized vitiligo as a treatment option for leukotrichia. MATERIALS AND METHODS: Fifty patients with 63 lesions of stable vitiligo over nonglabrous areas were treated with follicular unit grafts...
October 2015: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/26766790/association-of-ulcerative-colitis-with-fut2-and-fut3-polymorphisms-in-patients-from-southeast-china
#15
Dingyuan Hu, Daguan Zhang, Shuzi Zheng, Maodong Guo, Xinxin Lin, Yi Jiang
OBJECTIVES: Dysbiosis of intestinal microbiota has been implicated in ulcerative colitis (UC). Fucosyltransferase (FUT) 2 and FUT3 determine expression of histo-blood group antigens in the gut and may affect the intestinal microbiota. We investigated the association between FUT2 and FUT3 polymorphisms and UC in Chinese patients. METHODS: We genotyped FUT2 (rs281377, rs1047781 and rs601338) and FUT3 (rs28362459, rs3745635 and rs3894326) in 485 UC patients and 580 healthy controls using SNaPshot...
2016: PloS One
https://www.readbyqxmd.com/read/26538210/comparisons-of-caenorhabditis-fucosyltransferase-mutants-reveal-a-multiplicity-of-isomeric-n-glycan-structures
#16
COMPARATIVE STUDY
Shi Yan, Chunsheng Jin, Iain B H Wilson, Katharina Paschinger
Recent studies have shown a remarkable degree of plasticity in the N-glycome of the model nematode Caenorhabditis elegans; ablation of glycosylation-relevant genes can result in radically altered N-glycan profiles despite only minor biological phenotypic effects. Up to four fucose residues and five different linkages of fucose are known on the N-glycans of C. elegans. Due to the complexity in the wild type, we established three mutant strains defective in two core fucosyltransferases each (fut-1;fut-6, fut-1;fut-8, and fut-6;fut-8)...
December 4, 2015: Journal of Proteome Research
https://www.readbyqxmd.com/read/26370653/advances-in-hair-transplantation-longitudinal-partial-follicular-unit-transplantation
#17
REVIEW
Coen G Gho, H A Martino Neumann
There are different techniques of hair transplantation. The most common and known hair transplantation methods are the 'strip' method, where a strip of skin containing hair follicles is removed, cut into grafts and implanted in the recipient area, and the follicle unit extraction (FUE) method, in which whole follicle units are extracted one by one and implanted one by one back into the recipient area. The FUE method is more patient friendly and leaves only tiny scars compared to the strip method, which leaves visible linear scars at the donor area...
2015: Current Problems in Dermatology
https://www.readbyqxmd.com/read/26057124/disruption-of-the-c-elegans-intestinal-brush-border-by-the-fungal-lectin-ccl2-phenocopies-dietary-lectin-toxicity-in-mammals
#18
Katrin Stutz, Andres Kaech, Markus Aebi, Markus Künzler, Michael O Hengartner
Lectins are non-immunoglobulin carbohydrate-binding proteins without enzymatic activity towards the bound carbohydrates. Many lectins of e.g. plants or fungi have been suggested to act as toxins to defend the host against predators and parasites. We have previously shown that the Coprinopsis cinerea lectin 2 (CCL2), which binds to α1,3-fucosylated N-glycan cores, is toxic to Caenorhabditis elegans and results in developmental delay and premature death. In this study, we investigated the underlying toxicity phenotype at the cellular level by electron and confocal microscopy...
2015: PloS One
https://www.readbyqxmd.com/read/26002521/bisecting-galactose-as-a-feature-of-n-glycans-of-wild-type-and-mutant-caenorhabditis-elegans
#19
Shi Yan, Lothar Brecker, Chunsheng Jin, Alexander Titz, Martin Dragosits, Niclas G Karlsson, Verena Jantsch, Iain B H Wilson, Katharina Paschinger
The N-glycosylation of the model nematode Caenorhabditis elegans has proven to be highly variable and rather complex; it is an example to contradict the existing impression that "simple" organisms possess also a rather simple glycomic capacity. In previous studies in a number of laboratories, N-glycans with up to four fucose residues have been detected. However, although the linkage of three fucose residues to the N,N'-diacetylchitobiosyl core has been proven by structural and enzymatic analyses, the nature of the fourth fucose has remained uncertain...
August 2015: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/25934648/inflammatory-cytokines-regulate-the-expression-of-glycosyltransferases-involved-in-the-biosynthesis-of-tumor-associated-sialylated-glycans-in-pancreatic-cancer-cell-lines
#20
Sònia Bassagañas, Helena Allende, Lara Cobler, M Rosa Ortiz, Esther Llop, Carme de Bolós, Rosa Peracaula
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant stroma containing several pro-inflammatory cytokines, which are described to modulate the expression of important genes related to tumor promotion and progression. In the present work we have investigated the potential role of these cytokines in the biosynthesis of tumor-associated carbohydrate antigens such as sialyl-Lewis(x) (SLe(x)) through the regulation of specific glycosyltransferase genes. METHODS: Two human PDAC cell lines MDAPanc-3 and MDAPanc-28 were treated with pro-inflammatory cytokines IL-1β, TNFα, IL-6 or IL-8, and the content of tumor-associated carbohydrate antigens at the cell membrane was analyzed by flow cytometry...
September 2015: Cytokine
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