keyword
https://read.qxmd.com/read/37686317/macrophage-myofibroblast-transition-contributes-to-myofibroblast-formation-in-proliferative-vitreoretinal-disorders
#21
JOURNAL ARTICLE
Ahmed M Abu El-Asrar, Gert De Hertogh, Eef Allegaert, Mohd I Nawaz, Sara Abouelasrar Salama, Priscilla W Gikandi, Ghislain Opdenakker, Sofie Struyf
Inflammation and fibrosis are key features of proliferative vitreoretinal disorders. We aimed to define the macrophage phenotype and investigate the role of macrophage-myofibroblast transition (MMT) in the contribution to myofibroblast populations present in epiretinal membranes. Vitreous samples from proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR) and nondiabetic control patients, epiretinal fibrovascular membranes from PDR patients and fibrocellular membranes from PVR patients, human retinal Müller glial cells and human retinal microvascular endothelial cells (HRMECs) were studied by ELISA, immunohistochemistry and flow cytometry analysis...
August 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37653617/retinal-microenvironment-protected-rhein-gffye-nanofibers-attenuate-retinal-ischemia-reperfusion-injury-via-inhibiting-oxidative-stress-and-regulating-microglial-macrophage-m1-m2-polarization
#22
JOURNAL ARTICLE
Zhuhong Zhang, Shengjun Peng, Tengyan Xu, Jia Liu, Laien Zhao, Hui Xu, Wen Zhang, Yuanying Zhu, Zhimou Yang
Retinal ischemia is involved in the occurrence and development of various eye diseases, including glaucoma, diabetic retinopathy, and central retinal artery occlusion. To the best of our knowledge, few studies have reported self-assembling peptide natural products for the suppression of ocular inflammation and oxidative stress. Herein, a self-assembling peptide GFFYE is designed and synthesized, which can transform the non-hydrophilicity of rhein into an amphiphilic sustained-release therapeutic agent, and rhein-based therapeutic nanofibers (abbreviated as Rh-GFFYE) are constructed for the treatment of retinal ischemia-reperfusion (RIR) injury...
August 31, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37577690/retinoid-x-receptor-activation-prevents-diabetic-retinopathy-in-murine-models
#23
Iuliia Dorofeeva, Assylbek Zhylkibayev, Irina V Saltykova, Venkatram Atigadda, Bibek Adhikari, Oleg Gorbatyuk, Maria B Grant, Marina Gorbatyuk
Previously, the RXR agonist UAB126 demonstrated therapeutic potential to treat obese mice by controlling blood glucose levels (BGL) and altering the expression of genes associated with lipid metabolism and inflammatory response. The purpose of the study was to assess UAB126 effect in progression of diabetic retinopathy (DR) in rodent models of Type1 diabetes (T1D), streptozotocin-induced, and Type2 diabetes (T2D), the db/db mice. UAB126 treatment was delivered either by oral gavage for 6 weeks or by topical application of eye drops for 2 weeks...
August 4, 2023: bioRxiv
https://read.qxmd.com/read/37488883/the-roles-of-macrophage-migration-inhibitory-factor-in-retinal-diseases
#24
REVIEW
Hongbing Zhang, Xianjiao Zhang, Hongsong Li, Bing Wang, Pei Chen, Jiamin Meng
Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity. There are some evidences that MIF is involved in many vitreoretinal diseases. For example, MIF can exacerbate many types of uveitis; measurements of MIF levels can be used to monitor the effectiveness of uveitis treatment. MIF also alleviates trauma-induced and glaucoma-induced optic nerve damage. Furthermore, MIF is critical for retinal/choroidal neovascularization, especially complex neovascularization...
February 2024: Neural Regeneration Research
https://read.qxmd.com/read/37392853/redd1-dependent-gsk3%C3%AE-dephosphorylation-promotes-nf-%C3%AE%C2%BAb-activation-and-macrophage-infiltration-in-the-retina-of-diabetic-mice
#25
JOURNAL ARTICLE
Siddharth Sunilkumar, Ashley M VanCleave, Christopher M McCurry, Allyson L Toro, Shaunaci A Stevens, Scot R Kimball, Michael D Dennis
Increasing evidence supports a role for inflammation in the early development and progression of retinal complications caused by diabetes. We recently demonstrated that the stress response protein regulated in development and DNA damage response 1 (REDD1) promotes diabetes-induced retinal inflammation by sustaining canonical activation of nuclear transcription factor κB (NF-κB). The studies here were designed to identify signaling events whereby REDD1 promotes NF-κB activation in the retina of diabetic mice...
June 29, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37371942/mammalian-animal-and-human-retinal-organ-culture-as-pre-clinical-model-to-evaluate-oxidative-stress-and-antioxidant-intraocular-therapeutics
#26
JOURNAL ARTICLE
Martina Kropp, Mohit Mohit, Cristina Ioana Leroy-Ciocanea, Laura Schwerm, Nina Harmening, Thais Bascuas, Eline De Clerck, Andreas J Kreis, Bojan Pajic, Sandra Johnen, Gabriele Thumann
Oxidative stress (OS) is involved in the pathogenesis of retinal neurodegenerative diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) and an important target of therapeutic treatments. New therapeutics are tested in vivo despite limits in terms of transferability and ethical concerns. Retina cultures using human tissue can deliver critical information and significantly reduce the number of animal experiments along with increased transferability. We cultured up to 32 retina samples derived from one eye, analyzed the model's quality, induced OS, and tested the efficiency of antioxidative therapeutics...
June 3, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37343496/astaxanthin-inhibits-oxidative-stress-and-apoptosis-in-diabetic-retinopathy
#27
JOURNAL ARTICLE
Jian Fang, Wuxia Bai, Lina Yang
BACKGROUND: The pathophysiology of diabetic retinopathy (DR) is thought to be influenced by oxidative stress. Astaxanthin (ASX) is a natural product with antioxidant effect, but it is not clear whether its mechanism of inhibiting the development of DR is related to anti-oxidation. METHODS: Rats were intraperitoneally injected with streptozotocin (60 mg/kg) to create DR rat models followed by ASX (20 mg/kg) for 45 days. Retinal tissue was examined by Hematoxylin and Eosin staining...
June 19, 2023: Acta Histochemica
https://read.qxmd.com/read/37335016/integrating-human-ipsc-derived-macrophage-progenitors-into-retinal-organoids-to-generate-a-mature-retinal-microglial-niche
#28
JOURNAL ARTICLE
Ayumi Usui-Ouchi, Sarah Giles, Sarah Harkins-Perry, Elizabeth A Mills, Roberto Bonelli, Guoqin Wei, Yasuo Ouchi, Nobuyuki Ebihara, Shintaro Nakao, Martin Friedlander, Kevin T Eade
In the retina, microglia are resident immune cells that are essential for development and function. Retinal microglia play a central role in mediating pathological degeneration in diseases such as glaucoma, retinitis pigmentosa, age-related neurodegeneration, ischemic retinopathy, and diabetic retinopathy. Current models of mature human retinal organoids (ROs) derived from iPS cell (hiPSC) do not contain resident microglia integrated into retinal layers. Increasing cellular diversity in ROs by including resident microglia would more accurately represent the native retina and better model diseases in which microglia play a key role...
June 19, 2023: Glia
https://read.qxmd.com/read/37326707/bioinformatics-tools-for-bulk-gene-expression-deconvolution-in-diabetic-retinopathy
#29
JOURNAL ARTICLE
Ru Qi Teh, Guei-Sheung Liu, Jiang-Hui Wang
Retinal neovascularization is one of the leading causes of vision loss and a hallmark of proliferative diabetic retinopathy (PDR). The immune system is observed to be involved in the pathogenesis of diabetic retinopathy (DR). The specific immune cell type that contributes to retinal neovascularization can be identified via a bioinformatics analysis of RNA sequencing (RNA-seq) data, known as deconvolution analysis. Previous study has identified the infiltration of macrophages in the retina of rats with hypoxia-induced retinal neovascularization and patients with PDR through a deconvolution algorithm, known as CIBERSORTx...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/37208562/intravenous-injection-of-cyclosporin-a-loaded-lipid-nanocapsules-fights-inflammation-and-immune-system-activation-in-a-mouse-model-of-diabetic-retinopathy
#30
JOURNAL ARTICLE
Marilena Bohley, Andrea E Dillinger, Barbara M Braunger, Ernst R Tamm, Achim Goepferich
Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE's pivotal role, there is no therapeutic tool to specifically interfere with the RPE-related pathomechanism. A therapy that addresses RPE cells and counteracts inflammation and immune response would be of paramount value for the early treatment of DR, where currently are no specific therapies available...
May 19, 2023: Drug Delivery and Translational Research
https://read.qxmd.com/read/37191152/cd44-drives-m1-macrophage-polarization-in-diabetic-retinopathy
#31
JOURNAL ARTICLE
Zhujuan Pan, Yaoxin Zhao, Shaobo Zhou, Jing Wang, FeiHong Fan
PURPOSE: Diabetic retinopathy is a typical complication of diabetes, which can facilitate the risk of blindness in severe cases. We sought to determine the function of CD44 in inflammatory responses of human retinal microvascular endothelial cells (HRMECs) and macrophage polarization during diabetic retinopathy (DR). METHODS: The hub genes were tested based on two datasets from the Gene Expression Omnibus database. Gene Ontology and pathway enrichment analysis was conducted on the base of differentially expressed genes (DEGs)...
May 16, 2023: Current Eye Research
https://read.qxmd.com/read/37182831/emerging-roles-of-air-pollution-and-meteorological-factors-in-autoimmune-eye-diseases
#32
REVIEW
Fan Cao, Zhuo-Ran Liu, Qin-Yu Ni, Chen-Kai Zha, Shu-Jie Zhang, Jia-Min Lu, Yue-Yang Xu, Li-Ming Tao, Zheng-Xuan Jiang, Hai-Feng Pan
Autoimmune eye diseases (AEDs), a collection of autoimmune inflammatory ocular conditions resulting from the dysregulation of immune system at the ocular level, can target both intraocular and periorbital structures leading to severe visual deficit and blindness globally. The roles of air pollution and meteorological factors in the initiation and progression of AEDs have been increasingly attractive, among which the systemic and local mechanisms are both involved in. Exposure to excessive air pollution and extreme meteorological conditions including PM2...
August 15, 2023: Environmental Research
https://read.qxmd.com/read/37002291/elevated-number-and-density-of-macrophage-like-cell-as-a-novel-inflammation-biomarker-in-diabetic-macular-edema
#33
JOURNAL ARTICLE
Zongyi Wang, Haiyan An, Jiyang Tang, Enzhong Jin, Siying Li, Linqi Zhang, Lvzhen Huang, Jinfeng Qu
To quantitatively analyze the number and density of macrophage-like cells (MLCs) at the vitreoretinal interface at macular region in diabetic retinopathy (DR) with and without diabetic macular edema (DME). This cross-sectional study involved 240 eyes of 146 treatment-naïve DR patients, including 151 eyes with DME. The number and density of MLCs were analyzed quantitatively using optical coherence tomography angiography (OCTA) and were compared between DME and non-DME eyes as well as proliferative DR (PDR) and non-PDR (NPDR) eyes...
March 31, 2023: Scientific Reports
https://read.qxmd.com/read/36965774/glial-neuronal-vascular-rpe-and-inflammatory-cell-damage-in-a-new-western-diet-induced-primate-model-of-diabetic-retinopathy
#34
JOURNAL ARTICLE
Tailoi Chan-Ling, Ping Hu, Sergio Li Calzi, Jeff Warner, Nasir Uddin, Mariana DuPont, Martha Neuringer, Paul Kievit, Lauren Renner, Jonathan Stoddard, Renee Ryals, Michael E Boulton, Trevor McGill, Maria B Grant
This study investigated retinal changes in a Western diet (WD)-induced non-human primate (NHP) model of Type 2 diabetes (T2D). Rhesus NHP aged 15-17 years old were fed a high fat diet (n=7) for more than 5 years with the aim of reflecting the traditional WD. Age-matched controls (n=6) were fed a standard laboratory primate diet. Retinal fundus, OCT, autofluorescence imaging and fluorescein angiography were undertaken prior to euthanasia. To assess diabetic retinopathy, eyes were examined using trypsin digests, lipofuscin autofluorescence and multi-marker immunofluorescence on cross sections and wholemounts...
March 23, 2023: American Journal of Pathology
https://read.qxmd.com/read/36834633/ubiquitin-specific-proteases-usps-and-metabolic-disorders
#35
REVIEW
Hiroshi Kitamura
Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family. To date, accumulating evidence indicates that several USPs positively and negatively affect metabolic diseases. USP22 in pancreatic β-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyperglycemia...
February 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36768656/finerenone-a-non-steroidal-mineralocorticoid-receptor-antagonist-reduces-vascular-injury-and-increases-regulatory-t-cells-studies-in-rodents-with-diabetic-and-neovascular-retinopathy
#36
JOURNAL ARTICLE
Jack R Jerome, Devy Deliyanti, Varaporn Suphapimol, Peter Kolkhof, Jennifer L Wilkinson-Berka
Vision loss in diabetic retinopathy features damage to the blood-retinal barrier and neovascularization, with hypertension and the renin-angiotensin system (RAS) having causal roles. We evaluated if finerenone, a non-steroidal mineralocorticoid receptor (MR) antagonist, reduced vascular pathology and inflammation in diabetic and neovascular retinopathy. Diabetic and hypertensive transgenic (mRen-2)27 rats overexpressing the RAS received the MR antagonist finerenone (10 mg/kg/day, oral gavage) or the angiotensin-converting enzyme inhibitor perindopril (10 mg/kg/day, drinking water) for 12 weeks...
January 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36726090/proliferative-diabetic-retinopathy-and-diabetic-macular-edema-are-two-factors-that-increase-macrophage-like-cell-density-characterized-by-en-face-optical-coherence-tomography
#37
JOURNAL ARTICLE
Wenyu Wang, Gongpeng Sun, Amin Xu, Changzheng Chen
BACKGROUND: Macrophage-like cells (MLCs) located at the ILM were observed in live human retinas using adaptive optics optical coherence tomography (OCT) as well as clinically-used OCT. The study aimed to quantitatively analyzing MLCs at the vitreoretinal interface (VRI) in diabetic retinopathy (DR) using en face OCT and swept-source optical coherence tomography angiography (SS-OCTA). METHODS: 190 DR eyes were included in the study, with 70 proliferative diabetic retinopathy (PDR) eyes and 120 non- proliferative diabetic retinopathy (NPDR) eyes...
February 1, 2023: BMC Ophthalmology
https://read.qxmd.com/read/36611964/the-past-and-present-lives-of-the-intraocular-transmembrane-protein-cd36
#38
REVIEW
Rucui Yang, Qingping Liu, Mingzhi Zhang
Cluster of differentiation 36 (CD36) belongs to the B2 receptors of the scavenger receptor class B family, which is comprised of single-chain secondary transmembrane glycoproteins. It is present in a variety of cell types, including monocytes, macrophages, microvascular endothelial cells, adipocytes, hepatocytes, platelets, skeletal muscle cells, kidney cells, cardiomyocytes, taste bud cells, and a variety of other cell types. CD36 can be localized on the cell surface, mitochondria, endoplasmic reticulum, and endosomes, playing a role in lipid accumulation, oxidative stress injury, apoptosis, and inflammatory signaling...
December 31, 2022: Cells
https://read.qxmd.com/read/36586438/2-hydroxypropyl-%C3%AE-cyclodextrin-mitigates-pathological-changes-in-a-mouse-model-of-retinal-cholesterol-dyshomeostasis
#39
JOURNAL ARTICLE
Nicole El-Darzi, Natalia Mast, Sandra S Hammer, Tim F Dorweiler, Julia V Busik, Irina A Pikuleva
CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs. 2-Hydroxypropyl-β-cyclodextrin (HPCD), a Food and Drug Administration-approved formulation vehicle, is currently being investigated off-label for treatment of various diseases, including retinal diseases. HPCD was shown to lower retinal cholesterol content in mice but had not yet been evaluated for its therapeutic benefits...
February 2023: Journal of Lipid Research
https://read.qxmd.com/read/36552864/treatment-with-mdl-72527-ameliorated-clinical-symptoms-retinal-ganglion-cell-loss-optic-nerve-inflammation-and-improved-visual-acuity-in-an-experimental-model-of-multiple-sclerosis
#40
JOURNAL ARTICLE
Fang Liu, Moaddey Alfarhan, Leanna Baker, Nidhi Shenoy, Yini Liao, Harry O Henry-Ojo, Payaningal R Somanath, S Priya Narayanan
Multiple Sclerosis (MS) is a highly disabling neurological disease characterized by inflammation, neuronal damage, and demyelination. Vision impairment is one of the major clinical features of MS. Previous studies from our lab have shown that MDL 72527, a pharmacological inhibitor of spermine oxidase (SMOX), is protective against neurodegeneration and inflammation in the models of diabetic retinopathy and excitotoxicity. In the present study, utilizing the experimental autoimmune encephalomyelitis (EAE) model of MS, we determined the impact of SMOX blockade on retinal neurodegeneration and optic nerve inflammation...
December 16, 2022: Cells
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