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https://www.readbyqxmd.com/read/28929660/-establishment-of-biological-assess-for-quality-control-of-fuzi-based-on-determination-of-premature-ventricular-contractions-in-rats
#1
Zhi-Hao Zhao, Ding-Kun Zhang, Ming-Quan Wu, Chun-Yu Li, Li-Juan Cao, Ping Zhang, Cui-Zhe Liu, Jia-Bo Wang, Xiao-He Xiao
Aconiti Lateralis Radix (Fuzi) is a toxic traditional Chinese medicine with definite efficacy. In order to improve the quality control of its different prepared products and ensure the security in clinic, it is significant to establish a method of quality evaluation related to clinic adverse effects. Aiming at the important biological marker of early cardiac toxicity reaction, there was no method to detect it. In this manuscript, a novel approach for measuring the minimal toxic dose (MTD) of premature ventricular contractions (PVC) poisoning of rats was established...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28921787/myocardial-bridging-is-associated-with-exercise-induced-ventricular-arrhythmia-and-increases-in-qt-dispersion
#2
Makiko Nishikii-Tachibana, Vedant S Pargaonkar, Ingela Schnittger, Francois Haddad, Ian S Rogers, Jennifer A Tremmel, Paul J Wang
BACKGROUND: A myocardial bridge (MB) has been associated with ventricular arrhythmia and sudden death during exercise. QT dispersion (QTd) is a measure of abnormal repolarization and may predict ventricular arrhythmia. We investigated the frequency of ventricular arrhythmias during exercise and the QTd at rest and after exercise, in patients with an MB compared to a normal cohort. METHODS: We studied the rest and stress ECG tracings of patients with an MB suspected by focal septal buckling on exercise echocardiography (EE) (Echo-MB group, N = 510), those with an MB confirmed by another examination (MB group, N = 110), and healthy controls (Control group, N = 198)...
September 18, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28916173/a-new-anatomical-view-on-the-vector-cardiogram-the-mean-temporal-spatial-isochrones
#3
Peter M van Dam
AIM: This proof of principle study aims to show the direct relationship between cardiac anatomy and the mean cardiac activation path as captured by the 12 lead ECG derived mean temporal-spatial isochrones (mean TSI) path. METHODS: To obtain the mean TSI signal a vector cardiographic (VCG) signal is constructed from the 12 lead ECG. The construction of the VCG signal uses a model of the heart and torso with patient specific electrode extracted from a 3D photo. The propagation of the activation through the heart is captured by estimating the mean of a cardiac activation isochrone using this VCG signal...
August 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28894131/ecg-features-and-methods-for-automatic-classification-of-ventricular-premature-and-ischemic-heartbeats-a-comprehensive-experimental-study
#4
Lucie Maršánová, Marina Ronzhina, Radovan Smíšek, Martin Vítek, Andrea Němcová, Lukas Smital, Marie Nováková
Accurate detection of cardiac pathological events is an important part of electrocardiogram (ECG) evaluation and subsequent correct treatment of the patient. The paper introduces the results of a complex study, where various aspects of automatic classification of various heartbeat types have been addressed. Particularly, non-ischemic, ischemic (of two different grades) and subsequent ventricular premature beats were classified in this combination for the first time. ECGs recorded in rabbit isolated hearts under non-ischemic and ischemic conditions were used for analysis...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893945/zfp423-znf423-regulates-cell-cycle-progression-the-mode-of-cell-division-and-the-dna-damage-response-in-purkinje-neuron-progenitors
#5
Filippo Casoni, Laura Croci, Camilla Bosone, Roberta D'Ambrosio, Aurora Badaloni, Davide Gaudesi, Valeria Barili, Justyna R Sarna, Lino Tessarollo, Ottavio Cremona, Richard Hawkes, Søren Warming, G Giacomo Consalez
The Zfp423/ZNF423 gene encodes a 30-Zn-finger transcription factor involved in key developmental pathways. While null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations have been associated to Joubert Syndrome, a ciliopathy causing cerebellar vermis hypoplasia and ataxia. ZNF423 participates in the DNA damage response, raising questions regarding its role as a regulator of neural progenitor cell cycle progression in cerebellar development. To characterize in vivo the function of ZFP423 in neurogenesis, we analyzed allelic murine mutants in which distinct functional domains are deleted...
September 11, 2017: Development
https://www.readbyqxmd.com/read/28884872/the-tip-of-the-muscle-is-a-dominant-location-of-ventricular-ectopy-originating-from-papillary-muscles-in-the-left-ventricle
#6
Petr Peichl, Jakub Baran, Dan Wichterle, Robert Čihák, Tomáš Skála, Bashar Aldhoon, Matevž Jan, Bor Antolič, Josef Kautzner
INTRODUCTION: Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs may be abolished by catheter ablation, it may be challenging in case of their origin from the LV papillary muscles (PMs). Our collaborative study aimed to analyze in detail the site of origin and the outcome of ablation. METHODS: Consecutive 34 patients (males: 68%; aged 62±12 years; LV ejection fraction: 50±9%) undergoing catheter ablation of VPCs originating from PMs were included...
September 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28883303/accentuating-systolic-aortic-regurgitation-during-premature-ventricular-systole
#7
Serkan Duyuler, Pınar Türker Duyuler
No abstract text is available yet for this article.
September 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28882284/harmony-feasibility-trial-acute-and-short-term-outcomes-with-a-self-expanding-transcatheter-pulmonary-valve
#8
Lisa Bergersen, Lee N Benson, Matthew J Gillespie, Sharon L Cheatham, Andrew M Crean, Kan N Hor, Eric M Horlick, Te-Hsin Lung, Brian T McHenry, Mark D Osten, Andrew J Powell, John P Cheatham
OBJECTIVES: This study sought to obtain in vivo data to confirm assumptions on device loading conditions and assess procedural feasibility, safety, and valve performance. BACKGROUND: The Harmony transcatheter pulmonary valve (Medtronic, Minneapolis, Minnesota) was designed for patients with severe pulmonary regurgitation who require pulmonary valve replacement. METHODS: Three sites participated in this first Food and Drug Administration-approved early feasibility study using an innovative device design to accommodate the complex anatomy of the right ventricular outflow tract...
September 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28872359/ambulatory-blood-pressure-results-and-heart-rate-variability-in-patients-with-premature-ventricular-contractions
#9
Lutfu Askin, Mustafa Cetin, Serdar Turkmen
BACKGROUND: The presence of premature ventricular contractions (PVCs) is a sign of arrhythmia and typically trigerred by over stimulation of the sympathetic nervous system. This study examined the relationships among PVCs, heart rate variability (HRV), and 24-hour ambulatory blood pressure (ABP) results. METHODS: This observational clinical study evaluated a cohort of 100 consecutive patients (58 women and 42 men) with PVCs. The individuals were split into occasional (n = 50) and frequent (n = 50) PVCs groups...
September 5, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28867191/aging-related-mitochondrial-dysfunction-facilitates-the-occurrence-of-serious-arrhythmia-after-myocardial-infarction
#10
Florian Stöckigt, Thomas Beiert, Vincent Knappe, Olivier R Baris, Rudolf J Wiesner, Christoph S Clemen, Georg Nickenig, René P Andrié, Jan W Schrickel
BACKGROUND: During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. METHODS AND RESULTS: Myocardial cryoinfarction was performed in 12-month-old transgenic mice with accelerated accumulation of deletions in mitochondrial DNA. Occurrence and pathogenesis of arrhythmia was investigated after two weeks...
September 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28864213/how-pure-is-the-honey-distinguishing-premature-ventricular-complex-induced-from-premature-ventricular-complex-worsened-cardiomyopathy
#11
EDITORIAL
Timothy R Larsen, Jose Huizar, Alex Y Tan
No abstract text is available yet for this article.
August 31, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28863167/the-development-and-validation-of-an-easy-to-use-automatic-qt-interval-algorithm
#12
Ben J M Hermans, Arja S Vink, Frank C Bennis, Luc H Filippini, Veronique M F Meijborg, Arthur A M Wilde, Laurent Pison, Pieter G Postema, Tammo Delhaas
BACKGROUND: To evaluate QT-interval dynamics in patients and in drug safety analysis, beat-to-beat QT-interval measurements are increasingly used. However, interobserver differences, aberrant T-wave morphologies and changes in heart axis might hamper accurate QT-interval measurements. OBJECTIVE: To develop and validate a QT-interval algorithm robust to heart axis orientation and T-wave morphology that can be applied on a beat-to-beat basis. METHODS: Additionally to standard ECG leads, the root mean square (ECGRMS), standard deviation and vectorcardiogram were used...
2017: PloS One
https://www.readbyqxmd.com/read/28858645/simulation-study-of-the-ionic-mechanisms-underlying-torsade-de-pointes-in-a-2d-cardiac-tissue
#13
Ponnuraj Kirthi Priya, M Ramasubba Reddy
BACKGROUND: To understand the ionic mechanism behind the genesis of Torsade de Pointes (TdP) occurring with long QT syndrome 2 (LQTS2) in a remodelled transmural tissue. METHODS: The TP06 model is used to simulate the electrical activity of cells in a 2D transmural ventricular model. LQTS2 is realised by reducing the potassium current (IKr) to 0.5 in each cell. Each cell of the tissue is remodelled by increasing the conductance of calcium current (GCaL). The above two factors make the cells prone to early after depolarizations (EADs) development...
August 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28846146/paroxysmal-atrioventricular-block-electrophysiological-mechanism-of-phase-4-conduction-block-in-the-his-purkinje-system-a-comparison-with-phase-3-block
#14
Mohammad Shenasa, Mark E Josephson, Andrew L Wit
BACKGROUND: Paroxysmal atrioventricular (A-V) block is relatively rare, and due to its transient nature, it is often under recognized. It is often triggered by atrial, junctional or ventricular premature beats, and occurs in the presence of a diseased His-Purkinje system (HPS). Here we present a 45-year-old white male who was admitted for observation due to recurrent syncope and near-syncope, who had paroxysmal A-V block. The likely cellular electrophysiological mechanisms(s) of paroxysmal A-V block and its differential diagnosis and management are discussed...
August 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28845401/the-role-of-nt-probnp-in-the-diagnosis-of-ventricular-arrhythmias-in-patients-with-systemic-sclerosis
#15
Lucian Muresan, Ana Petcu, Crina Muresan, Mirela Rinzis, Gabriel Gusetu, Dana Pop, Dumitru Zdrenghea, Simona Rednic
BACKGROUND: In patients with systemic sclerosis, NT-proBNP is a useful diagnostic marker for pulmonary hypertension and ventricular dysfunction, with important prognostic significance. The aim of this study was to assess the relationship between the NT-proBNP levels and the presence and severity of ventricular arrhythmias in patients with scleroderma. METHODS: Forty consecutive patients with a diagnostic of systemic sclerosis according to the EULAR criteria admitted at the Rheumatology Clinic of Cluj-Napoca, Romania, from Jan 2014 to Apr 2014 were enrolled...
July 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28836312/premature-ventricular-contraction-induced-concealed-retrograde-penetration-electrocardiographic-manifestations-on-anterograde-ventricular-preexcitation
#16
Damián Longo, Adrian Baranchuk
In patients with manifest anterograde ventricular preexcitation, the electrocardiographic manifestation of the anomalous conduction through the simultaneous conduction over the atrioventricular (AV) node and the accessory pathway ("delta wave"); depends on several factors, the most representative being the conduction velocity over one or another connection. Occasionally, ventricular ectopic beats may present with retrograde penetration over one or both conduction pathways (AV node and/or accessory pathway), impacting on the morphology of the next immediate anterogradely conducted QRS...
August 24, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28819680/quantitative-approach-to-the-posterior-cranial-fossa-and-craniocervical-junction-in-asymptomatic-children-with-achondroplasia
#17
Rosalinda Calandrelli, Marco Panfili, Gabriella D'Apolito, Giuseppe Zampino, Alessandro Pedicelli, Fabio Pilato, Cesare Colosimo
PURPOSE: We propose an magnetic resonance imaging (MRI)-based quantitative morphovolumetric approach to the posterior cranial fossa (PCF) and craniocervical junction (CCJ) changes in achondroplastic patients investigating possible associations with ventriculomegaly and medullary compression. METHODS: We analyzed MRI of 13 achondroplastic children not treated by surgery. 3D FSPGR T1-weighted images were used to analyze (1) PCF synchondroses; (2) PCF volume (PCFV), PCF brain volume (PCFBV), PCFV/PCFBV ratio, cerebellar volume, cerebrospinal fluid (CSF) spaces volume, and IV ventricle volume; (3) PCF (clivus, supraocciput, exocciput lengths, tentorial angle) and CCJ (AP and LL diameters of foramen magnum (FM)) morphometry; (4) measurements of FM and jugular foramina (JF) areas; and (5) supratentorial ventricular volume...
August 17, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28818336/association-between-premature-ventricular-complexes-during-exercise-long-term-occurrence-of-life-threatening-arrhythmia-and-mortality
#18
Jorge Aviles-Rosales, Hermes Ilarraza-Lomeli, Marianna Garcia-Saldivia, Jessica Rojano-Castillo, Maria-Dolores Rius-Suarez, Juan-Pablo Nunez-Urquiza, Pedro Iturralde
OBJECTIVE: Exercise-induced premature ventricular complexes (EiPVCs) are often considered as benign arrhythmias, nevertheless they are associated with a high risk of all-cause death in general healthy population. However, an intermediate pathophysiological process remains unclear, particularly in patients with known cardiovascular disease. The aim of this study was to find an association between EiPVCs, the occurrence of life-threatening ventricular arrhythmias (LACO) and all-cause mortality in patients with cardiovascular disease...
August 14, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28802656/rethinking-papillary-muscle-resection-for-refractory-ventricular-tachycardia-in-the-lvad-era-a-case-report
#19
Zachary J Il'Giovine, Adam D DeVore, Chetan B Patel, Jason Koontz, Jacob Schroder
We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular contraction focus in the anterolateral papillary muscle, an area that has been previously identified as difficult to treat with radiofrequency catheter ablation. The hospital course was complicated by cardiogenic shock and VT-storm, and the patient ultimately underwent surgical resection of the anterolateral papillary muscle with left ventricular assist device placement as a successful bridge to cardiac transplantation...
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28797679/multiform-premature-ventricular-contractions-a-reason-not-to-ablate
#20
EDITORIAL
Roderick Tung
No abstract text is available yet for this article.
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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