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https://www.readbyqxmd.com/read/28534205/outflow-tract-ventricular-arrhythmias-electrocardiographic-features-in-relation-to-mapping-and-ablation
#1
REVIEW
Deepak Padmanabhan, Alan Sugrue, Prakriti Gaba, Samuel J Asirvatham
Ventricular arrhythmia arising from the outflow tracts can manifest itself as frequent premature ventricular complexes (PVCs), salvos of ventricular tachycardia (VT), and/or sustained VT. It is amenable to management with medication and catheter ablation without need for an intracardiac defibrillator. The electrocardiogram (ECG) is a crucial tool in the management of these patients as it is can help localize the site of origin, thereby helping guide the electrophysiologist. An appreciation of the unique anatomy of the outflow tracts as well as their relationships with the surrounding structures is essential in interpreting the ECG...
May 22, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28521038/ventricular-zone-disruption-in-human-neonates-with-intraventricular-hemorrhage
#2
James P McAllister, Maria Montserrat Guerra, Leandro Castaneyra Ruiz, Antonio J Jimenez, Dolores Dominguez-Pinos, Deborah Sival, Wilfred den Dunnen, Diego M Morales, Robert E Schmidt, Esteban M Rodriguez, David D Limbrick
To determine if ventricular zone (VZ) and subventricular zone (SVZ) alterations are associated with intraventricular hemorrhage (IVH) and posthemorrhagic hydrocephalus, we compared postmortem frontal and subcortical brain samples from 12 infants with IVH and 3 nonneurological disease controls without hemorrhages or ventriculomegaly. Birth and expiration estimated gestational ages were 23.0-39.1 and 23.7-44.1 weeks, respectively; survival ranges were 0-42 days (median, 2.0 days). Routine histology and immunohistochemistry for neural stem cells (NSCs), neural progenitors (NPs), multiciliated ependymal cells (ECs), astrocytes (AS), and cell adhesion molecules were performed...
May 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28520537/anomalous-origin-of-right-coronary-artery-from-left-coronary-sinus-13-cases-treated-with-the-reimplantation-technique
#3
Alain Cubero, Alejandro Crespo, Gadah Hamzeh, Andrés Cortes, Daniel Rivas, José Ignacio Aramendi
OBJECTIVES: Anomalous aortic origin of a coronary artery is uncommon but potentially clinically significant. Manifestations vary from asymptomatic patients to those who present with angina pectoris, myocardial infarction, heart failure, syncope, arrhythmias, and sudden death. We describe our experience with surgical reimplantation and results at midterm follow-up. METHODS: Between February 2003 and July 2016, a total of 13 patients with anomalous origin of the right coronary artery (RCA) from the left sinus underwent surgical reimplantation...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#4
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28509708/pvcs-pvc-induced-cardiomyopathy-and-the-role-of-catheter-ablation
#5
Esseim Sharma, Karuppiah Arunachalam, Mengyang Di, Antony Chu, Abhishek Maan
Premature ventricular contractions (PVCs) are common arrhythmias noticed in the clinical setting because of premature depolarization of the ventricular myocytes. Although often thought to be reflective of underlying disease rather than intrinsically harmful, PVCs have recently been linked with worse outcomes in patients without significant cardiac disease. Long-term exposure to a high PVC burden can lead to the development of PVC-induced cardiomyopathy. The pathogenesis of this condition is poorly understood at the current time...
June 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28506214/origins-location-of-the-outflow-tract-ventricular-arrhythmias-exhibiting-qrs-pattern-or-qs-pattern-with-a-notch-on-the-descending-limb-in-lead-v1
#6
Cong Lin, Cheng Zheng, De-Pu Zhou, Xiao-Wei Li, Shu-Jie Wu, Jia-Feng Lin
BACKGROUND: Ventricular outflow tract(VOT) ventricular arrhythmias(VAs) presenting qrS pattern or QS pattern with a notch on the descending limb in lead V1 were consistently thought of arising from the commissure between left and right coronary cusp (L-RCC) by previous studies. However, we found they could originate from other anatomic structures in VOT. This study aimed to investigate the exact origin of this kind VAs. METHODS: Forty-nine patients of VOT premature ventricular contrations/ventricular tachycardia(PVCs/VT) with lead V1 presenting qrS pattern or QS pattern with a notch on the descending limb undergoing successful radiofrequency catheter ablation(RFCA) in our center were analyzed...
May 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28502200/foetal-premature-atrial-contractions-during-the-second-and-third-trimester-are-not-associated-with-foetal-breathing
#7
Geoffrey H Gordon, Joelle Thomas, Barbara Trampe, J I Iruretagoyena
Foetal premature atrial contractions (PACs) are the most commonly encountered and also the most benign foetal arrhythmia. A retrospective cohort study was conducted with the objective to assess whether the presence of foetal breathing was associated with the presence of foetal PACs. A further objective was to evaluate whether this association would affect neonatal outcomes at a high volume referral centre. The diagnosis of PACs was based on the observation of a premature atrial contraction followed by a ventricular contraction on ultrasound myocardial M-mode...
May 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28500254/increased-thromboembolic-events-with-dabigatran-compared-with-vitamin-k-antagonism-in-left-ventricular-assist-device-patients-a-randomized-controlled-pilot-trial
#8
Martin Andreas, Roxana Moayedifar, Georg Wieselthaler, Michael Wolzt, Julia Riebandt, Thomas Haberl, Philipp Angleitner, Thomas Schlöglhofer, Dominik Wiedemann, Heinrich Schima, Guenther Laufer, Daniel Zimpfer
BACKGROUND: Left ventricular assist device-supported patients are usually anticoagulated with a combination of aspirin and vitamin K antagonists. Long-term vitamin K antagonist therapy can be complicated by unstable international normalized ratio values and patient-related compliance problems. Therefore, direct thrombin inhibitors may represent an alternative to vitamin K antagonists. METHODS AND RESULTS: Thirty HeartWare ventricular assist device patients with stable renal function were planned for this prospective, randomized, open-label, single-center study...
May 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28500176/mitral-aortic-flow-reversal-in-cardiac-resynchronization-therapy-coupling-with-ejection-and-impact-of-variations-in-atrioventricular-delay
#9
Daniel Rodríguez Muñoz, José Luis Moya Mur, Javier Moreno, Covadonga Fernández-Golfín, Eduardo Franco, Bostjan Berlot, Juan Manuel Monteagudo, Roberto Matía Francés, Antonio Hernández Madrid, José Luis Zamorano
BACKGROUND: Flow entering the left ventricle is reversed toward the outflow tract through rotating reversal flow around the mitral valve. This was thought to facilitate early ejection, but had not been proved to date. We hypothesized that perfect coupling between reversal and ejection flow would occur at optimal atrioventricular delay (AVD), contributing to its hemodynamic superiority, and evaluated its applicability for AVD optimization. METHODS AND RESULTS: Forty consecutive patients with cardiac resynchronization therapy underwent intracardiac flow analysis and AVD optimization...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28492868/efficacy-of-flecainide-in-the-treatment-of-catecholaminergic-polymorphic-ventricular-tachycardia-a-randomized-clinical-trial
#10
Prince J Kannankeril, Jeremy P Moore, Marina Cerrone, Silvia G Priori, Naomi J Kertesz, Pamela S Ro, Anjan S Batra, Elizabeth S Kaufman, David L Fairbrother, Elizabeth V Saarel, Susan P Etheridge, Ronald J Kanter, Michael P Carboni, Matthew V Dzurik, Darlene Fountain, Heidi Chen, E Wesley Ely, Dan M Roden, Bjorn C Knollmann
Importance: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal genetic arrhythmia syndrome characterized by polymorphic ventricular tachycardia with physical or emotional stress, for which current therapy with β-blockers is incompletely effective. Flecainide acetate directly suppresses sarcoplasmic reticulum calcium release-the cellular mechanism responsible for triggering ventricular arrhythmias in CPVT-but has never been assessed prospectively. Objective: To determine whether flecainide dosed to therapeutic levels and added to β-blocker therapy is superior to β-blocker therapy alone for the prevention of exercise-induced arrhythmias in CPVT...
May 10, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28491706/radiofrequency-catheter-ablation-for-treatment-of-premature-ventricular-contractions-triggering-ventricular-fibrillation-from-the-right-ventricular-outflow-tract-in-a-patient-with-early-repolarization-syndrome
#11
Jun Kakihara, Masahiko Takagi, Yusuke Hayashi, Hiroaki Tatsumi, Atsushi Doi, Minoru Yoshiyama
No abstract text is available yet for this article.
July 2016: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28490495/exclusion-of-alternative-exon-33-of-cav1-2-calcium-channels-in-heart-is-proarrhythmogenic
#12
Guang Li, Juejin Wang, Ping Liao, Peter Bartels, Hengyu Zhang, Dejie Yu, Mui Cheng Liang, Kian Keong Poh, Chye Yun Yu, Fengli Jiang, Tan Fong Yong, Yuk Peng Wong, Zhenyu Hu, Hua Huang, Guangqin Zhang, Mary Joyce Galupo, Jin-Song Bian, Sathivel Ponniah, Scott Lee Trasti, Kelvin See, Roger Foo, Uta C Hoppe, Stefan Herzig, Tuck Wah Soong
Alternative splicing changes the CaV1.2 calcium channel electrophysiological property, but the in vivo significance of such altered channel function is lacking. Structure-function studies of heterologously expressed CaV1.2 channels could not recapitulate channel function in the native milieu of the cardiomyocyte. To address this gap in knowledge, we investigated the role of alternative exon 33 of the CaV1.2 calcium channel in heart function. Exclusion of exon 33 in CaV1.2 channels has been reported to shift the activation potential -10...
May 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28487342/calcium-calmodulin-dependent-protein-kinase-ii-activity-persists-during-chronic-%C3%AE-adrenoceptor-blockade-in-experimental-and-human-heart-failure
#13
Matthias Dewenter, Stefan Neef, Christiane Vettel, Simon Lämmle, Christina Beushausen, Laura C Zelarayan, Sylvia Katz, Albert von der Lieth, Stefanie Meyer-Roxlau, Silvio Weber, Thomas Wieland, Samuel Sossalla, Johannes Backs, Joan H Brown, Lars S Maier, Ali El-Armouche
BACKGROUND: Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overactivity plays a crucial role in the pathophysiology of heart failure (HF), a condition characterized by excessive β-adrenoceptor (β-AR) stimulation. Recent studies indicate a significant cross talk between β-AR signaling and CaMKII activation presenting CaMKII as a possible downstream mediator of detrimental β-AR signaling in HF. In this study, we investigated the effect of chronic β-AR blocker treatment on CaMKII activity in human and experimental HF...
May 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28482867/afadin-controls-cell-polarization-and-mitotic-spindle-orientation-in-developing-cortical-radial-glia
#14
Jennifer Rakotomamonjy, Molly Brunner, Christoph Jüschke, Keling Zang, Eric J Huang, Louis F Reichardt, Anjen Chenn
BACKGROUND: In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a neurogenic niche that controls their behavior. How adherens junctions regulate radial glial cell polarity and/or differentiation in mammalian cortical development is poorly understood. RESULTS: Conditional deletion of Afadin, a protein required for formation and maintenance of epithelial tissues, leads to abnormalities in radial glial cell polarity and subsequent loss of adherens junctions...
May 8, 2017: Neural Development
https://www.readbyqxmd.com/read/28477226/-malignant-bileaflet-mitral-valve-prolapse-syndrome-in-otherwise-idiopathic-ventricular-fibrillation
#15
Dirk Vollmann, Claudius Hansen, Lars Lüthje, Ole A Breithardt
A 32-year-old, otherwise healthy woman was admitted after successful out-of-hospital resuscitation due to ventricular fibrillation. Established cardiac, pulmonary, metabolic, and toxicological causes were excluded. However, persisting (biphasic) negative T waves in the inferior ECG leads and premature ventricular contractions (PVC) were noted. PVC morphology indicated a focus alternating between the posterior papillary muscle/the left posterior fascicle and the left ventricular outflow tract region/anterior papillary muscle...
May 5, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28475802/complete-fusion-of-a-percutaneous-aortic-valve-placed-after-ventricular-assist-device
#16
Stephen L Derryberry, Renaldo D Williams, Joseph L Fredi, Stephen K Ball
Severe aortic insufficiency following continuous flow left ventricular assist device (LVAD) placement requires intervention. Conventional corrective approaches are varied and morbid. Increasingly, percutaneous solutions, such as transcatheter aortic valve replacement (TAVR), have been used to rescue these patients. The unique flow characteristics in the aortic root following LVAD implantation may have unintended consequences to the TAVR leaflets. We describe the premature fusion of TAVR leaflets following 159 days of LVAD support...
May 4, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28473110/impact-of-chronic-total-coronary-occlusion-on-recurrence-of-ventricular-arrhythmias-in-ischemic-secondary-prevention-implantable-cardioverter-defibrillator-recipients-vacto-secondary-study-insights-from-coronary-angiogram-and-electrogram-analysis
#17
Luis Nombela-Franco, Mario Iannaccone, Ignasi Anguera, Ignacio J Amat-Santos, Manuel Sanchez-Garcia, Daniel Bautista, Martin N Calvelo, Andrea Di Marco, Claudio Moretti, Roberto Pozzi, Marco Scaglione, Victoria Cañadas, María Sandin-Fuentes, Angel Arenal, Rodrigo Bagur, Nicasio Perez-Castellano, Cristina Fernandez-Perez, Fiorenzo Gaita, Carlos Macaya, Javier Escaned, Ignacio Fernández-Lozano
OBJECTIVES: This study sought to evaluate the incidence and clinical effect of coronary chronic total occlusions (CTOs) in patients with ischemic cardiomyopathy receiving an implantable cardioverter-defibrillator (ICD) for secondary prevention of sudden cardiac death (SCD). BACKGROUND: CTOs are common in patients with ischemic cardiomyopathy, which is the major cause of SCD. However, the impact of CTO in SCD survivors receiving an ICD is unknown. METHODS: A total of 425 patients who had survived an episode of ventricular arrhythmias and underwent ICD implantation for secondary prevention in 8 centers were included...
May 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28471536/assessment-of-subtle-cardiac-dysfunction-in-patients-with-frequent-premature-ventricular-complexes-by-real-time-three-dimensional-speckle-tracking-echocardiography
#18
Yunlong Ling, Quan Wan, Qingxing Chen, Wenqing Zhu
BACKGROUND: To evaluate subtle and early premature ventricular complex (PVC)-induced ventricular impairment in patients with frequent PVCs and without structural heart disease by real-time 3-dimensional (3D) speckle tracking echocardiography (RT3D-STE). HYPOTHESIS: Patients with frequent premature ventricular complexes with normal left ventricular ejection fraction have subtle left ventricular dysfunction. METHODS: Forty patients (22 male) with a single source of frequent PVCs and 40 healthy controls (24 male) underwent assessment by conventional 2-dimensional (2D) echocardiography and RT3D-STE...
May 4, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28470384/first-60-fetal-in-utero-myelomeningocele-repairs-at-saint-louis-fetal-care-institute-in-the-post-moms-trial-era-hydrocephalus-treatment-outcomes-endoscopic-third-ventriculostomy-versus-ventriculo-peritoneal-shunt
#19
Samer K Elbabaa, Anne M Gildehaus, Matthew J Pierson, J Andrew Albers, Emanuel J Vlastos
INTRODUCTION: The published results of the Management of Myelomeningocele Study (MOMS) trial in 2011 showed improved outcomes (reduced need for shunting, decreased incidence of Chiari II malformation, and improved scores of mental development and motor function) in the fetal prenatal repair group compared to the postnatal group. Historically, endoscopic third ventriculostomy (ETV) remains as a controversial hydrocephalus treatment option with high failure rates in pediatric patients with a history of myelomeningocele (MMC)...
May 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28468664/twenty-four-hour-ambulatory-electrocardiography-characterization-of-heart-rhythm-in-vipera-berus-envenomed-dogs
#20
Anna Rave Vestberg, Anna Tidholm, Ingrid Ljungvall
BACKGROUND: Vipera berus has a worldwide distribution and causes high morbidity in dogs annually. A complication to envenomation may be cardiac arrhythmias. The purpose of this study was to investigate the prevalence, types, and timing of arrhythmias, using 24-h ambulatory electrocardiography (24-AECG), in dogs bitten by V. berus in the first 24-32 h after envenomation. In addition, this study aimed to investigate if there were differences in selected clinical and hematological- and biochemical variables (including cardiac troponin I) at admission between V...
May 3, 2017: Acta Veterinaria Scandinavica
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