Ki Won Lee, Ki-Jun Ryu, Minju Kim, Seyeon Lim, Jisu Kim, Jeong Yoon Kim, Cheol Hwangbo, Jiyun Yoo, Yong-Yeon Cho, Kwang Dong Kim
Melanosomes are specific organelles dedicated to melanin synthesis and accumulation in melanocytes. Autophagy is suggestively involved in melanosome degradation, although the potential underlying molecular mechanisms remain elusive. In selective autophagy, autophagy receptors and E3-ligases are the key factors conferring cargo selectivity. In B16F10 cells, β-mangostin efficiently induced melanosome degradation without affecting other organelles such as mitochondria, peroxisomes, and the endoplasmic reticulum...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America