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https://www.readbyqxmd.com/read/28339750/downstream-overdrive-pacing-and-intracardiac-concealed-fusion-to-guide-rapid-identification-of-atrial-tachycardia-after-atrial-fibrillation-ablation
#1
Chirag R Barbhaiya, Samuel H Baldinger, Saurabh Kumar, Jason S Chinitz, Alan D Enriquez, Roy John, William G Stevenson, Gregory F Michaud
Aims: Atrial tachycardia (AT) related to atrial fibrillation (AF) ablation frequently poses a diagnostic challenge. Downstream overdrive pacing (DOP) can be used to rapidly detect reentry and assess proximity of a pacing site to an AT circuit or focus. We hypothesized that systematic DOP using multielectrode catheters would facilitate AT mapping. Methods and results: DOP identified constant fusion when the post-pacing interval (PPI)-tachycardia cycle length (TCL) <40 ms and stimulus to adjacent upstream atrial electrogram interval >75% of TCL...
February 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28287212/-the-pacemaker-and-implantable-cardioverter-defibrillator-registry-of-the-italian-association-of-arrhythmology-and-cardiac-pacing-annual-report-2015
#2
Alessandro Proclemer, Massimo Zecchin, Antonio D'Onofrio, Giuseppe Boriani, Giovanni Luca Botto, Domenico Facchin, Luca Rebellato, Marco Ghidina, Giulia Bianco, Emanuela Bernardelli, Elsa Pucher, Dario Gregori
BACKGROUND: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2015 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers. METHODS: The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards...
January 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28284503/renal-denervation-regulates-the-atrial-arrhythmogenic-substrates-through-reverse-structural-remodeling-in-heart-failure-rabbit-model
#3
Shinya Yamada, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shih-Ann Chen
BACKGROUND: Heart failure (HF) causes atrial remodeling and increases the incidence of atrial fibrillation (AF). Renal denervation (RDN) has been shown to decrease the development of AF. This study aimed to identify the effects of RDN on the atrial arrhythmogenic substrates in HF. METHODS: Rabbits were classified into four groups: control (n=9), RDN (n=10), HF (n=6) and HF-RDN (n=9). Surgical and chemical RDN was approached through bilateral retroperitoneal flank incisions in RDN and HF-RDN...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28274566/postoperative-atrial-fibrillation-the-role-of-the-inflammatory-response
#4
Yosuke Ishii, Richard B Schuessler, Sydney L Gaynor, Kiyomi Hames, Ralph J Damiano
OBJECTIVE: Abnormal atrial conduction has been shown to be a substrate for postoperative atrial fibrillation (POAF). This study aimed to determine the relationship between the location of the atrial reentry responsible for POAF, and degree of atrial inflammation. METHODS: Normal mongrel dogs (n = 18) were divided into 3 groups: anesthesia alone (anesthesia), lateral right atriotomy (atriotomy), and lateral right atriotomy with anti-inflammatory therapy (steroid)...
February 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28273109/recent-heart-rate-history-affects-qt-interval-duration-in-atrial-fibrillation
#5
Fady S Riad, Eathar Razak, Samir Saba, Alaa Shalaby, Jan Nemec
QT interval prolongation is associated with a risk of polymorphic ventricular tachycardia. QT interval shortens with increasing heart rate and correction for this effect is necessary for meaningful QT interval assessment. We aim to improve current methods of correcting the QT interval during atrial fibrillation (AF). Digitized Holter recordings were analyzed from patients with AF. Models of QT interval dependence on RR intervals were tested by sorting the beats into 20 bins based on corrected RR interval and assessing ST-T variability within the bins...
2017: PloS One
https://www.readbyqxmd.com/read/28262346/effective-suppression-of-atrial-fibrillation-by-ivabradine-novel-target-for-an-established-drug
#6
Gerrit Frommeyer, Magdalena Sterneberg, Dirk G Dechering, Christian Ellermann, Nils Bögeholz, Simon Kochhäuser, Christian Pott, Michael Fehr, Lars Eckardt
BACKGROUND: Ivabradine is an inhibitor of mixed Na(+)-K(+)-currents and routinely administered in chronic heart failure. Clinical studies reported divergent trends regarding proarrhythmic and antiarrhythmic effects in atrial fibrillation (AF). METHODS AND RESULTS: In 12 isolated rabbit hearts AF was induced in 7 of 12 hearts (13 episodes) under baseline conditions by a standardized protocol employing atrial burst pacing. Thereafter, a combination of acetylcholine and isoproterenol was employed to enhance AF occurrence...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28257761/membrane-potential-determines-calcium-alternans-through-modulation-of-sr-ca-2-load-and-l-type-ca-2-current
#7
Giedrius Kanaporis, Lothar A Blatter
Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular level alternans is observed as beat-to-beat alternations in contraction, action potential (AP) morphology and magnitude of the Ca(2+) transient (CaT). It is widely accepted that the bi-directional interplay between membrane voltage and Ca(2+) is crucial for the development of alternans, however recently the attention has shifted to instabilities in cellular Ca(2+) handling, while the role of AP alternation remains poorly understood...
February 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28257569/hyperleptinemia-exacerbates-high-fat-diet-mediated-atrial-fibrosis-and-fibrillation
#8
Akira Fukui, Yuki Ikebe-Ebata, Hidekazu Kondo, Shotaro Saito, Kohei Aoki, Naoya Fukunaga, Tetsuji Shinohara, Takayuki Masaki, Yasushi Teshima, Naohiko Takahashi
BACKGROUND: Obesity including metabolic syndrome is an independent risk factor of atrial fibrillation (AF). Although hyperleptinemia is usually a characteristic of obese subjects, the relationship with atrial fibrosis and AF is unknown. We tested the hypothesis that high-fat diet (HFD)-induced hyperleptinemia exacerbates atrial fibrosis and AF. METHODS AND RESULTS: Eight-week-old male C57BL/6 (WT) and leptin-deficient ob/ob (Ob) mice were treated with a normal-fat diet (NFD) or 60% HFD...
March 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28240435/ventricular-tachyarrhythmias-in-patients-with-hypertrophic-cardiomyopathy-and-defibrillators-triggers-treatment-and-implications
#9
Mark S Link, Katy Bockstall, Jonathan Weinstock, Alawi A Alsheikh-Ali, Christopher Semsarian, N A Mark Estes, Paolo Spirito, Tammy S Haas, Ethan J Rowin, Martin S Maron, Barry J Maron
INTRODUCTION: Triggers and ICD interventions of ventricular arrhythmias in patients with hypertrophic cardiomyopathy (HCM) offers insight into mechanisms and treatment. METHODS AND RESULTS: Intracardiac ICD electrograms from 71 HCM patients in the HCM I and II studies were analyzed by 3 individuals. Rhythms were defined as VF (polymorphic ventricular arrhythmia), VT (monomorphic ventricular tachycardia), and ventricular flutter (VFL) (VT ≥ 240 bpm). Physical activity and rhythm preceding the arrhythmia were ascertained...
February 27, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28225684/assessing-the-risks-associated-with-mri-in-patients-with-a-pacemaker-or-defibrillator
#10
MULTICENTER STUDY
Robert J Russo, Heather S Costa, Patricia D Silva, Jeffrey L Anderson, Aysha Arshad, Robert W W Biederman, Noel G Boyle, Jennifer V Frabizzio, Ulrika Birgersdotter-Green, Steven L Higgins, Rachel Lampert, Christian E Machado, Edward T Martin, Andrew L Rivard, Jason C Rubenstein, Raymond H M Schaerf, Jennifer D Schwartz, Dipan J Shah, Gery F Tomassoni, Gail T Tominaga, Allison E Tonkin, Seth Uretsky, Steven D Wolff
Background The presence of a cardiovascular implantable electronic device has long been a contraindication for the performance of magnetic resonance imaging (MRI). We established a prospective registry to determine the risks associated with MRI at a magnetic field strength of 1.5 tesla for patients who had a pacemaker or implantable cardioverter-defibrillator (ICD) that was "non-MRI-conditional" (i.e., not approved by the Food and Drug Administration for MRI scanning). Methods Patients in the registry were referred for clinically indicated nonthoracic MRI at a field strength of 1...
February 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28207381/personalized-models-of-human-atrial-electrophysiology-derived-from-endocardial-electrograms
#11
Cesare Corrado, John Whitaker, Henry Chubb, Steven Williams, Matthew Wright, Jaswinder Gill, Mark O'Neill, Steven Niederer
OBJECTIVE: Computational models represent a novel framework for understanding the mechanisms behind atrial fibrillation (AF) and offer a pathway for personalizing and optimizing treatment. The characterization of local electrophysiological properties across the atria during procedures remains a challenge. The aim of this work is to characterize the regional properties of the human atrium from multi-electrode catheter measurements. METHODS: We propose a novel method that characterizes regional electrophysiology properties by fitting parameters of an ionic model to conduction velocity and effective refractory period restitution curves obtained by a s1 s2 pacing protocol applied through a multi-electrode catheter...
May 30, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28204915/-acute-chest-pain-and-new-ecg-changes-in-pacemaker-patients-a%C3%A2-clinical-challenge
#12
Matthias Hoyme, Ralf Surber, P Christian Schulze, Dirk Prochnau
We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Coronary artery disease was excluded by immediate cardiac catheterization. A subsequent ECG three hours later showed a ventricular paced rhythm...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28191665/apical-left-ventricular-myocardial-dysfunction-is-an-early-feature-of-cardiac-involvement-in-myotonic-dystrophy-type-1
#13
Rodrigue Garcia, Quentin Labarre, Bruno Degand, Pierre Ingrand, François Le Gal, Benjamin Bonnet, Anne Delaubier, Claire Guillou, Barnabas Gellen, Damien Coisne, Claire Bouleti, Luc Christiaens
INTRODUCTION: Left ventricular (LV) dysfunction is a major prognostic determinant in myotonic dystrophy type 1 (DM1). Therefore, markers of early-stage LV impairment may be useful. The aim of this study was to evaluate 2D echocardiographic LV strain in a cohort of DM1 patients with preserved left ventricular ejection fraction (LVEF) and to compare the results with matched controls. METHODS: This prospective single-center study included 33 consecutive DM1 patients between February 2014 and February 2015...
February 2017: Echocardiography
https://www.readbyqxmd.com/read/28184198/local-left-ventricular-epicardial-j-waves-and-late-potentials-in-brugada-syndrome-patients-with-inferolateral-early-repolarization-pattern
#14
Satoshi Nagase, Masamichi Tanaka, Hiroshi Morita, Koji Nakagawa, Tadashi Wada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito, Tohru Ohe, Kengo F Kusano
Background: Brugada syndrome (BrS) is characterized by J-point or ST-segment elevation on electrocardiograms (ECGs) and increased risk of ventricular fibrillation (VF). In BrS, epicardial depolarization abnormality with delayed potential on the right ventricular outflow tract is reportedly the predominant mechanism underlying VF. Yet VF occurrence is also associated with early repolarization (ER) pattern in the inferolateral ECG leads, which may represent the inferior and/or left lateral ventricular myocardium...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28156008/a-device-histogram-based-simple-predictor-of-mortality-risk-in-icd-and-crt-d-patients-the-heart-rate-score
#15
Bruce L Wilkoff, Mark Richards, Arjun Sharma, Nicholas Wold, Paul Jones, David Perschbacher, Brian Olshansky
BACKGROUND: We hypothesized survival in cardioverter defibrillator (ICD) and cardiac resynchronization defibrillator (CRT-D) patients is predicted by baseline Heart rate Score. METHODS: Heart rate Score is determined from the atrial paced and sensed histogram of a DDD ICD or CRT-D, and defined as percent of beats in the histogram in the tallest 10 beat/minute range bin. It was calculated at initial remote monitoring for patients enrolled in LATITUDE® without persistent atrial fibrillation (AF), and with pulse generators implanted 2006-2011...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28155995/sinus-node-dysfunction-and-atrial-fibrillation-a-reversible-phenomenon
#16
REVIEW
Larry R Jackson Ii, Bharath Rathakrishnan, Kristen Campbell, Kevin L Thomas, Jonathan P Piccini, Tristram Bahnson, Jonathan A Stiber, James P Daubert
BACKGROUND: Symptomatic sinus node dysfunction (SND) consists of a variety of manifestations including tachycardia-bradycardia syndrome. Atrial fibrillation (AF) is commonly associated with SND, which complicates the management of both conditions. This paper reviews the epidemiology, pathophysiology, and clinical trial data investigating therapeutic approaches for treatment of patients with both SND and AF. METHODS: The authors reviewed articles published in English describing the epidemiology, pathophysiology, and therapeutic approaches for patients with SND and AF...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28132779/acute-infusion-of-levosimendan-enhances-atrial-fibrillation-in-an-experimental-whole-heart-model
#17
Gerrit Frommeyer, Anja Kohnke, Christian Ellermann, Dirk G Dechering, Simon Kochhäuser, Florian Reinke, Michael Fehr, Lars Eckardt
BACKGROUND: The calcium sensitizer levosimendan is clinically employed in decompensated heart failure. The aim of the present study was to assess effects of levosimendan on atrial electrophysiology in an experimental whole-heart model. METHODS AND RESULTS: 13 rabbit hearts were isolated and Langendorff-perfused. Thereafter, hearts were paced at cycle lengths of 350ms, 250ms and 200ms in the atrium. A standardized protocol employing atrial burst pacing induced atrial fibrillation (AF) in 4 of 13 hearts under baseline conditions (mean: 3...
January 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28118792/noteworthy-articles-in-2016-for-the-cardiothoracic-anesthesiologist
#18
Dirk J Varelmann, J Daniel Muehlschlegel
Clinical research and outcome studies dominated the publication spectrum for the cardiothoracic anesthesiologist in 2016. Echocardiography is an important tool in the armamentarium of the cardiothoracic anesthesiologist. Technology is advancing at a fast pace: A new method to quantify the regurgitant volume in mitral regurgitation has been described in an experimental model and been validated in humans. Interesting studies on key elements of our daily practice have been published: Does tranexamic acid decrease the transfusion requirements after cardiac surgery? Are patients with a postoperative cognitive deficit at risk for dementia 7...
January 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28109316/adenosine-induced-ventricular-fibrillation-in-a-structurally-normal-heart-a-case-report
#19
Christopher A Rajkumar, Norman Qureshi, Fu Siong Ng, Vasileios F Panoulas, Phang Boon Lim
BACKGROUND: Adenosine is the first-line pharmacotherapy for termination of supraventricular tachycardia through its action on the atrioventricular node. However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. In this case report, we describe the induction of ventricular fibrillation in a patient with no demonstrable accessory pathway, nor any other structural heart disease. This rare, idiosyncratic reaction has never previously been reported and is of relevance given the widespread and routine use of adenosine in clinical practice...
January 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28091409/effect-of-shensong-yangxin-on-the-progression-of-paroxysmal-atrial-fibrillation-is-correlated-with-regulation-of-autonomic-nerve-activity
#20
Hong-Yi Zhao, Shu-Di Zhang, Kai Zhang, Xi Wang, Qing-Yan Zhao, Shu-Juan Zhang, Zi-Xuan Dai, Yong-Sheng Qian, You-Jing Zhang, Hao-Tian Wei, Yan-Hong Tang, Cong-Xin Huang
BACKGROUND: Shensong Yangxin (SSYX), a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation (AF) is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. METHODS: Eighteen mongrel dogs were randomly divided into control group (n = 6), pacing group (n = 6), and pacing + SSYX group (n = 6)...
January 20, 2017: Chinese Medical Journal
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