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https://www.readbyqxmd.com/read/29681575/sinus-standstill-in-a-patient-after-intracoronary-papaverine-administration-for-a-coronary-fractional-flow-reserve
#1
Masahiro Nauchi, Tsuyoshi Sakai, Masahiro Yamawaki, Yoshiaki Ito
A 78-year-old woman had paroxysmal atrial fibrillation and effort angina. Two months before she was admitted for a coronary angiography, she had been feeling dizzy. A Holter 24-hour electrocardiography monitor exhibited an asymptomatic episode of 2.9 seconds of RR interval. She underwent a coronary angiography, which showed intermediate stenosis in the left descending artery. Fractional flow reserve (FFR) measurement using intracoronary papaverine administration was performed. After intracoronary papaverine (12 mg) administration, pause of 4 seconds led to polymorphic ventricular tachycardia (VT), although the VT terminated spontaneously...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29669504/atrial-fibrillation-in-autoimmune-rheumatic-diseases-from-the-pathogenesis-to-the-treatment
#2
Giuseppe Ciconte, Manuel Conti, Martina Evangelista, Carlo Pappone
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the general population and is associated with an increased number of adverse outcomes. The onset and maintenance of this arrhythmia requires a trigger event and the presence of a predisposing substrate. Atrial fibrosis, a major characteristic of AF-related structural remodeling, represents a process closely related to inflammation as demonstrated by emerging evidence. Aim of this article is to review the evidence linking AF to systemic autoimmune diseases...
April 17, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29666358/revisiting-atrioventricular-nodal-ablation-and-cardiac-pacing-of-atrial-fibrillation-in-a-patient-with-dextrocardia
#3
Munish Sharma, Ritesh Neupane, Koroush Khalighi
BACKGROUND Poorly controlled ventricular rate associated with atrial fibrillation (AF) leads to tachycardia-induced left ventricular dysfunction. Atrioventricular (AV) nodal ablation and cardiac pacing is the standard of care in refractory congestive heart failure (CHF) due to AF with moderate to rapid ventricular response that failed conventional medical therapy. If the patient is not a candidate for AF ablation with pulmonary vein isolation and elimination of AF foci, this is an effective approach, but it does have some challenges when done in a patient with dextrocardia and situs inversus...
April 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29660447/the-usefulness-of-ventricular-pacing-during-atrial-fibrillation-ablation-in-a-persistent-left-superior-vena-cava-a-case-report
#4
Sen Matsumoto, Yasuharu Matsunaga-Lee, Nobutaka Masunaga, Yuzuru Takano
A 69-year-old woman with palpitations was referred to our hospital for a second session of atrial fibrillation (AF) catheter ablation. She had a history of AF ablation including pulmonary vein (PV) isolation and persistent left superior vena cava (PLSVC) isolation. Electrophysiologic studies showed the veno-atrial connections that had recovered. After PV isolation was performed, AF was induced by atrial premature contraction (APC) from the PLSVC, and AF storm occurred. During PLSVC isolation, AF was not induced by APC from the PLSVC...
April 13, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29656325/dosing-of-the-second-generation-cryoballoon-using-acute-time-to-pulmonary-vein-isolation-as-an-indicator-of-durable-ablation-in-a-canine-model
#5
Wilber Su, Nicolas Coulombe, Nicole Kirchhof, Erin Grassl, Dan Wittenberger
BACKGROUND: Rigid time-based dosing protocol(s) currently used in the clinic for cryoballoon ablation of atrial fibrillation may be inadequate to guide the circumferential and transmural cryothermal energy transfer across the pulmonary vein (PV) and may result in injury to collateral tissues or electrical gaps between the PV and left atrium (LA). OBJECTIVE: A physiologic endpoint (e.g., acute time-to-PV isolation a.k.a. time-to-effect; TTE) may be effective in the determination of a transmural lesion formation and may allow for individualized ablation dosing across each PV...
April 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29652036/clinical-effects-of-selective-drug-regulating-vagus-nerve-signal-pathway-in-vagally-mediated-atrial-fibrillation
#6
Xue Lou, Yanmei Lu, Baopeng Tang, Xianhui Zhou
BACKGROUND The cardiac autonomic nervous system plays a crucial role in genesis and development of atrial fibrillation (AF) through the G protein signal transduction pathway. Therefore, intervening in the G protein signal transduction pathway may be a new "selective drug" method to regulate autonomic nerve activity to prevent vagally-mediated AF. MATERIAL AND METHODS Seventeen adult beagles were randomized into 3 groups: shame-operation control group (group A, n=5), empty vector gene control group (group B, n=6), and Gαi2ctp gene experimental group (group C, n=6)...
April 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29611175/initial-experience-with-the-subcutaneous-implantable-cardioverter-defibrillator-with-the-real-costs-of-hospitalization-analysis-in-a-single-polish-center
#7
Marcin Grabowski, Monika Gawałko, Marcin Michalak, Andrzej Cacko, Michał Kowara, Agnieszka Kołodzińska, Łukasz Januszkiewicz, Paweł Balsam, Laura Vitali Serdoz, Joachim Winter, Grzegorz Opolski
BACKGROUND: The recent introduction of an entirely subcutaneous implantable cardioverter-defibrillator (S-ICD) represents an important progress in the defibrillation technology towards a less invasive approach. This is a single-center observational study of S-ICD implantations in Poland. METHODS: The S-ICD was implanted in 11 patients with standard indications for an ICD. Patients in whom the device was implanted were evaluated for adverse events and device function at hospital discharge...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29609270/-effect-of-%C3%AE-7nachr-mediated-cholinergic-anti-inflammatory-pathway-on-inhibition-of-atrial-fibrillation-by-low-level-vagus-nerve-stimulation
#8
Y S Qian, Q Y Zhao, S J Zhang, Y J Zhang, Y C Wang, H Y Zhao, Z X Dai, Y H Tang, X Wang, T Wang, C X Huang
Objective: To investigate the effect of α7nAChR mediated cholinergic anti-inflammatory pathway on inhibition of atrial fibrillation by low-level vagus nerve stimulation(LL-VNS). Methods: Eighteen beagles were randomized into control group ( n =6), LL-VNS group ( n =6) and methyllycaconitine (MLA) + LL-VNS group ( n =6). All the beagles were subjected to rapid atrial pacing at 800 beats/min for 6 hours.And the effective refractory period (ERP) of atriums and pulmonary veins and induced atrial fibrillation (AF) were measured hourly during non-pacing...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29598935/indications-for-cardiac-resynchronization-therapy-a-comparison-of-the-major-international-guidelines
#9
Camilla Normand, Cecilia Linde, Jagmeet Singh, Kenneth Dickstein
OBJECTIVES: This study compares and contrasts the recommended indications for cardiac resynchronization therapy (CRT) according to the most recent guidelines from international cardiology societies. BACKGROUND: CRT has been shown to reduce morbidity and mortality in selected patients with systolic heart failure. Cardiology societies provide guidelines regarding the indications for CRT. As evidence evolves, it is challenging for the guideline committees to review the impact of newer evidence in a timely fashion...
April 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29598867/role-of-stress-kinase-jnk-in-binge-alcohol-evoked-atrial-arrhythmia
#10
Jiajie Yan, Justin K Thomson, Weiwei Zhao, Xianlong Gao, Fei Huang, Biyi Chen, Qingrong Liang, Long-Sheng Song, Michael Fill, Xun Ai
BACKGROUND: Excessive binge alcohol drinking has acute cardiac arrhythmogenic effects, including promotion of atrial fibrillation (AF), which underlies "Holiday Heart Syndrome." The mechanism that couples binge alcohol abuse with AF susceptibility remains unclear. We previously reported stress-activated c-Jun N-terminal kinase (JNK) signaling contributes to AF development. This is interesting because JNK is implicated in alcohol-caused organ malfunction beyond the heart. OBJECTIVES: The purpose of this study was to detail how JNK promotes binge alcohol-evoked susceptibility to AF...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29596906/atrial-electrogram-quality-in-single-pass-defibrillator-leads-with-floating-atrial-bipole-in-patients-with-permanent-atrial-fibrillation-and-cardiac-resynchronization-therapy
#11
Christian Sticherling, Dirk Müller, Beat A Schaer, Silke Krüger, Christof Kolb
Many patients receiving cardiac resynchronization therapy (CRT) suffer from permanent atrial fibrillation (AF). Knowledge of the atrial rhythm is important to direct pharmacological or interventional treatment as well as maintaining AV-synchronous biventricular pacing if sinus rhythm can be restored. A single pass single-coil defibrillator lead with a floating atrial bipole has been shown to obtain reliable information about the atrial rhythm but has never been employed in a CRT-system. The purpose of this study was to assess the feasibility of implanting a single coil right ventricular ICD lead with a floating atrial bipole and the signal quality of atrial electrograms (AEGM) in CRT-defibrillator recipients with permanent AF...
March 26, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29581222/device-therapies-among-patients-receiving-primary-prevention-implantable-cardioverter-defibrillators-in-the-cardiovascular-research-network
#12
Robert T Greenlee, Alan S Go, Pamela N Peterson, Andrea E Cassidy-Bushrow, Charles Gaber, Romel Garcia-Montilla, Karen A Glenn, Nigel Gupta, Jerry H Gurwitz, Stephen C Hammill, John J Hayes, Alan Kadish, David J Magid, David D McManus, Deborah Multerer, J David Powers, Liza M Reifler, Kristi Reynolds, Claudio Schuger, Param P Sharma, David H Smith, Mary Suits, Sue Hee Sung, Paul D Varosy, Humberto J Vidaillet, Frederick A Masoudi
BACKGROUND: Primary prevention implantable cardioverter-defibrillators (ICDs) reduce mortality in selected patients with left ventricular systolic dysfunction by delivering therapies (antitachycardia pacing or shocks) to terminate potentially lethal arrhythmias; inappropriate therapies also occur. We assessed device therapies among adults receiving primary prevention ICDs in 7 healthcare systems. METHODS AND RESULTS: We linked medical record data, adjudicated device therapies, and the National Cardiovascular Data Registry ICD Registry...
March 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29579617/benefits-of-left-ventricular-endocardial-pacing-comparing-failed-implants-and-prior-non-responders-to-conventional-cardiac-resynchronization-therapy-a-subanalysis-from-the-alsync-study
#13
Mauro Biffi, Pascal Defaye, Pierre Jaïs, Franco Ruffa, Christophe Leclercq, Daniel Gras, Zhongping Yang, Bart Gerritse, Matteo Ziacchi, John M Morgan
OBJECTIVE: Cardiac resynchronisation therapy (CRT) is limited by a substantial proportion of non-responders. Left ventricular endocardial pacing (LVEP) may offer enhanced possibility to deliver CRT in patients with a failed attempt at implantation and to improve clinical status of CRT non-responders. METHODS: The ALternate Site Cardiac ResYNChronisation (ALSYNC) study was a prospective, multi-centre cohort study that included 118 CRT patients with a successfully implanted endocardial left ventricular (LV) lead, including 90 failed coronary sinus (CS) implants and 28 prior non-responders who had worsened or unchanged heart failure status after at least 6 months of optimal conventional CRT therapy...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29563819/a-case-of-brucella-melitensis-endocarditis-in-a-patient-with-cardiovascular-implantable-electronic-device
#14
Wasl Al-Adsani, Ali Ahmad, Mohammad Al-Mousa
Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Preferred first-line treatment in adults with uncomplicated, nonlocalized disease consists of doxycycline-aminoglycoside combination. The recommended duration of treatment is 6 weeks...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29553490/electrophysiological-assessment-of-murine-atria-with-high-resolution-optical-mapping
#15
Kensuke Ihara, Koji Sugiyama, Kentaro Takahashi, Masahiro Yamazoe, Tetsuo Sasano, Tetsushi Furukawa
Recent genome-wide association studies targeting atrial fibrillation (AF) have indicated a strong association between the genotype and electrophysiological phenotype in the atria. That encourages us to utilize a genetically-engineered mouse model to elucidate the mechanism of AF. However, it is difficult to evaluate the electrophysiological properties in murine atria due to their small size. This protocol describes the electrophysiological evaluation of atria using an optical mapping system with a high temporal and spatial resolution in Langendorff perfused murine hearts...
February 22, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29537317/atrio-ventricular-junction-ablation-and-pacemaker-treatment-a-comparison-between-men-and-women
#16
Carina Carnlöf, Per Insulander, Mats Jensen-Urstad, Marie Iwarzon, Fredrik Gadler
OBJECTIVES: To explore sex differences regarding indication for atrio-ventricular junction ablation (AVJ), choice of pacing system, complications to pacemaker treatment, long-term outcome, and cause of death after AVJ ablation. DESIGN: 700 patients who had undergone AVJ ablation between January 1990 and December 2010 were included. Data were retrieved from the patients´ medical records and the Swedish Pacemaker and Implantable Cardioverter-Defibrillator Registry...
March 14, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29532527/prevalence-of-arrhythmias-and-impact-of-permanent-pacemaker-implantation-in-patients-undergoing-transcatheter-aortic-valve-replacement
#17
Rajkumar Doshi, Dean H Decter, Perwaiz Meraj
BACKGROUND: This study sought to analyze in-hospital outcomes associated with pre-existing and newly implanted Permanent Pacemaker (PPM) in patients who underwent Transcatheter Aortic Valvular Replacement (TAVR). PPM implantation following the development of conduction abnormalities is a common adverse event following TAVR. Furthermore, PPM implantation rates are higher in TAVR patients compared to the surgical alternative, thus we have analyzed the predictors of pacing post-TAVR. METHODS: The study population was identified from the National Inpatient Sample Database between 2012 and 2014...
March 13, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29531385/-the-pacemaker-and-implantable-cardioverter-defibrillator-registry-of-the-italian-association-of-arrhythmology-and-cardiac-pacing-annual-report-2016
#18
Alessandro Proclemer, Massimo Zecchin, Antonio D'Onofrio, Giuseppe Boriani, Domenico Facchin, Luca Rebellato, Marco Ghidina, Giulia Bianco, Emanuela Bernardelli, Elsa Pucher, Dario Gregori
BACKGROUND: The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2016 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers. METHODS: The registry collects prospectively national PM and ICD implantation activity on the basis of European cards...
February 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29526032/par1-contribution-in-acute-electrophysiological-properties-of-oral-anticoagulants-in-rabbit-pulmonary-vein-sleeve-preparations
#19
Jonaz Font, Mathilda Simeon, Christophe Simard, Stéphane Allouche, Anne-Flore Plane, Virginie Ferchaud, Marie Brionne, René Rouet, Marie Nowoczyn, Alain Manrique, Paolo Emilio Puddu, Paul Milliez, Joachim Alexandre
Whether oral anti-coagulants, vitamin K antagonists (VKAs) and non-vitamin K oral anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute rabbit model of superfused pulmonary veins (PVs) sleeves preparations using standard microelectrode technique. Fluindione 10 μmol/L (n = 6) increased the AP (action potential) duration (APD), induced a significantly Vmax depression (from 95±14 to 53±5 V/s, P < 0...
March 11, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29525787/intraoperative-inducibility-of-atrial-fibrillation-does-not-predict-early-postoperative-atrial-fibrillation
#20
Eva A H Lanters, Christophe P Teuwen, Ameeta Yaksh, Charles Kik, Lisette J M E van der Does, Elisabeth M J P Mouws, Paul Knops, Nicole J van Groningen, Thijmen Hokken, Ad J J C Bogers, Natasja M S de Groot
BACKGROUND: Early postoperative atrial fibrillation (EPoAF) is associated with thromboembolic events, prolonged hospitalization, and development of late PoAF (LPoAF). It is, however, unknown if EPoAF can be predicted by intraoperative AF inducibility. The aims of this study are therefore to explore (1) the value of intraoperative inducibility of AF for development of both EPoAF and LPoAF and (2) the predictive value of de novo EPoAF for recurrence of LPoAF. METHODS AND RESULTS: Patients (N=496, 75% male) undergoing cardiothoracic surgery for coronary and/or valvular heart disease were included...
March 10, 2018: Journal of the American Heart Association
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