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Sadanandam colon cancer

Anguraj Sadanandam, Xin Wang, Felipe de Sousa E Melo, Joe W Gray, Louis Vermeulen, Douglas Hanahan, Jan Paul Medema
Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted 5. Given that each ascribed clinical significance, distinctive biology, and therapeutic prognosis to the different subtypes, we sought to reconcile this apparent incongruity in subtype stratification of CRC, and to interrelate the results. To do so, we each evaluated the other's data sets and analytical methods and discovered that the subtypes and their classifiers are, in fact, clearly related to each other; indeed, the 5 subtype outcomes can be coalesced into the same three...
2014: Cell Cycle
Anguraj Sadanandam, Costas A Lyssiotis, Krisztian Homicsko, Eric A Collisson, William J Gibb, Stephan Wullschleger, Liliane C Gonzalez Ostos, William A Lannon, Carsten Grotzinger, Maguy Del Rio, Benoit Lhermitte, Adam B Olshen, Bertram Wiedenmann, Lewis C Cantley, Joe W Gray, Douglas Hanahan
Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six clinically relevant CRC subtypes...
May 2013: Nature Medicine
Jyothi Vantikommu, Sadanandam Palle, Punganuru Surendra Reddy, Vinodkumar Ramanatham, Mukkanti Khagga, Venkateswara Rao Pallapothula
A facile and highly efficient method for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles (β-keto 1,2,3-triazoles) in good to excellent yields from in-situ generated β-ketoazides and terminal alkynes through Cu(I) catalyzed 1,3 dipolar cycloaddition is described. This reaction proceeds smoothly either in water or in a 1:1 mixture of water and acetone at room temperature without use of any additive. The synthesized compounds were screened for their cytotoxicity in A549 (Lung Cancer), HT-29 (Colon Cancer), He La (Cervical Cancer) using MTT assay that exhibited significant cytotoxicity at modest doses...
November 2010: European Journal of Medicinal Chemistry
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