keyword
MENU ▼
Read by QxMD icon Read
search

Colon cancer subtype

keyword
https://www.readbyqxmd.com/read/29731961/macrophages-induce-budding-in-aggressive-human-colon-cancer-subtypes-by-protease-mediated-disruption-of-tight-junctions
#1
Kari Trumpi, Nicola Frenkel, Timo Peters, Nicoline M Korthagen, Jennifer M J Jongen, Daniëlle Raats, Helma van Grevenstein, Yara Backes, Leon M Moons, Miangela M Lacle, Jan Koster, Danny Zwijnenburg, Inne H M Borel Rinkes, Onno Kranenburg
Primary human colorectal tumors with a high stromal content have an increased capacity to metastasize. Cancer-associated fibroblasts (CAFs) promote metastasis, but the contribution of other stromal cell types is unclear. Here we searched for additional stromal cell types that contribute to aggressive tumor cell behavior. By making use of the 'immunome compendium'-a collection of gene signatures reflecting the presence of specific immune cell-types-we show that macrophage signatures are most strongly associated with a high CAF content and with poor prognosis in multiple large cohorts of primary tumors and liver metastases...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29723603/histology-of-colorectal-adenocarcinoma-with-double-somatic-mismatch-repair-mutations-is-indistinguishable-from-those-caused-by-lynch-syndrome
#2
Jessica A Hemminger, Rachel Pearlman, Sigurdis Haraldsdottir, Deborah Knight, Jon Gunnlaugur Jonasson, Colin C Pritchard, Heather Hampel, Wendy L Frankel
Lynch syndrome (LS) is the most common form of hereditary colon cancer (CRC). Germline mutations in the mismatch repair (MMR) genes MLH1, MSH2 (EPCAM), MSH6, and PMS2, followed by a second hit to the remaining allele leads to cancer development. Universal tumor screening for LS is routinely performed on CRC, and screening has identified patients with unexplained MMR deficiency that lack MLH1 methylation and a germline mutation. Tumor sequencing has since identified double somatic (DS) mutations in the MMR gene corresponding with the absent protein in 69% of these patients...
April 30, 2018: Human Pathology
https://www.readbyqxmd.com/read/29702299/diets-that-promote-colon-inflammation-associate-with-risk-of-colorectal-carcinomas-that-contain-fusobacterium-nucleatum
#3
Li Liu, Fred K Tabung, Xuehong Zhang, Jonathan A Nowak, Zhi Rong Qian, Tsuyoshi Hamada, Daniel Nevo, Susan Bullman, Kosuke Mima, Keisuke Kosumi, Annacarolina da Silva, Mingyang Song, Yin Cao, Tyler S Twombly, Yan Shi, Hongli Liu, Mancang Gu, Hideo Koh, Wanwan Li, Chunxia Du, Yang Chen, Chenxi Li, Wenbin Li, Raaj S Mehta, Kana Wu, Molin Wang, Aleksander D Kostic, Marios Giannakis, Wendy S Garrett, Curtis Hutthenhower, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino, Edward L Giovannucci
BACKGROUND & AIMS: Specific nutritional components are likely to induce intestinal inflammation, which is characterized by increased levels of interleukin 6 (IL6), C-reactive protein (CRP), and TNF receptor superfamily member 1B (TNFRSF1B) in the circulation and promotes colorectal carcinogenesis. The inflammatory effects of a diet can be estimated based on empirical dietary inflammatory pattern (EDIP) score, calculated based on intake of 18 foods associated with plasma levels of IL6, CRP, and TNFRSF1B...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29687728/exposure-to-permethrin-and-cancer-risk-a-systematic-review
#4
Paolo Boffetta, Vimi Desai
No systematic reviews are available on data from humans on cancer risk from exposure to permethrin, a widely used insecticide for which some animal studies have reported positive findings based on mechanisms that may not be relevant to humans. We identified potentially relevant articles through a search of electronic databases which included all studies of pesticide exposure and human cancer. A total of 18 articles were selected, including six identified from the list of references of other articles. Most articles were based on analyzes of the Agriculture Health Study (AHS); they provided no evidence of an increased risk of cancers of colon, rectum, pancreas, lung, melanoma, female breast, prostate, urinary bladder, as well as non-Hodgkin lymphoma (including its main subtypes), and leukemia...
April 24, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29678903/adjuvant-therapy-for-colon-cancer-genes-genes-and-the-patient-in-the-center
#5
Javier Rodriguez, Silvestre Vicent, Ana Chopitea, Mariano Ponz-Sarvise
Although molecular subtype-based stratification and genomic signatures of increasing complexity are becoming a new strategy to guide therapeutic decisions in stage II/III colon cancer, several prognostic factors that can be easily obtained from FFPE specimens should be considered in order to create combined models that better define individual patients needs.
April 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29666172/genetic-editing-of-colonic-organoids-provides-a-molecularly-distinct-and-orthotopic-preclinical-model-of-serrated-carcinogenesis
#6
Tamsin R M Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna Gieniec, Miao Yang, Jia Q Ng, Nobumi Suzuki, Mari Ichinose, Josephine A Wright, Hiroki Kobayashi, Tracey L Putoczki, Yoku Hayakawa, Simon J Leedham, Helen E Abud, Ömer H Yilmaz, Julie Marker, Sonja Klebe, Pratyaksha Wirapati, Siddhartha Mukherjee, Sabine Tejpar, Barbara A Leggett, Vicki L J Whitehall, Daniel L Worthley, Susan L Woods
OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF , and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progression and we begin to address this knowledge gap herein...
April 17, 2018: Gut
https://www.readbyqxmd.com/read/29660463/liposomal-cpg-odn-an-in-vitro-and-in-vivo-study-on-macrophage-subtypes-responses-biodistribution-and-subsequent-therapeutic-efficacy-in-mice-models-of-cancers
#7
Sara Nikoofal-Sahlabadi, Maryam Matbou Riahi, Kayvan Sadri, Ali Badiee, Amin Reza Nikpoor, Mahmoud Reza Jaafari
CpG oligodeoxynucleotides (CpG-ODN), a common immune stimulator and vaccine adjuvant, was reported to switch Tumor Associated Macrophages (TAMs) from M2 to M1 phenotype inducing anti-tumor responses. Liposomes are of the successfully applied carriers for CpG-ODN. The aim of present study was design and preparation of a liposomal formulation containing phosphodiester CpG-ODN, evaluation of its effect on macrophages responses, and subsequent antitumor responses in mice. Liposomal formulations containing phosphodiester CpG-ODN or non-CpG-ODN were prepared and characterized...
April 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29616421/analysis-of-the-vascular-interrelationships-among-the-first-jejunal-vein-the-superior-mesenteric-artery-and-the-middle-colic-artery
#8
Atsushi Hamabe, SungAe Park, Shunji Morita, Tsukasa Tanida, Yoshito Tomimaru, Hiroshi Imamura, Keizo Dono
BACKGROUND: The technical difficulty of laparoscopic surgery for transverse colon cancer is partly due to the vascular variability around the middle colic vessels. Although individual variations in the arteries or veins in this area were previously investigated, the vascular interrelationships between these vessels remain unknown. This study was designed to investigate the vascular interrelationships between the arteries and veins around the middle colic vessels and to provide practically useful classifications...
April 3, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29574929/impact-of-histological-subtype-on-the-prognosis-of-patients-undergoing-surgery-for-colon-cancer
#9
Fabio Bagante, Gaya Spolverato, Eliza Beal, Katiuscha Merath, Qinyu Chen, Ozgür Akgül, Robert A Anders, Timothy M Pawlik
BACKGROUND: The effect of the histological subtype on the prognosis of patients undergoing surgery for colon cancer (CC) is not completely understood. METHODS: The Surveillance, Epidemiology, and End Results (SEER) 2004-2014 database was used to compare the long-term outcomes of patients undergoing colon resection for classical adenocarcinoma (CA), mucinous adenocarcinoma (MUC), and signet-cell adenocarcinoma (SC). RESULTS: A total of 153 317 (89%) patients had CA, 16 660 (10%) MUC while 1810 (1%) patients had SC subtype...
March 25, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29567857/targeting-brain-adaptive-cancer-stem-cells-prohibits-brain-metastatic-colonization-of-triple-negative-breast-cancer
#10
Ding Ren, Xiaoping Zhu, Ren Kong, Zhen Zhao, Jianting Sheng, Jiang Wang, Xiaoyun Xu, Jiyong Liu, Kemi Cui, Xiang H-F Zhang, Hong Zhao, Stephen T C Wong
Triple-negative breast cancer (TNBC) exhibits more traits possessed by cancer stem cells (CSC) than other breast cancer subtypes and is more likely to develop brain metastases. TNBC patients usually have shorter survival time after diagnosis of brain metastasis, suggesting an innate ability of TNBC tumor cells in adapting to the brain. In this study, we establish novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived CSC-enriched brain metastasis tumorsphere cells into mice...
April 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29560130/stromal-mir-20a-controls-paracrine-cxcl8-secretion-in-colitis-and-colon-cancer
#11
Steven A Signs, Robert C Fisher, Uyen Tran, Susmita Chakrabarti, Samaneh K Sarvestani, Shao Xiang, David Liska, Veronique Roche, Wei Lai, Haley R Gittleman, Oliver Wessely, Emina H Huang
Inflammatory bowel disease (IBD) affects one million people in the US. Ulcerative colitis (UC) is a subtype of IBD that can lead to colitis-associated cancer (CAC). In UC, the rate of CAC is 3-5-fold greater than the rate of sporadic colorectal cancer (CRC). The pathogenesis of UC and CAC are due to aberrant interactions between host immune system and microenvironment, but precise mechanisms are still unknown. In colitis and CAC, microenvironmental fibroblasts exhibit an activated, inflammatory phenotype that contributes to tumorigenesis accompanied by excessive secretion of the chemokine CXCL8...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29558998/gelidiella-acerosa-inhibits-lung-cancer-proliferation
#12
Fazeela Mahaboob Begum S M, Kalai Chitra, Benin Joseph, Raji Sundararajan, Hemalatha S
BACKGROUND: Lung adenocarcinoma is the most common subtype of Non small cell lung cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression of the PI3K and the frequent inactivation of PTEN accounts for the prolonged survival, evasion of apoptosis and metastasis in cancer. This has led to the development of PI3K inhibitors in the treatment of cancer. Synthetic PI3K inhibitors undergoing clinical and preclinical studies are toxic in animals. Hence, there is a critical need to identify PI3K inhibitor(s) of natural origin...
March 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29477636/preclinical-analysis-of-jaa-f11-a-specific-anti-thomsen-friedenreich-antibody-via-immunohistochemistry-and-in-vivo-imaging
#13
Loukia G Karacosta, John C Fisk, Joseph Jessee, Swetha Tati, Bradley Turner, Diala Ghazal, Rachel Ludwig, Holly Johnson, Julia Adams, Munawwar Sajjad, Steven Koury, Rene Roy, James R Olson, Kate Rittenhouse-Olson
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials...
April 2018: Translational Oncology
https://www.readbyqxmd.com/read/29458272/difference-between-right-sided-and-left-sided-colorectal-cancers-from-embryology-to-molecular-subtype
#14
Seung Yoon Yang, Min Soo Cho, Nam Kyu Kim
Colorectal cancer is one of the most common malignancies in the world, and it exhibits differences in incidence, pathogenesis, molecular pathways, and outcome depending on the location of the tumor. Differences in the microbiome, clinical characteristics, and chromosomal and molecular characteristics have been reported between the right and left side of the colon. Areas covered: This review focuses on the latest developments in epidemiological and chromosomal and molecular studies, which have enhanced our understanding on the underlying genetic and immunological differences between the right-sided colon and the left-sided colorectum in metastatic colorectal cancer...
April 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29456991/estimation-and-projection-of-prevalence-of-colorectal-cancer-in-iran-2015-2020
#15
Hossein Molavi Vardanjani, AliAkbar Haghdoost, Kamran Bagheri-Lankarani, Maryam Hadipour
Background: Population aging and more prevalent westernized lifestyle would be expected to result in a markedly rising burden of colorectal cancer (CRC) in the future years. The aim of this study is to estimate the limited-time prevalence of CRC in Iran between 2015 and 2020. Materials and Methods: Aggregated CRC incidence data were extracted from the Iranian national cancer registry (IR.NCR) reports for 2003-2009 and from GLOBOCAN-2012 database for 2012. Incidence trends were analyzed by age groups, genders, histopathologic, and topographic subtypes to estimate annual percentage changes...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29435051/mutations-in-kras-codon-12-predict-poor-survival-in-chinese-patients-with-metastatic-colorectal-cancer
#16
Bingjun Bai, Lina Shan, Binbin Xie, Xuefeng Huang, Weifang Mao, Xiaowei Wang, Da Wang, Hongbo Zhu
KRAS mutations serve a function in tumorigenesis of colorectal cancer (CRC) and guide the use of targeted drugs. However, the prognostic value of KRAS mutations and their subtypes remain controversial. The present study aimed to investigate the correlations between KRAS mutations and clinicopathological characteristics, and their prognostic significance in Chinese patients with metastatic CRC (mCRC). A total of 135 patients with mCRC were analyzed for KRAS mutations. Mutations in codon 12 and 13 were identified in 45 (33...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29431204/is-it-time-for-a-new-classification-of-mast-cells-what-do-we-know-about-mast-cell-heterogeneity
#17
REVIEW
Barbara Frossi, Francesca Mion, Riccardo Sibilano, Luca Danelli, Carlo E M Pucillo
Mast cells (MCs) are derived from committed precursors that leave the hematopoietic tissue, migrate in the blood, and colonize peripheral tissues where they terminally differentiate under microenvironment stimuli. They are distributed in almost all vascularized tissues where they act both as immune effectors and housekeeping cells, contributing to tissue homeostasis. Historically, MCs were classified into 2 subtypes, according to tryptic enzymes expression. However, MCs display a striking heterogeneity that reflects a complex interplay between different microenvironmental signals delivered by various tissues, and a differentiation program that decides their identity...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29422117/inhibition-of-eukaryotic-initiation-factor-3b-suppresses-cells-proliferation-and-promotes-cells-apoptosis-in-chronic-myeloid-leukemia
#18
Laiquan Huang, Kun He, Jianxin Wang, Jiawei Yan, Yizhi Jiang, Zhongling Wei, Jun Zhang, Guangxi Li, Dongping Huang
Eukaryotic translation initiation factors 3B (eIF3b) is a subtype of the eIF3 category, which has been verified to be over-expressed in colon cancer, bladder, prostate cancers and glioblastoma due to its impact on the cellular activity of cancer cells. However, no related research on exploring the correlation of eIF3b gene expression with cell proliferation and apoptosis in chronic myeloid leukemia (CML) has been conducted until now. Our study showed that the expression of eIF3b mRNA in CML patients was higher compared with nonmalignancy controls...
February 8, 2018: Oncology Research
https://www.readbyqxmd.com/read/29412457/prospective-patient-stratification-into-robust-cancer-cell-intrinsic-subtypes-from-colorectal-cancer-biopsies
#19
Matthew Alderdice, Susan D Richman, Simon Gollins, James P Stewart, Chris Hurt, Richard Adams, Amy Mb McCorry, Aideen C Roddy, Dale Vimalachandran, Claudio Isella, Enzo Medico, Tim Maughan, Darragh G McArt, Mark Lawler, Philip D Dunne
Colorectal cancer (CRC) biopsies underpin accurate diagnosis, but are also relevant for patient stratification in molecularly-guided clinical trials. The consensus molecular subtypes (CMSs) and colorectal cancer intrinsic subtypes (CRISs) transcriptional signatures have potential clinical utility for improving prognostic/predictive patient assignment. However, their ability to provide robust classification, particularly in pretreatment biopsies from multiple regions or at different time points, remains untested...
May 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29399390/ccl3-augments-tumor-rejection-and-enhances-cd8-t-cell-infiltration-through-nk-and-cd103-dendritic-cell-recruitment-via-ifn%C3%AE
#20
Frederick Allen, Iuliana D Bobanga, Peter Rauhe, Deborah Barkauskas, Nathan Teich, Caryn Tong, Jay Myers, Alex Y Huang
Inflammatory chemokines are critical contributors in attracting relevant immune cells to the tumor microenvironment and driving cellular interactions and molecular signaling cascades that dictate the ultimate outcome of host anti-tumor immune response. Therefore, rational application of chemokines in a spatial-temporal dependent manner may constitute an attractive adjuvant in immunotherapeutic approaches against cancer. Existing data suggest that the macrophage inflammatory protein (MIP)-1 family and related proteins, consisting of CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES), can be major determinant of immune cellular infiltration in certain tumors through their direct recruitment of antigen presenting cells, including dendritic cells (DCs) to the tumor site...
2018: Oncoimmunology
keyword
keyword
73969
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"