Evangelia Razis, George Pentheroudakis, George Rigakos, Mattheos Bobos, George Kouvatseas, Olympia Tzaida, Thomas Makatsoris, Pavlos Papakostas, Maria Bai, Anna Goussia, Epaminontas Samantas, Demetrios Papamichael, Ourania Romanidou, Ioannis Efstratiou, Eleftheria Tsolaki, Amanda Psyrri, Wendy De Roock, Dimitrios Bafaloukos, George Klouvas, Sabine Tejpar, Konstantine T Kalogeras, Dimitrios Pectasides, George Fountzilas
INTRODUCTION: Cetuximab is a monoclonal epidermal growth factor receptor (EGFR)-targeting antibody, used in the treatment of colon cancer. KRAS mutation status is strongly predictive of cetuximab efficacy, but more predictive factors are needed for better patient selection. PTEN is a downstream inhibitor of the EGFR pathway and has been evaluated as a predictive factor of cetuximab efficacy in colorectal cancer. PATIENTS AND METHODS: Formalin-fixed paraffin-embedded tumor tissue samples were collected from 226 patients with advanced or metastatic colorectal cancer that had been treated with cetuximab...
May 2014: Journal of Cancer Research and Clinical Oncology