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https://www.readbyqxmd.com/read/28882088/slc7a11-xct-protein-expression-is-not-altered-in-the-depressed-brain-and-system-xc-deficiency-does-not-affect-depression-associated-behaviour-in-the-corticosterone-mouse-model
#1
Thomas Demuyser, Lauren Deneyer, Eduard Bentea, Giulia Albertini, Teresa Femenia, Laura Walrave, Hideyo Sato, Niels C Danbolt, Dimitri De Bundel, Alex Michotte, Maria Lindskog, Ann Massie, Ilse Smolders
OBJECTIVES: The cystine/glutamate antiporter (system xc-) is believed to contribute to nonvesicular glutamate release from glial cells in various brain areas. Although recent investigations implicate system xc- in mood disorders, unambiguous evidence has not yet been established. Therefore, we evaluated the possible role of system xc- in the depressive state. METHODS: We conducted a protein expression analysis of the specific subunit of system xc- (xCT) in brain regions of the corticosterone mouse model, Flinders Sensitive Line rat model and post-mortem tissue of depressed patients...
September 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28842277/olfactory-discrimination-and-memory-deficits-in-the-flinders-sensitive-line-rodent-model-of-depression
#2
A Cook, L-M Pfeiffer, S Thiele, V A Coenen, M D Döbrössy
Major Depressive Disorder (MDD) is a heterogeneous psychiatric disorder with broad symptomatic manifestations. The current study examined, for the first time, olfactory memory and discrimination in the Flinders Sensitive Line (FSL) rodent model of depression. Male FSL rats and controls were trained on an Olfactory Discrimination (OD) and a Social Interaction (SI) test. On the OD test, the FSL and controls performed similarly at the shortest inter-trial interval (5min), however, with extended delay of 30min, the FSLs had a recall and odour discrimination deficit...
October 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28835321/managing-chronic-conditions-care-across-primary-care-and-hospital-systems-lessons-from-an-australian-hospital-avoidance-risk-program-using-the-flinders-chronic-condition-management-program
#3
Sharon Lawn, Sara Zabeen, David Smith, Ellen Wilson, Cathie Miller, Malcolm Battersby, Kevin Masman
Objective The study aimed to determine the impact of the Flinders Chronic Condition Management Program for chronic condition self-management care planning and how to improve its use with Bendigo Health's Hospital Admission Risk Program (HARP).Methods A retrospective analysis of hospital admission data collected by Bendigo Health from July 2012 to September 2013 was undertaken. Length of stay during admission and total contacts post-discharge by hospital staff for 253 patients with 644 admissions were considered as outcome variables...
August 24, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28819456/therapeutic-effect-of-astroglia-like-mesenchymal-stem-cells-expressing-glutamate-transporter-in-a-genetic-rat-model-of-depression
#4
Amit Shwartz, Oshra Betzer, Noam Kronfeld, Gila Kazimirsky, Simona Cazacu, Susan Finniss, Hae Kyung Lee, Menachem Motiei, Shani Yael Dagan, Rachela Popovtzer, Chaya Brodie, Gal Yadid
Recent studies have proposed that abnormal glutamatergic neurotransmission and glial pathology play an important role in the etiology and manifestation of depression. It was postulated that restoration of normal glutamatergic transmission, by enhancing glutamate uptake, may have a beneficial effect on depression. We examined this hypothesis using unique human glial-like mesenchymal stem cells (MSCs), which in addition to inherent properties of migration to regions of injury and secretion of neurotrophic factors, were differentiated to express high levels of functional glutamate transporters (excitatory amino acid transporters; EAAT)...
2017: Theranostics
https://www.readbyqxmd.com/read/28801836/optimization-of-sample-preparation-and-instrumental-parameters-for-the-rapid-analysis-of-drugs-of-abuse-in-hair-samples-by-maldi-ms-ms-imaging
#5
Bryn Flinders, Emma Beasley, Ricky M Verlaan, Eva Cuypers, Simona Francese, Tom Bassindale, Malcolm R Clench, Ron M A Heeren
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) has been employed to rapidly screen longitudinally sectioned drug user hair samples for cocaine and its metabolites using continuous raster imaging. Optimization of the spatial resolution and raster speed were performed on intact cocaine contaminated hair samples. The optimized settings (100 × 150 μm at 0.24 mm/s) were subsequently used to examine longitudinally sectioned drug user hair samples. The MALDI-MS/MS images showed the distribution of the most abundant cocaine product ion at m/z 182...
August 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28771575/zl006-a-small-molecule-inhibitor-of-psd-95-nnos-interaction-does-not-induce-antidepressant-like-effects-in-two-genetically-predisposed-rat-models-of-depression-and-control-animals
#6
Sandra Tillmann, Vitor Silva Pereira, Nico Liebenberg, Anne Karina Christensen, Gregers Wegener
N-methyl-D-aspartate receptor (NMDA-R) antagonists and nitric oxide inhibitors have shown promising efficacy in depression but commonly induce adverse events. To circumvent these, a more indirect disruption of the nitric oxide synthase/postsynaptic density protein 95 kDa complex at the NMDA-R has been proposed. This disruption can be achieved using small molecule inhibitors such as ZL006, which has attracted attention as ischemic stroke therapy in rodents and has been proposed as a potential novel treatment for depression...
2017: PloS One
https://www.readbyqxmd.com/read/28756450/consumer-perspectives-on-myhealth-record-a-review
#7
Yasmin Van Kasteren, Anthony Maeder, Patricia A Williams, Raechel Damarell
The vision for Australia's national electronic health record system included empowering consumers to become active participants in their own health care. This paper aims to critically review the literature on consumer perspectives of Australia's My Health Record (formerly PCEHR). The review is based on a subset of articles (n=12) identified in the Australian EHR Repository (N=143), a repository of metadata of Australian Research on EHR located at Flinders University. Results show low levels of awareness and concerns about sharing records and equity of access for all Australians, which in view of the change from opt in to opt out raises concerns about explicit consent...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28684566/first-complete-genomic-sequence-of-a-rabies-virus-from-the-republic-of-tajikistan-obtained-directly-from-a-flinders-technology-associates-card
#8
H Goharriz, D A Marston, F Sharifzoda, R J Ellis, D L Horton, T Khakimov, A Whatmore, K Khamroev, A N Makhmadshoev, M Bazarov, A R Fooks, A C Banyard
A brain homogenate derived from a rabid dog in the district of Tojikobod, Republic of Tajikistan, was applied to a Flinders Technology Associates (FTA) card. A full-genome sequence of rabies virus (RABV) was generated from the FTA card directly without extraction, demonstrating the utility of these cards for readily obtaining genetic data.
July 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28547179/telomere-length-measurement-by-qpcr-in-birds-is-affected-by-storage-method-of-blood-samples
#9
Sophie Reichert, Hannah Froy, Winnie Boner, Theresa M Burg, Francis Daunt, Robert Gillespie, Kate Griffiths, Sue Lewis, Richard A Phillips, Dan H Nussey, Pat Monaghan
Given the potential role of telomeres as biomarkers of individual health and ageing, there is an increasing interest in studying telomere dynamics in a wider range of taxa in the fields of ecology and evolutionary biology. Measuring telomere length across the lifespan in wild animal systems is essential for testing these hypotheses, and may be aided by archived blood samples collected as part of longitudinal field studies. However, sample collection, storage, and DNA extraction methods may influence telomere length measurement, and it may, therefore, be difficult to balance consistency in sampling protocol with making the most of available samples...
June 2017: Oecologia
https://www.readbyqxmd.com/read/28523505/mass-spectrometry-imaging-of-drugs-of-abuse-in-hair
#10
Bryn Flinders, Eva Cuypers, Tiffany Porta, Emmanuel Varesio, Gérard Hopfgartner, Ron M A Heeren
Hair testing is a powerful tool routinely used for the detection of drugs of abuse. The analysis of hair is highly advantageous as it can provide prolonged drug detectability versus that in biological fluids and chronological information about drug intake based on the average growth of hair. However, current methodology requires large amounts of hair samples and involves complex time-consuming sample preparation followed by gas or liquid chromatography coupled with mass spectrometry. Mass spectrometry imaging is increasingly being used for the analysis of single hair samples, as it provides more accurate and visual chronological information in single hair samples...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28500814/fta-cards-facilitate-storage-shipment-and-detection-of-arboviruses-in-infected-aedes-aegypti-collected-in-adult-mosquito-traps
#11
Sonja Hall-Mendelin, Glen R Hewitson, Doris Genge, Peter J Burtonclay, Amanda J De Jong, Alyssa T Pyke, Andrew F van den Hurk
AbstractThe utility of applying infected Aedes aegypti to Flinders Technology Associates (FTA(®)) cards for storage, transport, and detection of dengue, Zika, and Barmah Forest viruses was assessed in laboratory-based experiments. The mosquitoes had been removed from Gravid Aedes Traps maintained under conditions of high temperature and humidity. RNA of all viruses could be detected in infected mosquitoes on FTA cards either individually or in pools with uninfected mosquitoes, and stored for up to 28 days...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28488309/medical-students-experience-of-performing-female-pelvic-examinations-opportunities-and-barriers
#12
Harsh Bhoopatkar, Andy Wearn, Anna Vnuk
BACKGROUND: Teaching and learning female pelvic examination within the undergraduate medical curriculum offers some potential challenges. One such is the extent to which students are provided practice opportunities with patients in the clinical setting. AIMS: To quantify how many pelvic examinations, on real patients, have been performed by medical students at the point of graduation, and to explore opportunities and barriers to performing these examinations. MATERIALS AND METHODS: A retrospective study using a self-completed, anonymous, electronic survey was developed as part of a multi-centre study...
May 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28468612/the-barriers-and-facilitators-that-indigenous-health-workers-experience-in-their-workplace-and-communities-in-providing-self-management-support-a-multiple-case-study
#13
Jessica Conway, George Tsourtos, Sharon Lawn
BACKGROUND: The inequality in health outcomes between Indigenous (Throughout the paper, the term Indigenous will be used to represent both Aboriginal Australians and Torres Strait Islander Australians.) and non-Indigenous Australians continues to be a major public health issue. Chronic conditions are responsible for the majority of the gap in life expectancy for this population. Evidence suggests that chronic condition management models focusing on self-management have led to improved health outcomes in Indigenous populations...
May 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28453177/validation-of-a-reaction-volume-reduction-protocol-for-analysis-of-y-chromosome-haplotypes-targeting-dna-databases
#14
C A Souza, T C Oliveira, S Crovella, S M Santos, K C N Rabêlo, E P Soriano, M V D Carvalho, A F Caldas Junior, G G Porto, R I C Campello, A A Antunes, R A Queiroz, S M Souza
The use of Y chromosome haplotypes, important for the detection of sexual crimes in forensics, has gained prominence with the use of databases that incorporate these genetic profiles in their system. Here, we optimized and validated an amplification protocol for Y chromosome profile retrieval in reference samples using lesser materials than those in commercial kits. FTA(®) cards (Flinders Technology Associates) were used to support the oral cells of male individuals, which were amplified directly using the SwabSolution reagent (Promega)...
April 28, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28450222/probiotic-treatment-protects-against-the-pro-depressant-like-effect-of-high-fat-diet-in-flinders-sensitive-line-rats
#15
Anders Abildgaard, Betina Elfving, Marianne Hokland, Sten Lund, Gregers Wegener
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that a high-fat diet (HFD) exacerbated depressive-like behaviour uniquely in Flinders Sensitive Line (FSL) rats that inherently present with an increased level of depressive-like behaviour compared with Flinders Resistant Line (FRL) rats. We therefore investigated whether multispecies probiotics possessed anti-depressant-like effect in FSL rats or protected against the pro-depressant-like effect of HFD...
April 25, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28407315/drugs-with-antidepressant-properties-affect-tryptophan-metabolites-differently-in-rodent-models-with-depression-like-behavior
#16
Amanda Eskelund, Yan Li, David P Budac, Heidi K Müller, Maria Gulinello, Connie Sanchez, Gregers Wegener
The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties (vortioxetine, fluoxetine, and ketamine) on various tryptophan metabolites in different brain regions and plasma were examined using tandem mass spectrometry (LC-MS/MS), in Flinders Sensitive Line rats, a genetic rat model of depression, and its controls: Flinders Sensitive Line and Sprague-Dawley rats. Protein levels of kynurenine pathway enzymes were measured in the brains and livers of these rat strains...
July 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28403767/tick-borne-infectious-diseases-in-australia
#17
REVIEW
Stephen R Graves, John Stenos
Tick bites in Australia can lead to a variety of illnesses in patients. These include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and Australian multisystem disorder. Rickettsial (Rickettsia spp.) infections (Queensland tick typhus, Flinders Island spotted fever and Australian spotted fever) and Q fever (Coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in Australia. Three species of local ticks transmit bacterial infection following a tick bite: the paralysis tick (Ixodes holocyclus) is endemic on the east coast of Australia and causes Queensland tick typhus due to R...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28370795/a-pair-of-glasses-and-beyond-impact-of-refractive-error-on-people-s-well-being
#18
Himal Kandel, Jyoti Khadka, Michael Goggin, Konrad Pesudovs
IMPORTANCE: This study qualitative explores the impact of refractive error on adults, particularly after correction. BACKGROUND: The study aimed to explore the impact of refractive error on people's quality of life. DESIGN: Cross sectional; In-depth telephone and face-to-face semi-structured interviews; Qualitative study with inductive and deductive processes PARTICIPANTS: 48 adults with refractive error (including presbyopia) were recruited from the Flinders Vision, the Ashford Advanced Eye Care and among Flinders University staff and students, in South Australia...
March 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28368036/rapid-simple-and-direct-detection-of-meloidogyne-hapla-from-infected-root-galls-using-loop-mediated-isothermal-amplification-combined-with-fta-technology
#19
Huan Peng, Haibo Long, Wenkun Huang, Jing Liu, Jiangkuan Cui, Lingan Kong, Xianqi Hu, Jianfeng Gu, Deliang Peng
The northern root-knot nematode (Meloidogyne hapla) is a damaging nematode that has caused serious economic losses worldwide. In the present study, a sensitive, simple and rapid method was developed for detection of M. hapla in infested plant roots by combining a Flinders Technology Associates (FTA) card with loop-mediated isothermal amplification (LAMP). The specific primers of LAMP were designed based on the distinction of internal transcribed spacer (ITS) sequences between M. hapla and other Meloidogyne spp...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215265/intrinsic-and-extrinsic-predictors-of-video-gaming-behaviour-and-adolescent-bedtimes-the-relationship-between-flow-states-self-perceived-risk-taking-device-accessibility-parental-regulation-of-media-and-bedtime
#20
Lisa J Smith, Michael Gradisar, Daniel L King, Michelle Short
How computer games affect the time at which adolescents go to bed is of growing research interest; however, the intrinsic individual and extrinsic sociocultural factors mediating the relationship between gaming and sleep have received minimal attention. This paper investigates how gaming duration mediates the relationship between intrinsic factors (perception of risky events and flow) and extrinsic factors (parental regulation and media accessibility) and adolescent bedtime. Adolescents (N = 422; age = 16...
February 2017: Sleep Medicine
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