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https://www.readbyqxmd.com/read/27881092/the-relationship-between-in-hospital-location-and-outcomes-of-care-in-patients-diagnosed-with-dementia-and-or-delirium-diagnoses-analysis-of-patient-journey
#1
Lua Perimal-Lewis, Clare Bradley, Paul H Hakendorf, Craig Whitehead, Louise Heuzenroeder, Maria Crotty
BACKGROUND: The discrepancy between the number of admissions and the allocation of hospital beds means that many patients admitted to hospital can be placed in units or wards other than that which specialise in the patient's primary health issue (home-ward). These patients are called 'outlier' patients. Risk factors and health system outcomes of hospital care for 'outlier' patients diagnosed with dementia and/or delirium are unknown. Therefore, the aim of this research was to examine patient journeys of people with dementia and/or delirium diagnoses, to identify risk factors for 'inlier' or 'outlier' status and patient or health system outcomes (consequences) of this status...
November 24, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27819195/long-term-effects-of-pre-pubertal-fluoxetine-on-behaviour-and-monoaminergic-stress-response-in-stress-sensitive-rats
#2
Nico Johan Badenhorst, Linda Brand, Brian Herbert Harvey, Susanna Maria Ellis, Christiaan Beyers Brink
OBJECTIVE: Although prescription rates of antidepressants for children and adolescents have increased, concerns have been raised regarding effects on neurodevelopment and long-term outcome. Using a genetic animal model of depression, this study investigated the long-term effects of pre-pubertal administration of fluoxetine (FLX) on depressive-like behaviour in early adulthood, as well as on central monoaminergic response to an acute stressor. We postulated that pre-pubertal FLX will have lasting effects on animal behaviour and monoaminergic stress responses in early adulthood...
November 7, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27815416/s-ketamine-rapidly-reverses-synaptic-and-vascular-deficits-of-hippocampus-in-genetic-animal-model-of-depression
#3
Maryam Ardalan, Gregers Wegener, Ali H Rafati, Jens R Nyengaard
BACKGROUND: The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce rapid antidepressant effect within hours. In a mechanistic proof-of-this concept, we examined whether ketamine leads to an increase in synaptogenesis and vascularization within 24 hours after a single injection in a genetic rat model of depression. METHODS: Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats were given a single intraperitoneal injection of ketamine (15 mg/kg) or saline...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27773117/comparing-expected-ratios-of-diagnostic-categories-of-thyroid-fine-needle-aspirates-at-flinders-medical-centre-fmc-using-old-reporting-systems-versus-the-new-rcpa-recommended-australasian-system
#4
https://www.readbyqxmd.com/read/27764188/running-opposes-the-effects-of-social-isolation-on-synaptic-plasticity-and-transmission-in-a-rat-model-of-depression
#5
Marta Gómez-Galán, Teresa Femenía, Elin Åberg, Lisette Graae, Ann Van Eeckhaut, Ilse Smolders, Stefan Brené, Maria Lindskog
Stress, such as social isolation, is a well-known risk factor for depression, most probably in combination with predisposing genetic factors. Physical exercise on the other hand, is depicted as a wonder-treatment that makes you healthier, happier and live longer. However, the published results on the effects of exercise are ambiguous, especially when it comes to neuropsychiatric disorders. Here we combine a paradigm of social isolation with a genetic rat model of depression, the Flinders Sensitive Line (FSL), already known to have glutamatergic synaptic alterations...
2016: PloS One
https://www.readbyqxmd.com/read/27754599/swinger-a-user-friendly-computer-program-to-establish-captive-breeding-groups-that-minimize-relatedness-without-pedigree-information
#6
Jonathan Sandoval-Castillo, Catherine R M Attard, Shashikanth Marri, Chris J Brauer, Luciana M Möller, Luciano B Beheregaray
Captive breeding programs are often a necessity for the continued persistence of a population or species. They typically have the goal of maintaining genetic diversity and minimizing inbreeding. However, most captive breeding programs have been based on the assumption that the founding breeders are unrelated and outbred, even though in situ anthropogenic impacts often mean these founders may have high relatedness and substantial inbreeding. In addition, polygamous group-breeding species in captivity often have uncertain pedigrees, making it difficult to select the group composition for subsequent breeding...
October 18, 2016: Molecular Ecology Resources
https://www.readbyqxmd.com/read/27749317/the-%C3%AE-2c-adrenoceptor-antagonist-orm-10921-exerts-antidepressant-like-effects-in-the-flinders-sensitive-line-rat
#7
Madeleine M Uys, Mohammed Shahid, Jukka Sallinen, Brian H Harvey
Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and procognitive properties. However, this has not been demonstrated in a genetic animal model of depression. The role of the α2C-AR in modulating two key depression-related behaviours in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0...
September 30, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27734613/pregnancy-screening-prior-to-chemotherapy-administration
#8
L Hu, G Kichenadasse, H Martin, A Roy, S Sukumaran, S Vatandoust, B Koczwara, C S Karapetis
A retrospective case notes review was performed to determine compliance with screening for undetected pregnancy prior to commencement of chemotherapy at Flinders Medical Centre. All female patients aged 18-55 who commenced chemotherapy between January and December 2014 were included. During the first 12 months, for women identified as having childbearing potential, pre-chemotherapy pregnancy screening was performed only in 40% of patients under 40 years and in 20.5% of the entire age range.
October 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27703478/corrigendum-to-ferritin-as-a-risk-factor-for-glucose-intolerance-amongst-men-and-women-originating-from-the-indian-subcontinent
#9
Jeetesh V Patel, Paramjit S Gill, Julia Chackathayil, Elif S Agaoglu, Zosia Bredow, Rebecca Mirrielees, Paul Flinders, Elizabeth A Hughes
[This corrects the article DOI: 10.1155/2015/924387.].
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27695727/urban-general-practice-and-medical-education-academic-outcomes-from-a-unique-urban-longitudinal-integrated-community-based-program
#10
Sarah Mahoney, Paul Worley, Helen Parry, Sally Clarke
BACKGROUND: In 2009, Flinders University established an urban, community-based, longitudinal integrated program providing medical students extended placements that offered continuities of patient care, clinical supervision and peer group. OBJECTIVE: The aim of this research was to analyse academic outcomes of the new placement program. METHODS: The results of all students undertaking Year 3 exams from 2011 to 2014 were collected and analysed...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27692010/exploring-a-post-traumatic-stress-disorder-paradigm-in-flinders-sensitive-line-rats-to-model-treatment-resistant-depression-ii-response-to-antidepressant-augmentation-strategies
#11
Sarel Jacobus Brand, Brian Herbert Harvey
OBJECTIVE: Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model of TRD and an abrogated response to imipramine. We extended the investigation by studying the behavioural and monoaminergic response to multiple antidepressants, viz. venlafaxine and ketamine with/without imipramine. METHODS: Male Flinders sensitive line (FSL) rats, a genetic model of depression, were exposed to a time-dependent sensitisation (TDS) model of PTSD and compared with stress naive controls...
October 3, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27650574/norharmane-matrix-enhances-detection-of-endotoxin-by-maldi-ms-for-simultaneous-profiling-of-pathogen-host-and-vector-systems
#12
Alison J Scott, Bryn Flinders, Joanna Cappell, Tao Liang, Rebecca S Pelc, Bao Tran, David P A Kilgour, Ron M A Heeren, David R Goodlett, Robert K Ernst
The discovery of novel pathogenic mechanisms engaged during bacterial infections requires the evolution of advanced techniques. Here, we evaluate the dual polarity matrix norharmane (NRM) to improve detection of bacterial lipid A (endotoxin), from host and vector tissues infected with Francisella novicida (Fn). We evaluated NRM for improved detection and characterization of a wide range of lipids in both positive and negative polarities, including lipid A and phospholipids across a range of matrix assisted laser desorption-ionization (MALDI)-coupled applications...
September 19, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27605523/emergency-psychiatry-a-product-of-circumstance-or-a-growing-sub-speciality-field
#13
Paul Cammell
OBJECTIVES: This article reviews recent trends in the provision of psychiatric services to the emergency departments of tertiary hospitals in Australia, involving the establishment of specialised in-reach or liaison services as well as various forms of short stay unit attached to emergency departments. The Emergency Psychiatry Service at Flinders Medical Centre, South Australia, is described as a case example. Its specialised models of assessment and clinical care are described, highlighting how these are differentiated from more traditional models in inpatient, community and general hospital consultation-liaison psychiatry...
September 6, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27589698/gene-expression-related-to-serotonergic-and-glutamatergic-neurotransmission-is-altered-in-the-flinders-sensitive-line-rat-model-of-depression-effect-of-ketamine
#14
Kristian Gaarn Du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfving
Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these systems relatively to their control strain Flinders Resistant Line (FRL). However, changes on transcript level related to serotonergic and glutamatergic signaling have only been sparsely studied in this model. The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has fast-onset antidepressant properties, and recent data implicate serotonergic neurotransmission in ketamine's antidepressant-like activities in rodents...
September 2, 2016: Synapse
https://www.readbyqxmd.com/read/27573792/exploring-a-post-traumatic-stress-disorder-paradigm-in-flinders-sensitive-line-rats-to-model-treatment-resistant-depression-i-bio-behavioural-validation-and-response-to-imipramine
#15
Sarel Jacobus Brand, Brian Herbert Harvey
OBJECTIVE: Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to produce an animal with more severe as well as treatment-resistant depressive-like behaviours. METHODS: Male Flinders sensitive line (FSL) rats, a genetic animal model of depression, were exposed to a stress re-stress model of PTSD [time-dependent sensitisation (TDS)] and compared with stress-naive controls...
August 30, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27544829/comparing-and-contrasting-therapeutic-effects-of-cognitive-behavior-therapy-for-older-adults-suffering-from-insomnia-with-short-and-long-objective-sleep-duration
#16
Nicole Lovato, Leon Lack, David J Kennaway
STUDY OBJECTIVES: This study evaluated the efficacy of a brief group-based program of cognitive-behavior therapy for insomnia (CBTi) for older adults suffering from chronic insomnia with short objective sleep relative to those with long sleep duration. METHOD: Ninety-one adults (male = 43, mean age = 63.34, standard deviation (SD) = 6.41) with sleep maintenance insomnia were selected from a community-based sample. The participants were classified as short sleepers (SS; <6 h total sleep time) or long sleepers (LS; ≥6 h total sleep time) based on one night of home-based polysomnography...
June 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27529677/elevation-of-il6-is-associated-with-disturbed-let-7-biogenesis-in-a-genetic-model-of-depression
#17
Y B Wei, J J Liu, J C Villaescusa, E Åberg, S Brené, G Wegener, A A Mathé, C Lavebratt
Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcriptionally. The lethal-7 (let-7) miRNA family was suggested to be involved in the inflammation process and IL-6 was shown to be one of its targets. In the present study, we report elevation of Il6 in the prefrontal cortex (PFC) of a genetic rat model of depression, the Flinders Sensitive Line (FSL) compared to the control Flinders Resistant Line...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27515015/groundwater-flow-and-geochemical-evolution-in-the-central-flinders-ranges-south-australia
#18
Alaa Ahmed, Ian Clark
The chemical characteristics of water in the Oratunga Area, Central Flinders Ranges, South Australia have been used to evaluate and determine the processes controlling water chemistry in addition to the sources of ions. The isotopic analysis results show that the groundwater is mainly meteoric. Based on the rock and water chemistry, ionic ratios, hydrochemical facies and saturation indices, the chemical evolution has been studied. The chemistry of groundwater revealed two types of water. Thus, in high topographic areas, low TDS, bicarbonate and mixed water types are dominated and support a rapid and direct recharge...
August 8, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27507301/microrna-101b-is-downregulated-in-the-prefrontal-cortex-of-a-genetic-model-of-depression-and-targets-the-glutamate-transporter-slc1a1-eaat3-in-vitro
#19
Ya Bin Wei, Philippe A Melas, J Carlos Villaescusa, Jia Jia Liu, Ning Xu, Søren Hofman Christiansen, Heidi Elbrønd-Bek, David Paul Drucker Woldbye, Gregers Wegener, Aleksander A Mathé, Catharina Lavebratt
BACKGROUND: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the pathophysiology and treatment of neuropsychiatric disorders, including major depressive disorder (MDD). METHODS: A miRNA expression assay that can simultaneously detect 423 rat miRNAs (miRBase v.17) was used to profile the prefrontal cortex (PFC) of a genetic rat model of MDD (the Flinders Sensitive Line [FSL]) and the controls, the Flinders Resistant Line (FRL)...
September 30, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27450570/predicting-success-in-medical-school-a-longitudinal-study-of-common-australian-student-selection-tools
#20
Ruth M Sladek, Malcolm J Bond, Linda K Frost, Kirsty N Prior
BACKGROUND: Medical student selection and assessment share an underlying high stakes context with the need for valid and reliable tools. This study examined the predictive validity of three tools commonly used in Australia: previous academic performance (Grade Point Average (GPA)), cognitive aptitude (a national admissions test), and non-academic qualities of prospective medical students (interview). METHODS: A four year retrospective cohort study was conducted at Flinders University Australia involving 382 graduate entry medical students first enrolled between 2006 and 2009...
2016: BMC Medical Education
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