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https://www.readbyqxmd.com/read/28523505/mass-spectrometry-imaging-of-drugs-of-abuse-in-hair
#1
Bryn Flinders, Eva Cuypers, Tiffany Porta, Emmanuel Varesio, Gérard Hopfgartner, Ron M A Heeren
Hair testing is a powerful tool routinely used for the detection of drugs of abuse. The analysis of hair is highly advantageous as it can provide prolonged drug detectability versus that in biological fluids and chronological information about drug intake based on the average growth of hair. However, current methodology requires large amounts of hair samples and involves complex time-consuming sample preparation followed by gas or liquid chromatography coupled with mass spectrometry. Mass spectrometry imaging is increasingly being used for the analysis of single hair samples, as it provides more accurate and visual chronological information in single hair samples...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28500814/fta-cards-facilitate-storage-shipment-and-detection-of-arboviruses-in-infected-aedes-aegypti-collected-in-adult-mosquito-traps
#2
Sonja Hall-Mendelin, Glen R Hewitson, Doris Genge, Peter J Burtonclay, Amanda J De Jong, Alyssa T Pyke, Andrew F van den Hurk
AbstractThe utility of applying infected Aedes aegypti to Flinders Technology Associates (FTA(®)) cards for storage, transport, and detection of dengue, Zika, and Barmah Forest viruses was assessed in laboratory-based experiments. The mosquitoes had been removed from Gravid Aedes Traps maintained under conditions of high temperature and humidity. RNA of all viruses could be detected in infected mosquitoes on FTA cards either individually or in pools with uninfected mosquitoes, and stored for up to 28 days...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28488309/medical-students-experience-of-performing-female-pelvic-examinations-opportunities-and-barriers
#3
Harsh Bhoopatkar, Andy Wearn, Anna Vnuk
BACKGROUND: Teaching and learning female pelvic examination within the undergraduate medical curriculum offers some potential challenges. One such is the extent to which students are provided practice opportunities with patients in the clinical setting. AIMS: To quantify how many pelvic examinations, on real patients, have been performed by medical students at the point of graduation, and to explore opportunities and barriers to performing these examinations. MATERIALS AND METHODS: A retrospective study using a self-completed, anonymous, electronic survey was developed as part of a multi-centre study...
May 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28468612/the-barriers-and-facilitators-that-indigenous-health-workers-experience-in-their-workplace-and-communities-in-providing-self-management-support-a-multiple-case-study
#4
Jessica Conway, George Tsourtos, Sharon Lawn
BACKGROUND: The inequality in health outcomes between Indigenous (Throughout the paper, the term Indigenous will be used to represent both Aboriginal Australians and Torres Strait Islander Australians.) and non-Indigenous Australians continues to be a major public health issue. Chronic conditions are responsible for the majority of the gap in life expectancy for this population. Evidence suggests that chronic condition management models focusing on self-management have led to improved health outcomes in Indigenous populations...
May 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28453177/validation-of-a-reaction-volume-reduction-protocol-for-analysis-of-y-chromosome-haplotypes-targeting-dna-databases
#5
C A Souza, T C Oliveira, S Crovella, S M Santos, K C N Rabêlo, E P Soriano, M V D Carvalho, A F Caldas Junior, G G Porto, R I C Campello, A A Antunes, R A Queiroz, S M Souza
The use of Y chromosome haplotypes, important for the detection of sexual crimes in forensics, has gained prominence with the use of databases that incorporate these genetic profiles in their system. Here, we optimized and validated an amplification protocol for Y chromosome profile retrieval in reference samples using lesser materials than those in commercial kits. FTA(®) cards (Flinders Technology Associates) were used to support the oral cells of male individuals, which were amplified directly using the SwabSolution reagent (Promega)...
April 28, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28450222/probiotic-treatment-protects-against-the-pro-depressant-like-effect-of-high-fat-diet-in-flinders-sensitive-line-rats
#6
Anders Abildgaard, Betina Elfving, Marianne Hokland, Sten Lund, Gregers Wegener
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that a high-fat diet (HFD) exacerbated depressive-like behaviour uniquely in Flinders Sensitive Line (FSL) rats that inherently present with an increased level of depressive-like behaviour compared with Flinders Resistant Line (FRL) rats. We therefore investigated whether multispecies probiotics possessed anti-depressant-like effect in FSL rats or protected against the pro-depressant-like effect of HFD...
April 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28407315/drugs-with-antidepressant-properties-affect-tryptophan-metabolites-differently-in-rodent-models-with-depression-like-behavior
#7
Amanda Eskelund, Yan Li, David P Budac, Heidi K Müller, Gulinello Maria, Connie Sanchez, Gregers Wegener
The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties (vortioxetine, fluoxetine and ketamine) on various tryptophan metabolites in different brain regions and plasma were examined using tandem mass spectrometry (LC-MS/MS), in Flinders Sensitive Line (FSL) rats, a genetic rat model of depression, and its controls: Flinders Resistant Line (FRL) and Sprague-Dawley (SD) rats. Protein levels of kynurenine pathway enzymes were measured in the brains and livers of these rat strains...
April 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28403767/tick-borne-infectious-diseases-in-australia
#8
REVIEW
Stephen R Graves, John Stenos
Tick bites in Australia can lead to a variety of illnesses in patients. These include infection, allergies, paralysis, autoimmune disease, post-infection fatigue and Australian multisystem disorder. Rickettsial (Rickettsia spp.) infections (Queensland tick typhus, Flinders Island spotted fever and Australian spotted fever) and Q fever (Coxiella burnetii) are the only systemic bacterial infections that are known to be transmitted by tick bites in Australia. Three species of local ticks transmit bacterial infection following a tick bite: the paralysis tick (Ixodes holocyclus) is endemic on the east coast of Australia and causes Queensland tick typhus due to R...
April 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28370795/a-pair-of-glasses-and-beyond-impact-of-refractive-error-on-people-s-well-being
#9
Himal Kandel, Jyoti Khadka, Michael Goggin, Konrad Pesudovs
IMPORTANCE: This study qualitative explores the impact of refractive error on adults, particularly after correction. BACKGROUND: The study aimed to explore the impact of refractive error on people's quality of life. DESIGN: Cross sectional; In-depth telephone and face-to-face semi-structured interviews; Qualitative study with inductive and deductive processes PARTICIPANTS: 48 adults with refractive error (including presbyopia) were recruited from the Flinders Vision, the Ashford Advanced Eye Care and among Flinders University staff and students, in South Australia...
March 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28368036/rapid-simple-and-direct-detection-of-meloidogyne-hapla-from-infected-root-galls-using-loop-mediated-isothermal-amplification-combined-with-fta-technology
#10
Huan Peng, Haibo Long, Wenkun Huang, Jing Liu, Jiangkuan Cui, Lingan Kong, Xianqi Hu, Jianfeng Gu, Deliang Peng
The northern root-knot nematode (Meloidogyne hapla) is a damaging nematode that has caused serious economic losses worldwide. In the present study, a sensitive, simple and rapid method was developed for detection of M. hapla in infested plant roots by combining a Flinders Technology Associates (FTA) card with loop-mediated isothermal amplification (LAMP). The specific primers of LAMP were designed based on the distinction of internal transcribed spacer (ITS) sequences between M. hapla and other Meloidogyne spp...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215265/intrinsic-and-extrinsic-predictors-of-video-gaming-behaviour-and-adolescent-bedtimes-the-relationship-between-flow-states-self-perceived-risk-taking-device-accessibility-parental-regulation-of-media-and-bedtime
#11
Lisa J Smith, Michael Gradisar, Daniel L King, Michelle Short
How computer games affect the time at which adolescents go to bed is of growing research interest; however, the intrinsic individual and extrinsic sociocultural factors mediating the relationship between gaming and sleep have received minimal attention. This paper investigates how gaming duration mediates the relationship between intrinsic factors (perception of risky events and flow) and extrinsic factors (parental regulation and media accessibility) and adolescent bedtime. Adolescents (N = 422; age = 16...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215232/validation-of-the-flinders-fatigue-scale-as-a-measure-of-daytime-fatigue
#12
Kate Cameron, Paul Williamson, Michelle A Short, Michael Gradisar
STUDY OBJECTIVES: To clinically validate the Flinders Fatigue Scale (FFS) as a brief measure of daytime fatigue, and to derive cut-off scores to classify fatigue severity. METHOD: The FFS was administered to 439 adult volunteers from the general population, 292 adults with insomnia, 132 adults with Obstructive Sleep Apnoea (OSA) and 66 adults with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), together with the Fatigue Severity Scale (FSS) and the Epworth Sleepiness Scale (ESS)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28193015/derivatization-strategies-for-the-detection-of-triamcinolone-acetonide-in-cartilage-by-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#13
Florian P Y Barré, Bryn Flinders, João P Garcia, Imke Jansen, Lennart R S Huizing, Tiffany Porta, Laura B Creemers, Ron M A Heeren, Berta Cillero-Pastor
Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular administered triamcinolone acetonide (TAA) is one of the drug treatments employed to ameliorate the inflammation and pain that characterizes OA. However, the penetration and distribution of TAA into the avascular cartilage is not well understood...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28145488/targeted-capture-to-assess-neutral-genomic-variation-in-the-narrow-leaf-hopbush-across-a-continental-biodiversity-refugium
#14
Matthew J Christmas, Ed Biffin, Martin F Breed, Andrew J Lowe
The Adelaide geosyncline, a mountainous region in central southern Australia, is purported to be an important continental refugium for Mediterranean and semi-arid Australian biota, yet few population genetic studies have been conducted to test this theory. Here, we focus on a plant species distributed widely throughout the region, the narrow-leaf hopbush, Dodonaea viscosa ssp. angustissima, and examine its genetic diversity and population structure. We used a hybrid-capture target enrichment technique to selectively sequence over 700 genes from 89 individuals across 17 sampling locations...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28143768/long-lasting-effects-of-fluoxetine-and-or-exercise-augmentation-on-bio-behavioural-markers-of-depression-in-pre-pubertal-stress-sensitive-rats
#15
Jacobus C Schoeman, Stephanus F Steyn, Brian H Harvey, Christiaan B Brink
Juvenile depression is of great concern with only limited treatment currently approved. Delayed onset of action, low remission and high relapse rates, and potential long-lasting consequences further complicates treatment and highlights the need for new treatment options. Studies reporting on long-lasting effects of early-life treatment have reported conflicting results, with the pre-adolescent period mostly overlooked. The anti-depressive effect of exercise, as a possible treatment option or augmentation strategy, is dependent on age and exercise intensity...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28087979/rapid-antidepressant-effect-of-ketamine-correlates-with-astroglial-plasticity-in-the-hippocampus
#16
Maryam Ardalan, Ali H Rafati, Jens R Nyengaard, Gregers Wegener
BACKGROUND AND PURPOSE: Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant action of ketamine is reflected in a rapid alteration of the astrocytes' morphology in a genetic animal model of depression. EXPERIMENTAL APPROACH: S-Ketamine (15 mg·kg(-1) ) or saline was administered as a single injection to Flinders Line (FSL/ FRL) rats...
March 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28076747/a-preliminary-investigation-of-the-partners-in-health-scale-measurement-properties-in-patients-with-end-stage-renal-disease
#17
Claire Baxter, Andrea Morello, David Smith, Lynda Norton, David Bentley
End-stage renal disease (ESRD) is becoming more prevalent in Australia. As a result, strategies to improve quality of life when living with ESRD are becoming increasingly important. The Flinders Program has been developed to help support and increase the self-management capacity of people living with chronic disease. The Partners in Health (PIH) scale is a self-management capacity assessment tool, which is an integral element of the Flinders Program. The primary aim of this study was to investigate the preliminary measurement properties of the PIH scale within the ESRD population...
January 12, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28073899/paper-based-microrna-expression-profiling-from-plasma-and-circulating-tumor-cells
#18
Sai Mun Leong, Karen Mei-Ling Tan, Hui Wen Chua, Mo-Chao Huang, Wai Chye Cheong, Mo-Huang Li, Steven Tucker, Evelyn Siew-Chuan Koay
BACKGROUND: Molecular characterization of circulating tumor cells (CTCs) holds great promise for monitoring metastatic progression and characterizing metastatic disease. However, leukocyte and red blood cell contamination of routinely isolated CTCs makes CTC-specific molecular characterization extremely challenging. METHODS: Here we report the use of a paper-based medium for efficient extraction of microRNAs (miRNAs) from limited amounts of biological samples such as rare CTCs harvested from cancer patient blood...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27981150/raising-the-awareness-of-undergraduate-nurses-to-the-psychosocial-impact-of-living-with-cancer-a-consumer-engagement-in-teaching-initiative
#19
Lana Zannettino, Jan Thompson, Julie Marker, Stephanie Agius
This article reflects on the development and implementation of a consumer engagement in teaching initiative by the authors. The authors highlight the challenges of engaging undergraduate nursing students on the psychosocial aspects of living with cancer and other chronic illnesses when students have very limited personal and professional experiences to draw on. The authors discuss how they have responded to these challenges by integrating the voices of consumers into their classrooms. Speakers from consumer advocacy organization, Cancer Voices SA, participated in a series of tutorials in a 1(st) year topic in the Undergraduate Nursing Program at the School of Nursing and Midwifery, Flinders University...
April 2016: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27881092/the-relationship-between-in-hospital-location-and-outcomes-of-care-in-patients-diagnosed-with-dementia-and-or-delirium-diagnoses-analysis-of-patient-journey
#20
Lua Perimal-Lewis, Clare Bradley, Paul H Hakendorf, Craig Whitehead, Louise Heuzenroeder, Maria Crotty
BACKGROUND: The discrepancy between the number of admissions and the allocation of hospital beds means that many patients admitted to hospital can be placed in units or wards other than that which specialise in the patient's primary health issue (home-ward). These patients are called 'outlier' patients. Risk factors and health system outcomes of hospital care for 'outlier' patients diagnosed with dementia and/or delirium are unknown. Therefore, the aim of this research was to examine patient journeys of people with dementia and/or delirium diagnoses, to identify risk factors for 'inlier' or 'outlier' status and patient or health system outcomes (consequences) of this status...
November 24, 2016: BMC Geriatrics
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