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Madeleine M Uys, Mohammed Shahid, Jukka Sallinen, Brian H Harvey
Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and procognitive properties. However, this has not been demonstrated in a genetic animal model of depression. The role of the α2C-AR in modulating two key depression-related behaviours in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0...
September 30, 2016: Behavioural Pharmacology
L Hu, G Kichenadasse, H Martin, A Roy, S Sukumaran, S Vatandoust, B Koczwara, C S Karapetis
A retrospective case notes review was performed to determine compliance with screening for undetected pregnancy prior to commencement of chemotherapy at Flinders Medical Centre. All female patients aged 18-55 who commenced chemotherapy between January and December 2014 were included. During the first 12 months, for women identified as having childbearing potential, pre-chemotherapy pregnancy screening was performed only in 40% of patients under 40 years and in 20.5% of the entire age range.
October 2016: Internal Medicine Journal
Jeetesh V Patel, Paramjit S Gill, Julia Chackathayil, Elif S Agaoglu, Zosia Bredow, Rebecca Mirrielees, Paul Flinders, Elizabeth A Hughes
[This corrects the article DOI: 10.1155/2015/924387.].
2016: International Journal of Endocrinology
Sarah Mahoney, Paul Worley, Helen Parry, Sally Clarke
BACKGROUND: In 2009, Flinders University established an urban, community-based, longitudinal integrated program providing medical students extended placements that offered continuities of patient care, clinical supervision and peer group. OBJECTIVE: The aim of this research was to analyse academic outcomes of the new placement program. METHODS: The results of all students undertaking Year 3 exams from 2011 to 2014 were collected and analysed...
October 2016: Australian Family Physician
Sarel Jacobus Brand, Brian Herbert Harvey
OBJECTIVE: Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model of TRD and an abrogated response to imipramine. We extended the investigation by studying the behavioural and monoaminergic response to multiple antidepressants, viz. venlafaxine and ketamine with/without imipramine. METHODS: Male Flinders sensitive line (FSL) rats, a genetic model of depression, were exposed to a time-dependent sensitisation (TDS) model of PTSD and compared with stress naive controls...
October 3, 2016: Acta Neuropsychiatrica
Alison J Scott, Bryn Flinders, Joanna Cappell, Tao Liang, Rebecca S Pelc, Bao Tran, David P A Kilgour, Ron M A Heeren, David R Goodlett, Robert K Ernst
The discovery of novel pathogenic mechanisms engaged during bacterial infections requires the evolution of advanced techniques. Here, we evaluate the dual polarity matrix norharmane (NRM) to improve detection of bacterial lipid A (endotoxin), from host and vector tissues infected with Francisella novicida (Fn). We evaluated NRM for improved detection and characterization of a wide range of lipids in both positive and negative polarities, including lipid A and phospholipids across a range of matrix assisted laser desorption-ionization (MALDI)-coupled applications...
September 19, 2016: Pathogens and Disease
Paul Cammell
OBJECTIVES: This article reviews recent trends in the provision of psychiatric services to the emergency departments of tertiary hospitals in Australia, involving the establishment of specialised in-reach or liaison services as well as various forms of short stay unit attached to emergency departments. The Emergency Psychiatry Service at Flinders Medical Centre, South Australia, is described as a case example. Its specialised models of assessment and clinical care are described, highlighting how these are differentiated from more traditional models in inpatient, community and general hospital consultation-liaison psychiatry...
September 6, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfving
Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these systems relatively to their control strain Flinders Resistant Line (FRL). However, changes on transcript level related to serotonergic and glutamatergic signaling have only been sparsely studied in this model. The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has fast-onset antidepressant properties, and recent data implicate serotonergic neurotransmission in ketamine's antidepressant-like activities in rodents...
September 2, 2016: Synapse
Sarel Jacobus Brand, Brian Herbert Harvey
OBJECTIVE: Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to produce an animal with more severe as well as treatment-resistant depressive-like behaviours. METHODS: Male Flinders sensitive line (FSL) rats, a genetic animal model of depression, were exposed to a stress re-stress model of PTSD [time-dependent sensitisation (TDS)] and compared with stress-naive controls...
August 30, 2016: Acta Neuropsychiatrica
Nicole Lovato, Leon Lack, David J Kennaway
STUDY OBJECTIVES: This study evaluated the efficacy of a brief group-based program of cognitive-behavior therapy for insomnia (CBTi) for older adults suffering from chronic insomnia with short objective sleep relative to those with long sleep duration. METHOD: Ninety-one adults (male = 43, mean age = 63.34, standard deviation (SD) = 6.41) with sleep maintenance insomnia were selected from a community-based sample. The participants were classified as short sleepers (SS; <6 h total sleep time) or long sleepers (LS; ≥6 h total sleep time) based on one night of home-based polysomnography...
June 2016: Sleep Medicine
Y B Wei, J J Liu, J C Villaescusa, E Åberg, S Brené, G Wegener, A A Mathé, C Lavebratt
Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcriptionally. The lethal-7 (let-7) miRNA family was suggested to be involved in the inflammation process and IL-6 was shown to be one of its targets. In the present study, we report elevation of Il6 in the prefrontal cortex (PFC) of a genetic rat model of depression, the Flinders Sensitive Line (FSL) compared to the control Flinders Resistant Line...
2016: Translational Psychiatry
Alaa Ahmed, Ian Clark
The chemical characteristics of water in the Oratunga Area, Central Flinders Ranges, South Australia have been used to evaluate and determine the processes controlling water chemistry in addition to the sources of ions. The isotopic analysis results show that the groundwater is mainly meteoric. Based on the rock and water chemistry, ionic ratios, hydrochemical facies and saturation indices, the chemical evolution has been studied. The chemistry of groundwater revealed two types of water. Thus, in high topographic areas, low TDS, bicarbonate and mixed water types are dominated and support a rapid and direct recharge...
August 8, 2016: Science of the Total Environment
Ya Bin Wei, Philippe A Melas, J Carlos Villaescusa, Jia Jia Liu, Ning Xu, Søren Hofman Christiansen, Heidi Elbrønd-Bek, David Paul Drucker Woldbye, Gregers Wegener, Aleksander A Mathé, Catharina Lavebratt
BACKGROUND: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the pathophysiology and treatment of neuropsychiatric disorders, including major depressive disorder (MDD). METHODS: A miRNA expression assay that can simultaneously detect 423 rat miRNAs (miRBase v.17) was used to profile the prefrontal cortex (PFC) of a genetic rat model of MDD (the Flinders Sensitive Line [FSL]) and the controls, the Flinders Resistant Line (FRL)...
September 30, 2016: International Journal of Neuropsychopharmacology
Ruth M Sladek, Malcolm J Bond, Linda K Frost, Kirsty N Prior
BACKGROUND: Medical student selection and assessment share an underlying high stakes context with the need for valid and reliable tools. This study examined the predictive validity of three tools commonly used in Australia: previous academic performance (Grade Point Average (GPA)), cognitive aptitude (a national admissions test), and non-academic qualities of prospective medical students (interview). METHODS: A four year retrospective cohort study was conducted at Flinders University Australia involving 382 graduate entry medical students first enrolled between 2006 and 2009...
2016: BMC Medical Education
Maryam Ardalan, Gregers Wegener, Benedetta Polsinelli, Torsten M Madsen, Jens R Nyengaard
Glutamatergic system and the structural plasticity hypothesis are principal components for rapid and sustained antidepressant effects of novel antidepressant therapeutics. This study represents the first investigation of the structural plasticity of the hippocampus as one of the main contributed mechanisms to the sustained anti-depressive effect of ketamine. Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats were given a single intraperitoneal injection of ketamine (15 mg/kg) or saline 7 days before perfusion-fixed...
July 11, 2016: Hippocampus
Xi-Cong Liu, Sophie Erhardt, Michel Goiny, Göran Engberg, Aleksander A Mathé
OBJECTIVE: There is a growing interest in the role of kynurenine pathway and tryptophan metabolites in the pathophysiology of depression. In the present study, the metabolism of tryptophan along the kynurenine pathway was analysed in a rat model of depression. METHODS: Kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were measured by high-performance liquid chromatography (HPLC) in prefrontal cortex (PFC) and frontal cortex (FC) in a rat model of depression, the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL) rats...
July 13, 2016: Acta Neuropsychiatrica
Robert W Taylor, Gary D Alpert
The 28 known species of Metapone are monographed and illustrated. Twelve are described as new: M. africana, Gabon; M. balinensis, Bali, Indonesia; M. enigmatica, northeast New Guinea; M. hoelldobleri, northeast Queensland, Australia; M. javana, Java, Indonesia; M. manni, Viti Levu, Fiji; M. mathinnae, Flinders Island, Tasmania, Australia; M. philwardi, northeast New Guinea; M. salomonis, Guadalcanal, Solomon Islands; M. tecklini, northeast Queensland; M. titan, New Ireland, Papua New Guinea; M. wallaceana, Lombok, Indonesia; spp...
2016: Zootaxa
Amy Hsin-Chieh Hsieh, Ganessan Kichenadasse, Sina Vatandoust, Amitesh Roy, Shawgi Sukumaran, Christos S Karapetis, Helen Martin, Li Chia Chong, Bogda Koczwara
BACKGROUND: Goserelin, a form of medical ovarian suppression (MOS), is an effective treatment for premenopausal women with breast cancer (PMBC). Meta-analysis data showed that similar efficacy is achieved with MOS and non-pharmacological ovarian suppression (NPOS) - oophorectomy or ovarian irradiation. Acceptance rate of NPOS remains low. AIMS: This study explored the reported toxicities of PMBC women and their preferred ovarian suppression method whilst on goserelin...
July 8, 2016: Internal Medicine Journal
Bart A Ellenbroek, Francesco Angelucci, Henriette Husum, Aleksander A Mathé
Although the etiology of major psychiatric disorders has not been elucidated, accumulating evidence indicates that both genetic and early environmental factors play a role. We have previously demonstrated behavioral and neurochemical changes both in non-manipulated genetic rat models of depression, such as Flinders Sensitive Line (FSL) and Fawn Hooded (FH), and in normal rats following maternal separation (MS). The aim of the present study was to extend this work by exploring whether neurotensin (NT), a peptide implicated in several psychiatric disorders, is altered in a new animal model based on gene - environment interactions...
May 25, 2016: Neuropeptides
Soo Khai Ng, Kathryn P Burdon, Jude T Fitzgerald, Tiger Zhou, Rhys Fogarty, Emmanuelle Souzeau, John Landers, Richard A Mills, Robert J Casson, Bronwyn Ridge, Stuart L Graham, Alex W Hewitt, David A Mackey, Paul R Healey, Jie Jin Wang, Paul Mitchell, Stuart MacGregor, Jamie E Craig
PURPOSE: Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aimed to determine whether any observed differences in genetic association at the 9p21 locus are influenced by sex. METHODS: Sex was assessed as a risk factor for POAG for 2241 glaucoma participants from the Australian and New Zealand Registry of Advanced Glaucoma, the Glaucoma Inheritance Study in Tasmania, and the Flinders Medical Centre...
June 1, 2016: Investigative Ophthalmology & Visual Science
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