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myocardial infarction physiology

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https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#1
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29774530/cardiomyocyte-programmed-necrosis-mitochondria-death-receptor-and-beyond
#2
REVIEW
Junxia Zhang, Dairu Liu, Mao Zhang, Yan Zhang
Excessive death of cardiac myocytes leads to multiple cardiac diseases, including myocardial infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades, most work on cell death has focused on apoptosis, which is generally considered as the only form of regulated cell death, whereas necrosis has been regarded to be an unregulated process. Recent findings reveal that necrosis also occurs in a regulated manner and that it is closely related to the physiology and pathophysiology of multiple organs, including the heart...
May 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29765562/a-myriad-of-roles-of-mir-25-in-health-and-disease
#3
REVIEW
Márta Sárközy, Zsuzsanna Kahán, Tamás Csont
Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as important regulators of gene expression. MicroRNAs play myriads of roles in physiological processes as well as in the pathogenesis of a number of diseases by translational repression or mRNA destabilization of numerous target genes. The miR-106b-25 cluster is highly conserved in vertebrates and consists of three members including miR-106b, miR-93 and miR-25. MiR-106b and miR-93 share the same seed sequences; however, miR-25 has only a similar seed sequence resulting in different predicted target mRNAs...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718158/management-of-left-main-disease-an-update
#4
Jean Fajadet, Davide Capodanno, Gregg W Stone
A severe narrowing of the left main coronary artery (LMCA), usually due to atherosclerosis, jeopardizes a large area of myocardium and increases the risk of major adverse cardiac events. Management strategies for LMCA disease include coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). In general, PCI offers more rapid recovery and a lower early adverse event rate, whereas CABG offers a more durable procedure. The largest of six LMCA trials comparing PCI with CABG recently reported that in patients with site-reported low or intermediate anatomical complexity PCI was non-inferior to CABG with respect to the composite of death, stroke, or myocardial infarction at 3 years...
April 30, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29709534/measurement-of-microvascular-function-in-patients-presenting-with-thrombolysis-for-st-elevation-myocardial-infarction-and-pci-for-non-st-elevation-myocardial-infarction
#5
Sonny Palmer, Jamie Layland, Heath Adams, Srikkumar Ashokkumar, Paul D Williams, Christopher Judkins, Andre La Gerche, Andrew T Burns, Robert J Whitbourn, Andrew I MacIsaac, Andrew M Wilson
BACKGROUND: In this prospective study, we compared the invasive measures of microvascular function in two subsets: patients with pharmacoinvasive thrombolysis for STEMI, and patients undergoing percutaneous coronary intervention (PCI) for NSTEMI. METHODS: The study consisted of 17 patients with STEMI referred for cardiac catheterisation post thrombolysis, and 20 patients with NSTEMI. Coronary physiological indexes were measured in each patient before and after PCI...
April 12, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29703907/microrna-199a-5p-induces-apoptosis-by-targeting-junb
#6
Mengjie Yan, Sibao Yang, Fanbo Meng, Zhihui Zhao, Zhisen Tian, Ping Yang
MicroRNAs participate in a variety of physiological and pathophysiological processes in various organs including the heart. Our previous work revealed that the level of miR-199a-5p was significantly higher in failing hearts than in control hearts. However, whether it is associated with the progression of heart failure (HF) and mediates cardiomyocyte apoptosis remained unclear. In the present study, we used various biochemical and molecular biological approaches to investigate the changes in miR-199a-5p levels in failing hearts in a rat model induced by acute myocardial infarction...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691397/non-invasive-detection-of-human-cardiomyocyte-death-using-methylation-patterns-of-circulating-dna
#7
Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor
Detection of cardiomyocyte death is crucial for the diagnosis and treatment of heart disease. Here we use comparative methylome analysis to identify genomic loci that are unmethylated specifically in cardiomyocytes, and develop these as biomarkers to quantify cardiomyocyte DNA in circulating cell-free DNA (cfDNA) derived from dying cells. Plasma of healthy individuals contains essentially no cardiomyocyte cfDNA, consistent with minimal cardiac turnover. Patients with acute ST-elevation myocardial infarction show a robust cardiac cfDNA signal that correlates with levels of troponin and creatine phosphokinase (CPK), including the expected elevation-decay dynamics following coronary angioplasty...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29688287/implications-of-coronary-artery-bypass-grafting-and-percutaneous-coronary-intervention-on-disease-progression-and-the-resulting-changes-to-the-physiology-and-pathology-of-the-native-coronary-arteries
#8
Jacqueline H Fortier, Giovanni Ferrari, David Glineur, Mario Gaudino, Richard E Shaw, Marc Ruel, Juan B Grau
Myocardial revascularization can be achieved through 2 different methods: coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). Clinical trials comparing PCI and CABG generally use the composite end points of death, stroke, myocardial infarction and target vessel revascularization to determine superiority. Other effects of these interventions, including the preservation of normal coronary physiology, the response of the coronary tree to stressors and the response of the vessel wall to the revascularization intervention, are not routinely considered, but these may have significant implications for patients in the medium and long term...
April 23, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29687888/epigenetics-of-aberrant-cardiac-wound-healing
#9
Adam Russell-Hallinan, Chris J Watson, John A Baugh
Remodeling of cardiac tissue architecture is essential for normal organ development and maintaining homeostasis after injury. Injurious insults to the heart, such as hypertension and myocardial infarction, promote cellular responses including stimulation of resident inflammatory cells, activation of endothelial cells and recruitment of immune cells, hypertrophy of cardiomyocytes, and activation of fibroblasts. The physiological goal of this coordinated cellular response is to repair damaged tissue while maintaining or restoring cardiac contractile function...
March 26, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29680826/inflammation-autophagy-and-apoptosis-after-myocardial-infarction
#10
Xianwei Wang, Zhikun Guo, Zufeng Ding, Jawahar L Mehta
BACKGROUND: There is evidence for inflammation, autophagy, and apoptosis in the ischemic heart. Autophagy is a physiologic process for tissue survival. Apoptosis, on the other hand, is a mechanism that serves to clear the debris in the setting of tissue injury. The balance between autophagy and apoptosis may be important in cell survival and cardiac function. METHODS AND RESULTS: We examined the interplay of inflammation and myocyte autophagy and apoptosis during the ischemic process...
April 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29671338/inhibition-of-mir-182-5p-protects-cardiomyocytes-from-hypoxia-induced-apoptosis-by-targeting-ciapin1
#11
Yunsong Zhang, Jun Fang, Huiwen Ma
Myocardial infarction (MI), a type of ischemic heart disease, is generally accompanied by cardiomyocytes apoptosis. MiRNAs play the vital roles in the development and physiology of MI. Here, we established a downregulation model of miR-182-5p in H9c2 cells under hypoxia condition for investigating the potential molecular mechanism of miR-182-5p in hypoxia-induced cardiomyocytes apoptosis (HICA). RT-qPCR indicated that miR-182-5p level exhibited a time-dependent manner increase in hypoxia-induced cells. The results of MTT and LDH assays indicated that cardiomyocytes injury was markedly amplified after hypoxia treatment...
April 19, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29668847/adiponectin-determines-farnesoid-x-receptor-agonism-mediated-cardioprotection-against-post-infarction-remodeling-and-dysfunction
#12
Yunlong Xia, Fuyang Zhang, Shihao Zhao, Yueyang Li, Xiyao Chen, Erhe Gao, Xinyue Xu, Zhenyu Xiong, Xiaomeng Zhang, Jinglong Zhang, Huishou Zhao, Wei Wang, Helin Wang, Yanjie Guo, Yi Liu, Congye Li, Shan Wang, Ling Zhang, Wenjun Yan, Ling Tao
Aims: The farnesoid X receptor (FXR) is a member of the metabolic nuclear receptor superfamily that plays a critical regulatory role in cardiovascular physiology/pathology. However, the role of systemic FXR activation in the chronic phase in myocardial infarction (MI)-induced cardiac remodeling and dysfunction remains unclear. In this study, we aimed to elucidate the role of long-term FXR activation on post-MI cardiac remodeling and dysfunction. Methods and Results: Mice underwent either MI surgery or sham operation...
April 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29659929/cross-associations-between-physical-activity-and-sedentary-time-on-metabolic-health-a-comparative-assessment-using-self-reported-and-objectively-measured-activity
#13
Niels Thakkar, Veronica Jamnik, Chris I Ardern
Purpose: Physical activity and sedentary time have distinct physiologic and metabolic effects, but little is known about their joint associations. Methods: The Canadian Health Measures Survey (n = 5950) was used to (i) examine the joint relationship between active/non-sedentary (referent group), active/sedentary, inactive/non-sedentary and inactive/sedentary phenotypes on obesity and metabolic health; and (ii) compare these relationships when using objective (accelerometer) total activity or subjective (self-report) leisure-time measures...
April 5, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29649768/the-level-of-circulating-fibroblast-activation-protein-correlates-with-incorporation-of-alpha-2-antiplasmin-into-the-fibrin-clot
#14
Shirley Uitte de Willige, Joyce J C M Malfliet, Shiraazkhan Abdul, Frank W G Leebeek, Dingeman C Rijken
INTRODUCTION: Circulating fibroblast activation protein (cFAP) cleaves alpha-2-antiplasmin (α2AP) N-terminally, converting native Met-α2AP into Asn-α2AP. Previous studies in purified model systems showed that Asn-α2AP is faster incorporated into a fibrin clot by activated factor XIII than Met-α2AP, making the fibrin clot more resistant to fibrinolysis. The objective was to investigate whether cFAP level in plasma associated with the amount of α2AP incorporation into fibrin in a new plasma-based clotting assay...
April 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29628963/the-effect-of-acupressure-on-physiological-parameters-of-myocardial-infarction-patients-a-randomized-clinical-trial
#15
Marzieh Batvani, Hojatollah Yousefi, Mahboubeh Valiani, Javad Shahabi, Hossein Mardanparvar
Background: Myocardial infarction is a major complication of coronary heart disease, and due to high mortality, is a part of important medical emergencies. Today, complementary and alternative medicine, as nonpharmacological and health promotion methods is considered. Therefore, this study was designed to evaluate the effectiveness of acupressure on physiological parameters of patients with myocardial infarction. Materials and Methods: This clinical trial was carried out among two groups and three stages in 2015...
March 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29627871/autonomic-regulation-and-ventricular-arrhythmias
#16
REVIEW
Lingjin Meng, Kalyanam Shivkumar, Olujimi Ajijola
Autonomic nervous system (ANS) has a crucial role of regulating cardiac function in the physiological state and contributes to the pathogenesis of arrhythmias in the diseased state. The cardiac neuraxis consists of multiple feedback loops consisting of efferent and afferent limbs, mediating neurotransmission to and from the heart. Efferent parasympathetic neurotransmission is mediated by the vagus nerve, while paravertebral sympathetic ganglia relay efferent sympathetic neurotransmission to the heart. The association between autonomic activity and ventricular arrhythmias (VAs) has been studied extensively in both experimental models and humans...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29626079/acute-versus-chronic-ischemic-mitral-regurgitation-an-echocardiographic-study-of-anatomy-and-physiology
#17
Shun Nishino, Nozomi Watanabe, Toshiyuki Kimura, Nehiro Kuriyama, Yoshisato Shibata
BACKGROUND: Little is known on the mechanism of acute ischemic mitral regurgitation (IMR) caused by sudden-onset left ventricular dysfunction in acute myocardial infarction (MI). We sought to investigate the mitral valve (MV) complex geometry in acute IMR in comparison with chronic IMR by 2-dimensional and 3-dimensional transthoracic echocardiography. METHODS AND RESULTS: Forty-four first-onset acute MI and 36 previous MI with ≥moderate IMR were examined by 2-dimensional/3-dimensional transthoracic echocardiography...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29623673/the-relationship-between-age-and-chronic-kidney-disease-in-patients-undergoing-pancreatic-resection
#18
Derrick Antoniak, Chandrakanth Are, Chad Vokoun, Kaeli Samson, Lynette Smith, Jason Shiffermiller
BACKGROUND: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65. METHODS: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery...
April 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29605246/influence-of-local-myocardial-damage-on-index-of-microcirculatory-resistance-and-fractional-flow-reserve-in-target-and-nontarget-vascular-territories-in-a-porcine-microvascular-injury-model
#19
Joo Myung Lee, Hyun Kuk Kim, Kyung Seob Lim, Jun-Kyu Park, Ki Hong Choi, Jonghanne Park, Doyeon Hwang, Tae-Min Rhee, Jeong Hoon Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Joo-Yong Hahn, Bon-Kwon Koo, Myung Ho Jeong
OBJECTIVES: The aim of this study was to investigate the influence of microvascular damage in one vessel territory on invasively measured physiological parameters in the other vessel, using a porcine microvascular damage model. BACKGROUND: Although fractional flow reserve (FFR)-guided decision-making for the nonculprit stenosis in patients with acute myocardial infarction has been reported to be better than angiography-guided revascularization, there have been debates regarding the influence of microvascular dysfunction on measured FFR in nonculprit vessels...
March 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29602596/mechanisms-of-vascular-aging-what-can-we-learn-from-hutchinson-gilford-progeria-syndrome
#20
Lara Del Campo, Magda R Hamczyk, Vicente Andrés, José Martínez-González, Cristina Rodríguez
Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD...
March 27, 2018: Clínica e Investigación en Arteriosclerosis
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