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myocardial infarction physiology

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https://www.readbyqxmd.com/read/29327399/plga-mpeg-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#1
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
January 12, 2018: Stem Cells
https://www.readbyqxmd.com/read/29324314/down-regulation-of-mir-133a-b-in-patients-with-myocardial-infarction-correlates-with-the-presence-of-ventricular-fibrillation
#2
Emanuela Boštjančič, Tanisa Brandner, Nina Zidar, Damjan Glavač, Dušan Štajer
MicroRNAs (miRNAs) are important regulators of physiologic and pathologic conditions of the heart. Animal models of heart diseases have shown that miRNAs may contribute to the development of arrhythmias. However, little is known about the expression of muscle- and cardiac-specific miRNAs in patients with myocardial infarction (MI) who have developed ventricular fibrillation (VF). Our study included 47 patients who had died from myocardial infarction (MI), 23 with clinically proven VF and 24 without VF. Autopsy samples of infarcted tissue and remote myocardium were available (n = 94)...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29323152/unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#3
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. Cardiac ATDPCs, grown on 3 different patterned surfaces, were mechanically stretched for 7 days at 1 Hz. A custom-designed, magnet-based, mechanical stimulator device was developed to apply ~10% mechanical stretching to monolayer cell cultures...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321822/pursuing-meaningful-end-points-for-stem-cell-therapy-assessment-in-ischemic-cardiac-disease
#4
REVIEW
Maria Dorobantu, Nicoleta-Monica Popa-Fotea, Mihaela Popa, Iulia Rusu, Miruna Mihaela Micheu
Despite optimal interventional and medical therapy, ischemic heart disease is still an important cause of morbidity and mortality worldwide. Although not included in standard of care rehabilitation, stem cell therapy (SCT) could be a solution for prompting cardiac regeneration. Multiple studies have been published from the beginning of SCT until now, but overall no unanimous conclusion could be drawn in part due to the lack of appropriate end-points. In order to appreciate the impact of SCT, multiple markers from different categories should be considered: Structural, biological, functional, physiological, but also major adverse cardiac events or quality of life...
December 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29277590/feasibility-of-a-modified-e-pass-and-possum-system-for-postoperative-risk-assessment-in-patients-with-spinal-disease
#5
Dong Hyun Chun, Do Young Kim, Sun Kyu Choi, Dong Ah Shin, Yoon Ha, Keung Nyun Kim, Do Heum Yoon, Seong Yi
STUDY DESIGN: Retrospective case control study OBJECTIVE: This study aimed to evaluate the feasibility of using Estimation of Physiological Ability and Surgical Stress (E-PASS) and Physiological and Operative Severity Score for the enumeration of Mortality and Morbidity (POSSUM) systems in patients undergoing spinal surgical procedures. SUMMARY OF BACKGROUND DATA: Degenerative spine disease has increased in incidence in aging societies, as has the number of older adult patients undergoing spinal surgery...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29276929/-choice-of-angiotensin-receptor-blocker-at-various-stages-of-the-cardiovascular-continuum
#6
V I Podzolkov, N A Dragomiretskaya
We present in this paper modern views on components, physiological and pathophysiological effects of the renin-angiotensin system, pathways of its hyperactivation at various stages of the cardiovascular continuum. Special emphasis is made on angiotensin receptor blockers (sartans). Basing on results of analysis of randomized clinical trials of these agents we have outlined clinical situations in which prescription of one or another drug from this group is preferable. For patients with multiple risk factors of cardiovascular complications preferable agent is telmisartan, for patients with nephropathy - irbesartan, for survivors of acute myocardial infarction - valsartan, while for patients with clinical signs of chronic heart failure with low ejection fraction 3 agents can be designated as preferrable - losartan, valsartan, and candesartan...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29243014/prognostic-value-of-lvedp-in-acute-myocardial-infarction-a-systematic-review-and-meta-analysis
#7
Stephen C Brienesse, Allan J Davies, Arshad Khan, Andrew J Boyle
Left ventricular end-diastolic pressure (LVEDP) is an easily obtained, physiologically integrative measure of total LV function. LVEDP may be a useful prognostic measure in patients with acute myocardial infarction and utilised to guide medical therapy and assess risk for post myocardial infarction heart failure. To assess the utility of LVEDP as a prognostic measure in patients presenting with acute myocardial infarction. We performed an unrestricted search of electronic databases (1946 to March 2017) using a predefined search strategy...
December 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29239839/the-formin-diaph1-is-a-key-modulator-of-myocardial-ischemia-reperfusion-injury
#8
Karen M O'Shea, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Devi Thiagarajan, Gopalkrishna Sreejit, Lingjie Wang, Hylde Zirpoli, Juan Francisco Aranda, Arthur S Alberts, Ann Marie Schmidt, Ravichandran Ramasamy
The biochemical, ionic, and signaling changes that occur within cardiomyocytes subjected to ischemia are exacerbated by reperfusion; however, the precise mechanisms mediating myocardial ischemia/reperfusion (I/R) injury have not been fully elucidated. The receptor for advanced glycation end-products (RAGE) regulates the cellular response to cardiac tissue damage in I/R, an effect potentially mediated by the binding of the RAGE cytoplasmic domain to the diaphanous-related formin, DIAPH1. The aim of this study was to investigate the role of DIAPH1 in the physiological response to experimental myocardial I/R in mice...
November 21, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29234935/cardiac-and-respiratory-gated-volumetric-murine-ultrasound
#9
Arvin H Soepriatna, Frederick W Damen, Pavlos P Vlachos, Craig J Goergen
Current cardiovascular ultrasound mainly employs planar imaging techniques to assess function and physiology. These techniques rely on geometric assumptions, which are dependent on the imaging plane, susceptible to inter-observer variability, and may be inaccurate when studying complex diseases. Here, we developed a gated volumetric murine ultrasound technique to visualize cardiovascular motion with high spatiotemporal resolution and directly evaluate cardiovascular health. Cardiac and respiratory-gated cine loops, acquired at 1000 frames-per-second from sequential positions, were temporally registered to generate a four-dimensional (4D) dataset...
December 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29222132/invasive-assessment-of-the-coronary-microvasculature-the-index-of-microcirculatory-resistance
#10
REVIEW
William F Fearon, Yuhei Kobayashi
Traditionally, invasive coronary physiological assessment has focused on the epicardial coronary artery. More recently, appreciation of the importance of the coronary microvasculature in determining patient outcomes has grown. Several invasive modalities for interrogating microvascular function have been proposed. Angiographic techniques have been limited by their qualitative and subjective nature. Doppler wire-derived coronary flow reserve has been applied in research studies, but its clinical role has been limited by its lack of reproducibility, its lack of a clear normal value, and the fact that it is not specific for the microvasculature but interrogates the entire coronary circulation...
December 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29222074/changes-of-oxygen-consumption-and-heart-rate-after-acute-myocardial-infarction-during-6-month-follow-up
#11
Yuri Choe, Jae-Young Han, In-Sung Choi, Hyeng-Kyu Park
BACKGROUND: Exercise intensity is a particularly important determinant of physiological responses to exercise training in patients with acute myocardial infarction. Heart rate (HR) is commonly used as a practical way of prescribing and monitoring exercise as specific intensities based on linear relationship between the percentage of maximum heart rate (%HRmax) and the percentage of maximum oxygen consumption (%VO2max) regardless of age, sex or exercise mode. OBJECTIVE: To examine the change in variability in the correlation between %HRmax and %VO2maxafter acute myocardial infarction...
December 5, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29216197/shift-toward-greater-pathologic-post-myocardial-infarction-remodeling-with-loss-of-the-adaptive-hypertrophic-signaling-of-alpha1-adrenergic-receptors-in-mice
#12
Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang, Paul C Simpson, Michael J Mann
RATIONALE: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate pro-adaptive hypertrophy during pressure overload, little is known about their role or downstream mediators after myocardial infarction. METHODS: We performed loss-of-function experiments via coronary ligation in alpha1A-AR knockout (AKO) mice...
2017: PloS One
https://www.readbyqxmd.com/read/29198461/nonculprit-stenosis-evaluation-using-instantaneous-wave-free-ratio-in-patients%C3%A2-with-st-segment-elevation-myocardial-infarction
#13
Troels Thim, Matthias Götberg, Ole Fröbert, Robin Nijveldt, Niels van Royen, Sergio Bravo Baptista, Sasha Koul, Thomas Kellerth, Hans Erik Bøtker, Christian Juhl Terkelsen, Evald Høj Christiansen, Lars Jakobsen, Steen Dalby Kristensen, Michael Maeng
OBJECTIVES: The aim of this study was to examine the level of agreement between acute instantaneous wave-free ratio (iFR) measured across nonculprit stenoses in patients with ST-segment elevation myocardial infarction (STEMI) and iFR measured at a staged follow-up procedure. BACKGROUND: Acute full revascularization of nonculprit stenoses in STEMI is debated and currently guided by angiography. Acute functional assessment of nonculprit stenoses may be considered...
November 18, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29198458/clinical-outcomes-according-to-fractional%C3%A2-flow-reserve-or-instantaneous-wave-free-ratio%C3%A2-in%C3%A2-deferred-lesions
#14
Joo Myung Lee, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Jonghanne Park, Kyung-Jin Kim, Jinlong Zhang, Chul Ahn, Bon-Kwon Koo
OBJECTIVES: The authors investigated 2-year clinical outcomes according to fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) values in deferred lesions. BACKGROUND: Invasive physiological indices such as FFR or iFR are used in clinical practice to select ischemia-causing stenosis and to guide the treatment strategy for patients with coronary artery disease. METHODS: From the 3V FFR-FRIENDS (3-Vessel Fractional Flow Reserve for the Assessment of Total Stenosis Burden and Its Clinical Impact in Patients With Coronary Artery Disease) study, 821 deferred lesions (374 patients) with both FFR and iFR available were included in this study...
November 20, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29187660/-nmda-receptor-and-its-role-in-cardiovascular-diseases
#15
Jinyan Xie, Kui Hong
Cardiovascular disease is the main threat to human health, which is one of the important causes of death in worldwide. N-methyl-D-aspartate receptor (NMDAR) is one of crucial ionic glutamate receptors. The physiology and pharmacology function of the composition of NMDAR are very complicated. Researches have shown that NMDAR with a high permeability to calcium and a unique feature of controlling numerous calcium-dependent processes. NMDAR affects the occurrence and development of cardiovascular disease such as hypertension, arrhythmia, myocardial infarction...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29179205/overexpression-of-timp3-protects-against-cardiac-ischemia-reperfusion-injury-by-inhibiting-myocardial-apoptosis-through-ros-mapks-pathway
#16
Hui Liu, Xibo Jing, Aiqiao Dong, Baobao Bai, Haiyan Wang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury remains a great challenge in clinical therapy. Tissue inhibitor of metalloproteinases 3 (TIMP3) plays a crucial role in heart physiological and pathophysiological processes. However, the effects of TIMP3 on I/R injury remain unknown. METHODS: C57BL/6 mice were infected with TIMP3 adenovirus by local delivery in myocardium followed by I/R operation or doxorubicin treatment. Neonatal rat cardiomyocytes were pretreated with TIMP3 adenovirus prior to anoxia/reoxygenation (A/R) treatment in vitro...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29179202/long-non-coding-rna-h19-protects-h9c2-cells-against-hypoxia-induced-injury-by-targeting-microrna-139
#17
Li-Cheng Gong, Hai-Ming Xu, Gong-Liang Guo, Tao Zhang, Jing-Wei Shi, Chang Hong
BACKGROUND/AIMS: Acute myocardial infarction (AMI) occurs when blood supply to the heart is diminished (ischemia) for long time; ischemia is primarily caused due to hypoxia. The present study evaluated the effects of long non-coding RNA H19 on hypoxic rat H9c2 cells and mouse HL-1 cells. METHODS: Hypoxic injury was confirmed by measuring cell viability, migration and invasion, and apoptosis using MTT, Transwell and flow cytometry assays, respectively. H19 expression after hypoxia was estimated by qRT-PCR...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29179133/improved-heart-repair-upon-myocardial-infarction-combination-of-magnetic-nanoparticles-and-tailored-magnets-strongly-increases-engraftment-of-myocytes
#18
Annika Ottersbach, Olga Mykhaylyk, Alexandra Heidsieck, Dietmar Eberbeck, Sarah Rieck, Katrin Zimmermann, Martin Breitbach, Britta Engelbrecht, Tobias Brügmann, Michael Hesse, Armin Welz, Philipp Sasse, Daniela Wenzel, Christian Plank, Bernhard Gleich, Michael Hölzel, Wilhelm Bloch, Alexander Pfeifer, Bernd K Fleischmann, Wilhelm Roell
Cell replacement in the heart is considered a promising strategy for the treatment of post-infarct heart failure. Direct intramyocardial injection of cells proved to be the most effective application route, however, engraftment rates are very low (<5%) strongly hampering its efficacy. Herein we combine magnetic nanoparticle (MNP) loading of EGFP labeled embryonic cardiomyocytes (eCM) and embryonic stem cell-derived cardiomyocytes (ES-CM) with application of custom designed magnets to enhance their short and long-term engraftment...
February 2018: Biomaterials
https://www.readbyqxmd.com/read/29178811/cell-ecm-mechanobiology-forceful-tools-and-emerging-needs-for-basic-and-translational-research
#19
Andrew W Holle, Jennifer L Young, Krystyn J Van Vliet, Roger D Kamm, Dennis E Discher, Paul A Janmey, Joachim P Spatz, M Taher Saif
Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth, motility, differentiation, apoptosis, gene expression, adhesion and signal transduction. Cells not only respond to definitively mechanical cues from the extracellular matrix (ECM), but can also sometimes alter the mechanical properties of the matrix and hence influence subsequent matrix-based cues in both physiological and pathological processes. Interactions between cells and materials in vitro can modify cell phenotype and ECM structure, whether intentionally or inadvertently...
November 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/29163642/potential-role-of-exosomes-in-mending-a-broken-heart-nanoshuttles-propelling-future-clinical-therapeutics-forward
#20
REVIEW
Julie A Dougherty, Muhamad Mergaye, Naresh Kumar, Chun-An Chen, Mark G Angelos, Mahmood Khan
Stem cell transplantation therapy is a promising adjunct for regenerating damaged heart tissue; however, only modest improvements in cardiac function have been observed due to poor survival of transplanted cells in the ischemic heart. Therefore, there remains an unmet need for therapies that can aid in attenuating cardiac damage. Recent studies have demonstrated that exosomes released by stem cells could serve as a potential cell-free therapeutic for cardiac repair. These exosomes/nanoshuttles, once thought to be merely a method of waste disposal, have been shown to play a crucial role in physiological functions including short- and long-distance intercellular communication...
2017: Stem Cells International
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