keyword
https://read.qxmd.com/read/38092063/trilateral-versus-bilateral-antegrade-cerebral-perfusion-in-frozen-elephant-trunk
#21
JOURNAL ARTICLE
Razan Salem, Arnaud Van Linden, Jan Hlavicka, Afsaneh Karimian-Tabrizi, Ina Ischewski, Thomas Walther, Tomas Holubec
BACKGROUND: Spinal cord injury (SCI) with subsequent paraplegia and/or stroke after arch repair with frozen elephant trunk (FET) remain the most devastating complications. In this study, we aim to examine the impact of different cerebral perfusion strategies on the neurological out-come comparing bilateral antegrade cerebral perfusion (bACP) and trilateral antegrade cerebral perfusion (tACP). METHODS: Between 2009 and 2021, 88 patients underwent total arch replacement using a hybrid prosthesis in FET technique for acute (40,4%) and chronic (59,6%) aortic pathologies...
December 13, 2023: Thoracic and Cardiovascular Surgeon
https://read.qxmd.com/read/38088459/impact-of-share-35-liver-transplantation-allocation-in-australia-and-new-zealand
#22
JOURNAL ARTICLE
Michael A Fink, Paul J Gow, Geoffrey W McCaughan, Peter Hodgkinson, John Chen, John McCall, Bryon Jaques, Michael Crawford, Simone I Strasser, Winita Hardikar, Mark Brooke-Smith, Graham Starkey, Gary P Jeffrey, Ed Gane, Michael Stormon, Helen Evans, Caroline Tallis, Amanda J Byrne, Robert M Jones
Patients with high model for end-stage liver disease (MELD) scores waiting for liver transplantation in Australia and New Zealand (ANZ) have had limited access to deceased donor livers and therefore binational sharing of livers, for patients with a MELD score ≥35 was introduced in February 2016. Waiting list mortality, post-transplant outcomes and intention-to-treat survival were compared between patients whose MELD score reached 35 on the waiting list between October 2013 and April 2015 (Pre-Share 35 group, n = 23) and patients who were Share 35 listed between February 2016 and May 2022 (Share 35 group, n = 112)...
December 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/38037915/a-new-sulphur-containing-metabolite-from-a-mangrove-endophytic-fungus-aspergillus-sp-gxnu-ma
#23
JOURNAL ARTICLE
Furong Wu, Wenxiu Zhang, Xianglong Bo, Qin Feng, Meijing Tan, Shichao Ju, Zishuo Song, Jun Li, Xishan Huang
A new sulphur-containing metabolite, asperiguxidione A ( 1 ), was isolated from a mangrove endophytic fungus Aspergillus sp. GXNU-MA, and four known alkaloids 2-5 , were isolated together from this strain. Their structures were determined by the com-bination of 1D and 2D NMR spectroscopy, HR-ESI-MS, and ECD analysis. Compounds 1 and 2 exhibited mediate activity against Staphylococcus aureus and Enterobacter aerogenes with equal MIC values of 12.5  μ g/mL. Compound 3 reduced NO production in LPS-stimulated cells with an IC50 value of 13...
December 1, 2023: Natural Product Research
https://read.qxmd.com/read/38035745/recruitment-of-participants-with-pancreatic-cancer-to-a-mixed-media-study-for-optimal-recruitment-in-an-australasian-survey-of-pancreatic-enzyme-replacement
#24
JOURNAL ARTICLE
Amanda Landers, Charlotte Cahill, Poppy McCall, Anu Kaw, Helen Brown, Clare McKenzie, Meera Agar, Vanessa Yenson, Kate Clarke, John Windsor
BACKGROUND: Pancreatic cancer is relatively rare and aggressive, with digestion and malabsorption issues often leading to significant weight loss. Recruitment of people with this malignancy into studies can be challenging, and innovative methods need to be explored to improve recruitment rates. AIM: To describe a mixed media methodology and the outcomes used to recruit patients to participate in a binational survey. METHODS: The details of the mixed media method used to identify and recruit people with pancreatic cancer are described...
November 30, 2023: BMJ Open
https://read.qxmd.com/read/38030251/restrictive-versus-standard-fluid-management-in-mechanically-ventilated-children-admitted-to-picu-study-protocol-for-a-pilot-randomised-controlled-trial-reduce-1
#25
JOURNAL ARTICLE
Sainath Raman, Sarfaraz Rahiman, Melanie Kennedy, Adrian Mattke, Prem Venugopal, Craig McBride, Quyen Tu, Florian Zapf, Eva Kuhlwein, Jemma Woodgate, Puneet Singh, Luregn J Schlapbach, Kristen S Gibbons
INTRODUCTION: Intravenous fluid therapy is the most common intervention in critically ill children. There is an increasing body of evidence questioning the safety of high-volume intravenous fluid administration in these patients. To date, the optimal fluid management strategy remains unclear. We aimed to test the feasibility of a pragmatic randomised controlled trial comparing a restrictive with a standard (liberal) fluid management strategy in critically ill children. METHODS AND ANALYSIS: Multicentre, binational pilot, randomised, controlled, open-label, pragmatic trial...
November 29, 2023: BMJ Open
https://read.qxmd.com/read/37964367/multi-center-pragmatic-cluster-randomized-controlled-trial-of-standardized-peritoneal-dialysis-pd-training-versus-usual-care-on-pd-related-infections-the-teach-pd-trial-trial-protocol
#26
JOURNAL ARTICLE
Josephine S F Chow, Neil Boudville, Yeoungjee Cho, Suetonia Palmer, Elaine M Pascoe, Carmel M Hawley, Donna M Reidlinger, Laura E Hickey, Ruth Stastny, Andrea Valks, Liza Vergara, Ramya Movva, Charani Kiriwandeniya, Hayley Candler, Gabor Mihala, Bernadette Buisman, Keri-Lu Equinox, Ana E Figueiredo, Trudi Fuge, Kirsten Howard, Martin Howell, Allison Jaure, Matthew D Jose, Anna Lee, Susana S Miguel, Jo-Anne Moodie, Thu T Nguyen, Geraldine Pinlac, Annie Reynolds, Walaa W M Saweirs, Genevieve Z Steiner-Lim, Bronwen TeWhare, Melinda Tomlins, Megan Upjohn, David Voss, Rachael C Walker, Joanne Wilson, David W Johnson
BACKGROUND: Peritoneal dialysis (PD)-related infections, such as peritonitis, exit site, and tunnel infections, substantially impair the sustainability of PD. Accordingly, PD-related infection is the top-priority research outcome for patients and caregivers. While PD nurse trainers teach patients to perform their own PD, PD training curricula are not standardized or informed by an evidentiary base and may offer a potential approach to prevent PD infections. The Targeted Education ApproaCH to improve Peritoneal Dialysis outcomes (TEACH-PD) trial evaluates whether a standardized training curriculum for PD nurse trainers and incident PD patients based on the International Society for Peritoneal Dialysis (ISPD) guidelines reduces PD-related infections compared to usual training practices...
November 14, 2023: Trials
https://read.qxmd.com/read/37954892/trail-making-test-b-in-postoperative-delirium-a-replication-study
#27
JOURNAL ARTICLE
Marinus Fislage, Insa Feinkohl, Friedrich Borchers, Maria Heinrich, Tobias Pischon, Dieuwke S Veldhuijzen, Arjen J C Slooter, Claudia D Spies, Georg Winterer, Norman Zacharias
BACKGROUND: The Trail Making Test B (TMT-B) is indicative of cognitive flexibility and several other cognitive domains. Previous studies suggest that it might be associated with the risk of developing postoperative delirium, but evidence is limited and conflicting. We therefore aimed to replicate the association of preoperative TMT-B results with postoperative delirium. METHODS: We included older adults (≥65 yr) scheduled for major surgery and without signs of dementia to participate in this binational two-centre longitudinal observational cohort study...
December 2023: BJA Open
https://read.qxmd.com/read/37945915/school-attendance-and-sport-participation-amongst-children-with-chronic-kidney-disease-a-cross-sectional-analysis-from-the-kids-with-ckd-kcad-study
#28
JOURNAL ARTICLE
Adam C Hudson, Anita van Zwieten, Kylie-Ann Mallitt, Anne Durkan, Deirdre Hahn, Chandana Guha, Rabia Khalid, Madeleine Didsbury, Anna Francis, Steven McTaggart, Fiona E Mackie, Chanel Prestidge, Armando Teixeira-Pinto, Suncica Lah, Martin Howell, Kirsten Howard, Natasha Nassar, Allison Jaure, Jonathan C Craig, Germaine Wong, Siah Kim
BACKGROUND: School attendance and life participation, particularly sport, is a high priority for children with chronic kidney disease (CKD). This study is aimed at assessing the association between CKD stage, sports participation, and school absences in children with CKD. METHODS: Using data from the binational Kids with CKD study (ages 6-18 years, n = 377), we performed multivariable regression to evaluate the association between CKD stage, school absences, and sports participation...
November 9, 2023: Pediatric Nephrology
https://read.qxmd.com/read/37891675/cross-border-utilization-of-cancer-care-by-patients-in-the-us-and-mexico-a-survey-of-mexican-oncologists
#29
JOURNAL ARTICLE
Michael LaPelusa, Haydeé Verduzco-Aguirre, Fernando Diaz, Fernando Aldaco, Enrique Soto-Perez-de-Celis
BACKGROUND: The US-Mexico border is the busiest in the world, with millions of people crossing it daily. However, little is known about cross-border utilization of cancer care, or about the reasons driving it. We designed a cross sectional online survey to understand the type of care patients with cancer who live in the US and Mexico seek outside their home country, the reasons why patients traveled across the border to receive care, and the barriers faced when seeking cross-border care...
October 27, 2023: Globalization and Health
https://read.qxmd.com/read/37889023/investigation-of-the-effects-of-umbilical-cord-derived-mesenchymal-stem-cells-and-curcumin-on-achilles-tendon-healing-can-they-act-synergistically
#30
JOURNAL ARTICLE
Tuğçe Merve Öztürk, İrfan Özyazgan, Gülay Sezer, Betül Yalçın, Rümeysa Göç, Menekşe Ülger, Hakan Özocak, Birkan Yakan
BACKGROUND: It is known that curcumin and umbilical cord-derived mesenchymal stem cells (UC-MSCs) positively affect experi-mental tendon injury healing. This study investigated individual effects and potential synergistic effects of using curcumin and UC-MSCs alone and together. METHODS: Eighty female Wistar albino rats were randomly divided into five groups: Control, curcumin, sesame oil, MSCs, and Curcumin+MSCs groups. In all rats, punch tendon defect was created in both right and left Achilles tendons...
November 2023: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/37717016/clsoilmaps-a-national-soil-gridded-database-of-physical-and-hydraulic-soil-properties-for-chile
#31
JOURNAL ARTICLE
Diego I Dinamarca, Mauricio Galleguillos, Oscar Seguel, Carlos Faúndez Urbina
Spatially explicit soil information is crucial for comprehending and managing many of Earth´s processes related to carbon, water, and other biogeochemical cycles. We introduced a gridded database of soil physical properties and hydraulic parameters at 100 meters spatial resolution. It covers the continental area of Chile and binational basins shared with Argentina for six standardized depths following the specifications of the GlobalSoilMap project. We generated soil maps based on digital soil mapping techniques based on more than 4000 observations, including unpublished data from remote areas...
September 16, 2023: Scientific Data
https://read.qxmd.com/read/37674306/multicentre-registry-analysis-of-incremental-peritoneal-dialysis-incidence-and-associations-with-patient-outcomes
#32
MULTICENTER STUDY
Melissa S Cheetham, Yeoungjee Cho, Rathika Krishnasamy, Elasma Milanzi, Josephine Chow, Carmel Hawley, Jo-Anne Moodie, Matthew D Jose, Robert MacGinley, Thu Nguyen, Suetonia C Palmer, Rachael Walker, Jeffrey Wong, Arsh K Jain, Neil Boudville, David W Johnson, Louis L Huang
BACKGROUND: Incremental peritoneal dialysis (PD) is increasingly advocated to reduce treatment burden and costs, with potential to better preserve residual kidney function. Global prevalence of incremental PD use is unknown and use in Australia and New Zealand has not been reported. METHODS: Binational registry analysis including incident adult PD patients in Australia and New Zealand (2007-2017), examining incidence of and outcomes associated with incremental PD (first recorded PD exchange volume <42 L/week (incremental) vs...
September 2023: Peritoneal Dialysis International
https://read.qxmd.com/read/37632077/clinical-validity-of-a-machine-learning-decision-support-system-for-early-detection-of-hepatitis-b-virus-a-binational-external-validation-study
#33
JOURNAL ARTICLE
Busayo I Ajuwon, Alice Richardson, Katrina Roper, Brett A Lidbury
HepB LiveTest is a machine learning decision support system developed for the early detection of hepatitis B virus (HBV). However, there is a lack of evidence on its generalisability. In this study, we aimed to externally assess the clinical validity and portability of HepB LiveTest in predicting HBV infection among independent patient cohorts from Nigeria and Australia. The performance of HepB LiveTest was evaluated by constructing receiver operating characteristic curves and estimating the area under the curve...
August 14, 2023: Viruses
https://read.qxmd.com/read/37562400/refractory-pseudomonas-aeruginosa-infections-treated-with-phage-pasa16-a-compassionate-use-case-series
#34
JOURNAL ARTICLE
Hadil Onallah, Ronen Hazan, Ran Nir-Paz, Michael J Brownstein, Joseph R Fackler, Bri'Anna Horne, Robert Hopkins, Subhendu Basu, Ortal Yerushalmy, Sivan Alkalay-Oren, Ron Braunstein, Amit Rimon, Daniel Gelman, Leron Khalifa, Karen Adler, Mohanad Abdalrhman, Shira Gelman, Eyal Katvan, Shunit Coppenhagen-Glazer, Allon Moses, Yonatan Oster, Michal Dekel, Ronen Ben-Ami, Amal Khoury, Daniel J Kedar, Suzy E Meijer, Itay Ashkenazi, Nancy Bishouty, Dafna Yahav, Eran Shostak, Gilat Livni, Mical Paul, Menachem Gross, Matityahou Ormianer, Saima Aslam, Michele Ritter, Kenneth L Urish, Ricardo M La Hoz, Ameneh Khatami, Philip N Britton, Ruby C Y Lin, Jonathan R Iredell, Aleksandra Petrovic-Fabijan, Stephanie Lynch, Pranita D Tamma, Alexandra Yamshchikov, Emil Lesho, Megan Morales, Alissa Werzen, Kapil Saharia
BACKGROUND: A growing number of compassionate phage therapy cases were reported in the last decade, with a limited number of clinical trials conducted and few unsuccessful clinical trials reported. There is only a little evidence on the role of phages in refractory infections. Our objective here was to present the largest compassionate-use single-organism/phage case series in 16 patients with non-resolving Pseudomonas aeruginosa infections. METHODS: We summarized clinical phage microbiology susceptibility data, administration protocol, clinical data, and outcomes of all cases treated with PASA16 phage...
August 8, 2023: Med
https://read.qxmd.com/read/37544992/insights-from-a-cross-sectional-binational-study-comparing-obesity-among-nonimmigrant-colombians-in-their-home-country-and-colombian-immigrants-in-the-u-s
#35
JOURNAL ARTICLE
Carlos Devia, Karen R Flórez, Sergio A Costa, Terry T-K Huang
BACKGROUND: Latinos in the United States (U.S.) represent a heterogeneous minority population disproportionally impacted by obesity. Colombians in the U.S. are routinely combined with other South Americans in most obesity studies. Moreover, most studies among Latino immigrants in the U.S. solely focus on factors in the destination context, which largely ignores the prevalence of obesity and contextual factors in their country of origin, and warrant transnational investigations. METHODS: Using 2013-17 data from the New York City Community Health Survey (NYC CHS, U...
August 6, 2023: BMC Public Health
https://read.qxmd.com/read/37496340/a-reanalysis-of-historical-figures-with-depression-and-dropsy
#36
JOURNAL ARTICLE
Davide Viggiano, David Widmer
OBJECTIVES: Recent studies suggest a link between chronic kidney disease and brain dysfunctions such as depression and cognitive problems. A review of medieval and early-modern historical figures with aspects of both kidney disease (gout and edema [dropsy]) and depression (melancholia) shows that these conditions were observed together in the past. MATERIALS AND METHODS: References to the diseases of gout, dropsy, and melancholia were compared in literature on historical subjects...
June 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37475011/insomnia-and-distress-as-mediators-on-the-relationship-from-cyber-victimization-to-self-reported-psychotic-experiences-a-binational-study-from-tunisia-and-lebanon
#37
JOURNAL ARTICLE
Feten Fekih-Romdhane, Manel Stambouli, Diana Malaeb, Nour Farah, Majda Cheour, Sahar Obeid, Souheil Hallit
BACKGROUND: While expansive research has accumulated concerning the association between traditional, face-to-face peer victimization and psychosis, a paucity of empirical research has been undertaken so far to investigate these associations with experiences of new and evolving ways of victimization through the digital world. Exploring these associations is highly relevant and timely, given that emerging adults are heavy users of digital technologies, highly exposed to online risks, and are at the peak age of onset of psychosis...
July 20, 2023: BMC Psychiatry
https://read.qxmd.com/read/37462895/early-treatment-response-to-piperacillin-tazobactam-in-patients-with-bloodstream-infections-caused-by-non-esbl-ampicillin-sulbactam-resistant-escherichia-coli-a-binational-cohort-study
#38
JOURNAL ARTICLE
Selma Tobudic, Christina Bahrs, Lisa Schneider, Emilia Paulussen, Lucie Bartonickova, Stefan Hagel, Peter Starzengruber, Heinz Burgmann, Mathias W Pletz
PURPOSE: This study aimed to compare treatment outcomes for bloodstream infections (BSI) caused by a piperacillin/tazobactam (PIP/TAZ)-susceptible E. coli among three patient groups: BSI caused by ampicillin/sulbactam (AMP/SLB)-resistant isolates treated with PIP/TAZ, BSI caused by AMP/SLB-sensitive isolates treated with PIP/TAZ, and BSI caused by AMP/SLB-resistant isolates treated with another monotherapy. METHODS: This retrospective study was conducted in two academic centres in Europe...
July 18, 2023: Infection
https://read.qxmd.com/read/37407927/mokpe-drug-target-interaction-prediction-via-manifold-optimization-based-kernel-preserving-embedding
#39
JOURNAL ARTICLE
Oğuz C Binatlı, Mehmet Gönen
BACKGROUND: In many applications of bioinformatics, data stem from distinct heterogeneous sources. One of the well-known examples is the identification of drug-target interactions (DTIs), which is of significant importance in drug discovery. In this paper, we propose a novel framework, manifold optimization based kernel preserving embedding (MOKPE), to efficiently solve the problem of modeling heterogeneous data. Our model projects heterogeneous drug and target data into a unified embedding space by preserving drug-target interactions and drug-drug, target-target similarities simultaneously...
July 5, 2023: BMC Bioinformatics
https://read.qxmd.com/read/37400843/social-and-environmental-determinants-influencing-injection-drug-use-and-hiv-risk-among-two-sister-cities-on-the-us-mexico-border-a-comparative-cross-sectional-study-2016-2018
#40
JOURNAL ARTICLE
Julia Lechuga, Rebeca Ramos, Natasha Ludwig-Barron, Gilberto Perez, Maria Elena Ramos, João B Ferreira-Pinto, Jacquelin I Cordero, John Sauceda, Jorge Salazar
The economic, social, cultural and political milieus that influence injection drug-related HIV risk behaviors along the US-Mexico border in the previous decade have been studied comparing cities on an East-West axis. In an effort to inform interventions targeting factors beyond the individual level, we used a cross-sectional study design comparing people who inject drugs during 2016-2018, living on a North-South axis, in two cities-Ciudad Juárez, Chihuahua, Mexico and El Paso, Texas, USA-situated at the midpoint of the 2000 US-Mexico borderland stretch...
July 3, 2023: Harm Reduction Journal
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