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https://www.readbyqxmd.com/read/27936388/nanoliposome-encapsulated-anesthetics-for-local-anesthesia-application
#1
REVIEW
Sepideh Vahabi, Ali Eatemadi
The systemic administration of opioids leads to potentially severe and undesirable and side effects like sedation and drowsiness, vomiting and nausea, allergies, respiratory depression, and neutrophil dysfunction. The application of nanotechnology in medical field has drawn a great attention in recent times. Several treatments available are tedious and expensive. Application of nanotechnology brings about faster cure and cost effectiveness. Nanoliposomes are one of the widely used names for nanoparticles used in medicine...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27935993/development-of-a-search-strategy-for-an-evidence-based-retrieval-service
#2
Gah Juan Ho, Su May Liew, Chirk Jenn Ng, Ranita Hisham Shunmugam, Paul Glasziou
BACKGROUND: Physicians are often encouraged to locate answers for their clinical queries via an evidence-based literature search approach. The methods used are often not clearly specified. Inappropriate search strategies, time constraint and contradictory information complicate evidence retrieval. AIMS: Our study aimed to develop a search strategy to answer clinical queries among physicians in a primary care setting. METHODS: Six clinical questions of different medical conditions seen in primary care were formulated...
2016: PloS One
https://www.readbyqxmd.com/read/27935856/environmental-pah-exposure-and-male-idiopathic-infertility-a-review-on-early-life-exposures-and-adult-diagnosis
#3
Erin P Madeen, David E Williams
The male reproductive system is acutely and uniquely sensitive to a variety of toxicities, including those induced by environmental pollutants throughout the lifespan. Early life hormonal and morphological development results in several especially sensitive critical windows of toxicity risk associated with lifelong decreased reproductive health and fitness. Male factor infertility can account for over 40% of infertility in couples seeking treatment, and 44% of infertile men are diagnosed with idiopathic male infertility...
December 9, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27935822/adipose-tissue-in-control-of-metabolism
#4
REVIEW
Liping Luo, Meilian Liu
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity...
December 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27935802/perceptions-on-diabetes-care-provision-among-health-providers-in-rural-tanzania-a-qualitative-study
#5
Mary Mwangome, Eveline Geubbels, Paul Klatser, Marjolein Dieleman
Diabetes prevalence in Tanzania was estimated at 9.1% in 2012 among adults aged 24-65 years - higher than the HIV prevalence in the general population at that time. Health systems in lower- and middle-income countries are not designed for chronic health care, yet the rising burden of non-communicable diseases such as diabetes demands chronic care services. To inform policies on diabetes care, we conducted a study on the health services in place to diagnose, treat and care for diabetes patients in rural Tanzania...
October 22, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27935799/strengthening-health-information-systems-for-disability-related-rehabilitation-in-lmics
#6
Anna McPherson, Jo Durham, Nicola Richards, Hebe Gouda, Rasika Rampatige, Maxine Whittaker
The purpose of this study was to describe the state of rehabilitation health information systems (HIS) in different settings, and identify key processes and actions which contribute to the development of HIS which can effectively support low- and middle-income countries (LMICs) allocate resources to health-related rehabilitation to people with disabilities. Nine case studies were conducted across different disability and developmental settings using documentary review and semi-structured key informant interviews (N = 41)...
October 10, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27935773/lung-protective-ventilation
#7
Rex A Marley, Kaycee Simon
Historically, mechanical ventilation of the lungs utilizing relatively large tidal volumes was common practice in the operating room and intensive care unit (ICU). The rationale behind this treatment strategy was to yield better patient outcomes, that is, fewer pulmonary complications, and a reduction in morbidity and mortality. As evidence-based practice has evolved, potential harmful effects of traditional, nonphysiological mechanical ventilation (ventilation with larger tidal volumes and the tolerance of high airway pressures) even in shortterm treatment have been shown to correlate with systemic inflammation and the development of ventilator-associated lung injury...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935772/anesthetic-implications-of-obesity-and-obstructive-sleep-apnea
#8
Jennifer Greenwood
The incidence of morbid obesity has tripled within the past 25 years in developed countries, with the highest rate of growth noted among people with body mass index (BMI) greater than 50. The physiologic derangements that accompany obesity affect almost every organ system leading to a vast array of comorbid conditions including obstructive sleep apnea (OSA). This review focuses on the unique perioperative management considerations that the nurse anesthetist must address when caring for these patients as well as the impact of obesity and OSA on postoperative complications and mortality rates...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935742/risk-factors-for-premenstrual-asthma-a-systematic-review-and-meta-analysis
#9
J L Sanchez, A Pereira-Vega, F Alvarado-Gómez, J A Maldonado, C Svanes, F Real
Asthma in women can deteriorate in specific phases during the menstrual cycle. Deterioration in the premenstrual phase (increase in symptoms or deterioration in peak flow measurements) is known as premenstrual asthma. The etiology remains mostly unknown. Areas covered: This paper systematically reviews risk factors for premenstrual asthma. Medline, Embase, CINAHL, Scopus, Web of Science, LILACS and secondary sources were searched. The selection criteria were met by 20 articles. Expert commentary: Women with pre-menstrual asthma are older, have more severe asthma, a higher body-mass index, a longer duration of asthma and a greater likelihood of aspirin sensitive asthma...
December 9, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27935741/barriers-to-evidence-based-physician-decision-making-at-the-point-of-care-a-narrative-literature-review
#10
Kara Contreary, Anna Collins, Eugene C Rich
We conduct a narrative literature review using four real-world cases of clinical decisions to show how barriers to the use of evidence-based medicine affect physician decision-making at the point of care, and where adjustments could be made in the healthcare system to address these barriers. Our four cases constitute decisions typical of the types physicians make on a regular basis: diagnostic testing, initial treatment and treatment monitoring. To shed light on opportunities to improve patient care while reducing costs, we focus on barriers that could be addressed through changes to policy and/or practice at a particular level of the healthcare system...
December 9, 2016: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/27935611/insight-into-the-interactions-between-nanoparticles-and-cells
#11
REVIEW
Jingchao Li, Hongli Mao, Naoki Kawazoe, Guoping Chen
Multifunctional nanoparticles (NPs) have been widely used in biomedical applications because of their versatile properties. The properties of NPs should be well designed and controlled according to various applications because they may directly affect the functions and performances of NPs in biological systems. Cellular uptake is a prerequisite for the success of NP-based biomedical applications. However, the internalized NPs inside cells may have some adverse effects. Therefore, the interactions between NPs and cells should be thoroughly investigated and elucidated...
December 9, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27935600/pseudodacryocystitis-paediatric-case-series-of-infected-atypical-ethmoid-air-cells-masquerading-as-recurrent-dacryocystitis
#12
A Mohite, T Jenyon, B Manoj, S Sandramouli, K Foster, A Oates, A-L McDermott, M V Parulekar
PurposeTo highlight the clinical and surgical considerations in treating patients with apparent recurrent acute dacryocystitis with a patent lacrimal system.MethodsThree children referred to a tertiary unit as recurrent acute dacryocystitis were reviewed retrospectively. Imaging and subsequent surgical intervention revealed the underlying diagnosis.ResultsAll three cases presented with recurrent abscesses in the region of the lacrimal sac that failed to respond to incision and drainage. The lesions were lower and more lateral to the usual location of a sac abscess and closer to the inferior orbital rim...
December 9, 2016: Eye
https://www.readbyqxmd.com/read/27935438/assessing-proprioception-in-children-a-review
#13
Virginia Way Tong Chu
Proprioception is the subconscious and conscious awareness of the spatial and mechanical status of the musculoskeletal framework. When working with children with motor delays and sensory integrative dysfunction, occupational therapists routinely assess the client's proprioceptive system. However, currently available assessments for occupational therapists are primarily observer-based and concerns have been raised about the reliability of observer-based assessments of sensation. The author's purpose was to review measures of proprioception currently available to occupational therapists and explore direct measures of proprioception from neuroscience and rehabilitation that can be adapted for pediatric clinical use...
December 9, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27935123/efficacy-and-safety-of-nucleoside-antiviral-drugs-for-treatment-of-recurrent-herpes-labialis-a-systematic-review-and-meta-analysis
#14
REVIEW
Fangman Chen, Hao Xu, Jinli Liu, Yuan Cui, Xiaobo Luo, Yu Zhou, Qianming Chen, Lu Jiang
OBJECTIVES: To evaluate the effectiveness and safety of nucleoside antiviral drugs for the treatment of recurrent herpes labialis. METHODS: Randomized controlled trials that examined the effectiveness and/or safety of nucleoside antiviral drugs for recurrent herpes labialis were identified via a literature search. The parameters used to measure efficacy were time-to-healing of classic and all lesions, time-to-resolution of pain, and percentage of aborted lesions...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27935057/crosstalk-among-uv-induced-inflammatory-mediators-dna-damage-and-epigenetic-regulators-facilitates-suppression-of-the-immune-system
#15
Ram Prasad, Santosh K Katiyar
The suppression of the immune system by overexposure to ultraviolet (UV) radiation has been implicated in the initiation and progression of photocarcinogenesis. Numerous changes occur in the skin on UVB exposure, including the generation of inflammatory mediators, DNA damage, epigenetic modifications, and migration and functional alterations in the antigen-presenting dendritic cells. Although each of these alterations can elicit a cascade of events that have the potential to modulate immune sensitivity alone, there is emerging evidence that there is considerable crosstalk between these cascades...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27935049/engineering-chloroplasts-to-improve-rubisco-catalysis-prospects-for-translating-improvements-into-food-and-fiber-crops
#16
REVIEW
Robert E Sharwood
I. II. III. IV. V. VI. VII. VIII. IX. X. References SUMMARY: The uncertainty of future climate change is placing pressure on cropping systems to continue to provide stable increases in productive yields. To mitigate future climates and the increasing threats against global food security, new solutions to manipulate photosynthesis are required. This review explores the current efforts available to improve carbon assimilation within plant chloroplasts by engineering Rubisco, which catalyzes the rate-limiting step of CO2 fixation...
December 9, 2016: New Phytologist
https://www.readbyqxmd.com/read/27934842/infections-related-to-granulicatella-adiacens-report-of-two-cases-and-review-of-literature
#17
S Macin, A Ç İnkaya, Ö Tuncer, S Ünal, Y Akyön
Infections due to nutritionally variant streptococci are diagnosed rarely due to difficulties encountered during identification and isolation. Mortality rate in these infections is high therefore appropriate supplemented media and reliable detection systems should be implemented to isolate these fastidious organisms. Here, we describe two cases of Granulicatella adiacens infections. All microbiologic identifications were made with MALDI-TOF Vitek MS (BioMerieux, France), and the results confirmed by 16S ribotyping...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27934817/exploring-the-hidden-potential-of-fosfomycin-for-the-fight-against-severe-gram-negative-infections
#18
REVIEW
P V Saiprasad, K Krishnaprasad
Gram-negative resistance is a serious global crisis putting the world on the cusp of 'pre-antibiotic era'. This serious crisis has been catalysed by the rapid increase in carbapenem-resistant Enterobacteriaceae (CRE). Spurge in colistin usage to combat CRE infections leads to the reports of (colistin and carbapenem resistant enterobacteriaceae) CCRE (resistance to colistin in isolates of CRE) infections further jeopardising our last defence. The antibacterial apocalypse imposed by global resistance crisis requires urgent alternative therapeutic options...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27934796/plga-loaded-nanomedicines-in-melanoma-treatment-future-prospect-for-efficient-drug-delivery
#19
REVIEW
Sreemanti Das, Anisur Rahman Khuda-Bukhsh
Current treatment methods for melanoma have some limitations such as less target-specific action, severe side effects and resistance to drugs. Significant progress has been made in exploring novel drug delivery systems based on suitable biochemical mechanisms using nanoparticles ranging from 10 to 400 nm for drug delivery and imaging, utilizing their enhanced penetration and retention properties. Poly-lactide-co-glycolide (PLGA), a copolymer of poly-lactic acid and poly-glycolic acid, provides an ideally suited performance-based design for better penetration into skin cells, thereby having a greater potential for the treatment of melanoma...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934651/a-perspective-on-the-safety-of-supplemental-tryptophan-based-on-its-metabolic-fates
#20
REVIEW
John D Fernstrom
Over the past 50 y, tryptophan has been ingested in amounts well in excess of its dietary requirement. This use is based on extensive findings that ingesting tryptophan increases brain tryptophan concentrations, which stimulates the synthesis and release of the neurotransmitter serotonin, from which it is derived. Such increases in serotonin function may improve mood and sleep. However, tryptophan ingestion has other effects, such as increasing serotonin production in the gut, increasing serotonin concentrations in blood, stimulating the production of the hormone melatonin (a tryptophan metabolite), stimulating tryptophan metabolism via the kynurenine pathway, and possibly stimulating the production of tryptophan metabolites in the gut microbiome...
December 2016: Journal of Nutrition
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