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https://www.readbyqxmd.com/read/27895416/practice-guidelines-for-the-pathological-diagnosis-of-primary-liver-cancer-2015-update
#1
REVIEW
Wen-Ming Cong, Hong Bu, Jie Chen, Hui Dong, Yu-Yao Zhu, Long-Hai Feng, Jun Chen, Guideline Committee
In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies (including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma (SHCC), microvascular invasion (MVI), satellite nodules, and immunohistochemical and molecular diagnosis...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27890752/delayed-development-of-aneurysms-following-gamma-knife-surgery-for-trigeminal-neuralgia-report-of-2-cases
#2
Hiroki Uchikawa, Toru Nishi, Yasuyuki Kaku, Tomoaki Goto, Jun-Ichi Kuratsu, Shigetoshi Yano
BACKGROUND: Delayed development of intracranial aneurysms is an extremely rare complication of gamma knife surgery (GKS), and so far only 6 cases have been reported. Furthermore, there are no reported cases after GKS for trigeminal neuralgia (TN). Of the above cases, none referred to the natural history or pathophysiology of GKS-related intracranial aneurysm formation. CASE DESCRIPTION: We treated 2 patients who suffered subarachnoid hemorrhage (SAH) due to ruptures of intracranial aneurysms that developed long after GKS...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27871294/newly-designed-retentive-posts-of-mandibular-reconstruction-plate-in-oral-cancer-patients-based-on-preliminary-fem-study
#3
Ik Jae Kwon, Mi Young Eo, Sung Jae Park, Soung Min Kim, Jong Ho Lee
BACKGROUND: The reconstruction of a large mandibular defect poses a challenging issue in oral cancer ablation surgery. One popular option for mandibular continuity reconstruction after tumor resection involves the use of a reconstruction plate (R-plate), which maintains space and contour without bone harvesting. An R-plate, however, cannot provide final functional loading rehabilitation with implants or dentures. METHODS: We suggest a new method of functional mandibular reconstruction using retentive posts and an upper prosthesis...
November 21, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27858701/contrast-enhanced-ultrasonography-as-a-new-method-for-assessing-autonomization-of-pedicle-and-microvascular-free-flaps-in-head-and-neck-reconstructive-surgery
#4
Steffen Mueller, Christina M Wendl, Tobias Ettl, Christoph Klingelhöffer, Sebastian Geis, Lukas Prantl, Torsten E Reichert, Ernst Michael Jung
OBJECTIVE: Evaluating vascular autonomization of pedicle and microvascular free flaps for soft tissue reconstruction in the head and neck area by means of postoperative quantitative measurement of dynamic contrast values obtained with contrast-enhanced ultrasound. METHODS: 8/18 patients underwent lip reconstruction with a pedicle flap, 10 patients reconstruction of other parts of the head with a microvascular free transplant. Ultrasound examinations were within the 1st postoperative week and 4 weeks after surgery...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27857878/magnetic-resonance-imaging-assessment-of-vascular-contact-of-the-facial-nerve-in-the-asymptomatic-patient
#5
Nicholas L Deep, Geoffrey P Fletcher, Kent D Nelson, Ameet C Patel, David M Barrs, Bernard R Bendok, Joseph M Hoxworth
Objective The objective of this study was to determine the prevalence of facial nerve vascular contact on magnetic resonance imaging (MRI) in patients without hemifacial spasm (HFS). Study Design Our radiology database was queried to identify consecutive adult patients without a history of HFS, intracranial tumor, brain radiation therapy, intracranial surgery, traumatic brain injury, or trigeminal nerve vascular compression. One hundred high-resolution MRIs of the posterior fossa were independently reviewed by two neuroradiologists for facial nerve vascular contact (200 sides)...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27854307/mast-cells-density-positive-to-tryptase-correlate-with-microvascular-density-in-both-primary-gastric-cancer-tissue-and-loco-regional-lymph-node-metastases-from-patients-that-have-undergone-radical-surgery
#6
Michele Ammendola, Rosario Sacco, Valeria Zuccalà, Maria Luposella, Rosa Patruno, Pietro Gadaleta, Nicola Zizzo, Cosmo Damiano Gadaleta, Giovambattista De Sarro, Giuseppe Sammarco, Mihai Oltean, Girolamo Ranieri
Mast Cells (MCs) play a role in immune responses and more recently MCs have been involved in tumoral angiogenesis. In particular MCs can release tryptase, a potent in vivo and in vitro pro-angiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosphorylation. MCs can release tryptase following c-Kit receptor activation. Nevertheless, no data are available concerning the relationship among MCs Density Positive to Tryptase (MCDPT) and Microvascular Density (MVD) in both primary gastric cancer tissue and loco-regional lymph node metastases...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27847734/surgical-implications-of-anatomical-variation-in-anterolateral-thigh-flaps-for-the-reconstruction-of-oral-and-maxillofacial-soft-tissue-defects-focus-on-perforators-and-pedicles
#7
Ji-Wan Kim, Dong-Young Kim, Kang-Min Ahn, Jee-Ho Lee
OBJECTIVES: To gain information on anatomical variation in anterolateral thigh (ALT) flaps in a series of clinical cases, with special focus on perforators and pedicles, for potential use in reconstruction of oral and maxillofacial soft tissue defects. MATERIALS AND METHODS: Eight patients who underwent microvascular reconstructive surgery with ALT free flaps after ablative surgery for oral cancer were included. The number of perforators included in cutaneous flaps, location of perforators (septocutaneous or musculocutaneous), and the course of vascular pedicles were intraoperatively investigated...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27847579/a-clinical-analysis-of-secondary-surgery-in-trigeminal-neuralgia-patients-who-failed-prior-treatment
#8
Il Ho Kang, Bong Jin Park, Chang Kyu Park, Hridayesh Pratap Malla, Sung Ho Lee, Bong Arm Rhee
OBJECTIVE: Although many treatment modalities have been introduced for trigeminal neuralgia (TN), the long-term clinical results remain unsatisfactory. It has been particularly challenging to determine an appropriate treatment strategy for patients who have responded poorly to initial therapies. We analyzed the surgical outcomes in TN patients who failed prior treatments. METHODS: We performed a retrospective analysis of 37 patients with recurrent or persistent TN symptoms who underwent surgery at our hospital between January 2010 and December 2014...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27846250/reduced-microvascular-density-in-omental-biopsies-of-children-with-chronic-kidney-disease
#9
Dorothea Burkhardt, Maria Bartosova, Betti Schaefer, Niels Grabe, Bernd Lahrmann, Hamoud Nasser, Christian Freise, Axel Schneider, Anja Lingnau, Petra Degenhardt, Bruno Ranchin, Peter Sallay, Rimante Cerkauskiene, Michal Malina, Gema Ariceta, Claus Peter Schmitt, Uwe Querfeld
BACKGROUND: Endothelial dysfunction is an early manifestation of cardiovascular disease (CVD) and consistently observed in patients with chronic kidney disease (CKD). We hypothesized that CKD is associated with systemic damage to the microcirculation, preceding macrovascular pathology. To assess the degree of "uremic microangiopathy", we have measured microvascular density in biopsies of the omentum of children with CKD. PATIENTS AND METHODS: Omental tissue was collected from 32 healthy children (0-18 years) undergoing elective abdominal surgery and from 23 age-matched cases with stage 5 CKD at the time of catheter insertion for initiation of peritoneal dialysis...
2016: PloS One
https://www.readbyqxmd.com/read/27833295/successful-penile-reconstruction-following-prior-arteriovenous-loop-thrombosis-due-to-undiagnosed-protein-s-deficiency-and-exogenous-testosterone
#10
Parameswaran Anoop, Vithal Malmande, M N Prakash Kumar, Naveen Rao
Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein-S deficiency in addition to long-term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti-coagulation in such situations are described here...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27832991/evaluating-transient-hemifacial-spasm-that-reappears-after-microvascular-decompression-specifically-focusing-on-the-real-culprit-location-of-vascular-compression
#11
Hee Sup Shin, Seung Hwan Lee, Hak Cheol Ko, Jun Seok Koh
Even though microvascular decompression (MVD) is the standard treatment for hemifacial spasm (HFS), the treatment is not always 100% successful. Some patients experience the reappearance of HFS following temporary relief after surgery. We analyzed our data to elucidate the reasons for, and prognosis in, HFS reappearance, specifically focusing on exact compressive location of facial nerve. The patients were divided into 2 groups: group A, the patients whose symptoms of spasm disappeared immediately after surgery but recurred within a month, and group B, the patients whose symptoms of spasm completely disappeared and never recurred...
November 7, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27826336/the-association-between-whole-blood-viscosity-and-coronary-collateral-circulation-in-patients-with-chronic-total-occlusion
#12
Mehmet Serkan Cetin, Elif Hande Ozcan Cetin, Kevser Gülcihan Balcı, Selahattin Aydin, Emek Ediboglu, Muhammed Fatih Bayraktar, Mustafa Mücahit Balcı, Orhan Maden, Ahmet Temizhan, Sinan Aydogdu
BACKGROUND AND OBJECTIVES: Coronary collateral circulation (CCC) has been attributed as inborn bypass mechanisms supporting ischemic myocardium. Various factors have been postulated in CCC. Whole blood viscosity (WBV) has been an underappreciated entity despite close relationships between multiple cardiovascular diseases. WBV can be calculated with a validated equation from hematocrit and total plasma protein levels for a low and high shear rate. On the grounds, we aimed to evaluate the association between WBV and CCC in patients with chronic total occlusion...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27817008/trigeminal-neuralgia-due-to-venous-neurovascular-conflicts-outcome-after-microvascular-decompression-in-a-series-of-55-consecutive-patients
#13
Chloe Dumot, Andrei Brinzeu, Julien Berthiller, Marc Sindou
BACKGROUND: Implication of veins as neurovascular conflict (NVC) in the genesis of trigeminal neuralgia (TN) remains a matter of debate. Few reports dealing with venous NVC have been published. The objective of this study is to describe the outcome in a historical cohort of consecutive patients with classical TN due to venous compression. METHODS: All patients with TN treated by microvascular decompression (MVD) from 2005 to 2013 were included if a marked venous compression was found at the surgery either alone or accompanied by an artery...
November 5, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27817006/failed-microvascular-decompression-surgery-for-hemifacial-spasm-a-retrospective-clinical-study-of-reoperations
#14
Chengrong Jiang, Wu Xu, Yuxiang Dai, Tianyu Lu, Wei Jin, Weibang Liang
BACKGROUND: To investigate the repeat microvascular decompression on hemifacial spasm patients who failed the first MVD. METHODS: Twenty-six patients underwent late redo MVD in our institution from January 1, 2011 to December 31, 2015. The clinical features, surgical findings, outcomes, and complications of the repeat MVD were analyzed retrospectively. RESULTS: Twenty-four (92.3 %) patients were cured immediately after the redo MVD. Delayed relief was found in two (7...
November 5, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27810548/immediate-transoral-allogeneic-bone-grafting-for-large-mandibular-defects-less-morbidity-more-bone-a-paradigm-in-benign-tumor-mandibular-reconstruction
#15
James C Melville, Nader N Nassari, Issa A Hanna, Jonathan W Shum, Mark E Wong, Simon Young
PURPOSE: Reconstruction of hard tissue continuity defects caused by ablative tumor surgery has been traditionally reconstructed with autogenous bone grafts or microvascular free flaps. Although results have been predictable from these 2 methods of reconstruction, the morbidity associated with bone harvest is quite serious for the patient. Predictable results have been obtained with using a combination of 100% cadaver bone, bone marrow aspirate concentrate (BMAC), and recombinant human bone morphogenic protein in immediate reconstruction for benign tumor extirpations through the extraoral approach...
October 6, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27810163/surgical-site-infection-in-clean-contaminated-wounds-after-multimodal-treatment-of-advanced-oral-squamous-cell-carcinoma
#16
Christina Eder-Czembirek, Cornelia Czembirek, Pamela Braun, Christos Perisanidis, Rudolf Seemann
OBJECTIVES: The aim of this study was to assess the incidence rate for surgical site infections (SSI), patient- and therapy-related risk factors in UICC stage III and IV oral squamous cell carcinoma patients treated with preoperative radiochemotherapy, ablative surgery and immediate microvascular free flap reconstruction. MATERIAL AND METHODS: This retrospective analysis included 85 patients with oral squamous cell carcinoma treated by neoadjuvant radiochemotherapy, tumor surgery and immediate free flap reconstruction...
September 29, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27801401/-perfusion-criteria-of-the-eicma-efficacy-in-patients-with-symptomatic-occlusion-of-the-internal-carotid-artery
#17
V A Lukshin, D Yu Usachev, I N Pronin, A D Akhmedov, E I Shul'ts
AIM: To investigate changes in cerebral perfusion in patients with unilateral internal carotid artery occlusion before and after surgical revascularization of the brain, depending on the clinical efficacy of surgical treatment. MATERIAL AND METHODS: The study included 60 patients with unilateral ICA occlusions who underwent placement of an extra-intracranial microvascular anastomosis (EICMA). All patients underwent a CT perfusion study before and after cerebral revascularization...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/27783168/what-range-of-stimulus-intensities-should-we-apply-to-elicit-abnormal-muscle-response-in-microvascular-decompression-for-hemifacial-spasm
#18
Ge Jia, Li Zhang, Hongxiang Ren, Jun Xu, Xiaoli Xu, Yanbing Yu
BACKGROUND: Abnormal muscle response (AMR) has been considered as a predictor of the prognosis after microvascular decompression (MVD) for hemifacial spasm (HFS). However, its predictive value has not always been satisfactory. The objective of this work was to confirm an optimal range of stimulus intensities to elicit AMR in surgery. METHODS: Seventy-two consecutive patients with primary HFS treated by MVD were retrospectively included in this study. A wide range of stimulus intensities from 1 to 100 mA was applied in AMR monitoring...
October 25, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27778375/mycophenolate-mofetil-improves-renal-hemodynamics-microvascular-oxygenation-and-inflammation-in-a-rat-model-of-supra-renal-aortic-clamping-mediated-renal-ischemia-reperfusion-injury
#19
Bulent Ergin, Michal Heger, Asli Kandil, Cihan Demirci-Tansel, Can Ince
Ischemia/reperfusion (I/R) is one of the main causes of acute kidney injury (AKI), which is characterized by sterile inflammation and oxidative stress. Immune cell activation can provoke overproduction of inflammatory mediators and reactive oxygen species (ROS), leading to perturbation of the microcirculation and tissue oxygenation associated with local and remote tissue injury. This study investigated whether the clinically employed immunosuppressant mycophenolate mofetil (MMF) was able to reduce I/R-induced renal oxygenation defects and oxidative stress by preventing sterile inflammation...
October 25, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27771041/one-versus-two-venous-anastomoses-in-microvascular-lower-extremity-reconstruction-using-gracilis-muscle-or-anterolateral-thigh-flaps
#20
Paul I Heidekrueger, Denis Ehrl, Albrecht Heine-Geldern, Milomir Ninkovic, P Niclas Broer
INTRODUCTION: Free tissue transfers are a highly reliable procedure routinely performed for reconstruction of a wide range of defects. Main complication in free flap surgery is usually venous thrombosis. Many technical controversies exist regarding the technical details of the microvascular anastomosis in order to prevent occurrence of thrombosis and optimize outcomes. We therefore evaluated our results regarding the execution of one versus two venous anastomoses in a variety of free flaps (fasciocutaneous- or muscle free flap) utilized for lower limb reconstruction...
December 2016: Injury
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